AC T22380
XX
ID T22380
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DT 10.03.2005 (created); nvo.
DT 23.12.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA Smad7
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SY Smad-7.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T02872 beta-catenin; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T16471 SRF; Mammalia.
IN T27177 Tsc-22-isoform2; human, Homo sapiens.
XX
MX M00974 V$SMAD_Q6_01.
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BS R36783.
BS R36786.
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DR TRANSPATH: MO000047065.
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RN [1]; RE0018942.
RX PUBMED: 10757800.
RA Datta P. K., Moses H. L.
RT STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling
RL Mol. Cell. Biol. 20:203157-3167 (2000).
RN [2]; RE0020503.
RX PUBMED: 9738003.
RA Souchelnytskyi S., Nakayama T., Nakao A., Moren A., Heldin C.-H., Christian J. L., ten Dijke P.
RT Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors
RL J. Biol. Chem. 273:25364-25370 (1998).
RN [3]; RE0020643.
RX PUBMED: 11278251.
RA Ebisawa T., Fukuchi M., Murakami G., Chiba T., Tanaka K., Imamura T., Miyazono K.
RT Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
RL J. Biol. Chem. 276:12477-12480 (2001).
RN [4]; RE0022894.
RX PUBMED: 12589052.
RA Edlund S., Bu S., Schuster N., Aspenstrom P., Heuchel R., Heldin N. E., ten Dijke P., Heldin C. H., Landstrom M.
RT Transforming Growth Factor-beta1 (TGF-beta)-induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-beta-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3.
RL Mol. Biol. Cell 14:529-544 (2003).
RN [5]; RE0022931.
RX PUBMED: 12023024.
RA Liu X., Nagarajan R. P., Vale W., Chen Y.
RT Phosphorylation regulation of the interaction between Smad7 and activin type I receptor.
RL FEBS Lett. 519:93-98 (2002).
RN [6]; RE0025738.
RX PUBMED: 12118366.
RA Ferrigno O., Lallemand F., Verrecchia F., L'Hoste S., Camonis J., Atfi A., Mauviel A.
RT Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling.
RL Oncogene 21:4879-84 (2002).
RN [7]; RE0029297.
RX PUBMED: 11737269.
RA Yanagisawa M., Nakashima K., Takeda K., Ochiai W., Takizawa T., Ueno M., Takizawa M., Shibuya H., Taga T.
RT Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7.
RL Genes Cells 6:1091-9 (2001).
RN [8]; RE0031911.
RX PUBMED: 15253713.
RA Nakagawa T., Li J. H., Garcia G., Mu W., Piek E., Bottinger E. P., Chen Y., Zhu H. J., Kang D. H., Schreiner G. F., Lan H. Y., Johnson R. J.
RT TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways.
RL Kidney Int. 66:605-13 (2004).
RN [9]; RE0033126.
RX PUBMED: 14633701.
RA Liu X., Lee J., Cooley M., Bhogte E., Hartley S., Glick A.
RT Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma.
RL Cancer Res. 63:7760-8 (2003).
RN [10]; RE0033793.
RX PUBMED: 12707256.
RA Denton C. P., Zheng B., Evans L. A., Shi-wen X., Ong V. H., Fisher I., Lazaridis K., Abraham D. J., Black C. M., de Crombrugghe B.
RT Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.
RL J. Biol. Chem. 278:25109-19 (2003).
RN [11]; RE0034303.
RX PUBMED: 14718519.
RA Shi W., Sun C., He B., Xiong W., Shi X., Yao D., Cao X.
RT GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor.
RL J. Cell Biol. 164:291-300 (2004).
RN [12]; RE0034771.
RX PUBMED: 14722222.
RA Wen F. Q., Liu X., Kobayashi T., Abe S., Fang Q., Kohyama T., Ertl R., Terasaki Y., Manouilova L., Rennard S. I.
RT Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
RL Am. J. Respir. Cell Mol. Biol. 30:816-22 (2004).
RN [13]; RE0039135.
RX PUBMED: 14657019.
RA Koinuma D., Shinozaki M., Komuro A., Goto K., Saitoh M., Hanyu A., Ebina M., Nukiwa T., Miyazawa K., Imamura T., Miyazono K.
RT Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7
RL EMBO J. 22:6458-70 (2003).
RN [14]; RE0041180.
RX PUBMED: 12815042.
RA Imoto S., Sugiyama K., Muromoto R., Sato N., Yamamoto T., Matsuda T.
RT Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3
RL J. Biol. Chem. 278:34253-8 (2003).
RN [15]; RE0042810.
RX PUBMED: 12408818.
RA Gronroos E., Hellman U., Heldin C. H., Ericsson J.
RT Control of Smad7 stability by competition between acetylation and ubiquitination
RL Mol. Cell 10:483-93 (2002).
RN [16]; RE0045812.
RX PUBMED: 11180003.
RA Dahler A. L., Cavanagh L. L., Saunders N. A.
RT Suppression of keratinocyte growth and differentiation by transforming growth factor beta1 involves multiple signaling pathways
RL J. Invest. Dermatol 116:266-74 (2001).
RN [17]; RE0045987.
RX PUBMED: 14993265.
RA Kim B. C., Lee H. J., Park S. H., Lee S. R., Karpova T. S., McNally J. G., Felici A., Lee D. K., Kim S. J.
RT Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation
RL Mol. Cell. Biol. 24:2251-62 (2004).
RN [18]; RE0046082.
RX PUBMED: 11483516.
RA Itoh F., Asao H., Sugamura K., Heldin C. H., ten Dijke P., Itoh S.
RT Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
RL EMBO J. 20:4132-42 (2001).
RN [19]; RE0049221.
RX PUBMED: 12151385.
RA Suzuki C., Murakami G., Fukuchi M., Shimanuki T., Shikauchi Y., Imamura T., Miyazono K.
RT Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.
RL J. Biol. Chem. 277:39919-39925 (2002).
RN [20]; RE0049244.
RX PUBMED: 14728725.
RA Ibarrola N., Kratchmarova I., Nakajima D., Schiemann W. P., Moustakas A., Pandey A., Mann M.
RT Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling.
RL BMC Cell Biol. 5:2 (2004).
RN [21]; RE0049583.
RX PUBMED: 17327236.
RA Seong H. A., Jung H., Kim K. T., Ha H.
RT 3-phosphoinositide-dependent protein kinase-1 (PDK1) negatively regulates TGF-beta -induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.
RL J. Biol. Chem. 282:12272-12289 (2007).
RN [22]; RE0049605.
RX PUBMED: 16251192.
RA Seong H. A., Jung H., Choi H. S., Kim K. T., Ha H.
RT Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.
RL J. Biol. Chem. 280:42897-42908 (2005).
RN [23]; RE0054638.
RX PUBMED: 18593713.
RA Tang Y., Liu Z., Zhao L., Clemens T. L., Cao X.
RT Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion.
RL J. Biol. Chem. 283:23956-23963 (2008).
RN [24]; RE0060832.
RX PUBMED: 16690609.
RA Camoretti-Mercado B., Fernandes D. J., Dewundara S., Churchill J., Ma L., Kogut P. C., McConville J. F., Parmacek M. S., Solway J.
RT Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7.
RL J. Biol. Chem. 281:20383-20392 (2006).
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