AC T00040
XX
ID T00040
XX
DT 25.01.1993 (created); hse.
DT 19.10.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA AR
XX
SY AIS; androgen receptor; androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease); AR; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; KD, Kennedy disease; NR3C4; RP11-383C12.1; SBMA; SMAX1; spinal and bulbar muscular atrophy; testicular feminization; TFM.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004953 AR; HGNC: AR.
XX
CL C0002; CC (rec); 2.1.1.1.4.
XX
SF androgen exposure required for dimerization and subsequent DNA-binding;
SF dimerization is inhibited by region A/B [6];
SF nuclear uptake may occur constitutively [8];
SF nuclear uptake may be hormone-dependent [9] [10];
SF there may be tissue-specific splice variants [11];
XX
EX liver,,,adult; detectable; Northern blot; mRNA (poly-A); [7].
EX prepuce of penis,fibroblast,,adult; detectable; Northern blot; mRNA (poly-A); [7].
XX
FF LY294002 treatment increases the protein expression in LNCaP cells [86];
FF by binding to androgen-responsive elements, AR regulates expression of target genes [6] [1];
XX
IN T00040 AR; human, Homo sapiens.
IN T09553 ATF-3; human, Homo sapiens.
IN T22424 BAF57; human, Homo sapiens.
IN T00105 C/EBPalpha; human, Homo sapiens.
IN T02776 DAX1; human, Homo sapiens.
IN T02944 Daxx; human, Homo sapiens.
IN T33762 DRIP205; human, Homo sapiens.
IN T00241 Egr-1; human, Homo sapiens.
IN T00250 Elk-1; human, Homo sapiens.
IN T08230 ER81; human, Homo sapiens.
IN T02936 FOXO1A; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T06042 HDAC4; human, Homo sapiens.
IN T05085 Hey1; human, Homo sapiens.
IN T23099 Hey1; Mammalia.
IN T02512 HNF-3alpha; human, Homo sapiens.
IN T09317 HOXB13; human, Homo sapiens.
IN T00992 Hsp90; human, Homo sapiens.
IN T05110 Ku70; human, Homo sapiens.
IN T18783 MRF1; human, Homo sapiens.
IN T04687 NCOR1; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T14055 PARP; human, Homo sapiens.
IN T02336 PLZF; human, Homo sapiens.
IN T14288 PLZF; Mammalia.
IN T32689 RAI17; human, Homo sapiens.
IN T29717 SIRT1; human, Homo sapiens.
IN T08728 SKIP; human, Homo sapiens.
IN T04689 SMRT; human, Homo sapiens.
IN T04632 SRC-1; human, Homo sapiens.
IN T04640 SRC3; human, Homo sapiens.
IN T14063 SRF; Mammalia.
IN T01493 STAT3; human, Homo sapiens.
IN T02918 TCF-4; human, Homo sapiens.
IN T19335 TIF1a-short; human, Homo sapiens.
IN T02482 TIF2; mouse, Mus musculus.
IN T02483 TIF2; human, Homo sapiens.
IN T08660 YY1; human, Homo sapiens.
IN T05150 ZAC-1b; mouse, Mus musculus.
XX
MX M00481 V$AR_01.
MX M00953 V$AR_02.
MX M00956 V$AR_03.
MX M01201 V$AR_04.
MX M07204 V$AR_10.
MX M08189 V$AR_11.
MX M08907 V$AR_13.
MX M08908 V$AR_14_H.
MX M00447 V$AR_Q2.
MX M00962 V$AR_Q6.
MX M01996 V$AR_Q6_01.
XX
BS R02124.
BS R10326.
BS R71887.
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BS R71339.
BS R55746.
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BS R64442.
BS R57492.
BS R34889.
BS R34890.
BS R28699.
BS R68931.
BS R68934.
BS R64439.
BS R14261.
BS R14264.
BS R24833.
BS R34747.
BS R34878.
BS R39324.
BS R64434.
BS R69767.
BS R73277.
BS R73278.
BS R34875.
BS R72332.
BS R65042.
BS R41500.
BS R41501.
BS R41502.
BS R64283.
BS R64288.
BS R68936.
BS R68939.
BS R69457.
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BS R67681.
BS R71712.
BS R71714.
BS R63186.
BS R69460.
BS R63163.
BS R39274.
