AC T00333
XX
ID T00333
XX
DT 15.10.1992 (created); ewi.
DT 28.09.2015 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA GR
XX
SY GCR; glucocorticoid receptor; NR3C1.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G000742 Nr3c1.
XX
CL C0002; CC (rec); 2.1.1.1.1.
XX
SF data from crystal structure, CD, NMR of the DBD available [26] [50];
SF native folding of the DBD to full alpha-helix content requires zinc ions [25];
SF DNA-binding to a GRE half-site is suppressed by the A/B region;
SF first zinc finger binds specifically to GRE, the second enhances affinity [37];
SF free in solution, GR exists predominantly as homodimer [40];
SF AGRND in the second zinc finger mediates homodimerization and discrimination against DNA-binding of other nuclear receptors [26];
SF cooperative DNA-binding to repeated GREs requires trans-activating domain 1 [12];
SF DBD is necessary for direct physical interactions and functional synergy with c-Ets-2 [58];
XX
EX liver,,,adult; detectable.
XX
FF mediates gene induction / repression by glucocorticoids via direct binding to DNA glucocorticoid response elements [42] [39];
FF ligand binding leads to dissociation from hsp90 and allows nuclear translocation [47];
FF GR can functionally cooperate with other transcription factors, including Oct, NF-1, Sp1 [49];
FF can functionally cooperate with AP-1 [59];
FF represses Oct-1 DNA binding [56];
FF functionally cooperates with c-Ets-2 to provide glucocorticoid-dependent induction of the cyp27 gene [58];
FF often provides glucocorticoid-dependent gene activation acting as a co-activator rather than DNA-binding factor, may function as a co-activator for STAT5 [61] [54];
XX
IN T00029 AP-1; human, Homo sapiens.
IN T00113 c-Ets-2; human, Homo sapiens.
IN T00131 c-Jun; mouse, Mus musculus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00134 c-Jun; chick, Gallus gallus.
IN T00135 c-Jun; hamster, Cricetulus sp.
IN T00990 FKBP59; human, Homo sapiens.
IN T25707 FUS-L; human, Homo sapiens.
IN T00333 GR; rat, Rattus norvegicus.
IN T00993 hsp56; human, Homo sapiens.
IN T00992 Hsp90; human, Homo sapiens.
IN T00959 POU2F1; monkey, Cercopithecus aethiops.
IN T01466 POU2F1; Chinese hamster (Gray hamster), Cricetulus griseus.
IN T00644 POU2F1a; mouse, Mus musculus.
IN T02453 Sp3; rat, Rattus norvegicus.
IN T08256 SRC-1A; human, Homo sapiens.
IN T06605 STAT3; rat, Rattus norvegicus.
XX
MX M00205 V$GRE_C.
MX M00955 V$GR_01.
MX M07355 V$GR_Q4.
MX M00192 V$GR_Q6.
MX M00921 V$GR_Q6_01.
MX M01836 V$GR_Q6_02.
MX M00960 V$PR_Q2.
XX
BS R02163.
BS R12350.
BS R13056.
BS R35376.
BS R35379.
BS R12380.
BS R00593.
BS R00595.
BS R21739.
BS R21743.
BS R01106.
BS R01107.
BS R01108.
BS R57486.
BS R57499.
BS R57508.
BS R38789.
BS R38790.
BS R38793.
BS R38794.
BS R38800.
BS R38810.
BS R38812.
BS R01698.
BS R60545.
BS R62036.
BS R62037.
BS R62039.
BS R62040.
BS R62042.
BS R62044.
BS R62045.
BS R62046.
BS R69809.
BS R27218.
BS R35523.
BS R38649.
BS R74032.
BS R65837.
BS R74043.
BS R74044.
BS R02021.
BS R68241.
BS R68244.
BS R68272.
BS R56906.
BS R35998.
BS R35632.
BS R27204.
BS R73874.
BS R33035.
BS R66508.
XX
DR TRANSPATH: MO000021742.
DR TRANSCOMPEL: C00043.
DR TRANSCOMPEL: C00128.
DR TRANSCOMPEL: C00287.
DR TRANSCOMPEL: C00298.
DR TRANSCOMPEL: C00405.
DR UniProtKB: P06536;
DR PDB: 1gdc.
DR PDB: 2gda.
XX
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RT Sequence-Specific Binding of Glucocorticoid Receptor to MTV DNA at Sites within and Upstream of the Transcribed Region
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RT Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene
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RT Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome
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RT The nucleotide sequences recognized by the glucocorticoid receptor in the rabbit uteroglobin gene region are located far upstream from the initiation of transcription
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XX
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