TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02944 XX ID T02944 XX DT 04.02.2000 (created); rio. DT 29.04.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA Daxx XX SY BING2; DAP6; death-associated protein 6; hDaxx. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003519 DAXX; HGNC: DAXX. XX SF interaction with Pax-3 and Pax-3-FKHR within the serine-/proline/threonine-rich C-terminus [1]; SF interacts with p53 family members, p53 T00671, p63alpha T06132 and p73alpha T04931 [3]; XX FF interaction with Pax3 represses the transcriptional activity of Pax-3 but not of Pax-3-FKHR (probably the same for Pax-7) [1]; FF sensitizes cells to p53-dependent cell death [3]; FF concluded to be able to differentially modulate p53-responsive genes [3]; XX IN T00040 AR; human, Homo sapiens. IN T08495 c-Ets-1; human, Homo sapiens. IN T00112 c-Ets-1A; human, Homo sapiens. IN T18378 CBP; human, Homo sapiens. IN T02944 Daxx; human, Homo sapiens. IN T22413 DMAP1; human, Homo sapiens. IN T04106 HDAC1; human, Homo sapiens. IN T01042 HSF1-L; human, Homo sapiens. IN T04465 JIP1; human, Homo sapiens. IN T04687 NCOR1; human, Homo sapiens. IN T00671 p53; human, Homo sapiens. IN T06132 p63-isoform1; human, Homo sapiens. IN T06135 p63-isoform5; human, Homo sapiens. IN T04931 p73alpha; human, Homo sapiens. IN T06137 p73beta; human, Homo sapiens. IN T00679 Pax-3; human, Homo sapiens. IN T10279 Pax-3; Mammalia. IN T00396 Pax-7-long; human, Homo sapiens. IN T30717 Pax-7; Mammalia. IN T06377 PML; human, Homo sapiens. IN T27182 rad54; human, Homo sapiens. IN T04292 Smad4; human, Homo sapiens. IN T16010 TCF-4; Mammalia. XX DR TRANSPATH: MO000020269. DR UniProtKB: Q9UER7; XX RN [1]; RE0014042. RX PUBMED: 10393185. RA Hollenbach A. D., Sublett J. E., McPherson C. J., Grosveld G. RT The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx RL EMBO J. 18:3702-3711 (1999). RN [2]; RE0034501. RX PUBMED: 14505347. RA Song J. J., Lee Y. J. RT Catalase, but not MnSOD, inhibits glucose deprivation-activated ASK1-MEK-MAPK signal transduction pathway and prevents relocalization of Daxx: hydrogen peroxide as a major second messenger of metabolic oxidative stress. RL J. Cell. Biochem. 90:304-14 (2003). RN [3]; RE0035196. RX PUBMED: 15339933. RA Gostissa M., Morelli M., Mantovani F., Guida E., Piazza S., Collavin L., Brancolini C., Schneider C., Del Sal G. RT The transcriptional repressor hDaxx potentiates p53-dependent apoptosis. RL J. Biol. Chem. 279:48013-48023 (2004). RN [4]; RE0035890. RX PUBMED: 14637155. RA Kim Y. Y., Park B. J., Seo G. J., Lim J. Y., Lee S. M., Kimm K. C., Park C., Kim J., Park S. I. RT Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation. RL Biochem. Biophys. Res. Commun. 312:426-433 (2003). RN [5]; RE0042428. RX PUBMED: 11799127. RA Emelyanov A. V., Kovac C. R., Sepulveda M. A., Birshtein B. K. RT The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells RL J. Biol. Chem. 277:11156-64 (2002). RN [6]; RE0047936. RX PUBMED: 10669754. RA Li H., Leo C., Zhu J., Wu X., O'Neil J., Park E. J., Chen J. D. RT Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. RL Mol. Cell. Biol. 20:1784-1796 (2000). RN [7]; RE0048258. RX PUBMED: 12743594. RA Pei H., Yordy J. S., Leng Q., Zhao Q., Watson D. K., Li R. RT EAPII interacts with ETS1 and modulates its transcriptional function. RL Oncogene 22:2699-2709 (2003). RN [8]; RE0048539. RX PUBMED: 15572661. RA Lin D. Y., Fang H. I., Ma A. H., Huang Y. S., Pu Y. S., Jenster G., Kung H. J., Shih H. M. RT Negative modulation of androgen receptor transcriptional activity by Daxx. RL Mol. Cell. Biol. 24:10529-10541 (2004). RN [9]; RE0048834. RX PUBMED: 15016915. RA Boellmann F., Guettouche T., Guo Y., Fenna M., Mnayer L., Voellmy R. RT DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. RL Proc. Natl. Acad. Sci. USA 101:4100-4105 (2004). RN [10]; RE0048880. RX PUBMED: 12529400. RA Ecsedy J. A., Michaelson J. S., Leder P. RT Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. RL Mol. Cell. Biol. 23:950-960 (2003). RN [11]; RE0050232. RX PUBMED: 16524876. RA Kwon J. E., La M., Oh K. H., Oh Y. M., Kim G. R., Seol J. H., Baek S. H., Chiba T., Tanaka K., Bang O. S., Joe C. O., Chung C. H. RT BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. RL J. Biol. Chem. 281:12664-12672 (2006). RN [12]; RE0050471. RX PUBMED: 17210684. RA Li Q., Wang X., Wu X., Rui Y., Liu W., Wang J., Wang X., Liou Y. C., Ye Z., Lin S. C. RT Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death. RL Cancer Res. 67:66-74 (2007). RN [13]; RE0050491. RX PUBMED: 16569639. RA Tzeng S. L., Cheng Y. W., Li C. H., Lin Y. S., Hsu H. C., Kang J. J. RT Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells. RL J. Biol. Chem. 281:15405-15411 (2006). RN [14]; RE0050504. RX PUBMED: 16845383. RA Tang J., Qu L. K., Zhang J., Wang W., Michaelson J. S., Degenhardt Y. Y., El-Deiry W. S., Yang X. RT Critical role for Daxx in regulating Mdm2. RL Nat. Cell Biol. 8:855-862 (2006). RN [15]; RE0050611. RX PUBMED: 10698492. RA Li R., Pei H., Watson D. K., Papas T. S. RT EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. RL Oncogene 19:745-753 (2000). RN [16]; RE0050614. RX PUBMED: 16810318. RA Kitagawa D., Kajiho H., Negishi T., Ura S., Watanabe T., Wada T., Ichijo H., Katada T., Nishina H. RT Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. RL EMBO J. 25:3286-3297 (2006). RN [17]; RE0065251. RX PUBMED: 18566590. RA Song M. S., Song S. J., Kim S. Y., Oh H. J., Lim D. S. RT The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. RL EMBO J. 27:1863-1874 (2008). XX //