TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T23091 XX ID T23091 XX DT 10.03.2005 (created); nvo. DT 30.06.2016 (updated); mom. CO Copyright (C), QIAGEN. XX FA p300 XX SY CBP/p300; E1A associated protein; E1A-associated protein p300; p300-HAT; transcriptional co-activator p300. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX CP Expression of transcriptional co-activator p300 in pancreatic beta cells [194]. XX FF the C-terminal sequences of p300 interacts with the N-terminal activation domain region of PDX-1 [80]; FF coactivator [80]; FF transcriptional stimulation requires direct interactions between the insuline-bound activators (BETA2:E47) and the p300 coactivator [80]; FF E1A also inhibited PDX-1 activation through binding to p300 [80]; FF p300 enhanced PDX-1 activation and stimulated synergistically in conjunction with the BETA2:E47 complex the insulin gene transcription activation [80]; XX IN T23080 AhR; Mammalia. IN T02245 AML1b; human, Homo sapiens. IN T09248 AML2-isoform1; human, Homo sapiens. IN T02223 AML2; human, Homo sapiens. IN T09552 AML3; Mammalia. IN T10504 AP-2alpha; Mammalia. IN T08487 AR-isoform1; human, Homo sapiens. IN T00040 AR; human, Homo sapiens. IN T10818 arnt; Mammalia. IN T10237 ATF-1; Mammalia. IN T23082 ATF-4; Mammalia. IN T16043 BCL-6; Mammalia. IN T02872 beta-catenin; human, Homo sapiens. IN T14513 beta-catenin; Mammalia. IN T18820 BMAL1-isoform4; mouse, Mus musculus. IN T23329 BMAL1; Mammalia. IN T08887 brca1-isoform1; human, Homo sapiens. IN T04074 brca1; human, Homo sapiens. IN T15204 brca1; Mammalia. IN T16987 BRG1; Mammalia. IN T15079 BTEB2-isoform1; human, Homo sapiens. IN T17201 BTEB2; Mammalia. IN T00111 c-Ets-1; mouse, Mus musculus. IN T10873 c-Ets-1; Mammalia. IN T00113 c-Ets-2; human, Homo sapiens. IN T01397 c-Ets-2; mouse, Mus musculus. IN T15312 c-Ets-2; Mammalia. IN T10346 c-Fos; Mammalia. IN T09446 c-Jun; Mammalia. IN T18005 c-MAF; Mammalia. IN T17679 c-Myb; Mammalia. IN T00140 c-Myc-isoform1; human, Homo sapiens. IN T14435 c-Myc; Mammalia. IN T11261 c-Rel; Mammalia. IN T22204 Cdx-2; Mammalia. IN T18364 Clock; Mammalia. IN T09117 E2F-1; human, Homo sapiens. IN T17403 E2F-2; Mammalia. IN T17404 E2F-3; Mammalia. IN T10751 E2F-4; Mammalia. IN T15303 E2F-6; Mammalia. IN T01676 EKLF; mouse, Mus musculus. IN T08300 ER-alpha-L; human, Homo sapiens. IN T00261 ER-alpha; human, Homo sapiens. IN T09637 ER-alpha; Mammalia. IN T08515 ER-beta; human, Homo sapiens. IN T08214 ER81; mouse, Mus musculus. IN T17209 ERK2; Mammalia. IN T08100 EWS; human, Homo sapiens. IN T10391 FKLF; Mammalia. IN T14067 FOXO1A; Mammalia. IN T10677 FOXO3a; Mammalia. IN T30385 Fra-2; Mammalia. IN T08358 GATA-4; mouse, Mus musculus. IN T08629 GATA-4; Mammalia. IN T14002 GKLF; mouse, Mus musculus. IN T14202 GKLF; Mammalia. IN T10446 GR; Mammalia. IN T21852 HDAC1; Mammalia. IN T08994 HIF-1alpha-isoform1; human, Homo sapiens. IN T10516 HIF-1alpha; Mammalia. IN T10332 ipf1; Mammalia. IN T14446 IRF-2; Mammalia. IN T17460 IRF-3; Mammalia. IN T18466 IRF-7; Mammalia. IN T00436 JunB; mouse, Mus musculus. IN T10510 JunB; Mammalia. IN T08296 Kaiso; human, Homo sapiens. IN T11439 KR3; human, Homo sapiens. IN T32444 Ku80; Mammalia. IN T09402 MEF-2C; Mammalia. IN T13873 MITF; Mammalia. IN T17701 Miz-1; Mammalia. IN T32083 MRG-1; Mammalia. IN T30592 Msx-1; Mammalia. IN T10027 MyoD; Mammalia. IN T14436 NeuroD-1; Mammalia. IN T11025 NFATc1; Mammalia. IN T11024 NFATc2; Mammalia. IN T14193 NR1B1; Mammalia. IN T09645 Nrf2-isoform1; human, Homo sapiens. IN T13730 Nrf2; Mammalia. IN T10625 Nur77; Mammalia. IN T00671 p53; human, Homo sapiens. IN T09500 p53; Mammalia. IN T24127 p63gamma; Mammalia. IN T16759 p73; Mammalia. IN T13888 pax6; Mammalia. IN T08255 PGC-1-isoform1; mouse, Mus musculus. IN T14288 PLZF; Mammalia. IN T03731 PPARgamma2; human, Homo sapiens. IN T09963 PPARgamma; Mammalia. IN T04878 Ref-1; human, Homo sapiens. IN T10571 Ref-1; Mammalia. IN T00594 RelA-p65-isoform1; human, Homo sapiens. IN T10397 RelA-p65; Mammalia. IN T28752 