AC T00644
XX
ID T00644
XX
DT 15.10.1992 (created); ewi.
DT 22.11.2005 (updated); oke.
CO Copyright (C), QIAGEN.
XX
FA POU2F1a
XX
SY alpha-H1; IgNF-A; NF-A; NF-A1; NF-III; OBP100; Oct-1; oct-B1A; oct-B1B; octamer-binding factor; OTF-1; TRF.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009187 Pou2f1.
XX
CL C0007; POU.
XX
SZ 770 AA; 79.5 kDa (cDNA) (calc.), 90-100 kDa (SDS)
XX
SQ MNNPSETNKSSMESEDASTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS
SQ LQAAAQSLNVQSKSSEESGDSQQSSQPSSQPPSVQSAIPQTQLMLAGGQITGLTLTPAQQ
SQ QLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQL
SQ QQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQP
SQ QPSITLTSQPTTPTRTIAAASVQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRR
SQ IKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSD
SQ STASSPSALNSPGLGAEGLNRRRKKRTSIETNIRVALEKSFMENQKPTSEDITLIAEQLN
SQ MEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPASLVATTPSLVTSSTATTLT
SQ VNPVLPLTSAAVTNLSLTDQDLRRGCSWEVLRSLPDRVTTTAGTTDSTSNNNTATVISTA
SQ PPASSAVTSPSLSPSPSASASTSEASSASETNTTQTTSTPLPSPLGASQVMVTTPGLQTA
SQ AAALQGAGQLPANASLAAMAAAAGLSPGLMAPSQFAAGGALLSLSPGTLGSALSPALMSN
SQ STLATIQALASSGSLPITSLDATGNLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLV
SQ SAAAASTGNSAPTASLHASSTSTESIQSSLFTVASASGPASTTTAASKAQ
XX
SC Swiss-Prot#P25425-1
XX
FT 281 355 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 281 355 
SM00352; pou.
FT 380 440 
PS50071; HOMEOBOX_2.
FT 380 442 
PS50550; POU_HOMEODOMAIN.
FT 382 444 
SM00389; HOX_1.
FT 383 439 
PF00046; Homeobox domain.
FT 454 731 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 499 522 
missing in Oct-1B and Oct-1C [14].
FT 717 770 
replaced by 693-701 in Oct-1C [14].
XX
SF at least 3 splice variants are encoded by the murine oct-1 gene [14];
SF compared to the human homolog, mouse Oct-1 exhibits four AA exchanges within helix 1 and 2 making its sequence more similar to (human) Oct-2 and thus causing a much weaker interaction with VP16 [14] [16];
SF homeo domain essential for GR interaction [11];
XX
CP ubiquitous [3].
XX
FF DNA-binding is reduced by GR in a ligand-dependent manner [11];
XX
IN T01030 CCF; human, Homo sapiens.
IN T00337 GR-alpha; human, Homo sapiens.
IN T01920 GR-beta; human, Homo sapiens.
IN T00333 GR; rat, Rattus norvegicus.
IN T02142 OCA-B; mouse, Mus musculus.
IN T00649 Oct-2; cat, Felis silvestris catus.
IN T00650 Oct-2; rat, Rattus rattus.
IN T00894 Vmw65; HSV-1, herpes simplex virus type 1.
XX
MX M00135 V$OCT1_01.
MX M00136 V$OCT1_02.
MX M00137 V$OCT1_03.
MX M00138 V$OCT1_04.
MX M00161 V$OCT1_05.
MX M00162 V$OCT1_06.
MX M00248 V$OCT1_07.
MX M01354 V$OCT1_08.
MX M00342 V$OCT1_B.
MX M00930 V$OCT1_Q5_01.
MX M00195 V$OCT1_Q6.
MX M00210 V$OCT_C.
MX M00795 V$OCT_Q6.
MX M07059 V$POU2F1_Q4_01.
MX M03561 V$POU2F1_Q6.
XX
BS R16342.
BS R16343.
BS R03333.
BS R03334.
BS R03335.
BS R16335.
BS R16349.
BS R16350.
BS R16351.
BS R16352.
BS R16208.
BS R16346.
BS R16344.
BS R16340.
BS R16341.
BS R15439.
BS R00810.
BS R02824.
BS R13419.
BS R13422.
BS R13423.
BS R13427.
BS R13428.
BS R00303.
BS R00304.
BS R00305.
BS R00306.
BS R15140.
BS R00864.
BS R00870.
BS R00872.
BS R01884.
BS R01885.
BS R01886.
BS R16347.
BS R16348.
BS R16334.
BS R16355.
BS R16357.
BS R15132.
BS R02225.
BS R04594.
BS R04595.
BS R04602.
