TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00333 XX ID T00333 XX DT 15.10.1992 (created); ewi. DT 28.09.2015 (updated); hna. CO Copyright (C), QIAGEN. XX FA GR XX SY GCR; glucocorticoid receptor; NR3C1. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G000742 Nr3c1. XX CL C0002; CC (rec); XX SF data from crystal structure, CD, NMR of the DBD available [26] [50]; SF native folding of the DBD to full alpha-helix content requires zinc ions [25]; SF DNA-binding to a GRE half-site is suppressed by the A/B region; SF first zinc finger binds specifically to GRE, the second enhances affinity [37]; SF free in solution, GR exists predominantly as homodimer [40]; SF AGRND in the second zinc finger mediates homodimerization and discrimination against DNA-binding of other nuclear receptors [26]; SF cooperative DNA-binding to repeated GREs requires trans-activating domain 1 [12]; SF DBD is necessary for direct physical interactions and functional synergy with c-Ets-2 [58]; XX EX liver,,,adult; detectable. XX FF mediates gene induction / repression by glucocorticoids via direct binding to DNA glucocorticoid response elements [42] [39]; FF ligand binding leads to dissociation from hsp90 and allows nuclear translocation [47]; FF GR can functionally cooperate with other transcription factors, including Oct, NF-1, Sp1 [49]; FF can functionally cooperate with AP-1 [59]; FF represses Oct-1 DNA binding [56]; FF functionally cooperates with c-Ets-2 to provide glucocorticoid-dependent induction of the cyp27 gene [58]; FF often provides glucocorticoid-dependent gene activation acting as a co-activator rather than DNA-binding factor, may function as a co-activator for STAT5 [61] [54]; XX IN T00029 AP-1; human, Homo sapiens. IN T00113 c-Ets-2; human, Homo sapiens. IN T00131 c-Jun; mouse, Mus musculus. IN T00132 c-Jun; rat, Rattus norvegicus. IN T00133 c-Jun; human, Homo sapiens. IN T00134 c-Jun; chick, Gallus gallus. IN T00135 c-Jun; hamster, Cricetulus sp. IN T00990 FKBP59; human, Homo sapiens. IN T25707 FUS-L; human, Homo sapiens. IN T00333 GR; rat, Rattus norvegicus. IN T00993 hsp56; human, Homo sapiens. IN T00992 Hsp90; human, Homo sapiens. IN T00959 POU2F1; monkey, Cercopithecus aethiops. IN T01466 POU2F1; Chinese hamster (Gray hamster), Cricetulus griseus. IN T00644 POU2F1a; mouse, Mus musculus. IN T02453 Sp3; rat, Rattus norvegicus. IN T08256 SRC-1A; human, Homo sapiens. IN T06605 STAT3; rat, Rattus norvegicus. XX MX M00205 V$GRE_C. MX M00955 V$GR_01. MX M07355 V$GR_Q4. MX M00192 V$GR_Q6. MX M00921 V$GR_Q6_01. MX M01836 V$GR_Q6_02. MX M00960 V$PR_Q2. XX BS R02163. BS R12350. BS R13056. BS R35376. BS R35379. BS R12380. BS R00593. BS R00595. BS R21739. BS R21743. BS R01106. BS R01107. BS R01108. BS R57486. BS R57499. BS R57508. BS R38789. BS R38790. BS R38793. BS R38794. BS R38800. BS R38810. BS R38812. BS R01698. BS R60545. BS R62036. BS R62037. BS R62039. BS R62040. BS R62042. BS R62044. BS R62045. BS R62046. BS R69809. BS R27218. BS R35523. BS R38649. BS R74032. BS R65837. BS R74043. BS R74044. BS R02021. BS R68241. BS R68244. BS R68272. BS R56906. BS R35998. BS R35632. BS R27204. BS R73874. BS R33035. BS R66508. XX DR TRANSPATH: MO000021742. DR TRANSCOMPEL: C00043. DR TRANSCOMPEL: C00128. DR TRANSCOMPEL: C00287. DR TRANSCOMPEL: C00298. DR TRANSCOMPEL: C00405. DR UniProtKB: P06536; DR PDB: 1gdc. DR PDB: 2gda. XX RN [1]; RE0000113. RX PUBMED: 6317184. RA Payvar F., DeFranco D., Firestone G. L., Edgar B., Wrange Oe., Okret S., Gustafsson J.