RPB1; human, Homo sapiens. IN T08348 RXR-alpha; mouse, Mus musculus. IN T08433 RXR-alpha; human, Homo sapiens. IN T09964 RXR-alpha; Mammalia. IN T14156 SATB1; Mammalia. IN T10138 SF-1; Mammalia. IN T10783 Smad1; Mammalia. IN T24830 Smad2; Mammalia. IN T09538 Smad3; Mammalia. IN T13998 Smad4; Mammalia. IN T22380 Smad7; Mammalia. IN T17043 Sox-4; human, Homo sapiens. IN T09454 Sox-9; mouse, Mus musculus. IN T08326 Sp1; Mammalia. IN T08327 Sp3; Mammalia. IN T21552 SRC-1; Mammalia. IN T22422 SRC3-xbb2; human, Homo sapiens. IN T01556 SREBP-1a; human, Homo sapiens. IN T23076 STAT1; Mammalia. IN T16670 STAT2; Mammalia. IN T14458 STAT3; Mammalia. IN T16819 STAT5A; Mammalia. IN T09516 STAT6; Mammalia. IN T27798 Tal-1; Mammalia. IN T14175 TBP; Mammalia. IN T16010 TCF-4; Mammalia. IN T17428 TFIIB; Mammalia. IN T16205 Twist; Mammalia. IN T10348 YB-1; human, Homo sapiens. IN T16163 YB-1; Mammalia. IN T09133 YY1; Mammalia. IN T05150 ZAC-1b; mouse, Mus musculus. IN T05149 ZAC-isoform1; human, Homo sapiens. IN T10142 ZAC; mouse, Mus musculus. IN T14846 ZEB; Mammalia. IN T04994 ZNF76; human, Homo sapiens. XX MX M00033 V$P300_01. MX M07266 V$P300_Q5. XX BS R62309. XX DR TRANSPATH: MO000048073. XX RN [1]; RE0006163. RX PUBMED: 8848048. RA Bhattacharya S., Eckner R., Grossman S., Oldread E., Arany Z., D Andrea A., Livingston D. M. RT Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha RL Nature 383:344-347 (1996). RN [2]; RE0006734. RX PUBMED: 7758944. RA Lee J.-S., Galvin K. M., See R. H., Eckner R., Livingstone D., Moran E., Shi Y. RT Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300 RL Genes Dev. 9:1188-1198 (1995). RN [3]; RE0015233. RX PUBMED: 9001254. RA Sartorelli V., Huang J., Hamamori Y., Kedes L. RT Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C RL Mol. Cell. Biol. 17:1010-1026 (1997). RN [4]; RE0015891. RX PUBMED: 10753885. RA Marzio G., Wagener C., Gutierrez M. I., Cartwright P., Helin K., Giacca M. RT E2F family members are differentially regulated by reversible acetylation. RL J. Biol. Chem. 275:10887-10892 (2000). RN [5]; RE0016085. RX PUBMED: 10636916. RA de Caestecker M. P., Yahata T., Wang D., Parks W. T., Huang S., Hill C. S., Shioda T., Roberts A. B., Lechleider R. J. RT The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain. RL J. Biol. Chem. 275:2115-2122 (2000). RN [6]; RE0016777. RX PUBMED: 9632793. RA Ebert B. L., Bunn H. F. RT Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. RL Mol. Cell. Biol. 18:4089-4096 (1998). RN [7]; RE0016813. RX PUBMED: 10336495. RA Dowell P., Ishmael J. E., Avram D., Peterson V. J., Nevrivy D. J., Leid M. RT Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein RL J. Biol. Chem. 274:15901-15907 (1999). RN [8]; RE0018197. RX PUBMED: 10075656. RA Gelman L., Zhou G., Fajas L., Raspe E., Fruchart J. C., Auwerx J. RT p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively. RL J. Biol. Chem. 274:7681-7688 (1999). RN [9]; RE0018232. RX PUBMED: 8754832. RA Lee J. S., See R. H., Deng T., Shi Y. RT Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300. RL Mol. Cell. Biol. 16:4312-4326 (1996). RN [10]; RE0021077. RX PUBMED: 9660747. RA Price E. R., Ding H. F., Badalian T., Bhattacharya S., Takemoto C., Yao T. P., Hemesath T. J., Fisher D. E. RT Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia RL J. Biol. Chem. 273:17983-17986 (1998). RN [11]; RE0021242. RX PUBMED: 8502484. RA Abraham S. E., Lobo S., Yaciuk P., Wang H. G., Moran E. RT p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes RL Oncogene 8:1639-1647 (1993). RN [12]; RE0022264. RX PUBMED: 10373589. RA Gingras S., Simard J., Groner B., Pfitzner E. RT p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6. RL Nucleic Acids Res. 27:2722-2729 (1999). RN [13]; RE0022748. RX PUBMED: 12586840. RA Braganca J., Eloranta J. J., Bamforth S. D., Ibbitt J. C., Hurst H. C., Bhattacharya S. RT Physical and functional interactions between AP-2 transcription factors, p300/CBP, and CITED2. RL J. Biol. Chem. 278:16021-16029 (2003). RN [14]; RE0023654. RX