BS R04708.
BS R04726.
BS R04727.
BS R04728.
BS R16177.
BS R16178.
BS R16180.
BS R16181.
BS R01933.
XX
DR TRANSPATH: MO000046030.
DR EMBL: X56230; MMOCT1R.
DR EMBL: X68362; MMOCT1A.
DR EMBL: X70325; MMOCT1AA.
DR UniProtKB: P25425-1;
XX
RN [1]; RE0000088.
RX PUBMED: 3091258.
RA Sen R., Baltimore D.
RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences
RL Cell 46:705-716 (1986).
RN [2]; RE0000405.
RX PUBMED: 2826127.
RA Rosales R., Vigneron M., Macchi M., Davidson I., Xiao J. H., Chambon P.
RT In vitro binding of cell-specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancers
RL EMBO J. 6:3015-3025 (1987).
RN [3]; RE0000423.
RX PUBMED: 2573523.
RA Schoeler H. R., Hatzopoulos A. K., Balling R., Suzuki N., Gruss P.
RT A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor
RL EMBO J. 8:2543-2550 (1989).
RN [4]; RE0000424.
RX PUBMED: 2573524.
RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P.
RT Octamer binding proteins confer transcriptional activity in early mouse embryogenesis
RL EMBO J. 8:2551-2557 (1989).
RN [5]; RE0000891.
RX PUBMED: 2498322.
RA Takimoto M., Quinn J. P., Farina A. R., Staudt L. M., Levens D.
RT fos/jun and Octamer-binding Protein Interact with a Common Site in a Negative Element of the Human c-myc Gene
RL J. Biol. Chem. 264:8982-8999 (1989).
RN [6]; RE0001367.
RX PUBMED: 2113179.
RA Nelms K., van Ness B.
RT Identification of an Octamer-Binding Site in the Human Kappa Light-Chain Enhancer
RL Mol. Cell. Biol. 10:3843-3846 (1990).
RN [7]; RE0001800.
RX PUBMED: 3095662.
RA Staudt L. M., Singh H., Sen R., Wirth T., Sharp P. A., Baltimore D.
RT A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes
RL Nature 323:640-643 (1986).
RN [8]; RE0002315.
RX PUBMED: 3259319.
RA Hanke J. H., Landolfi N. F., Tucker P. W., Capra J. D.
RT Identification of murine nuclear proteins that bind to the conserved octamer sequence of the immunoglobulin promoter region
RL Proc. Natl. Acad. Sci. USA 85:3560-3564 (1988).
RN [9]; RE0002378.
RX PUBMED: 2508087.
RA Hermanson G. G., Briskin M., Sigman D., Wall R.
RT Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene
RL Proc. Natl. Acad. Sci. USA 86:7341-7345 (1989).
RN [10]; RE0002740.
RX PUBMED: 2357966.
RA Schoeler H. R., Dressler G. R., Balling R., Rohdewohld H., Gruss P.
RT Oct-4: a germline-specific transcription factor mapping to the mouse t-complex
RL EMBO J. 9:2185-2195 (1990).
RN [11]; RE0002981.
RX PUBMED: 1406672.
RA Kutoh E., Stroemstedt P.-E., Poellinger L.
RT Functional interference between the ubiquitous and constitutive octamer transcription factor 1 (OTF-1) and the glucocorticoid receptor by direct protein-protein interaction involving the homeo subdomain of OTF-1
RL Mol. Cell. Biol. 12:4960-4969 (1992).
RN [12]; RE0004178.
RX PUBMED: 1561098.
RA Stepchenko A. G.
RT The nucleotide sequence of mouse OCT-1 cDNA
RL Nucleic Acids Res. 20:1419 (1992).
RN [13]; RE0004184.
RX PUBMED: 7622033.
RA Herr W., Cleary M. A.
RT The POU domain: versatility in tanscriptional regulation by a flexible two-in-one DNA-binding domain
RL Genes Dev. 9:1679-1693 (1995).
RN [14]; RE0004185.
RX PUBMED: 8441632.
RA Suzuki N., Peter W., Ciesiolka T., Gruss P., Schoeler H. R.
RT Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2
RL Nucleic Acids Res. 21:245-252 (1993).
RN [15]; RE0004186.
RX PUBMED: 1970171.
RA Goldsborough A., Ashworth A., Willison K. R.
RT Cloning and sequencing of POU-boxes expressed in mouse testis
RL Nucleic Acids Res. 18:1634-1634 (1990).
RN [16]; RE0004213.
RX PUBMED: 8422989.
RA Cleary M. A., Stern S., Tanaka M., Herr W.
RT Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment
RL Genes Dev. 7:72-83 (1993).
XX
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