-A., Yamamoto K. RT Sequence-Specific Binding of Glucocorticoid Receptor to MTV DNA at Sites within and Upstream of the Transcribed Region RL Cell 35:381-392 (1983). RN [2]; RE0000127. RX PUBMED: 2881624. RA Jantzen H.-M., Straehle U., Gloss B., Stewart F., Schmid W., Boshart M., Miksicek R., Schuetz G. RT Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene RL Cell 49:29-38 (1987). RN [3]; RE0000128. RX PUBMED: 3167984. RA Tsai S. Y., Carlstedt-Duke J., Weigel N. L., Dahlmann K., Gustafsson J.-A., Tsai M.-J., O'Malley B. W. RT Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation RL Cell 55:361-369 (1988). RN [4]; RE0000248. RX PUBMED: 2169352. RA Yang-Yen H.-F., Chambard J.-C., Sun Y.-L., Smeal T., Schmidt T. J., Drouin J., Karin M. RT Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction RL Cell 62:1205-1215 (1990). RN [5]; RE0000303. RX PUBMED: 2118106. RA Lucibello F. C., Slater E. P., Jooss K. U., Beato M., Mueller R. RT Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB RL EMBO J. 9:2827-2834 (1990). RN [6]; RE0000360. RX PUBMED: 2828035. RA Gloss B., Bernard H. U., Seedorf K., Klock G. RT The upstream regulatory region of the human papilloma virus-16 contains an E2 protein-independent enhancer which is specific for cervical carcinoma cells and regulated by glucocorticoid hormones RL EMBO J. 6:3735-3743 (1987). RN [7]; RE0000379. RX PUBMED: 3416833. RA Hecht A., Berkenstam A., Stroemstedt P.-E., Gustafsson J.-A., Sippel A. E. RT A progesterone responsive element maps to the far upstream steroid DNase hypersensitive site of chicken lysozyme chromatin RL EMBO J. 7:2063-2073 (1988). RN [8]; RE0000386. RX PUBMED: 2846275. RA Perlmann T., Wrange Oe. RT Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome RL EMBO J. 7:3073-3079 (1988). RN [9]; RE0000407. RX PUBMED: 3582368. RA Danesch U., Gloss B., Schmid W., Schuetz G., Schuele R., Renkawitz R. RT Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements RL EMBO J. 6:625-630 (1987). RN [10]; RE0000410. RX PUBMED: 3816760. RA Bailly A., Le Page C., Rauch M., Milgrom E. RT Sequence-specific DNA binding of the progesterone receptor to the uteroglobin gene: effects of hormone, antihormone and receptor phosphorylation RL EMBO J. 5:3235-3241 (1986). RN [11]; RE0000411. RX PUBMED: 6098443. RA Cato A. C. B., Geisse S., Wenz M., Westphal H. M., Beato M. RT The nucleotide sequences recognized by the glucocorticoid receptor in the rabbit uteroglobin gene region are located far upstream from the initiation of transcription RL EMBO J. 3:2771-2778 (1984). RN [12]; RE0000425. RX PUBMED: 2792086. RA Schmid W., Straehle U., Schuetz G., Schmitt J., Stunnenberg H. RT Glucocorticoid receptor binds cooperatively to adjacent recognition sites RL EMBO J. 8:2257-2263 (1989). RN [13]; RE0000858. RX PUBMED: 2494184. RA Wrange O., Eriksson P., Perlmann T. RT The Purified Activated Glucocorticoid Receptor Is a Homodimer RL J. Biol. Chem. 264:5253-5259 (1989). RN [14]; RE0000879. RX PUBMED: 2153679. RA Nemoto T., Mason G. F., Wilhelmsson A., Cuthill S., Hapgood J., Gustafsson J. A., Poellinger L. RT Activation of the Dioxin and Glucocorticoid Receptors to a DNA Binding State under Cell-free Conditions RL J. Biol. Chem. 256:2269-2277 (1990). RN [15]; RE0001002. RX PUBMED: 2040629. RA Cairns W., Cairns C., Pongratz I., Poellinger L., Okret S. RT Assembly of a glucocorticoid receptor complex prior to DNA binding enhances its specific interaction with a glucocorticoid response element RL J. Biol. Chem. 266:11221-11226 (1991). RN [16]; RE0001245. RX PUBMED: 2454390. RA Guertin M., LaRue H., Bernier D., Wrange O., Chevrette M., Gingras M.