BS R28692.
BS R28693.
BS R59200.
BS R69907.
BS R69908.
BS R34744.
BS R34745.
BS R65536.
BS R37851.
BS R40671.
BS R14294.
BS R59568.
BS R59570.
BS R35633.
BS R32428.
BS R73675.
BS R31666.
BS R32450.
BS R71227.
BS R71228.
BS R68941.
BS R72942.
BS R60516.
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BS R57172.
BS R34617.
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BS R37579.
BS R14301.
BS R14272.
BS R14276.
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BS R63201.
BS R63205.
BS R57486.
BS R57502.
BS R63194.
BS R63193.
BS R14300.
BS R67251.
BS R67252.
BS R14308.
BS R63262.
BS R63263.
BS R63264.
BS R32041.
BS R14287.
BS R26023.
XX
DR TRANSPATH: MO000021454.
DR UniProtKB: P10275; ANDR_HUMAN.
XX
RN [1]; RE0001011.
RX PUBMED: 1995608.
RA de Vos P., Claessens F., Winderickx J., van Dijck P., Celis L., Peeters B., Rombauts W., Heyns W., Verhoeven G.
RT Interaction of androgen response elements with the DNA-binding domain of the rat androgen receptor expressed in Escherichia coli
RL J. Biol. Chem. 266:3439-3443 (1991).
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RA Forman B. M., Samuels H. H.
RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model
RL Mol. Endocrinol. 4:1293-1301 (1990).
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RA Chang C., Kokontis J., Liao S.
RT Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors
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RT Characterization and expression of a cDNA encoding the human androgen receptor
RL Proc. Natl. Acad. Sci. USA 86:327-331 (1989).
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RA Chang C., Kokontis J., Liao S.
RT Molecular cloning of human and rat complementary DNA encoding androgen receptors
RL Science 240:324-326 (1988).
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RA Wong C.-i., Zhou Z.-x., Sar M., Wilson E. M.
RT Steroid requirement for androgen receptor dimerization and DNA binding. Modulation by intramolecular interactions between the NH2-terminal and steroid-binding domains
RL J. Biol. Chem. 268:19004-19012 (1993).
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RT Cloning of the human androgen receptor complementary DNA and localization to the X chromosome
RL Science 240:327-330 (1988).
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RT Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization
RL Mol. Endocrinol. 5:1396-1404 (1991).
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RT Transcriptional activation and nuclear targeting signals of the human androgen receptor
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RT A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor
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RT Characterization of the human androgen receptor transcription unit
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RA Veldscholte J., Berrevoets C. A., Brinkmann A. O., Grootegoed J. A., Mulder E.
RT Anti-androgens and mutated receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation
RL Biochemistry 31:2393-2399 (1992).
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RA Chang C., Wang C., DeLuca H. F., Ross T. K., Shih C.C.-Y.
RT Charactirization of human androgen receptor overexpressed in the baculovirus system
RL Proc. Natl. Acad. Sci. USA 89:5946-5950 (1992).
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RX PUBMED: 3377788.
RA Trapman J., Klaassen P., Kuiper G. G. J. M., van der Korput J. A. B. M., Faber P. W., van Rooij H. C. J., van Kessel A. G., Voorhorst M. M., Mulder E., Brinkmann A. O.
RT Cloning, stucture and expression of a cDNA encoding the human androgen receptor
RL Biochem. Biophys. Res. Commun. 153:241-248 (1988).
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RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
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RT The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate
RL Mol. Endocrinol. 2:1265-1275 (1988).
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RT Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3
RL J. Biol. Chem. 274:22618-22626 (1999).
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RX PUBMED: 9115274.
RA Thenot S., Henriquet C., Rochefort H., Cavailles V.
RT Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1
RL J. Biol. Chem. 272:12062-12068 (1997).
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RA Migliaccio A., Castoria G., Di Domenico M., de Falco A., Bilancio A., Lombardi M., Barone M. V., Ametrano D., Zannini M. S., Abbondanza C., Auricchio F.
RT Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation
RL EMBO J. 19:5406-5417 (2000).
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RA Lin H. K., Yeh S., Kang H. Y., Chang C.
RT Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.
RL Proc. Natl. Acad. Sci. USA 98:7200-7205 (2001).
