TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00040 XX ID T00040 XX DT 25.01.1993 (created); hse. DT 19.10.2016 (updated); mkl. CO Copyright (C), QIAGEN. XX FA AR XX SY AIS; androgen receptor; androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease); AR; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; KD, Kennedy disease; NR3C4; RP11-383C12.1; SBMA; SMAX1; spinal and bulbar muscular atrophy; testicular feminization; TFM. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004953 AR; HGNC: AR. XX CL C0002; CC (rec); XX SF androgen exposure required for dimerization and subsequent DNA-binding; SF dimerization is inhibited by region A/B [6]; SF nuclear uptake may occur constitutively [8]; SF nuclear uptake may be hormone-dependent [9] [10]; SF there may be tissue-specific splice variants [11]; XX EX liver,,,adult; detectable; Northern blot; mRNA (poly-A); [7]. EX prepuce of penis,fibroblast,,adult; detectable; Northern blot; mRNA (poly-A); [7]. XX FF LY294002 treatment increases the protein expression in LNCaP cells [86]; FF by binding to androgen-responsive elements, AR regulates expression of target genes [6] [1]; XX IN T00040 AR; human, Homo sapiens. IN T09553 ATF-3; human, Homo sapiens. IN T22424 BAF57; human, Homo sapiens. IN T00105 C/EBPalpha; human, Homo sapiens. IN T02776 DAX1; human, Homo sapiens. IN T02944 Daxx; human, Homo sapiens. IN T33762 DRIP205; human, Homo sapiens. IN T00241 Egr-1; human, Homo sapiens. IN T00250 Elk-1; human, Homo sapiens. IN T08230 ER81; human, Homo sapiens. IN T02936 FOXO1A; human, Homo sapiens. IN T04106 HDAC1; human, Homo sapiens. IN T06042 HDAC4; human, Homo sapiens. IN T05085 Hey1; human, Homo sapiens. IN T23099 Hey1; Mammalia. IN T02512 HNF-3alpha; human, Homo sapiens. IN T09317 HOXB13; human, Homo sapiens. IN T00992 Hsp90; human, Homo sapiens. IN T05110 Ku70; human, Homo sapiens. IN T18783 MRF1; human, Homo sapiens. IN T04687 NCOR1; human, Homo sapiens. IN T23091 p300; Mammalia. IN T14055 PARP; human, Homo sapiens. IN T02336 PLZF; human, Homo sapiens. IN T14288 PLZF; Mammalia. IN T32689 RAI17; human, Homo sapiens. IN T29717 SIRT1; human, Homo sapiens. IN T08728 SKIP; human, Homo sapiens. IN T04689 SMRT; human, Homo sapiens. IN T04632 SRC-1; human, Homo sapiens. IN T04640 SRC3; human, Homo sapiens. IN T14063 SRF; Mammalia. IN T01493 STAT3; human, Homo sapiens. IN T02918 TCF-4; human, Homo sapiens. IN T19335 TIF1a-short; human, Homo sapiens. IN T02482 TIF2; mouse, Mus musculus. IN T02483 TIF2; human, Homo sapiens. IN T08660 YY1; human, Homo sapiens. IN T05150 ZAC-1b; mouse, Mus musculus. XX MX M00481 V$AR_01. MX M00953 V$AR_02. MX M00956 V$AR_03. MX M01201 V$AR_04. MX M07204 V$AR_10. MX M08189 V$AR_11. MX M08907 V$AR_13. MX M08908 V$AR_14_H. MX M00447 V$AR_Q2. MX M00962 V$AR_Q6. MX M01996 V$AR_Q6_01. XX BS R02124. BS R10326. BS R71887. BS R71888. BS R71889. BS R71890. BS R71891. BS R71892. BS R71893. BS R71894. BS R71895. BS R71896. BS R71897. BS R71898. BS R71899. BS R71900. BS R71901. BS R71902. BS R71903. BS R71904. BS R71905. BS R71906. BS R71907. BS R71908. BS R71909. BS R71910. BS R71911. BS R71912. BS R71913. BS R71914. BS R71915. BS R71916. BS R71917. BS R71918. BS R71919. BS R71920. BS R71921. BS R71922. BS R71923. BS R71924. BS R71925. BS R68923. BS R68925. BS R37853. BS R37857. BS R64209. BS R68926. BS R68927. BS R69456. BS R31237. BS R31241. BS R32438. BS R37995. BS R14312. BS R67722. BS R72814. BS R72815. BS R72816. BS R72817. BS R68928. BS R73615. BS