AC T00111
XX
ID T00111
XX
DT 27.10.1992 (created); ewi.
DT 15.06.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA c-Ets-1
XX
SY c-Ets-1; Ets1; p54.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006040 Ets1.
XX
CL C0016; ETS; 3.5.2.1.1.
XX
SF monomeric DNA-binding, spanning about 20 nucleotides of one face of the DNA double helix [4] [2];
SF major groove contacts within the contact core region, minor groove binding in the flanking sequences [2];
SF phosphorylation (Ca-dependent) [1];
SF crystal structure of c-Ets-1/DNA complex and of a ternary complex Pax-5/c-Ets-1/DNA has been solved [12];
SF contacts with Pax-5 result in conformational changes and reorientation of c-Ets-1 DBD on DNA [12];
SF binding of c-Ets-1 to DNA resulted in a 27� bend on the DNA, in the ternary complex Pax-5/c-Ets-1/DNA this is changed to 14� [12];
XX
CP T-cells (predom.); lymphoid cells: thymocytes, bursal lymphocytes (all cell lines) [5]; Dimethylsulfoxide treated FLC [16].
EX Meckel's cartilage,,,Theiler Stage 22; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX adrenal gland (right + left),,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX adrenal gland (right + left),,,Theiler Stage 23; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX adrenal gland (right + left),,,Theiler Stage 24; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX adrenal gland (right + left),,,adult; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX adrenal gland (right + left),mesodermal cell,,Theiler Stage 16; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX brain,,,Theiler Stage 22; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX brain,,,Theiler Stage 24; medium; Northern blot; total RNA; [5].
EX brain,,,adult; none; Northern blot; mRNA (poly-A); [5].
EX brain,,,neonate (during the first month after birth); high; Northern blot; total RNA; [5].
EX brain,mesenchyme cell,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX cartilage,,,Theiler Stage 22; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX cerebral cortex,,,Theiler Stage 23; very high; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX distal extremity of Meckel's cartilage,,,Theiler Stage 22; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX exoccipital pre-cartilage condensation,,,Theiler Stage 22; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX fourth ventricle,,,Theiler Stage 23; very high; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX future brain,mesenchyme cell,,Theiler Stage 14; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX grey substance of spinal cord,,,Theiler Stage 23; very high; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX heart,,,Theiler Stage 23; high; Northern blot; total RNA; [5].
EX heart,,,Theiler Stage 24; medium; Northern blot; total RNA; [5].
EX heart,,,adult; none; Northern blot; mRNA (poly-A); [5].
EX heart,,,neonate (during the first month after birth); detectable; Northern blot; total RNA; [5].
EX hindfoot plate,,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX intestine,,,Theiler Stage 23; high; Northern blot; total RNA; [5].
EX intestine,,,Theiler Stage 24; low; Northern blot; total RNA; [5].
EX intestine,,,Theiler Stage 25; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX intestine,,,Theiler Stage 26; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX intestine,,,adult; none; Northern blot; mRNA (poly-A); [5].
EX intestine,,,neonate (during the first month after birth); detectable; Northern blot; total RNA; [5].
EX intestine,,,neonate (during the first month after birth); none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX kidney (right and left),,,Theiler Stage 23; high; Northern blot; total RNA; [5].
EX kidney (right and left),,,Theiler Stage 24; medium; Northern blot; total RNA; [5].
EX kidney (right and left),,,adult; none; Northern blot; mRNA (poly-A); [5].
EX kidney (right and left),,,neonate (during the first month after birth); detectable; Northern blot; total RNA; [5].
EX large intestine,,,Theiler Stage 24; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX large intestine,epithelial cell,,Theiler Stage 22; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX large intestine,mesenchyme cell,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX liver,,,Theiler Stage 23; high; Northern blot; total RNA; [5].
EX liver,,,Theiler Stage 24; medium; Northern blot; total RNA; [5].
EX liver,,,adult; none; Northern blot; mRNA (poly-A); [5].