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RA Wellington C. L., Ellerby L. M., Hackam A. S., Margolis R. L., Trifiro M. A., Singaraja R., McCutcheon K., Salvesen G. S., Propp S. S., Bromm M., Rowland K. J., Zhang T., Rasper D., Roy S., Thornberry N., Pinsky L., Kakizuka A., Ross C. A., Nicholson D. W., Bredesen D. E., Hayden M. R.
RT Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
RL J. Biol. Chem. 273:9158-9167 (1998).
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RA Moilanen A. M., Karvonen U., Poukka H., Janne O. A., Palvimo J. J.
RT Activation of androgen receptor function by a novel nuclear protein kinase.
RL Mol. Biol. Cell 9:2527-43 (1998).
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RA Lin H. K., Wang L., Hu Y. C., Altuwaijri S., Chang C.
RT Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase.
RL EMBO J. 21:4037-48 (2002).
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RA Poukka H., Karvonen U., Janne O. A., Palvimo J. J.
RT Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1)
RL Proc. Natl. Acad. Sci. USA 97:14145-50 (2000).
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RX PUBMED: 10734072.
RA Lee D. K., Duan H. O., Chang C.
RT From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator.
RL J. Biol. Chem. 275:9308-13 (2000).
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RX PUBMED: 11713275.
RA Lee L. F., Guan J., Qiu Y., Kung H. J.
RT Neuropeptide-induced androgen independence in prostate cancer cells: roles of nonreceptor tyrosine kinases etk/bmx, SRC, and focal adhesion kinase.
RL Mol. Cell. Biol. 21:8385-97 (2001).
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RA Fu M., Wang C., Wang J., Zhang X., Sakamaki T., Yeung Y. G., Chang C., Hopp T., Fuqua S. A., Jaffray E., Hay R. T., Palvimo J. J., Janne O. A., Pestell R. G.
RT Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function.
RL Mol. Cell. Biol. 22:3373-88 (2002).
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RX PUBMED: 11994312.
RA Gaughan L., Logan I. R., Cook S., Neal D. E., Robson C. N.
RT Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.
RL J. Biol. Chem. 277:25904-13 (2002).
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RX PUBMED: 12163482.
RA Ueda T., Mawji N. R., Bruchovsky N., Sadar M. D.
RT Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells.
RL J. Biol. Chem. 277:38087-94 (2002).
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RX PUBMED: 12218053.
RA Wang Q., Sharma D., Ren Y., Fondell J. D.
RT A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.
RL J. Biol. Chem. 277:42852-8 (2002).
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RA Agoulnik I. U., Krause W. C., Bingman W. E. 3rd, Rahman H. T., Amrikachi M., Ayala G. E., Weigel N. L.
RT Repressors of androgen and progesterone receptor action.
RL J. Biol. Chem. 278:31136-48 (2003).
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RA Nishida T., Yasuda H.
RT PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription.
RL J. Biol. Chem. 277:41311-7 (2002).
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RA Yang F., Li X., Sharma M., Sasaki C. Y., Longo D. L., Lim B., Sun Z.
RT Linking beta-catenin to androgen-signaling pathway.
RL J. Biol. Chem. 277:11336-44 (2002).
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RA Gnanapragasam V. J., Leung H. Y., Pulimood A. S., Neal D. E., Robson C. N.
RT Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer.
RL Br. J. Cancer 85:1928-36 (2001).
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RA Zhou Z. X., He B., Hall S. H., Wilson E. M., French F. S.
RT Domain interactions between coregulator ARA(70) and the androgen receptor (AR).
RL Mol. Endocrinol. 16:287-300 (2002).
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RA Hsu C. L., Chen Y. L., Ting H. J., Lin W. J., Yang Z., Zhang Y., Wang L., Wu C. T., Chang H. C., Yeh S., Pimplikar S. W., Chang C.
RT Androgen receptor (AR) NH2- and COOH-terminal interactions result in the differential influences on the AR-mediated transactivation and cell growth.
RL Mol. Endocrinol. 19:350-361 (2005).
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RA He B., Minges J. T., Lee L. W., Wilson E. M.
RT The FXXLF motif mediates androgen receptor-specific interactions with coregulators.
RL J. Biol. Chem. 277:10226-10235 (2002).
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RA Ting H. J., Yeh S., Nishimura K., Chang C.