R65921. BS R67068. BS R32462. BS R31628. BS R31629. BS R68929. BS R68930. BS R60756. BS R31773. BS R71339. BS R55746. BS R09458. BS R64442. BS R57492. BS R34889. BS R34890. BS R28699. BS R68931. BS R68934. BS R64439. BS R14261. BS R14264. BS R24833. BS R34747. BS R34878. BS R39324. BS R64434. BS R69767. BS R73277. BS R73278. BS R34875. BS R72332. BS R65042. BS R41500. BS R41501. BS R41502. BS R64283. BS R64288. BS R68936. BS R68939. BS R69457. BS R69458. BS R69459. BS R67681. BS R71712. BS R71714. BS R63186. BS R69460. BS R63163. BS R39274. BS R28692. BS R28693. BS R59200. BS R69907. BS R69908. BS R34744. BS R34745. BS R65536. BS R37851. BS R40671. BS R14294. BS R59568. BS R59570. BS R35633. BS R32428. BS R73675. BS R31666. BS R32450. BS R71227. BS R71228. BS R68941. BS R72942. BS R60516. BS R73657. BS R37573. BS R57172. BS R34617. BS R37855. BS R64416. BS R72818. BS R72819. BS R37858. BS R61696. BS R61697. BS R61695. BS R37576. BS R37579. BS R14301. BS R14272. BS R14276. BS R14278. BS R63201. BS R63205. BS R57486. BS R57502. BS R63194. BS R63193. BS R14300. BS R67251. BS R67252. BS R14308. BS R63262. BS R63263. BS R63264. BS R32041. BS R14287. BS R26023. XX DR TRANSPATH: MO000021454. DR UniProtKB: P10275; ANDR_HUMAN. XX RN [1]; RE0001011. RX PUBMED: 1995608. RA de Vos P., Claessens F., Winderickx J., van Dijck P., Celis L., Peeters B., Rombauts W., Heyns W., Verhoeven G. RT Interaction of androgen response elements with the DNA-binding domain of the rat androgen receptor expressed in Escherichia coli RL J. Biol. Chem. 266:3439-3443 (1991). RN [2]; RE0001752. RX PUBMED: 2172797. RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [3]; RE0002368. RX PUBMED: 3174628. RA Chang C., Kokontis J., Liao S. RT Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors RL Proc. Natl. Acad. Sci. USA 85:7211-7215 (1988). RN [4]; RE0002369. RX PUBMED: 2911578. RA Tilley W., Marcelli M., Wilson J. D., McPhaul M. J. RT Characterization and expression of a cDNA encoding the human androgen receptor RL Proc. Natl. Acad. Sci. USA 86:327-331 (1989). RN [5]; RE0002641. RX PUBMED: 3353726. RA Chang C., Kokontis J., Liao S. RT Molecular cloning of human and rat complementary DNA encoding androgen receptors RL Science 240:324-326 (1988). RN [6]; RE0003755. RX PUBMED: 8360187. RA Wong C.-i., Zhou Z.-x., Sar M., Wilson E. M. RT Steroid requirement for androgen receptor dimerization and DNA binding. Modulation by intramolecular interactions between the NH2-terminal and steroid-binding domains RL J. Biol. Chem. 268:19004-19012 (1993). RN [7]; RE0003756. RX PUBMED: 3353727. RA Lubahn D. B., Joseph D. R., Sullivan P. M., Willard H. F., French F. S., Wilson E. M. RT Cloning of the human androgen receptor complementary DNA and localization to the X chromosome RL Science 240:327-330 (1988). RN [8]; RE0003757. RX PUBMED: 1775129. RA Jenster G., van der Korput H. A. G. M., van Vroonhoven C., van der Kwast T. H., Trapman J., Brinkmann A. O. RT Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization RL Mol. 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RT Anti-androgens and mutated receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation RL Biochemistry 31:2393-2399 (1992). RN [13]; RE0003765. RX PUBMED: 1631078. RA Chang C., Wang C., DeLuca H. F., Ross T. K., Shih C.C.