AC T18378
XX
ID T18378
XX
DT 19.01.2006 (created); jma.
DT 05.11.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA CBP
XX
SY CBP; CREB binding protein; CREB binding protein (Rubinstein-Taybi syndrome); CREB-binding protein; CREBBP; KAT3A; RSTS; RTS.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004619 CREBBP; HGNC: CREBBP.
XX
CP NS2T2A1, S2T2, S1T3 [23]; tBHQ-treated HepG2/GFP-B [1].
XX
IN T01067 AML1; human, Homo sapiens.
IN T08796 ASC-2; human, Homo sapiens.
IN T10136 ATF-2; human, Homo sapiens.
IN T02872 beta-catenin; human, Homo sapiens.
IN T04074 brca1; human, Homo sapiens.
IN T15204 brca1; Mammalia.
IN T00133 c-Jun; human, Homo sapiens.
IN T09998 c-Myc; human, Homo sapiens.
IN T04891 CLOCK; human, Homo sapiens.
IN T01112 COE1-long; mouse, Mus musculus.
IN T08562 CREB1; human, Homo sapiens.
IN T19664 CREB1{pS133}; human, Homo sapiens.
IN T09585 CREM; human, Homo sapiens.
IN T02944 Daxx; human, Homo sapiens.
IN T15605 E2A; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T09637 ER-alpha; Mammalia.
IN T10390 FKLF-isoform1; human, Homo sapiens.
IN T02936 FOXO1A; human, Homo sapiens.
IN T10353 FOXO1A; human, Homo sapiens.
IN T10059 GCMa; human, Homo sapiens.
IN T01732 HOXB6; human, Homo sapiens.
IN T06376 ING1; human, Homo sapiens.
IN T25685 ING1a; human, Homo sapiens.
IN T06375 ING1b; human, Homo sapiens.
IN T27548 IRF-3; human, Homo sapiens.
IN T05110 Ku70; human, Homo sapiens.
IN T05056 Max; human, Homo sapiens.
IN T33892 MTA-1; Mammalia.
IN T05299 NR1B1; human, Homo sapiens.
IN T08469 Nrf2; mouse, Mus musculus.
IN T21984 p300; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T08711 RelA-p65; human, Homo sapiens.
IN T10783 Smad1; Mammalia.
IN T24830 Smad2; Mammalia.
IN T00759 Sp1; human, Homo sapiens.
IN T19539 ZASC1; human, Homo sapiens.
IN T16107 zbtb2; human, Homo sapiens.
XX
BS R72633.
BS R72638.
BS R72642.
BS R72647.
XX
DR TRANSPATH: MO000057745.
DR UniProtKB: Q92793;
XX
RN [1]; RE0017305.
RX PUBMED: 11708801.
RA Zhu M., Fahl W. E.
RT Functional characterization of transcription regulators that interact with the electrophile response element
RL Biochem. Biophys. Res. Commun. 289:212-219 (2001).
RN [2]; RE0029643.
RX PUBMED: 12015309.
RA Vieyra D., Loewith R., Scott M., Bonnefin P., Boisvert F. M., Cheema P., Pastyryeva S., Meijer M., Johnston R. N., Bazett-Jones D. P., McMahon S., Cole M. D., Young D., Riabowol K.
RT Human ING1 proteins differentially regulate histone acetylation.
RL J. Biol. Chem. 277:29832-9 (2002).
RN [3]; RE0030381.
RX PUBMED: 13678586.
RA Marambaud P., Wen P. H., Dutt A., Shioi J., Takashima A., Siman R., Robakis N. K.
RT A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations.
RL Cell 114:635-45 (2003).
RN [4]; RE0033289.
RX PUBMED: 15220471.
RA Daitoku H., Hatta M., Matsuzaki H., Aratani S., Ohshima T., Miyagishi M., Nakajima T., Fukamizu A.
RT Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 101:10042-7 (2004).
RN [5]; RE0033324.
RX PUBMED: 14976190.