PUBMED: 12665576. RA Edelstein L. C., Lagos L., Simmons M., Tirumalai H., Gelinas C. RT NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1. RL Mol. Cell. Biol. 23:2749-2761 (2003). RN [15]; RE0024014. RX PUBMED: 11106736. RA Agalioti T., Lomvardas S., Parekh B., Yie J., Maniatis T., Thanos D. RT Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. RL Cell 103:667-678 (2000). RN [16]; RE0024064. RX PUBMED: 12200429. RA Jang S. I., Steinert P. M. RT Loricrin expression in cultured human keratinocytes is controlled by a complex interplay between transcription factors of the Sp1, CREB, AP1, and AP2 families. RL J. Biol. Chem. 277:42268-42279 (2002). RN [17]; RE0024351. RX PUBMED: 10648616. RA Zeng X., Li X., Miller A., Yuan Z., Yuan W., Kwok R. P., Goodman R., Lu H. RT The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis. RL Mol. Cell. Biol. 20:1299-1310 (2000). RN [18]; RE0024612. RX PUBMED: 12391150. RA Wallberg A. E., Pedersen K., Lendahl U., Roeder R. G. RT p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. RL Mol. Cell. Biol. 22:7812-7819 (2002). RN [19]; RE0025681. RX PUBMED: 11864601. RA Tini M., Benecke A., Um S. J., Torchia J., Evans R. M., Chambon P. RT Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. RL Mol. Cell 9:265-77 (2002). RN [20]; RE0026505. RX PUBMED: 10866654. RA Zhang Q., Vo N., Goodman R. H. RT Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB RL Mol. Cell. Biol. 20:4970-8 (2000). RN [21]; RE0026618. RX PUBMED: 10918613. RA Ghosh A. K., Yuan W., Mori Y., Varga J. RT Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators. RL Oncogene 19:3546-55 (2000). RN [22]; RE0027754. RX PUBMED: 10558993. RA Puigserver P., Adelmant G., Wu Z., Fan M., Xu J., O'Malley B., Spiegelman B. M. RT Activation of PPARgamma coactivator-1 through transcription factor docking. RL Science 286:1368-71 (1999). RN [23]; RE0028372. RX PUBMED: 11486036. RA Yao Y. L., Yang W. M., Seto E. RT Regulation of transcription factor YY1 by acetylation and deacetylation. RL Mol. Cell. Biol. 21:5979-91 (2001). RN [24]; RE0028965. RX PUBMED: 11581164. RA Yahata T., Shao W., Endoh H., Hur J., Coser K. R., Sun H., Ueda Y., Kato S., Isselbacher K. J., Brown M., Shioda T. RT Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. RL Genes Dev. 15:2598-612 (2001). RN [25]; RE0029304. RX PUBMED: 11606780. RA Liu Z., Wong J., Tsai S. Y., Tsai M. J., O'Malley B. W. RT Sequential recruitment of steroid receptor coactivator-1 (SRC-1) and p300 enhances progesterone receptor-dependent initiation and reinitiation of transcription from chromatin. RL Proc. Natl. Acad. Sci. USA 98:12426-31 (2001). RN [26]; RE0029309. RX PUBMED: 11971970. RA Fu M., Wang C., Wang J., Zhang X., Sakamaki T., Yeung Y. G., Chang C., Hopp T., Fuqua S. A., Jaffray E., Hay R. T., Palvimo J. J., Janne O. A., Pestell R. G. RT Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. RL Mol. Cell. Biol. 22:3373-88 (2002). RN [27]; RE0029453. RX PUBMED: 11940591. RA Hoffmeister A., Ropolo A., Vasseur S., Mallo G. V., Bodeker H., Ritz-Laser B., Dressler G. R., Vaccaro M. I., Dagorn J. C., Moreno S., Iovanna J. L. RT The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter. RL J. Biol. Chem. 277:22314-9 (2002). RN [28]; RE0029513. RX PUBMED: 11923478. RA Ray S., Sherman C. T., Lu M., Brasier A. R. RT Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity. RL Mol. Endocrinol. 16:824-36 (2002). RN [29]; RE0030177. RX PUBMED: 12730195. RA Watanabe N., Wachi S., Fujita T. RT Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. RL J. Biol. Chem. 278:26102-10 (2003). RN [30]; RE0030300. RX PUBMED: 12743039. RA Postigo A. A., Depp J. L., Taylor J. J., Kroll K. L. RT Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. RL EMBO J. 22:2453-62 (2003). RN [31]; RE0030488. RX PUBMED: 12507421. RA Picard F., Gehin M., Annicotte J., Rocchi S., Champy M. F., O'Malley B. W., Chambon P., Auwerx J. RT SRC-1 and TIF2 control energy balance between white and brown adipose tissues. RL Cell 111:931-41 (2002). RN [32]; RE0030528. RX PUBMED: 12379484. RA Yuan L. W., Soh J. W., Weinstein I. B. RT Inhibition of histone acetyltransferase function of p300 by PKCdelta. RL Biochim. Biophys. Acta 1592:205-11 (2002). RN [33]; RE0030588. RX PUBMED: 14636573. RA Wallberg A. E., Yamamura S., Malik S., Spiegelman B. M., Roeder R. G. RT Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. RL Mol. Cell 12:1137-49 (2003). RN [34]; RE0030635. RX PUBMED: 14645514. RA Bachurski C. J., Yang G. H., Currier T. A., Gronostajski R. M., Hong D. RT Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. RL Mol. Cell. Biol. 23:9014-24 (2003). RN [35]; RE0030933. RX PUBMED: 10919667. RA Kominsky S. L., Hobeika A. C., Lake F. A., Torres B. A., Johnson H. M. RT Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells. RL Cancer Res. 60:3904-8 (2000). RN [36]; RE0031348. RX PUBMED: 12665587. RA Magenta A., Cenciarelli C., De Santa F., Fuschi P., Martelli F., Caruso M., Felsani A. RT MyoD stimulates RB promoter activity via the CREB/p300 nuclear transduction pathway. RL Mol. Cell. Biol. 23:2893-906 (2003). RN [37]; RE0031368. RX PUBMED: 12789260. RA La Sala D., Macaluso M., Trimarchi C., Giordano A., Cinti C. RT Triggering of p73-dependent apoptosis in osteosarcoma is under the control of E2Fs-pRb2/p130 complexes. RL Oncogene 22:3518-3529 (2003). RN [38]; RE0031551. RX PUBMED: 11997499. RA Lee Y. H., Koh S. S., Zhang X., Cheng X., Stallcup M. R. RT Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. RL Mol. Cell. Biol. 22:3621-32 (2002). RN [39]; RE0031772. RX PUBMED: 14612453. RA Buryskova M., Pospisek M., Grothey A., Simmet T., Burysek L. RT Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes. RL J. Biol. Chem. 279:4017-26 (2004). RN [40]; RE0032776. RX PUBMED: 15117818. RA Kawamura T., Ono K., Morimoto T., Akao M., Iwai-Kanai E., Wada H., Sowa N., Kita T., Hasegawa K. RT Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes. RL Circ. Res. 94:1492-9 (2004). RN [41]; RE0032786. RX PUBMED: 14500836. RA Takizawa T., Ochiai W., Nakashima K., Taga T. RT Enhanced gene activation by Notch and BMP signaling cross-talk. RL Nucleic Acids Res. 31:5723-31 (2003). RN [42]; RE0032922. RX PUBMED: 10651903. RA Suzuki T., Kimura A., Nagai R., Horikoshi M. RT Regulation of interaction of the acetyltransferase region of p300 and the DNA-binding domain of Sp1 on and through DNA binding. RL Genes Cells 5:29-41 (2000). RN [43]; RE0032930. RX PUBMED: 9773981. RA Pfitzner E., Jahne R., Wissler M., Stoecklin E., Groner B. RT p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response. RL Mol. Endocrinol. 12:1582-93 (1998). RN [44]; RE0032995. RX PUBMED: 15145939. RA Arimura A., vn Peer M., Schroder A. J., Rothman P. B. RT The transcriptional co-activator p/CIP (NCoA-3) is up-regulated by STAT6 and serves as a positive regulator of transcriptional activation by STAT6. RL J. Biol. Chem. 279:31105-12 (2004). RN [45]; RE0033054. RX PUBMED: 14752053. RA Kim J. Y., Chu K., Kim H. J., Seong H. A., Park K. C., Sanyal S., Takeda J., Ha H., Shong M., Tsai M. J., Choi H. S. RT Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. RL Mol. Endocrinol. 18:776-90 (2004). RN [46]; RE0033215. RX PUBMED: 11733503. RA Johnson L. R., Johnson T. K., Desler M., Luster T. A., Nowling T., Lewis R. E., Rizzino A. RT Effects of B-Myb on gene transcription: phosphorylation-dependent activity ans acetylation by p300. RL J. Biol. Chem. 277:4088-97 (2002). RN [47]; RE0033358. RX PUBMED: 15225550. RA Yu J., de Belle I., Liang H., Adamson E. D. RT Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. RL Mol. Cell 15:83-94 (2004). RN [48]; RE0033477. RX PUBMED: 15084519. RA Ziel K. A., Campbell C. C., Wilson G. L., Gillespie M. N. RT Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene. RL FASEB J. 18:986-8 (2004). RN [49]; RE0033527. RX PUBMED: 14605447. RA Fujii Y., Kumatori A., Nakamura M. RT SATB1 makes a complex with p300 and represses gp91(phox) promoter activity. RL Microbiol. Immunol. 