-C., Belanger L. RT Enhancer and Promoter Elements Directing Activation and Glucocorticoid Repression of the alpha1-Fetoprotein Gene in Hepatocytes RL Mol. Cell. Biol. 8:1398-1407 (1988). RN [17]; RE0001408. RX PUBMED: 2586521. RA Drouin J., Trifiro M. A., Plante R. K., Nemer M., Eriksson P., Wrange Oe. RT Glucocorticoid Receptor Binding to a Specific DNA Sequence Is Required for Hormone-Dependent Repression of Pro-Opiomelanocortin Gene Transcription RL Mol. Cell. Biol. 9:5305-5314 (1989). RN [18]; RE0001556. RX PUBMED: 2388623. RA Imai E., Stromstedt P.-E., Quinn P. G., Carlstedt-Duke J., Gustafsson J.-A., Granner D. K. RT Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene RL Mol. Cell. Biol. 10:4712-4719 (1990). RN [19]; RE0001579. RX PUBMED: 1846670. RA Archer T. K., Cordingley M. G., Wolford R. G., Hager G. L. RT Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter RL Mol. Cell. Biol. 11:688-698 (1991). RN [20]; RE0001811. RX PUBMED: 2983219. RA von der Ahe D., Janich S., Scheidereit C., Renkawitz R., Schuetz G., Beato M. RT Glucocorticoid and progesterone receptors bind the same sites in two hormonally regulated promoters RL Nature 313:706-709 (1985). RN [21]; RE0001812. RX PUBMED: 6323998. RA Karin M., Haslinger A., Holtgreve H., Richards R. I., Krauter P., Westphal H. M., Beato M. RT Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene RL Nature 308:513-519 (1984). RN [22]; RE0001815. RX PUBMED: 3025742. RA Willmann T., Beato M. RT Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumor virus DNA RL Nature 324:688-691 (1986). RN [23]; RE0001816. RX PUBMED: 6310405. RA Scheidereit C., Geisse S., Westphal H. M., Beato M. RT The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumor virus RL Nature 304:749-752 (1983). RN [24]; RE0001825. RX PUBMED: 2879246. RA Becker P. B., Gloss B., Schmid W., Straehle W., Schuetz G. RT In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone RL Nature 324:686-688 (1986). RN [25]; RE0001836. RX PUBMED: 3043231. RA Freedman L. P., Luisi B. F., Korszun Z. R., Basavappa R., Sigler P. B., Yamamoto K. R. RT The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain RL Nature 334:543-546 (1988). RN [26]; RE0001893. RX PUBMED: 1865905. RA Luisi B. F., Xu W. X., Otwinowski Z., Freedman L. P., Yamamoto K. R., Sigler P. B. RT Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA RL Nature 352:497-505 (1991). RN [27]; RE0002011. RX PUBMED: 2848219. RA Chalepakis G., Postma J. P. M., Beato M. RT A model for hormone receptor binding to the mouse mammary tumor virus regulatory element based on hydroxyl radical footprinting RL Nucleic Acids Res. 16:10237-10248 (1988). RN [28]; RE0002033. RX PUBMED: 3453115. RA Jantzen K., Fritton H. P., Igo-Kemenes T., Espel E., Janich S., Cato A. C. B., Mugele K., Beato M. RT Partial overlapping of binding sequences for steroid hormone receptors and DNaseI hypersensitive sites in the rabbit uteroglobin gene region RL Nucleic Acids Res. 15:4535-4552 (1987). RN [29]; RE0002076. RX PUBMED: 2377462. RA Jaiswal A. K., Haaparanta T., Luc P.-V., Schembri J., Adesnik M. RT Glucocorticoid regulation of a phenobarbital-inducible cytochrome P-450 gene: the presence of a functional glucocorticoid response element in the 5'-flanking region of the CYP2B2 gene RL Nucleic Acids Res. 18:4237 (1990). RN [30]; RE0002291. RX PUBMED: 3016728. RA Okret S., Poellinger L., Dong Y., Gustafsson J.