RA Catley M. C., Cambridge L. M., Nasuhara Y., Ito K., Chivers J. E., Beaton A., Holden N. S., Bergmann M. W., Barnes P. J., Newton R.
RT Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding.
RL J. Biol. Chem. 279:18457-66 (2004).
RN [6]; RE0035781.
RX PUBMED: 15929978.
RA Fang X., Stachowiak E. K., Dunham-Ems S. M., Klejbor I., Stachowiak M. K.
RT Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation.
RL J. Biol. Chem. 280:28451-28462 (2005).
RN [7]; RE0039427.
RX PUBMED: 9606182.
RA Kitabayashi I., Yokoyama A., Shimizu K., Ohki M.
RT Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
RL EMBO J. 17:2994-3004 (1998).
RN [8]; RE0042428.
RX PUBMED: 11799127.
RA Emelyanov A. V., Kovac C. R., Sepulveda M. A., Birshtein B. K.
RT The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells
RL J. Biol. Chem. 277:11156-64 (2002).
RN [9]; RE0048217.
RX PUBMED: 11971985.
RA Wu R. C., Qin J., Hashimoto Y., Wong J., Xu J., Tsai S. Y., Tsai M. J., O'Malley B. W.
RT Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.
RL Mol. Cell. Biol. 22:3549-3561 (2002).
RN [10]; RE0048220.
RX PUBMED: 12776737.
RA Vervoorts J., Luscher-Firzlaff J. M., Rottmann S., Lilischkis R., Walsemann G., Dohmann K., Austen M., Luscher B.
RT Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.
RL EMBO Rep. 4:484-490 (2003).
RN [11]; RE0048301.
RX PUBMED: 15023334.
RA Cohen H. Y., Lavu S., Bitterman K. J., Hekking B., Imahiyerobo T. A., Miller C., Frye R., Ploegh H., Kessler B. M., Sinclair D. A.
RT Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
RL Mol. Cell 13:627-638 (2004).
RN [12]; RE0048566.
RX PUBMED: 15572696.
RA Foulds C. E., Nelson M. L., Blaszczak A. G., Graves B. J.
RT Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.
RL Mol. Cell. Biol. 24:10954-10964 (2004).
RN [13]; RE0048766.
RX PUBMED: 16287980.
RA Kuo H. Y., Chang C. C., Jeng J. C., Hu H. M., Lin D. Y., Maul G. G., Kwok R. P., Shih H. M.
RT SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.
RL Proc. Natl. Acad. Sci. USA 102:16973-16978 (2005).
RN [14]; RE0048844.
RX PUBMED: 12748286.
RA Zhao F., McCarrick-Walmsley R., Akerblad P., Sigvardsson M., Kadesch T.
RT Inhibition of p300/CBP by early B-cell factor.
RL Mol. Cell. Biol. 23:3837-3846 (2003).
RN [15]; RE0048848.
RX PUBMED: 15269212.
RA Shen W., Chrobak D., Krishnan K., Lawrence H. J., Largman C.
RT HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process.
RL J. Biol. Chem. 279:39895-39904 (2004).
RN [16]; RE0048931.
RX PUBMED: 12435739.
RA Bradney C., Hjelmeland M., Komatsu Y., Yoshida M., Yao T. P., Zhuang Y.
RT Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.
RL J. Biol. Chem. 278:2370-2376 (2003).
RN [17]; RE0049106.
RX PUBMED: 16166624.
RA Chang C. W., Chuang H. C., Yu C., Yao T. P., Chen H.
RT Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa.
RL Mol. Cell. Biol. 25:8401-8414 (2005).
RN [18]; RE0049158.
RX PUBMED: 16319895.
RA Turnell A. S., Stewart G. S., Grand R. J., Rookes S. M., Martin A., Yamano H., Elledge S. J., Gallimore P. H.
RT The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.
RL Nature 438:690-695 (2005).
RN [19]; RE0049228.
RX PUBMED: 9722503.
RA Pouponnot C., Jayaraman L., Massague J.
RT Physical and functional interaction of SMADs and p300/CBP.
RL J. Biol. Chem. 273:22865-22868 (1998).
RN [20]; RE0049637.