47:803-11 (2003). RN [50]; RE0034655. RX PUBMED: 15280364. RA Kato H., Tamamizu-Kato S., Shibasaki F. RT Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. RL J. Biol. Chem. 279:41966-74 (2004). RN [51]; RE0035546. RX PUBMED: 9859997. RA Boyes J., Byfield P., Nakatani Y., Ogryzko V. RT Regulation of activity of the transcription factor GATA-1 by acetylation. RL Nature 396:594-598 (1998). RN [52]; RE0035581. RX PUBMED: 10656693. RA Tomita A., Towatari M., Tsuzuki S., Hayakawa F., Kosugi H., Tamai K., Miyazaki T., Kinoshita T., Saito H. RT c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300. RL Oncogene 19:444-451 (2000). RN [53]; RE0035584. RX PUBMED: 10490830. RA Huang S., Qiu Y., Stein R. W., Brandt S. J. RT p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein. RL Oncogene 18:4958-4967 (1999). RN [54]; RE0035591. RX PUBMED: 10358095. RA Jayaraman G., Srinivas R., Duggan C., Ferreira E., Swaminathan S., Somasundaram K., Williams J., Hauser C., Kurkinen M., Dhar R., Weitzman S., Buttice G., Thimmapaya B. RT p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter. RL J. Biol. Chem. 274:17342-17352 (1999). RN [55]; RE0036091. RX PUBMED: 11994297. RA Dai Y. S., Cserjesi P., Markham B. E., Molkentin J. D. RT The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. RL J. Biol. Chem. 277:24390-24398 (2002). RN [56]; RE0037174. RX PUBMED: 11349124. RA Gizard F., Lavallee B., DeWitte F., Hum D. W. RT A novel zinc finger protein trep-132 interacts with cbp/p300 to regulate human cyp11a1 gene expression RL J. Biol. Chem. 276:33881-92 (2001). RN [57]; RE0037431. RX PUBMED: 10675335. RA Martinez-Balbas M. A., Bauer U. M., Nielsen S. J., Brehm A., Kouzarides T. RT Regulation of E2F1 activity by acetylation RL EMBO J. 19:662-71 (2000). RN [58]; RE0037527. RX PUBMED: 11912212. RA Misra P., Qi C., Yu S., Shah S. H., Cao W. Q., Rao M. S., Thimmapaya B., Zhu Y., Reddy J. K. RT Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation RL J. Biol. Chem. 277:20011-9 (2002). RN [59]; RE0037945. RX PUBMED: 9121451. RA Datto M. B., Hu P. P., Kowalik T. F., Yingling J., Wang X. F. RT The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B RL Mol. Cell. Biol. 17:2030-7 (1997). RN [60]; RE0038389. RX PUBMED: 15141028. RA Eeckhoute J., Formstecher P., Laine B. RT Hepatocyte nuclear factor 4alpha enhances the hepatocyte nuclear factor 1alpha-mediated activation of transcription RL Nucleic Acids Res. 32:2586-93 (2004). RN [61]; RE0038960. RX PUBMED: 10722728. RA Yahata T., de Caestecker M. P., Lechleider R. J., Andriole S., Roberts A. B., Isselbacher K. J., Shioda T. RT The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors RL J. Biol. Chem. 275:8825-34 (2000). RN [62]; RE0039427. RX PUBMED: 9606182. RA Kitabayashi I., Yokoyama A., Shimizu K., Ohki M. RT Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation RL EMBO J. 17:2994-3004 (1998). RN [63]; RE0039437. RX PUBMED: 11967287. RA Subramanian C., Hasan S., Rowe M., Hottiger M., Orre R., Robertson E. S. RT Epstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation RL J. Virol. 76:4699-708 (2002). RN [64]; RE0039707. RX PUBMED: 12778114. RA Freedman S. J., Sun Z. Y., Kung A. L., France D. S., Wagner G., Eck M. J. RT Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2 RL Nat. Struct. Biol. 10:504-12 (2003). RN [65]; RE0040343. RX PUBMED: 10805757. RA Kumar K. P., McBride K. M., Weaver B. K., Dingwall C., Reich N. C. RT Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1 RL Mol. Cell. Biol. 20:4159-68 (2000). RN [66]; RE0040563. RX PUBMED: 10906119. RA Miyagishi M., Fujii R., Hatta M., Yoshida E., Araya N., Nagafuchi A., Ishihara S., Nakajima T., Fukamizu A. RT Regulation of lef-mediated transcription and p53-dependent pathway by associating beta -catenin with CBP/p300 RL J. Biol. Chem. 275:35170-5 (2000). RN [67]; RE0040875. RX PUBMED: 9407140. RA Dowell P., Ishmael J. E., Avram D., Peterson V. J., Nevrivy D. J., Leid M. RT p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha RL J. Biol. Chem. 272:33435-43 (1997). RN [68]; RE0040910. RX PUBMED: 15075319. RA Wang H., Fang R., Cho J. Y., Libermann T. A., Oettgen P. RT Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86 RL J. Biol. Chem. 279:25241-50 (2004). RN [69]; RE0041230. RX PUBMED: 10747867. RA Kobayashi Y., Kitamoto T., Masuhiro Y., Watanabe M., Kase T., Metzger D., Yanagisawa J., Kato S. RT p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domains RL J. 