AC T00650
XX
ID T00650
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DT 27.01.1993 (created); hse.
DT 09.05.2013 (updated); msr.
CO Copyright (C), QIAGEN.
XX
FA Oct-2
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SY Oct-2; Oct-2.2; Oct-2A; POU2F2.
XX
OS rat, Rattus rattus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
CL C0007; POU; 3.1.10.2.2.
XX
SZ 479 AA; 51.2 kDa (cDNA) (calc.), 60 kDa (SDS)
XX
SQ MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQNPQNKASPFSVSPTGPS
SQ TKIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGDIQQLLQLQQLVLVPGHHL
SQ QPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQPRAGLPTQAMTRPTLPDPHLS
SQ HPQPSKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTT
SQ ISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDGLPGRRRKK
SQ RTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQKEKRINPCSA
SQ APMLPSPGKPTSYSPHLVTPQGGAGTLPLSQASSSLSTTVTTLSSAVGTLHPSRTAGGGG
SQ GGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLTGLNPSAGPGLWWNPAPYQP
XX
SC translated from EMBL #L25864
XX
FT 195 269 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 195 269 
SM00352; pou.
FT 295 355 
PS50071; HOMEOBOX_2.
FT 295 357 
PS50550; POU_HOMEODOMAIN.
FT 297 359 
SM00389; HOX_1.
FT 298 354 
PF00046; Homeobox domain.
XX
SF the four known splice variants (Oct-2.1, Oct-2/Oct2A/Oct-2.2, Oct-2.7, and Oct-2.8) differ in their DNA-binding specificity [3];
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CP lymphoid cells, intestine, testis, kidney, nervous system, here in suprachiasmatic and medial mammillary nuclei of hypothalamus, granule and red nucleus (adults), widespread expression in embryonal nervous system [1].
CN embryonal telencephalon [1].
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FF up-regulated by nerve growth factor (NGF) [2];
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IN T00641 POU2F1-isoform1; human, Homo sapiens.
IN T00642 POU2F1; clawed frog, Xenopus laevis.
IN T00643 POU2F1; rat, Rattus norvegicus.
IN T00959 POU2F1; monkey, Cercopithecus aethiops.
IN T01031 POU2F1; chick, Gallus gallus.
IN T01157 POU2F1; gibbon ape, Hylobates lar.
IN T00644 POU2F1a; mouse, Mus musculus.
XX
MX M01368 V$OCT2_01.
MX M03836 V$OCT2_Q6.
MX M00210 V$OCT_C.
MX M00795 V$OCT_Q6.
MX M08836 V$POU2F2_09.
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BS R02226.
BS R55945.
BS R55953.
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DR TRANSPATH: MO000025082.
DR EMBL: L25864;
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RN [1]; RE0004221.
RX PUBMED: 2739723.
RA He X., Treacy M. N., Simmons D. M., Ingraham H. A., Swanson L. W., Rosenfeld M. G.
RT Expression of a large family of POU-domain regulatory genes in mammalian brain development
RL Nature 340:35-42 (1989).
RN [2]; RE0004280.
RX PUBMED: 1381354.
RA Wood J. N., Lillycrop K. A., Dent C. L., Ninkina N. N., Beech M. M., Willoughby J. J., Winter J., Latchman D. S.
RT Regulation of expression of the neuronal POU Protein Oct-2 by nerve growth factor
RL J. Biol. Chem. 267:17787-17791 (1992).
RN [3]; RE0004288.
RX PUBMED: 1281152.
RA Lillycrop K. A., Latchman D. S.
RT Alternative splicing of the Oct-2 transcription factor RNA is differentially regulated in neuronal cells and B cells and results in protein isoforms with opposite effects on the activity of octamer/TAATGARAT-containing promoters
RL J. Biol. Chem. 267:24960-24965 (1992).
XX
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