AC T00113
XX
ID T00113
XX
DT 26.10.1992 (created); ewi.
DT 04.04.2012 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA c-Ets-2
XX
SY c-Ets-2; c-Ets-2 58-64; Ets-2; Ets2; p58-64c-Ets-2.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004958 ETS2; HGNC: Ets2.
XX
CL C0016; ETS.
XX
SZ 469 AA; 53.0 kDa (cDNA) (calc.), 56 kDa (SDS)
XX
SQ MNDFGIKNMDQVAPVANSYRGTLKRQPAFDTFDGSLFAVFPSLNEEQTLQEVPTGLDSIS
SQ HDSANCELPLLTPCSKAVMSQALKATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATN
SQ EFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEE
SQ NSHLTSVPHWINSNTLGFGTEQAPYGMQTQNYPKGGLLDSMCPASTPSVLSSEQEFQMFP
SQ KSRLSSVSVTYCSVSQDFPGSNLNLLTNNSGTPKDHDSPENGADSFESSDSLLQSWNSQS
SQ SLLDVQRVPSFESFEDDCSQSLCLNKPTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGS
SQ GPIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRG
SQ LRYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED
XX
SC Swiss-Prot#P15036
XX
FT 87 170 
PF02198; Sterile alpha motif (SAM)/Pointed domain.
FT 87 170 
SM00251; SAM2_3.
FT 102 168 
POINTED domain of homology [9].
FT 285 310 
auxiliary for repression of DNA-binding [2].
FT 311 364 
repression of DNA-binding [2].
FT 362 445 
PF00178; Ets-domain.
FT 362 447 
SM00413; etsneu2.
FT 363 443 
PS50061; ETS_DOMAIN_3.
FT 365 433 
PS50140; HSF_ETS.
FT 454 469 
repression of DNA-binding [5].
XX
SF DBD of c-Ets-2 is necessary for direct physical interactions with GR [11];
SF transactivation domain of c-Ets-2 is involved in its functional synergy with GR [11];
XX
CP predominant expression in T cells.
XX
FF increases after T-cell induction;
FF mediates response to IL-1 and TPA by an inducible transactivation domain in the regulatory system of the uPA gene [10];
FF c-Ets-2 is phosphorylated by MAPK p41 which is stimulated by several growth factors, including EGF [6];
FF can functionally cooperate and physically interact with GR, and thus is involved in glucocorticoid-dependent induction of the rat cyp27 gene G009035 [11];
XX
IN T05499 BAF47; human, Homo sapiens.
IN T27820 BAF57; mouse, Mus musculus.
IN T05451 BRG1; human, Homo sapiens.
IN T16150 BRG1; mouse, Mus musculus.
IN T16987 BRG1; Mammalia.
IN T19411 BS69; mouse, Mus musculus.
IN T19412 BS69; mouse, Mus musculus.
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T15118 CBP; Mammalia.
IN T09920 CREB1; Mammalia.
IN T00333 GR; rat, Rattus norvegicus.
IN T23091 p300; Mammalia.
XX
MX M07379 V$ETS2_Q4.
MX M01207 V$ETS2_Q6.
MX M08881 V$ETSLIKE_Q4.
MX M00340 V$ETS_B.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
XX
BS R02100.
BS R73934.
BS R36052.
BS R04350.
BS R04338.
BS R04339.
BS R04343.
BS R14537.
BS R14491.
BS R14492.
BS R73050.
BS R38325.
BS R17066.
BS R17067.
BS R17068.
BS R73990.
BS R73992.
BS R17177.
BS R18147.
BS R74010.
BS R08492.
BS R12088.
BS R14803.
BS R36061.
BS R04985.
BS R18424.
BS R73871.
BS R36051.
BS R36054.
BS R18145.
BS R01224.
BS R26228.
BS R14393.
BS R18127.
BS R18128.
BS R18130.
XX
DR TRANSPATH: MO000019545.
DR TRANSCOMPEL: C00020.
DR TRANSCOMPEL: C00083.
DR TRANSCOMPEL: C00084.
DR TRANSCOMPEL: C00135.
DR TRANSCOMPEL: C00238.
DR TRANSCOMPEL: C00240.
DR TRANSCOMPEL: C00263.
DR TRANSCOMPEL: C00405.
DR TRANSCOMPEL: C00512.
DR TRANSCOMPEL: C00513.
DR TRANSCOMPEL: C00524.
DR TRANSCOMPEL: C00640.
DR EMBL: J04102;
DR EMBL: X55181; HSETS23.