-Y. RT Charactirization of human androgen receptor overexpressed in the baculovirus system RL Proc. Natl. Acad. Sci. USA 89:5946-5950 (1992). RN [14]; RE0003768. RX PUBMED: 3377788. RA Trapman J., Klaassen P., Kuiper G. G. J. M., van der Korput J. A. B. M., Faber P. W., van Rooij H. C. J., van Kessel A. G., Voorhorst M. M., Mulder E., Brinkmann A. O. RT Cloning, stucture and expression of a cDNA encoding the human androgen receptor RL Biochem. Biophys. Res. Commun. 153:241-248 (1988). RN [15]; RE0013625. RX PUBMED: 10219237. RA Nuclear Receptors Nomenclature Committee. RT A unified nomenclature system for the nuclear receptor superfamily RL Cell 97:161-163 (1999). RN [16]; RE0013629. RX PUBMED: 3216866. RA Lubahn D. B., Joseph D. R., Sar M., Tan J., Higgs H. N., Larson R. E., French F. S., Wilson E. M. RT The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate RL Mol. Endocrinol. 2:1265-1275 (1988). RN [17]; RE0016449. RX PUBMED: 10428842. RA Hong H., Yang L., Stallcup M. R. RT Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3 RL J. Biol. Chem. 274:22618-22626 (1999). RN [18]; RE0017308. RX PUBMED: 9115274. RA Thenot S., Henriquet C., Rochefort H., Cavailles V. RT Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1 RL J. Biol. Chem. 272:12062-12068 (1997). RN [19]; RE0020843. RX PUBMED: 11032808. RA Migliaccio A., Castoria G., Di Domenico M., de Falco A., Bilancio A., Lombardi M., Barone M. V., Ametrano D., Zannini M. S., Abbondanza C., Auricchio F. RT Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation RL EMBO J. 19:5406-5417 (2000). RN [20]; RE0022712. RX PUBMED: 11404460. RA Lin H. K., Yeh S., Kang H. Y., Chang C. RT Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. RL Proc. Natl. Acad. Sci. USA 98:7200-7205 (2001). RN [21]; RE0024204. RX PUBMED: 9535906. RA Wellington C. L., Ellerby L. M., Hackam A. S., Margolis R. L., Trifiro M. A., Singaraja R., McCutcheon K., Salvesen G. S., Propp S. S., Bromm M., Rowland K. J., Zhang T., Rasper D., Roy S., Thornberry N., Pinsky L., Kakizuka A., Ross C. A., Nicholson D. W., Bredesen D. E., Hayden M. R. RT Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. RL J. Biol. Chem. 273:9158-9167 (1998). RN [22]; RE0025612. RX PUBMED: 9725910. RA Moilanen A. M., Karvonen U., Poukka H., Janne O. A., Palvimo J. J. RT Activation of androgen receptor function by a novel nuclear protein kinase. RL Mol. Biol. Cell 9:2527-43 (1998). RN [23]; RE0025770. RX PUBMED: 12145204. RA Lin H. K., Wang L., Hu Y. C., Altuwaijri S., Chang C. RT Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. RL EMBO J. 21:4037-48 (2002). RN [24]; RE0027318. RX PUBMED: 11121022. RA Poukka H., Karvonen U., Janne O. A., Palvimo J. J. RT Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1) RL Proc. Natl. Acad. Sci. USA 97:14145-50 (2000). RN [25]; RE0027437. RX PUBMED: 10734072. RA Lee D. K., Duan H. O., Chang C. RT From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator. RL J. Biol. Chem. 275:9308-13 (2000). RN [26]; RE0028809. RX PUBMED: 11713275. RA Lee L. F., Guan J., Qiu Y., Kung H. J. RT Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases etk/bmx, SRC, and focal adhesion kinase. RL Mol. Cell. Biol. 21:8385-97 (2001). RN [27]; RE0029309. RX PUBMED: 11971970. RA Fu M., Wang C., Wang J., Zhang X., Sakamaki T., Yeung Y. G., Chang C., Hopp T., Fuqua S. A., Jaffray E., Hay R. T., Palvimo J. J., Janne O. A., Pestell R. G. RT Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. RL Mol. Cell. Biol. 22:3373-88 (2002). RN [28]; RE0029628. RX PUBMED: 11994312. RA Gaughan L., Logan I. R., Cook S., Neal D. E., Robson C. N. RT Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor. RL