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RT p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation RL J. Biol. Chem. 275:20853-60 (2000). RN [74]; RE0041690. RX PUBMED: 12208951. RA Kino T., Gragerov A., Slobodskaya O., Tsopanomichalou M., Chrousos G. P., Pavlakis G. N. RT Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators RL J. Virol. 76:9724-34 (2002). RN [75]; RE0041692. RX PUBMED: 10713736. RA Preston G. A., Srinivasan D., Barrett J. C. RT Apoptotic response to growth factor deprivation involves cooperative interactions between c-Fos and p300 RL Cell Death Differ. 7:215-26 (2000). RN [76]; RE0041697. RX PUBMED: 11481322. RA Dai Y. S., Markham B. E. RT p300 Functions as a coactivator of transcription factor GATA-4 RL J. Biol. Chem. 276:37178-85 (2001). RN [77]; RE0041698. RX PUBMED: 11268218. RA Hasan S., Hassa P. O., Imhof R., Hottiger M. O. RT Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis RL Nature 410:387-91 (2001). RN [78]; RE0041699. RX PUBMED: 12937166. RA Hong R., Chakravarti D. RT The human proliferating Cell nuclear antigen regulates transcriptional coactivator p300 activity and promotes transcriptional repression RL J. Biol. Chem. 278:44505-13 (2003). RN [79]; RE0041700. RX PUBMED: 12384703. RA Kasper L. H., Boussouar F., Ney P. A., Jackson C. W., Rehg J., van Deursen J. M., Brindle P. K. RT A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis RL Nature 419:738-43 (2002). RN [80]; RE0041701. RX PUBMED: 11756538. RA Qiu Y., Guo M., Huang S., Stein R. RT Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47 RL Mol. Cell. Biol. 22:412-20 (2002). RN [81]; RE0041995. RX PUBMED: 15224190. RA Chen J., Halappanavar S. 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RA Masumi A., Yamakawa Y., Fukazawa H., Ozato K., Komuro K. RT Interferon regulatory factor-2 regulates cell growth through its acetylation RL J. Biol. Chem. 278:25401-7 (2003). RN [86]; RE0042305. RX PUBMED: 10216070. RA Oike Y., Takakura N., Hata A., Kaname T., Akizuki M., Yamaguchi Y., Yasue H., Araki K., Yamamura K., Suda T. RT Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis RL Blood 93:2771-9 (1999). RN [87]; RE0042314. RX PUBMED: 11505407. RA Gires O., Kieu C., Fix P., Schmitt B., Munz M., Wollenberg B., Zeidler R. RT Tumor necrosis factor alpha negatively regulates the expression of the carcinoma-associated antigen epithelial cell adhesion molecule RL Cancer 92:620-8 (2001). RN [88]; RE0042378. RX PUBMED: 14722092. RA Matsuda S., Harries J. C., Viskaduraki M., Troke P. J., Kindle K. B., Ryan C., Heery D. M. RT A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP RL J. Biol. Chem. 279:14055-64 (2004). RN [89]; RE0042409. RX PUBMED: 10363932. RA Liu Y. Z., Thomas N. S., Latchman D. S. RT CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment RL Neuroreport 10:1239-43 (1999). RN [90]; RE0042430. RX PUBMED: 14521911. RA Ota K., Kameoka M., Tanaka Y., Itaya A., Yoshihara K. RT Expression of histone acetyltransferases was down-regulated in poly(ADP-ribose) polymerase-1-deficient murine cells RL Biochem. Biophys. Res. Commun. 