-A. RT Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone RL Proc. Natl. Acad. Sci. USA 83:5899-5903 (1986). RN [31]; RE0002294. RX PUBMED: 2983311. RA Moore D. D., Marks A. R., Buckley D. I., Kapler G., Payvar F., Goodman H. M. RT The first intron of the human growth hormone gene contains a binding site for glucocorticoid receptor RL Proc. Natl. Acad. Sci. USA 82:699-702 (1985). RN [32]; RE0002323. RX PUBMED: 3458241. RA von der Ahe D., Renoir J.-M., Buchou T., Baulieu E.-E., Beato M. RT Receptors for glucocorticosteroid and progesterone recognize distinct features of a DNA regulatory element RL Proc. Natl. Acad. Sci. USA 83:2817-2821 (1986). RN [33]; RE0002331. RX PUBMED: 6328488. RA Scheidereit C., Beato M. RT Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus RL Proc. Natl. Acad. Sci. USA 81:3029-3033 (1984). RN [34]; RE0002522. RX PUBMED: 2120703. RA Archer T. K., Hager G. L., Omichinski J. G. RT Sequence-specific DNA binding by glucocorticoid receptor zinc finger peptides RL Proc. Natl. Acad. Sci. USA 87:7560-7564 (1990). RN [35]; RE0002597. RX PUBMED: 2838908. RA Akerblom I., Slater E. P., Beato M., Baxter J. D., Mellon P. L. RT Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer RL Science 241:350-353 (1988). RN [36]; RE0002622. RX PUBMED: 2473529. RA Freedman L. P., Yoshinaga S. K., Vanderbilt J. N., Yamamoto K. RT In vitro transcription enhancement by purified derivates of the glucocorticoid receptor RL Science 245:298-301 (1989). RN [37]; RE0002694. RX PUBMED: 2115209. RA Haerd T., Kelenbach E., Boelens R., Maler B. A., Dahlmann K., Freedman L. P., Carlstedt-Duke J., Yamamoto K. R., Gustafsson J.-A., Kaptein R. RT Solution structure of the glucocorticoid receptor DNA-binding domain RL Science 249:157-160 (1990). RN [38]; RE0002743. RX PUBMED: 2162765. RA Gutman A., Wasylyk B. RT The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites RL EMBO J. 9:2241-2246 (1990). RN [39]; RE0002749. RX PUBMED: 1970570. RA Dong Y., Cairns W., Okret S., Gustafsson J.-A. RT A glucocorticoid-resistant rat hepatoma cell variant contains functional glucocorticoid receptors RL J. Biol. Chem. 265:7526-7531 (1990). RN [40]; RE0002807. RX PUBMED: 2303460. RA Eriksson P., Wrange Oe. RT Protein-protein contacts in the glucocorticoid receptor homodimer influence its DNA binding properties RL J. Biol. Chem. 265:3535-3542 (1990). RN [41]; RE0002810. RX PUBMED: 2365707. RA Howard K. J., Holley S. J., Yamamoto K. R., Distelhorst C. W. RT Mapping the HSP90 binding region of the glucocorticoid receptor RL J. Biol. Chem. 265:11928-11935 (1990). RN [42]; RE0002817. RX PUBMED: 2038339. RA Stroemstedt P.-E., Poellinger L., Gustafsson J.-A., Carlstedt-Duke J. RT The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: A potential mechanism for negative regulation RL Mol. Cell. Biol. 11:3379-3383 (1991). RN [43]; RE0002981. RX PUBMED: 1406672. RA Kutoh E., Stroemstedt P.-E., Poellinger L. RT Functional interference between the ubiquitous and constitutive octamer transcription factor 1 (OTF-1) and the glucocorticoid receptor by direct protein-protein interaction involving the homeo subdomain of OTF-1 RL Mol. Cell. Biol. 12:4960-4969 (1992). RN [44]; RE0003695. RX PUBMED: 3755378. RA Miesfeld R., Rusconi S., Godowski P. J., Maler B. A., Okret S., Wikstroem A.-C., Gustafsson J.-A., Yamamoto K. R. RT Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA RL Cell 46:389-399 (1986). RN [45]; RE0003698. RX PUBMED: 479195. RA Wrange O., Carlstedt-Duke J., Gustafsson J.