AC T00648
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ID T00648
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DT 15.10.1992 (created); ewi.
DT 10.08.2006 (updated); jul.
CO Copyright (C), QIAGEN.
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FA Oct-2.2
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SY IgNF-A; NF-A; NF-A2; NF-III; Oct-2; Oct-2.2; Oct-2A; OTF-2; OTF-2A; POU2F2A.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009189 Pou2f2.
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CL C0007; POU; 3.1.10.2.2.1.
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SZ 479 AA; 51.3 kDa (cDNA) (calc.), 60 kDa (SDS)
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SQ MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSPTGPS
SQ TKIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
SQ QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAMTRPTLPDPHLS
SQ HPQPPKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT
SQ ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK
SQ RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA
SQ APMLPSPGKPTSYSPHLVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG
SQ GGGGRALPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLSGLNPSAGPGLWWNPAPYQP
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SC translated from EMBL #X57937
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FT 195 269 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 195 269 
SM00352; pou.
FT 295 355 
PS50071; HOMEOBOX_2.
FT 295 357 
PS50550; POU_HOMEODOMAIN.
FT 297 359 
SM00389; HOX_1.
FT 298 354 
PF00046; Homeobox domain.
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SF at least six splice variants known: Oct-2.1, Oct-2/Oct-2A/Oct-2.2 (this entry), Oct-2.3, Oct-2.4, Oct-2B/Oct-2.5 T00964, and Oct-2.6 [3];
SF the glutamine-rich region acts as trans-activation domain through proximal octamer elements exclusively [5];
SF the C-terminal, proline-rich trans-activation domain depends on additional B-cell specific factors [5];
SF this domain varies among alternative splice products [4] [3];
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CP B cells, induced pre-B cells; brain, kidney; sperm; 12d embryo.
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FF activator [5];
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IN T02142 OCA-B; mouse, Mus musculus.
IN T00643 POU2F1; rat, Rattus norvegicus.
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MX M01368 V$OCT2_01.
MX M03836 V$OCT2_Q6.
MX M00210 V$OCT_C.
MX M00795 V$OCT_Q6.
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BS R01176.
BS R16342.
BS R16343.
BS R03333.
BS R03334.
BS R03335.
BS R16335.
BS R16340.
BS R16341.
BS R13391.
BS R00841.
BS R00870.
BS R01884.
BS R03426.
BS R02226.
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DR TRANSPATH: MO000025080.
DR EMBL: X51961;
DR EMBL: X57937;
DR EMBL: X81031;
DR UniProtKB: Q00196-2;
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RN [1]; RE0000423.
RX PUBMED: 2573523.
RA Schoeler H. R., Hatzopoulos A. K., Balling R., Suzuki N., Gruss P.
RT A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor
RL EMBO J. 8:2543-2550 (1989).
RN [2]; RE0001492.
RX PUBMED: 1922024.
RA Miller C. L., Feldhaus A. L., Rooney J. W., Rhodes L. D., Sibley C. H., Singh H.
RT Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation
RL Mol. Cell. Biol. 11:4885-4894 (1991).
RN [3]; RE0002095.
RX PUBMED: 2011512.
RA Wirth T., Priess A., Annweiler A., Zwilling S., Oeler B.
RT Multiple Oct2 isoforms are generated by alternative splicing
RL Nucleic Acids Res. 19:43-51 (1991).
RN [4]; RE0004288.
RX PUBMED: 1281152.
RA Lillycrop K. A., Latchman D. S.
RT Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-containing promoters
RL J. Biol. Chem. 267:24960-24965 (1992).
RN [5]; RE0004292.
RX PUBMED: 7937153.
RA Annweiler A., Zwilling S., Wirth T.
RT Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms
RL Nucleic Acids Res. 22:4250-4258 (1994).
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