DR UniProtKB: P15036; ETS2_HUMAN.
XX
RN [1]; RE0000479.
RX PUBMED: 2209540.
RA Bosselut R., Duvall J. F., Gegonne A., Bailly M., Hemar A., Brady J., Ghysdael J.
RT The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1
RL EMBO J. 9:3137-3144 (1990).
RN [2]; RE0000799.
RX PUBMED: 1592263.
RA Wasylyk C., Kerckaert J.-P., Wasylyk B.
RT A novel modulator domain of Ets transcription factors
RL Genes Dev. 6:965-974 (1992).
RN [3]; RE0002411.
RX PUBMED: 2187191.
RA Bhat N. K., Thompson C. B., Lindsten T., June C. H., Fujiware S., Koizumi S., Fischer R. J., Papas T. S.
RT Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: Regulatory role for the protooncogene ETS1
RL Proc. Natl. Acad. Sci. USA 87:3723-3727 (1990).
RN [4]; RE0002437.
RX PUBMED: 1741383.
RA Dudek H., Tantravahi R. V., Rao V. N., Reddy E. Sh., Reddy E. P.
RT Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter
RL Proc. Natl. Acad. Sci. USA 89:1291-1295 (1992).
RN [5]; RE0002584.
RX PUBMED: 1409581.
RA Hagman J., Grosschedl R.
RT An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of Ets family factors to promoter sequences of the mb-1 gene
RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992).
RN [6]; RE0004123.
RX PUBMED: 7559524.
RA Albanese C., Johnson J., Watanabe G., Eklund N., Vu D., Arnold A., Pestell R. C.
RT Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
RL J. Biol. Chem. 270:23589-23597 (1995).
RN [7]; RE0005309.
RX PUBMED: 2997781.
RA Watson D. K., McWilliams-Smith M. J., Nunn M. F., Duesberg P. H., O'Brien S. J., Papas T. S.
RT The ets sequence from the transforming gene of avian erythroblastosis virus
RL Proc. Natl. Acad. Sci. USA 82:7294-7298 (1985).
RN [8]; RE0005310.
RX PUBMED: 2847145.
RA Watson D. K., McWilliams-Smith M. J., Lapis P., Lautenberger J. A., Schweinfest C. W., Papas T. S.
RT Mammalian ets-1 and ets-2 genes encode highly conserved proteins
RL Proc. Natl. Acad. Sci. USA 85:7862-7866 (1988).
RN [9]; RE0005316.
RX PUBMED: 8223245.
RA Klaembt C.
RT The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells
RL Development 117:163-176 (1993).
RN [10]; RE0013940.
RX PUBMED: 10454570.
RA Cirillo G., Casalino L., Vallone D., Caracciolo A., De Cesare D., Verde P.
RT Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate
RL Mol. Cell. Biol. 19:6340-6252 (1999).
RN [11]; RE0023549.
RX PUBMED: 11279115.
RA Mullick J., Anandatheerthavarada H. K., Amuthan G., Bhagwat S. V., Biswas G., Camasamudram V., Bhat N. K., Reddy S. E., Rao V., Avadhani N. G.
RT Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter.
RL J. Biol. Chem. 276:18007-18017 (2001).
RN [12]; RE0030266.
RX PUBMED: 12637547.
RA Baker K. M., Wei G., Schaffner A. E., Ostrowski M. C.
RT Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter.
RL J. Biol. Chem. 278:17876-84 (2003).
RN [13]; RE0048238.
RX PUBMED: 11027273.
RA Smith J. L., Schaffner A. E., Hofmeister J. K., Hartman M., Wei G., Forsthoefel D., Hume D. A., Ostrowski M. C.
RT ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice.
RL Mol. Cell. Biol. 20:8026-8034 (2000).
RN [14]; RE0048259.
RX PUBMED: 12894593.
RA Wei G., Schaffner A. E., Baker K. M., Mansky K. C., Ostrowski M. C.
RT Ets-2 interacts with co-repressor BS69 to repress target gene expression.
RL Anticancer Res. 23:2173-2178 (2003).
RN [15]; RE0048279.
RX PUBMED: 15637148.
RA Ghosh D., Sachdev S., Hannink M., Roberts R. M.
RT Coordinate regulation of basal and cyclic 5'-adenosine monophosphate (cAMP)-activated expression of human chorionic gonadotropin-alpha by Ets-2 and cAMP-responsive element binding protein.
RL Mol. Endocrinol. 19:1049-1066 (2005).
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