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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T00650 XX ID T00650 XX DT 27.01.1993 (created); hse. DT 09.05.2013 (updated); msr. CO Copyright (C), QIAGEN. XX FA Oct-2 XX SY Oct-2; Oct-2.2; Oct-2A; POU2F2. XX OS rat, Rattus rattus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0007; POU; 3.1.10.2.2. XX SZ 479 AA; 51.2 kDa (cDNA) (calc.), 60 kDa (SDS) XX SQ MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSPTGPS SQ TKIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL SQ QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAMTRPTLPDPHLS SQ HPQPSKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT SQ ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK SQ RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA SQ APMLPSPGKPTSYSPHLVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG SQ GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLTGLNPSAGPGLWWNPAPYQP XX SC translated from EMBL #L25864 XX FT 195 269 PF00157; Pou domain - N-terminal to homeobox domain. FT 195 269 SM00352; pou. FT 295 355 PS50071; HOMEOBOX_2. FT 295 357 PS50550; POU_HOMEODOMAIN. FT 297 359 SM00389; HOX_1. FT 298 354 PF00046; Homeobox domain. XX SF the four known splice variants (Oct-2.1, Oct-2/Oct2A/Oct-2.2, Oct-2.7, and Oct-2.8) differ in their DNA-binding specificity [3]; XX CP lymphoid cells, intestine, testis, kidney, nervous system, here in suprachiasmatic and medial mammillary nuclei of hypothalamus, granule and red nucleus (adults), widespread expression in embryonal nervous system [1]. CN embryonal telencephalon [1]. XX FF up-regulated by nerve growth factor (NGF) [2]; XX IN T00641 POU2F1-isoform1; human, Homo sapiens. IN T00642 POU2F1; clawed frog, Xenopus laevis. IN T00643 POU2F1; rat, Rattus norvegicus. IN T00959 POU2F1; monkey, Cercopithecus aethiops. IN T01031 POU2F1; chick, Gallus gallus. IN T01157 POU2F1; gibbon ape, Hylobates lar. IN T00644 POU2F1a; mouse, Mus musculus. XX MX M01368 V$OCT2_01. MX M03836 V$OCT2_Q6. MX M00210 V$OCT_C. MX M00795 V$OCT_Q6. MX M08836 V$POU2F2_09. XX BS R02226. BS R55945. BS R55953. XX DR TRANSPATH: MO000025082. DR EMBL: L25864; XX RN [1]; RE0004221. RX PUBMED: 2739723. RA He X., Treacy M. N., Simmons D. M., Ingraham H. A., Swanson L. W., Rosenfeld M. G. RT Expression of a large family of POU-domain regulatory genes in mammalian brain development RL Nature 340:35-42 (1989). RN [2]; RE0004280. RX PUBMED: 1381354. RA Wood J. N., Lillycrop K. A., Dent C. L., Ninkina N. N., Beech M. M., Willoughby J. J., Winter J., Latchman D. S. RT Regulation of expression of the neuronal POU Protein Oct-2 by nerve growth factor RL J. Biol. Chem. 267:17787-17791 (1992). RN [3]; RE0004288. RX PUBMED: 1281152. RA Lillycrop K. A., Latchman D. S. RT Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-containing promoters RL J. Biol. Chem. 267:24960-24965 (1992). XX //