-A. RT Purification of the glucocorticoid receptor from the rat liver cytosol RL J. Biol. Chem. 254:9284-9289 (1979). RN [46]; RE0003699. RX PUBMED: 7188251. RA Westphal H. M., Moldenhauer G., Beato M. RT Monoclonal antibodies to the rat liver glucocorticoid receptor RL EMBO J. 1:1467-1471 (1982). RN [47]; RE0003700. RX PUBMED: 8407992. RA Pratt W. B. RT The role of the heat shock proteins in regulating the function, folding and trafficking of the glucocorticoid receptor RL J. Biol. Chem. 268:21455-21458 (1993). RN [48]; RE0003706. RX PUBMED: 3123217. RA Picard D., Yamamoto K. R. RT Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor RL EMBO J. 6:3333-3340 (1987). RN [49]; RE0003714. RX PUBMED: 3201230. RA Schuele R., Muller M., Kaltschmidt C., Renkawitz R. RT Many transcription factors interact synergistically with steroid receptors RL Science 242:1418-1420 (1988). RN [50]; RE0003715. RX PUBMED: 8108380. RA Eriksson M. A. L., Berglund H., Haerd T., Wilsson L. RT A comparison of 15N NMR relaxion measurement with a molecular dynamics simulation: backbone dynamics of the glucocorticoid receptor DNA-binding domain RL Proteins 17:375-390 (1993). RN [51]; RE0003717. RX PUBMED: 6549049. RA Miesfeld R., Okret S., Wistroem A.-C., Gustafsson J.-A., Yamamoto K. R. RT Characterization of a steroid hormone receptor gene and mRNA in wild-type and mutant cells RL Nature 312:779-781 (1984). RN [52]; RE0003718. RX PUBMED: 1310618. RA Schulman G., Bodine P. V., Litwack G. RT Modulators of the glucocorticoid receptor also regulate mineralocorticoid receptor function. RL Biochemistry 31:1734-1741 (1992). RN [53]; RE0003719. RX PUBMED: 3684608. RA Chang C., Kokontis J., Chang C.-T., Liao S. RT Cloning and sequence analysis of the rat ventral prostate glucocorticoid receptor cDNA RL Nucleic Acids Res. 15:9603 (1987). RN [54]; RE0006153. RX PUBMED: 8878484. RA Stoecklin E., Wissler M., Goullieux F., Groner B. RT Functinal interactions between Stat5 and the glucocorticoid receptor RL Nature 383:726-728 (1996). RN [55]; RE0013603. RX PUBMED: 3474612. RA Carlstedt-Duke J., Stromstedt P. E., Wrange O., Bergman T., Gustafsson J. A., Jornvall H. RT Domain structure of the glucocorticoid receptor protein RL Proc. Natl. Acad. Sci. USA 84:4437-4440 (1987). RN [56]; RE0016547. RX PUBMED: 1846780. RA Brueggemeier U., Kalff M., Franke S., Scheidereit C., Beato M. RT Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors. RL Cell 64:565-572 (1991). RN [57]; RE0020597. RX PUBMED: 11005817. RA Widen C., Zilliacus J., Gustafsson J. A., Wikstrom A. C. RT Glucocorticoid receptor interaction with 14-3-3 and Raf-1, a proposed mechanism for cross-talk of two signal transduction pathways RL J. Biol. Chem. 275:39296-39301 (2000). RN [58]; RE0023549. RX PUBMED: 11279115. RA Mullick J., Anandatheerthavarada H. K., Amuthan G., Bhagwat S. V., Biswas G., Camasamudram V., Bhat N. K., Reddy S. E., Rao V., Avadhani N. G. RT Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter. RL J. Biol. Chem. 276:18007-18017 (2001). RN [59]; RE0023552. RX PUBMED: 9804760. RA Pearce D., Matsui W., Miner J. N., Yamamoto K. R. RT Glucocorticoid receptor transcriptional activity determined by spacing of receptor and nonreceptor DNA sites. RL J. Biol. Chem. 273:30081-30085 (1998). RN [60]; RE0023554. RX PUBMED: 9973262. RA Wyszomierski S. L., Yeh J., Rosen J. M. RT Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation. RL Mol. Endocrinol. 13:330-343 (1999). RN [61]; RE0023558. RX PUBMED: 9343435. RA Stoecklin E., Wissler M., Moriggl R., Groner B. RT Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription. RL Mol. Cell. Biol. 17:6708-6716 (1997). RN [62]; RE0037501. RX PUBMED: 10508170. RA Hittelman A. B., Burakov D., Iniguez-Lluhi J. A., Freedman L. P., Garabedian M. J. 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