310:312-7 (2003). RN [91]; RE0042433. RX PUBMED: 10942771. RA Bhakat K. K., Mitra S. RT Regulation of the human O6-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300 RL J. Biol. Chem. 275:34197-204 (2000). RN [92]; RE0042437. RX PUBMED: 12732631. RA Tsuda M., Takahashi S., Takahashi Y., Asahara H. RT Transcriptional co-activators CREB-binding protein and p300 regulate chondrocyte-specific gene expression via association with Sox9 RL J. Biol. Chem. 278:27224-9 (2003). RN [93]; RE0042444. RX PUBMED: 11943779. RA Chen Q., Dowhan D. H., Liang D., Moore D. D., Overbeek P. A. RT CREB-binding protein/p300 co-activation of crystallin gene expression RL J. Biol. Chem. 277:24081-9 (2002). RN [94]; RE0042445. RX PUBMED: 12183445. RA Gobin S. J., Biesta P., de Steenwinkel J. E., Datema G., van den Elsen P. J. RT HLA-G transactivation by cAMP-response element-binding protein (CREB). An alternative transactivation pathway to the conserved major histocompatibility complex (MHC) class I regulatory routes RL J. Biol. Chem. 277:39525-31 (2002). RN [95]; RE0042556. RX PUBMED: 10946277. RA Sisk T. J., Gourley T., Roys S., Chang C. H. RT MHC class II transactivator inhibits IL-4 gene transcription by competing with NF-AT to bind the coactivator CREB binding protein (CBP)/p300 RL J. Immunol. 165:2511-7 (2000). RN [96]; RE0042557. RX PUBMED: 15138260. RA Jin Y. H., Jeon E. J., Li Q. L., Lee Y. H., Choi J. K., Kim W. J., Lee K. Y., Bae S. C. RT Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation RL J. Biol. Chem. 279:29409-17 (2004). RN [97]; RE0042621. RX PUBMED: 11940655. RA Asahara H., Tartare-Deckert S., Nakagawa T., Ikehara T., Hirose F., Hunter T., Ito T., Montminy M. RT Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro RL Mol. Cell. Biol. 22:2974-83 (2002). RN [98]; RE0042629. RX PUBMED: 11567019. RA Kim R. H., Flanders K. C., Birkey Reffey S., Anderson L. A., Duckett C. S., Perkins N. D., Roberts A. B. RT SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators RL J. Biol. Chem. 276:46297-304 (2001). RN [99]; RE0042631. RX PUBMED: 14585496. RA Ji A., Dao D., Chen J., MacLellan W. R. RT EID-2, a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD RL Gene 318:35-43 (2003). RN [100]; RE0042632. RX PUBMED: 10025406. RA Hamamori Y., Sartorelli V., Ogryzko V., Puri P. L., Wu H. Y., Wang J. Y., Nakatani Y., Kedes L. RT Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A RL Cell 96:405-13 (1999). RN [101]; RE0042685. RX PUBMED: 10753971. RA Bergel M., Herrera J. E., Thatcher B. J., Prymakowska-Bosak M., Vassilev A., Nakatani Y., Martin B., Bustin M. RT Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes RL J. Biol. Chem. 275:11514-20 (2000). 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RA Miyamoto S., Suzuki T., Muto S., Aizawa K., Kimura A., Mizuno Y., Nagino T., Imai Y., Adachi N., Horikoshi M., Nagai R. RT Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain RL Mol. Cell. Biol. 23:8528-41 (2003). RN [114]; RE0042943. RX PUBMED: 15184875. RA Grabmaier K., A. de Weijert MC, Verhaegh G. W., Schalken J. A., Oosterwijk E. RT Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma RL Oncogene 23:5624-31 (2004). RN [115]; RE0043438. RX PUBMED: 12453427. RA Hasan S., El-Andaloussi N., Hardeland U., Hassa P. O., Burki C., Imhof R., Schar P., Hottiger M. O. RT Acetylation regulates the DNA end-trimming activity of DNA polymerase beta RL Mol. Cell 10:1213-22 (2002). RN [116]; RE0043446. RX PUBMED: 9858599. RA Kasper L. H., Brindle P. K., Schnabel C. A., Pritchard C. E., Cleary M. L., van Deursen J. M. RT CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity RL Mol. Cell. Biol. 19:764-76 (1999). RN [117]; RE0043449. RX PUBMED: 12640139. RA Giandomenico V., Simonsson M., Gronroos E., Ericsson J. RT Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors RL Mol. Cell. Biol. 23:2587-99 (2003). RN [118]; RE0044043. RX PUBMED: 11755530. RA Mandolesi G., Gargano S., Pennuto M., Illi B., Molfetta R., Soucek L., Mosca L., Levi A., Jucker R., Nasi S. RT NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction RL FEBS Lett. 510:50-6 (2002). RN [119]; RE0045620. RX PUBMED: 12750254. RA Shiseki M., Nagashima M., Pedeux R. M., Kitahama-Shiseki M., Miura K., Okamura S., Onogi H., Higashimoto Y., Appella E., Yokota J., Harris C. C. RT p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity RL Cancer Res. 63:2373-8 (2003). RN [120]; RE0046933. RX PUBMED: 11429405. RA Sugihara T. M., Kudryavtseva E. I., Kumar V., Horridge J. J., Andersen B. RT The POU domain