AC T00894
XX
ID T00894
XX
DT 15.10.1992 (created); ewi.
DT 23.05.1996 (updated); rkn.
CO Copyright (C), QIAGEN.
XX
FA Vmw65
XX
SY alpha-TIF; ICP25; Vmw65; VP16.
XX
OS HSV-1, herpes simplex virus type 1
OC viridae; ds-DNA enveloped viruses; herpesviridae; alphaherpesviridae
XX
SZ 490 AA; 54.3 kDa (cDNA) (calc.), 64 kDa (SDS)
XX
SQ MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAA
SQ LFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYV
SQ PERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALY
SQ RYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILW
SQ AAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIRE
SQ HLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMR
SQ EHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSL
SQ GDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFT
SQ DALGIDEYGG
XX
SC Swiss-Prot#P06492
XX
FT 26 387 
PF02232; Alpha trans-inducing protein (Alpha-TIF).
XX
FF induces transcription of immediate-early viral (HSV) genes;
XX
IN T02144 Ada2p; yeast, Saccharomyces cerevisiae.
IN T00118 HCF1-isoform1; human, Homo sapiens.
IN T00641 POU2F1-isoform1; human, Homo sapiens.
IN T00642 POU2F1; clawed frog, Xenopus laevis.
IN T00643 POU2F1; rat, Rattus norvegicus.
IN T00959 POU2F1; monkey, Cercopithecus aethiops.
IN T01031 POU2F1; chick, Gallus gallus.
IN T01157 POU2F1; gibbon ape, Hylobates lar.
IN T00644 POU2F1a; mouse, Mus musculus.
IN T01862 POU2F1b; mouse, Mus musculus.
IN T01863 POU2F1c; mouse, Mus musculus.
IN T00798 Spt15p; yeast, Saccharomyces cerevisiae.
IN T02113 TAFII31; human, Homo sapiens.
IN T02125 TAFII40; fruit fly, Drosophila melanogaster.
IN T00794 TBP; human, Homo sapiens.
IN T00795 TBP; fission yeast, Schizosaccharomyces pombe.
IN T00796 TBP; mouse, Mus musculus.
IN T00797 TBP; fruit fly, Drosophila melanogaster.
IN T00818 TFIIB; human, Homo sapiens.
IN T02262 TFIIH; human, Homo sapiens.
XX
BS R00810.
BS R01917.
BS R00812.
BS R02733.
BS R00814.
BS R00815.
BS R00820.
BS R00824.
XX
DR TRANSPATH: MO000045998.
DR EMBL: X03141; HEHSV165.
DR EMBL: X14112; HE1CG.
DR UniProtKB: P06492; ATIN_HSV11.
XX
RN [1]; RE0000087.
RX PUBMED: 2830986.
RA Preston C. M., Frame M. C., Campbell M. E. M.
RT A Complex formed between Cell Components and an HSV Structural Polypeptide Binds to a Viral Immediate Early Gene Regulatory DNA Sequence
RL Cell 52:425-434 (1988).
RN [2]; RE0001180.
RX PUBMED: 1645782.
RA Spector D., Purves F., Roizman B.
RT Role of alpha-transducing factor (VP16) in the induction of alpha genes within the context of viral genomes
RL J. Virol. 65:3504-3513 (1991).
RN [3]; RE0001881.
RX PUBMED: 1646402.
RA Ingles C. J., Shales M., Cress W. D., Triezenberg S. J., Greenblatt J.
RT Reduced binding of TFIID to transcriptionally compromised mutants of VP16
RL Nature 351:588-590 (1991).
RN [4]; RE0001882.
RX PUBMED: 2193231.
RA Stringer K. F., Ingles C. J., Greenblatt J.
RT Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID
RL Nature 345:783-786 (1990).
RN [5]; RE0002148.
RX PUBMED: 2175881.
RA Katan M., Haigh A., Verrijzer C. P., van der Vliet P. C., O'Hare P.
RT Characterization of a cellular factor which interacts functionally with Oct-1 in the assembly of a multicomponent transcription complex
RL Nucleic Acids Res. 18:6871-6880 (1990).
RN [6]; RE0002311.
RX PUBMED: 3025864.
RA Kristie T. M., Roizman B.
RT Host cell proteins bind to the cis-acting site required for virion-mediated induction of herpes simplex virus 1 alpha genes
RL Proc. Natl. Acad. Sci. USA 84:71-75 (1987).
RN [7]; RE0002312.
RX PUBMED: 2823252.
RA McKnight J. L. C., Kristie T. M., Roizman B.
RT Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins
RL Proc. Natl. Acad. Sci. USA 84:7061-7065 (1987).
XX
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