RX PUBMED: 16061203.
RA Karetsou Z., Martic G., Sflomos G., Papamarcaki T.
RT The histone chaperone SET/TAF-Ibeta interacts functionally with the CREB-binding protein.
RL Biochem. Biophys. Res. Commun. 335:322-327 (2005).
RN [21]; RE0049641.
RX PUBMED: 15695103.
RA Long A. A., Chapman N. R., Innes B., Europe-Finner G. N., Robson S. C.
RT Expression and interaction of the transcriptional coregulators, CBP/p300, in the human myometrium during pregnancy and labor.
RL J. Soc. Gynecol. Invest. 12:92-97 (2005).
RN [22]; RE0049976.
RX PUBMED: 17434128.
RA Huang W. C., Ju T. K., Hung M. C., Chen C. C.
RT Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
RL Mol. Cell 26:75-87 (2007).
RN [23]; RE0050143.
RX PUBMED: 17321669.
RA Hamzaoui H., Rizk-Rabin M., Gordon J., Offutt C., Bertherat J., Bouizar Z.
RT PTHrP P3 promoter activity in breast cancer cell lines: role of Ets1 and CBP (CREB binding protein).
RL Mol. Cell. Endocrinol. 268:75-84 (2007).
RN [24]; RE0050936.
RX PUBMED: 16417649.
RA Crowe D. L., Lee M. K.
RT New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines.
RL Breast Cancer Res. 8:R1 (2006).
RN [25]; RE0052325.
RX PUBMED: 17313370.
RA Zhang J., Hosoya T., Maruyama A., Nishikawa K., Maher J. M., Ohta T., Motohashi H., Fukamizu A., Shibahara S., Itoh K., Yamamoto M.
RT Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.
RL Biochem. J. 404:459-466 (2007).
RN [26]; RE0053001.
RX PUBMED: 11481323.
RA Vadlamudi R. K., Wang R. A., Mazumdar A., Kim Y., Shin J., Sahin A., Kumar R.
RT Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha.
RL J. Biol. Chem. 276:38272-38279 (2001).
RN [27]; RE0053061.
RX PUBMED: 17296604.
RA Johnson J., Albarani V., Nguyen M., Goldman M., Willems F., Aksoy E.
RT Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.
RL J. Biol. Chem. 282:15022-15032 (2007).
RN [28]; RE0053870.
RX PUBMED: 17923090.
RA Tang X., Gao J. S., Guan Y. J., McLane K. E., Yuan Z. L., Ramratnam B., Chin Y. E.
RT Acetylation-dependent signal transduction for type I interferon receptor.
RL Cell 131:93-105 (2007).
RN [29]; RE0054060.
RX PUBMED: 12789342.
RA Yamamoto Y., Verma U. N., Prajapati S., Kwak Y. T., Gaynor R. B.
RT Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.
RL Nature 423:655-659 (2003).
RN [30]; RE0054653.
RX PUBMED: 10490106.
RA Chen H., Lin R. J., Xie W., Wilpitz D., Evans R. M.
RT Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.
RL Cell 98:675-686 (1999).
RN [31]; RE0055057.
RX PUBMED: 15502848.
RA Sarkar S. N., Peters K. L., Elco C. P., Sakamoto S., Pal S., Sen G. C.
RT Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling.
RL Nat. Struct. Mol. Biol. 11:1060-1067 (2004).
RN [32]; RE0056060.
RX PUBMED: 17038621.
RA Huang H., Regan K. M., Lou Z., Chen J., Tindall D. J.
RT CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.
RL Science 314:294-297 (2006).
RN [33]; RE0065817.
RX PUBMED: 17932106.
RA Nettles K. W., Gil G., Nowak J., Metivier R., Sharma V. B., Greene G. L.
RT CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.
RL Mol. Endocrinol. 22:263-272 (2008).
RN [34]; RE0071171.
RX PUBMED: 16007092.
RA Martin M., Rehani K., Jope R. S., Michalek S. M.
RT Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.
RL Nat. Immunol. 6:777-784 (2005).
XX
//