AC T00964
XX
ID T00964
XX
DT 29.06.1993 (created); ewi.
DT 10.08.2006 (updated); jul.
CO Copyright (C), QIAGEN.
XX
FA Oct-2.5
XX
SY Oct-2.5; Oct-2B; OTF-2B; POU2F2B.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009189 Pou2f2.
XX
CL C0007; POU.
XX
SZ 583 AA; 60.2 kDa (cDNA) (calc.), 70 kDa (SDS) [6]
XX
SQ MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSPTGPS
SQ TKIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
SQ QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQPPKCLEPPSHPEE
SQ PSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCK
SQ LKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKKRTSIETNVRFALEKSF
SQ LANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSAAPMLPSPGKPTSYSPH
SQ LVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGGGGGGRALPLNSIPSVT
SQ PPPPATTNSTNPSPQGSHSAIGLSGLNPSAGSTMVGLSSGLSPALMSNNPLATIQALASG
SQ GTLPLTSLDGSGNLVLGAAGAAPGSPSLVTSPLFLNHTGLPLLSAPPGVGLVSAAAAAVA
SQ ASISSKSPGLSSSSSSSSSSTCSDVAAQTPGGPGGPEAGSKAE
XX
SC translated from EMBL #X57940
XX
FT 179 253 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 179 253 
SM00352; pou.
FT 270 556 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 279 339 
PS50071; HOMEOBOX_2.
FT 279 341 
PS50550; POU_HOMEODOMAIN.
FT 281 343 
SM00389; HOX_1.
FT 282 338 
PF00046; Homeobox domain.
XX
SF at least six splice variants known: Oct-2.1, Oct-2/Oct-2A/Oct-2.2 T00648, Oct-2.3, Oct-2.4, Oct-2B/Oct-2.5 (this entry), and Oct-2.6 [2];
SF the glutamine-rich trans-activation domain which acts through proximal octamer elements exclusively is N-terminally truncated [5];
SF the C-terminal, proline-rich trans-activation domain of other Oct-2 isoforms is replaced by a serine-/threonine-rich domain [4] [5] [2];
XX
CP B cells, induced pre-B cells, lower levels in brain, kidney, sperm; 12d embryos.
CN liver [6].
XX
FF higher levels of Oct-2B than of Oct-2 in brain, testis, and 12d embryo, equal concentrations of both isoforms in kidney, less Oct-2B than Oct-2 in B cells and intestine [6];
XX
MX M01368 V$OCT2_01.
MX M03836 V$OCT2_Q6.
MX M00210 V$OCT_C.
MX M00795 V$OCT_Q6.
XX
BS R00870.
BS R03426.
BS R02226.
XX
DR TRANSPATH: MO000025303.
DR EMBL: X53654;
DR EMBL: X57940;
DR UniProtKB: Q00196-5; PO2F2_MOUSE.
XX
RN [1]; RE0001492.
RX PUBMED: 1922024.
RA Miller C. L., Feldhaus A. L., Rooney J. W., Rhodes L. D., Sibley C. H., Singh H.
RT Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation
RL Mol. Cell. Biol. 11:4885-4894 (1991).
RN [2]; RE0002095.
RX PUBMED: 2011512.
RA Wirth T., Priess A., Annweiler A., Zwilling S., Oeler B.
RT Multiple Oct2 isoforms are generated by alternative splicing
RL Nucleic Acids Res. 19:43-51 (1991).
RN [3]; RE0002315.
RX PUBMED: 3259319.
RA Hanke J. H., Landolfi N. F., Tucker P. W., Capra J. D.
RT Identification of murine nuclear proteins that bind to the conserved octamer sequence of the immunoglobulin promoter region
RL Proc. Natl. Acad. Sci. USA 85:3560-3564 (1988).
RN [4]; RE0004288.
RX PUBMED: 1281152.
RA Lillycrop K. A., Latchman D. S.
RT Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-containing promoters
RL J. Biol. Chem. 267:24960-24965 (1992).
RN [5]; RE0004292.
RX PUBMED: 7937153.
RA Annweiler A., Zwilling S., Wirth T.
RT Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms
RL Nucleic Acids Res. 22:4250-4258 (1994).
RN [6]; RE0004386.
RX PUBMED: 1976089.
RA Hatzopoulos A. K., Stoykova A. S., Erselius J. R., Goulding M., Neuman T., Gruss P.
RT Structure and expression of the mouse Oct2a and Oct2b, two differentially spliced products of the same gene
RL Development 109:349-362 (1990).
XX
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