J. Biol. Chem. 277:25904-13 (2002). RN [29]; RE0029979. RX PUBMED: 12163482. RA Ueda T., Mawji N. R., Bruchovsky N., Sadar M. D. RT Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. RL J. Biol. Chem. 277:38087-94 (2002). RN [30]; RE0029988. RX PUBMED: 12218053. RA Wang Q., Sharma D., Ren Y., Fondell J. D. RT A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. RL J. Biol. Chem. 277:42852-8 (2002). RN [31]; RE0030408. RX PUBMED: 12771131. RA Agoulnik I. U., Krause W. C., Bingman W. E. 3rd, Rahman H. T., Amrikachi M., Ayala G. E., Weigel N. L. RT Repressors of androgen and progesterone receptor action. RL J. Biol. Chem. 278:31136-48 (2003). RN [32]; RE0031300. RX PUBMED: 12177000. RA Nishida T., Yasuda H. RT PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. RL J. Biol. Chem. 277:41311-7 (2002). RN [33]; RE0031743. RX PUBMED: 11792709. RA Yang F., Li X., Sharma M., Sasaki C. Y., Longo D. L., Lim B., Sun Z. RT Linking beta-catenin to androgen-signaling pathway. RL J. Biol. Chem. 277:11336-44 (2002). RN [34]; RE0033835. RX PUBMED: 11747336. RA Gnanapragasam V. J., Leung H. Y., Pulimood A. S., Neal D. E., Robson C. N. RT Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. RL Br. J. Cancer 85:1928-36 (2001). RN [35]; RE0035340. RX PUBMED: 11818501. RA Zhou Z. X., He B., Hall S. H., Wilson E. M., French F. S. RT Domain interactions between coregulator ARA(70) and the androgen receptor (AR). RL Mol. Endocrinol. 16:287-300 (2002). RN [36]; RE0035341. RX PUBMED: 15514032. RA Hsu C. L., Chen Y. L., Ting H. J., Lin W. J., Yang Z., Zhang Y., Wang L., Wu C. T., Chang H. C., Yeh S., Pimplikar S. W., Chang C. RT Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth. RL Mol. Endocrinol. 19:350-361 (2005). RN [37]; RE0035344. RX PUBMED: 11779876. 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RT Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenase RL Hum. Mol. Genet. 5:1311-8 (1996). RN [45]; RE0044905. RX PUBMED: 11773441. RA Lee S. R., Ramos S. M., Ko A., Masiello D., Swanson K. D., Lu M. L., Balk S. P. RT AR and ER interaction with a p21-activated kinase (PAK6) RL Mol. Endocrinol. 16:85-99 (2002). RN [46]; RE0047127. RX PUBMED: 14517289. RA Shatkina L., Mink S., Rogatsch H., Klocker H., Langer G., Nestl A., Cato A. C. RT The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor RL Mol. Cell. Biol. 23:7189-97 (2003). RN [47]; RE0047132. RX PUBMED: 11278309. RA Lu M. L., Schneider M. C., Zheng Y., Zhang X., Richie J. P. RT Caveolin-1 interacts with androgen receptor. a positive modulator of androgen receptor mediated transactivation RL J. Biol. Chem. 276:13442-51 (2001). RN [48]; RE0047144. RX PUBMED: 15256534. RA Masiello D., Chen S. Y., Xu Y., Verhoeven M. C., Choi E., Hollenberg A. N., Balk S. P. RT Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells RL Mol. Endocrinol. 18:2388-401 (2004). RN [49]; RE0047145. RX PUBMED: 11043577. RA Ozanne D. M., Brady M. E., Cook S., Gaughan L., Neal D. E., Robson C. N. RT Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin RL Mol. Endocrinol. 14:1618-26 (2000). RN [50]; RE0047150. RX PUBMED: 11923464. RA Dotzlaw H., Moehren U., Mink S., Cato A. C., Iniguez Lluhi J. A., Baniahmad A. RT The amino terminus of the human AR is target for corepressor action and antihormone agonism RL Mol. Endocrinol. 