EX liver,,,neonate (during the first month after birth); detectable; Northern blot; total RNA; [5].
EX lung,,,Theiler Stage 23; high; Northern blot; total RNA; [5].
EX lung,,,Theiler Stage 24; high; Northern blot; total RNA; [5].
EX lung,,,adult; very low; Northern blot; mRNA (poly-A); [5].
EX lung,,,neonate (during the first month after birth); detectable; Northern blot; total RNA; [5].
EX mouse, Mus musculus,,,Theiler Stage 12; high; Northern blot; total RNA; [5].
EX mouse, Mus musculus,,,Theiler Stage 14; high; Northern blot; total RNA; [5].
EX mouse, Mus musculus,,,Theiler Stage 16; high; Northern blot; total RNA; [5].
EX mouse, Mus musculus,,,Theiler Stage 18; detectable; Northern blot; total RNA; [5].
EX mouse, Mus musculus,,,Theiler Stage 20; low; Northern blot; total RNA; [5].
EX neural crest of future mesencephalon,neural crest cell,,Theiler Stage 14; high; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX optic stalk,,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX otic placode,mesenchyme cell,,Theiler Stage 16; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX proximal extremity of Meckel's cartilage,,,Theiler Stage 22; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX retina,,,Theiler Stage 22; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX skeleton of forelimb,,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX skeleton of hindlimb,,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX skeleton of tail,,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX skeleton,,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX small intestine,epithelial cell,,Theiler Stage 22; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX small intestine,mesenchyme cell,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX spleen,,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX spleen,,,Theiler Stage 23; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX spleen,,,Theiler Stage 23; high; Northern blot; total RNA; [5].
EX spleen,,,Theiler Stage 24; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX spleen,,,Theiler Stage 24; medium; Northern blot; total RNA; [5].
EX spleen,,,adult; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX spleen,,,adult; low; Northern blot; mRNA (poly-A); [5].
EX spleen,,,neonate (during the first month after birth); high; Northern blot; total RNA; [5].
EX spleen,mesodermal cell,,Theiler Stage 16; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX stomach,,,Theiler Stage 23; high; Northern blot; total RNA; [5].
EX stomach,,,Theiler Stage 24; low; Northern blot; total RNA; [5].
EX stomach,,,adult; none; Northern blot; mRNA (poly-A); [5].
EX stomach,,,neonate (during the first month after birth); detectable; Northern blot; total RNA; [5].
EX thymus,,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX thymus,,,Theiler Stage 23; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX thymus,,,Theiler Stage 23; high; Northern blot; total RNA; [5].
EX thymus,,,Theiler Stage 24; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX thymus,,,Theiler Stage 24; medium; Northern blot; total RNA; [5].
EX thymus,,,adult; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX thymus,,,adult; low; Northern blot; mRNA (poly-A); [5].
EX thymus,,,neonate (during the first month after birth); high; Northern blot; total RNA; [5].
EX thymus,mesodermal cell,,Theiler Stage 16; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX vertebra,,,Theiler Stage 22; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX vertebral canal,mesenchyme cell,,Theiler Stage 16; detectable; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX white substance of spinal cord,,,Theiler Stage 23; none; RNA-in situ hybridization (radioactive); RNA (undefined); [5].
EX yolk sac,,,Theiler Stage 12; high; Northern blot; total RNA; [5].
EX yolk sac,,,Theiler Stage 14; high; Northern blot; total RNA; [5].
EX yolk sac,,,Theiler Stage 16; high; Northern blot; total RNA; [5].
EX yolk sac,,,Theiler Stage 18; detectable; Northern blot; total RNA; [5].
EX yolk sac,,,Theiler Stage 20; low; Northern blot; total RNA; [5].