factor Skin-1a represses the keratin 14 promoter independent of DNA binding. A possible role for interactions between Skn-1a and CREB-binding protein/p300 RL J. Biol. Chem. 276:33036-44 (2001). RN [121]; RE0047138. RX PUBMED: 15123687. RA Fu M., Rao M., Wu K., Wang C., Zhang X., Hessien M., Yeung Y. G., Gioeli D., Weber M. J., Pestell R. G. RT The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity RL J. Biol. Chem. 279:29436-49 (2004). RN [122]; RE0047163. RX PUBMED: 14612401. RA Fu M., Rao M., Wang C., Sakamaki T., Wang J., Di Vizio D., Zhang X., Albanese C., Balk S., Chang C., Fan S., Rosen E., Palvimo J. J., Janne O. A., Muratoglu S., Avantaggiati M. L., Pestell R. G. RT Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth RL Mol. Cell. Biol. 23:8563-75 (2003). RN [123]; RE0047167. RX PUBMED: 15137909. RA Huang S. M., Cheng Y. S. RT Analysis of two CBP (cAMP-response-element-binding protein-binding protein) interacting sites in GRIP1 (glucocorticoid-receptor-interacting protein), and their importance for the function of GRIP1 RL Biochem. J. 382:111-9 (2004). RN [124]; RE0047371. RX PUBMED: 15623506. RA Furumatsu T., Tsuda M., Taniguchi N., Tajima Y., Asahara H. RT Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment. RL J. Biol. Chem. 280:8343-8350 (2005). RN [125]; RE0047502. RX PUBMED: 16024799. RA Pedeux R., Sengupta S., Shen J. C., Demidov O. N., Saito S., Onogi H., Kumamoto K., Wincovitch S., Garfield S. H., McMenamin M., Nagashima M., Grossman S. R., Appella E., Harris C. C. RT ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. RL Mol. Cell. Biol. 25:6639-6648 (2005). RN [126]; RE0047504. RX PUBMED: 15964811. RA Guidez F., Howell L., Isalan M., Cebrat M., Alani R. M., Ivins S., Hormaeche I., McConnell M. J., Pierce S., Cole P. A., Licht J., Zelent A. RT Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. RL Mol. Cell. Biol. 25:5552-5566 (2005). RN [127]; RE0047680. RX PUBMED: 9812988. RA Na S. Y., Choi H. S., Kim J. W., Na D. S., Lee J. W. RT Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor. RL J. Biol. Chem. 273:30933-30938 (1998). RN [128]; RE0047810. RX PUBMED: 14701856. RA Debril M. B., Gelman L., Fayard E., Annicotte J. S., Rocchi S., Auwerx J. RT Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. RL J. Biol. 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R., Gu W., Dalla-Favera R. RT Acetylation inactivates the transcriptional repressor BCL6. RL Nat. Genet. 32:606-613 (2002). RN [133]; RE0048186. RX PUBMED: 15383283. RA Wu R. C., Qin J., Yi P., Wong J., Tsai S. Y., Tsai M. J., O'Malley B. W. RT Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. RL Mol. Cell 15:937-949 (2004). RN [134]; RE0048280. RX PUBMED: 16434977. RA Gong J., Zhu J., Goodman OB J. r., Pestell R. G., Schlegel P. N., Nanus D. M., Shen R. RT Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells. RL Oncogene 25:2011-2021 (2006). RN [135]; RE0048301. RX PUBMED: 15023334. RA Cohen H. Y., Lavu S., Bitterman K. J., Hekking B., Imahiyerobo T. A., Miller C., Frye R., Ploegh H., Kessler B. M., Sinclair D. A. RT Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. RL Mol. Cell 13:627-638 (2004). RN [136]; RE0048582. RX PUBMED: 11919190. RA Czuwara-Ladykowska J., Sementchenko V. I., Watson D. K., Trojanowska M. RT Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta. RL J. Biol. Chem. 277:20399-20408 (2002). RN [137]; RE0048617. RX PUBMED: 16574662. RA Tanaka T., Nishimura D., Wu R. C., Amano M., Iso T., Kedes L., Nishida H., Kaibuchi K., Hamamori Y. RT Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. RL J. Biol. Chem. 281:15320-15329 (2006). RN [138]; RE0048797. RX PUBMED: 11279135. RA Wang C., Fu M., Angeletti R. H., Siconolfi-Baez L., Reutens A. T., Albanese C., Lisanti M. P., Katzenellenbogen B. S., Kato S., Hopp T., Fuqua S. A., Lopez G. N., Kushner P. J., Pestell R. G. RT Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity. RL J. Biol. Chem. 276:18375-18383 (2001). 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