16:661-73 (2002). RN [51]; RE0047163. RX PUBMED: 14612401. RA Fu M., Rao M., Wang C., Sakamaki T., Wang J., Di Vizio D., Zhang X., Albanese C., Balk S., Chang C., Fan S., Rosen E., Palvimo J. J., Janne O. A., Muratoglu S., Avantaggiati M. L., Pestell R. G. RT Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth RL Mol. Cell. Biol. 23:8563-75 (2003). RN [52]; RE0047173. RX PUBMED: 15466214. RA Unni E., Sun S., Nan B., McPhaul M. J., Cheskis B., Mancini M. A., Marcelli M. RT Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence RL Cancer Res. 64:7156-68 (2004). RN [53]; RE0047189. RX PUBMED: 15062576. RA Dotzlaw H., Papaioannou M., Moehren U., Claessens F., Baniahmad A. RT Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor RL Mol. Cell. Endocrinol. 213:79-85 (2003). RN [54]; RE0047212. RX PUBMED: 15755991. RA Gregory C. W., Whang Y. E., McCall W., Fei X., Liu Y., Ponguta L. A., French F. S., Wilson E. M., Earp H. S. 3rd. RT Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth RL Clin. Cancer Res. 11:1704-12 (2005). RN [55]; RE0047215. RX PUBMED: 15831525. RA Cheung-Flynn J., Prapapanich V., Cox M. B., Riggs D. L., Suarez-Quian C., Smith D. F. RT Physiological role for the cochaperone FKBP52 in androgen receptor signaling RL Mol. Endocrinol. 19:1654-66 (2005). RN [56]; RE0047216. RX PUBMED: 15623502. RA Vlahopoulos S., Zimmer W. E., Jenster G., Belaguli N. S., Balk S. P., Brinkmann A. O., Lanz R. B., Zoumpourlis V. C., Schwartz R. J. RT Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene RL J. Biol. Chem. 280:7786-92 (2005). RN [57]; RE0047219. RX PUBMED: 15604245. RA Verras M., Brown J., Li X., Nusse R., Sun Z. RT Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells RL Cancer Res. 64:8860-6 (2004). RN [58]; RE0047229. RX PUBMED: 15731171. RA Gao S., Lee P., Wang H., Gerald W., Adler M., Zhang L., Wang Y. F., Wang Z. RT The androgen receptor directly targets the cellular Fas/FasL-associated death domain protein-like inhibitory protein gene to promote the androgen-independent growth of prostate cancer cells RL Mol. Endocrinol. 19:1792-802 (2005). RN [59]; RE0047258. RX PUBMED: 11719514. RA Pero R., Lembo F., Palmieri E. A., Vitiello C., Fedele M., Fusco A., Bruni C. B., Chiariotti L. RT PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription RL J. Biol. Chem. 277:3280-5 (2002). RN [60]; RE0047267. RX PUBMED: 15107424. RA He B., Bai S., Hnat A. T., Kalman R. I., Minges J. T., Patterson C., Wilson E. M. RT An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP) RL J. Biol. Chem. 279:30643-53 (2004). RN [61]; RE0047268. RX PUBMED: 12559985. RA Cardozo C. P., Michaud C., Ost M. C., Fliss A. E., Yang E., Patterson C., Hall S. J., Caplan A. J. 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RX PUBMED: 16434977. RA Gong J., Zhu J., Goodman OB J. r., Pestell R. G., Schlegel P. N., Nanus D. M., Shen R. RT Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells. RL Oncogene 25:2011-2021 (2006). RN [66]; RE0048356. RX PUBMED: 16455820. RA Chattopadhyay S., Gong E. Y., Hwang M., Park E., Lee H. J., Hong C. Y., Choi H. S., Cheong J. H., Kwon H. B., Lee K. RT The CCAAT enhancer-binding protein-alpha negatively regulates the transactivation of androgen receptor in prostate cancer cells. RL Mol. Endocrinol. 20:984-995 (2006). RN [67]; RE0048364. RX PUBMED: 15781642. RA Cha T. L., Qiu L., Chen C. T., Wen Y., Hung M. C. RT Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. RL Cancer Res. 65:2287-2295 (2005). RN [68]; RE0048426. RX PUBMED: 15539430. RA Burd C. J., Petre C. E., Moghadam H., Wilson E. M., Knudsen K. E. 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