XX
FF Binding activity of Ets-1 upon Transferrin Receptor gene is downmodulated during erythroid maturation in response to the dimethyl sulfoxide treatment. [16];
FF activator;
FF recognizes GGA core sequence;
FF acts synergistically with a number of transcription factors, AP-1, NF-kappaB, SRF, Sp1, PEBP2alpha, ATF/CREB, LEF-1, and some others;
FF may play an important role in mesodermal cell development for organ formation and tissue modeling [5];
FF mitogenic stimuli cause Ca-dependent phosphorylation [1];
FF acts synergistically and interacts directly with Pax-5 upon regulation of B-cell specific genes [10] [11];
XX
IN T02266 AML3-isoform2; mouse, Mus musculus.
IN T01062 AML3; mouse, Mus musculus.
IN T00032 AP-1; mouse, Mus musculus.
IN T23418 HDAC1; mouse, Mus musculus.
IN T23091 p300; Mammalia.
XX
MX M00032 V$CETS1P54_01.
MX M00074 V$CETS1P54_02.
MX M01078 V$CETS1P54_03.
MX M01986 V$CETS1_01.
MX M01870 V$CETS1_Q6.
MX M07211 V$ETS1_09.
MX M00339 V$ETS1_B.
MX M08881 V$ETSLIKE_Q4.
MX M00340 V$ETS_B.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
XX
BS R19160.
BS R04053.
BS R04054.
BS R04055.
BS R04056.
BS R04057.
BS R04058.
BS R04059.
BS R04060.
BS R04061.
BS R04062.
BS R04063.
BS R24065.
BS R04547.
BS R12538.
BS R14492.
BS R04450.
BS R24059.
BS R24064.
BS R14623.
BS R14624.
BS R14625.
BS R73954.
BS R25987.
BS R19554.
BS R18125.
BS R03475.
BS R66858.
BS R26372.
BS R60226.
BS R60229.
BS R25788.
BS R68279.
BS R56502.
BS R04065.
BS R26190.
BS R16699.
BS R19142.
BS R19143.
BS R40181.
BS R25618.
BS R19681.
BS R74013.
BS R59665.
BS R56498.
BS R19663.
BS R18139.
BS R18141.
BS R18143.
BS R18144.
BS R60231.
BS R73955.
BS R08168.
BS R62468.
BS R28557.
BS R01224.
BS R35032.
BS R19595.
BS R34776.
XX
DR TRANSPATH: MO000024714.
DR TRANSCOMPEL: C00134.
DR TRANSCOMPEL: C00170.
DR TRANSCOMPEL: C00174.
DR TRANSCOMPEL: C00184.
DR TRANSCOMPEL: C00185.
DR TRANSCOMPEL: C00231.
DR TRANSCOMPEL: C00239.
DR TRANSCOMPEL: C00252.
DR TRANSCOMPEL: C00273.
DR TRANSCOMPEL: C00275.
DR TRANSCOMPEL: C00466.
DR TRANSCOMPEL: C00524.
DR UniProtKB: P27577;
XX
RN [1]; RE0000480.
RX PUBMED: 3136014.
RA Pognonec P., Boulukos K. E., Gesquiere J. C., Stehelin D., Ghysdael J.
RT Mitogenic stimulation of thymocytes results in the calcium-dependent phosphorylation of c-ets-1 proteins
RL EMBO J. 7:977-983 (1988).
RN [2]; RE0000800.
RX PUBMED: 1592264.
RA Nye J. A., Petersen J. M., Gunther C. V., Jonsen M. D., Graves B. J.
RT Interaction of murine Ets-1 with GGA-binding sites establishes the Ets domain as a new DNA-binding motif
RL Genes Dev. 6:975-990 (1992).
RN [3]; RE0001139.
RX PUBMED: 1964178.
RA Major E. O., Ameniya K., Elder G., Houff S. A.
RT Glial cells of the human developing brain and B cells of the immune system share a common DNA binding factor for recognition of the regulatroy sequences of the human polyomavirus, JCV
RL J. Neurosci. Res. 27:461-471 (1990).
RN [4]; RE0002584.
RX PUBMED: 1409581.
RA Hagman J., Grosschedl R.