RT Supervillin associates with androgen receptor and modulates its transcriptional activity
RL Proc. Natl. Acad. Sci. USA 99:661-6 (2002).
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RA Kotaja N., Karvonen U., Janne O. A., Palvimo J. J.
RT PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases
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RT Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma
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RA Fu M., Wang C., Reutens A. T., Wang J., Angeletti R. H., Siconolfi-Baez L., Ogryzko V., Avantaggiati M. L., Pestell R. G.
RT p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation
RL J. Biol. Chem. 275:20853-60 (2000).
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RA Sharma M., Li X., Wang Y., Zarnegar M., Huang C. Y., Palvimo J. J., Lim B., Sun Z.
RT hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci
RL EMBO J. 22:6101-14 (2003).
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RT Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT
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RT Spinocerebellar ataxia type-1 and spinobulbar muscular atrophy gene products interact with glyceraldehyde-3-phosphate dehydrogenase
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RA Lee S. R., Ramos S. M., Ko A., Masiello D., Swanson K. D., Lu M. L., Balk S. P.
RT AR and ER interaction with a p21-activated kinase (PAK6)
RL Mol. Endocrinol. 16:85-99 (2002).
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RA Shatkina L., Mink S., Rogatsch H., Klocker H., Langer G., Nestl A., Cato A. C.
RT The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor
RL Mol. Cell. Biol. 23:7189-97 (2003).
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RA Lu M. L., Schneider M. C., Zheng Y., Zhang X., Richie J. P.
RT Caveolin-1 interacts with androgen receptor. a positive modulator of androgen receptor mediated transactivation
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RA Masiello D., Chen S. Y., Xu Y., Verhoeven M. C., Choi E., Hollenberg A. N., Balk S. P.
RT Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells
RL Mol. Endocrinol. 18:2388-401 (2004).
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RA Ozanne D. M., Brady M. E., Cook S., Gaughan L., Neal D. E., Robson C. N.
RT Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin
RL Mol. Endocrinol. 14:1618-26 (2000).
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RA Dotzlaw H., Moehren U., Mink S., Cato A. C., Iniguez Lluhi J. A., Baniahmad A.
RT The amino terminus of the human AR is target for corepressor action and antihormone agonism
RL Mol. Endocrinol. 16:661-73 (2002).
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RA Fu M., Rao M., Wang C., Sakamaki T., Wang J., Di Vizio D., Zhang X., Albanese C., Balk S., Chang C., Fan S., Rosen E., Palvimo J. J., Janne O. A., Muratoglu S., Avantaggiati M. L., Pestell R. G.
RT Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth
RL Mol. Cell. Biol. 23:8563-75 (2003).
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RA Unni E., Sun S., Nan B., McPhaul M. J., Cheskis B., Mancini M. A., Marcelli M.
RT Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence
RL Cancer Res. 64:7156-68 (2004).
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RA Dotzlaw H., Papaioannou M., Moehren U., Claessens F., Baniahmad A.
RT Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor
RL Mol. Cell. Endocrinol. 213:79-85 (2003).
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RA Gregory C. W., Whang Y. E., McCall W., Fei X., Liu Y., Ponguta L. A., French F. S., Wilson E. M., Earp H. S. 3rd.
RT Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth
RL Clin. Cancer Res. 11:1704-12 (2005).
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RA Cheung-Flynn J., Prapapanich V., Cox M. B., Riggs D. L., Suarez-Quian C., Smith D. F.
RT Physiological role for the cochaperone FKBP52 in androgen receptor signaling
RL Mol. Endocrinol. 19:1654-66 (2005).
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RA Vlahopoulos S., Zimmer W. E., Jenster G., Belaguli N. S., Balk S. P., Brinkmann A. O., Lanz R. B., Zoumpourlis V. C., Schwartz R. J.
RT Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene
RL J. Biol. Chem. 280:7786-92 (2005).
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RX PUBMED: 15604245.
RA Verras M., Brown J., Li X., Nusse R., Sun Z.
RT Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells
RL Cancer Res. 64:8860-6 (2004).
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RT Suppression of Androgen Receptor Transactivation and Prostate Cancer Cell Growth by Heterogeneous Nuclear Ribonucleoprotein A1 via Interaction with Androgen Receptor Coregulator ARA54.
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RT Induction of androgen receptor expression by phosphatidylinositol 3-kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP prostate cancer cells.
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