AC T02142
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ID T02142
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DT 23.05.1997 (created); hiwi.
DT 11.07.2014 (updated); pos.
CO Copyright (C), QIAGEN.
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FA OCA-B
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SY B-cell Oct-binding protein 1; Bob1; OBF1; OCA-B; Oct coactivator from B cells; POU2AF1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006571 Pou2af1.
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SF interacts with POU domains of Oct-1 and Oct-2 in a DNA-independent manner [4] [5] [3];
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CP B cells (all stages) [5].
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FF no DNA-binding activity by the isolated factor [3];
FF stimulates octamer-dependent promoters, but not enhancers, in non-B cell cotransfection studies [3];
FF PORE and MORE have different potential to mediate synergism between Oct1 T00644 and OBF1: the coactivator OBF1 failed to stimulate MORE-mediated transcription R16341 alone or in conjunction with either Oct1 T00644 or Oct2 T00648 in 293 cells, in contrast PORE-mediated transcription R16340 was significantly stimulated with either Oct1 or Oct2 [4];
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IN T00648 Oct-2.2; mouse, Mus musculus.
IN T00644 POU2F1a; mouse, Mus musculus.
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MX M02113 V$OCAB_Q6.
MX M00795 V$OCT_Q6.
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BS R16342.
BS R16343.
BS R16349.
BS R16350.
BS R16346.
BS R16340.
BS R16347.
BS R16348.
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DR TRANSPATH: MO000026192.
DR UniProtKB: Q64693;
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RN [1]; RE0004287.
RX PUBMED: 1620119.
RA Annweiler A., Mueller-Immerglueck M., Wirth T.
RT Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity
RL Mol. Cell. Biol. 12:3107-3116 (1992).
RN [2]; RE0005622.
RX PUBMED: 8157005.
RA Pfisterer P., Annweiler A., Ullmer C., Corcoran L. M., Wirth T.
RT Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities
RL EMBO J. 13:1654-1663 (1994).
RN [3]; RE0005627.
RX PUBMED: 8530384.
RA Pfisterer P., Zwilling S., Hess J., Wirth T.
RT Functional characterization of the murine homolog of the B cell-specific coactivator BOB.1/OBF.1
RL J. Biol. Chem. 270:29870-29880 (1995).
RN [4]; RE0025445.
RX PUBMED: 11136971.
RA Tomilin A., Remenyi A., Lins K., Bak H., Leidel S., Vriend G., Wilmanns M., Scholer H. R.
RT Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration.
RL Cell 103:853-864 (2000).
RN [5]; RE0005623.
RX PUBMED: 8657574.
RA Schubart D. B., Sauter P., Massa S., Friedl E. M., Schwarzenbach H., Matthias P.
RT Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1
RL Nucleic Acids Res. 24:1913-1920 (1996).
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