RT An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of Ets family factors to promoter sequences of the mb-1 gene
RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992).
RN [5]; RE0005315.
RX PUBMED: 7689222.
RA Kola I., Brookes S., Green A. R., Garber R., Tymms M., Papas T. S., Setz A.
RT The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation
RL Proc. Natl. Acad. Sci. USA 90:7588-7592 (1993).
RN [6]; RE0005316.
RX PUBMED: 8223245.
RA Klaembt C.
RT The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells
RL Development 117:163-176 (1993).
RN [7]; RE0005318.
RX PUBMED: 2204020.
RA Chen J. H.
RT Cloning, sequencing, and expression of mouse c-ets-1 cDNA in baculovirus expression system
RL Oncogene Res. 5:277-285 (1990).
RN [8]; RE0013315.
RX PUBMED: 8557686.
RA Logan S. K., Garabedian M. J., Campbell C. E., Werb Z.
RT Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors
RL J. Biol. Chem. 271:774-782 (1996).
RN [9]; RE0016625.
RX PUBMED: 7774816.
RA Giese K., Kingsley C., Kirshner J. R., Grosschedl R.
RT Assembly and function of a TCR alpha enhancer complex id dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.
RL Genes Dev. 9:995-1008 (1995).
RN [10]; RE0016685.
RX PUBMED: 8804314.
RA Fitzsimmons D., Hodsdon W., Wheat W., Maira S. M., Wasylyk B., Hagman J.
RT Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter.
RL Genes Dev. 10:2198-2211 (1996).
RN [11]; RE0016687.
RX PUBMED: 10022910.
RA Wheat W., Fitzsimmons D., Lennox H., Krautkramer S. R., Gentile L. N., McIntosh L. P., Hagman J.
RT The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes.
RL Mol. Cell. Biol. 19:2231-2241 (1999).
RN [12]; RE0023824.
RX PUBMED: 11779502.
RA Garvie C. W., Hagman J., Wolberger C.
RT Structural studies of Ets-1/Pax5 complex formation on DNA.
RL Mol. Cell 8:1267-1276 (2001).
RN [13]; RE0035772.
RX PUBMED: 11782450.
RA Seidel J. J., Graves B. J.
RT An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors.
RL Genes Dev. 16:127-137 (2002).
RN [14]; RE0048003.
RX PUBMED: 9566892.
RA Hedge S. P., Kumar A., Kurschner C., Shapiro L. H.
RT c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation.
RL Mol. Cell. Biol. 18:2729-2737 (1998).
RN [15]; RE0048408.
RX PUBMED: 16854466.
RA Martin C. B., Ingersoll S. A., Martin B. K.
RT Transcriptional control of the C3a receptor gene in glial cells: Dependence upon AP-1 but not Ets.
RL Mol. Immunol. 44:703-712 (2007).
RN [16]; RE0052679.
RX PUBMED: 12439744.
RA Marziali G., Perrotti E., Ilari R., Lulli V., Coccia E. M., Moret R., Kuhn L. C., Testa U., Battistini A.
RT Role of Ets-1 in transcriptional regulation of transferrin receptor and erythroid differentiation.
RL Oncogene 21:7933-7944 (2002).
RN [17]; RE0066901.
RX PUBMED: 18958307.
RA De la Houssaye G., Vieira V., Masson C., Beermann F., Dufier J. L., Menasche M., Abitbol M.
RT ETS-1 and ETS-2 are upregulated in a transgenic mouse model of pigmented ocular neoplasm.
RL Mol. Vis. 14:1912-1928 (2008).
RN [18]; RE0070213.
RX PUBMED: 21148801.
RA Grenningloh R., Tai T. S., Frahm N., Hongo T. C., Chicoine A. T., Brander C., Kaufmann D. E., Ho I. C.
RT Ets-1 maintains IL-7 receptor expression in peripheral T cells.
RL J. Immunol. 186:969-976 (2011).
XX
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