AC T01862
XX
ID T01862
XX
DT 02.08.1996 (created); ewi.
DT 21.02.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA POU2F1b
XX
SY 2810482H01Rik; alpha-H1; IgNF-A; NF-A; NF-A1; NF-III; OBP100; Oct-1; Oct-1A; Oct-1B; Oct-1C; oct-B1A; oct-B1B; octamer-binding factor; OTF-1; OTF1; POU domain, class 2, transcription factor 1; POU2F1; TRF.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009187 Pou2f1.
XX
CL C0007; POU; 3.1.10.2.1.1.
XX
SZ 746 AA; 76.8 kDa (cDNA) (calc.).
XX
SQ MNNPSETNKSSMESEDASTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTS
SQ LQAAAQSLNVQSKSSEESGDSQQSSQPSSQPPSVQSAIPQTQLMLAGGQITGLTLTPAQQ
SQ QLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQL
SQ QQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQP
SQ QPSITLTSQPTTPTRTIAAASVQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRR
SQ IKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSD
SQ STASSPSALNSPGLGAEGLNRRRKKRTSIETNIRVALEKSFMENQKPTSEDITLIAEQLN
SQ MEKEVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPASLVATTPSLVTSSTATTLT
SQ VNPVLPLTSAAVTNLSLTGTTDSTSNNNTATVISTAPPASSAVTSPSLSPSPSASASTSE
SQ ASSASETNTTQTTSTPLPSPLGASQVMVTTPGLQTAAAALQGAGQLPANASLAAMAAAAG
SQ LSPGLMAPSQFAAGGALLSLSPGTLGSALSPALMSNSTLATIQALASSGSLPITSLDATG
SQ NLVFANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASTGNSAPTASLHASSTSTE
SQ SIQSSLFTVASASGPASTTTAASKAQ
XX
SC translated from EMBL #X68363
XX
FT 111 707 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 281 355 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 281 355 
SM00352; pou.
FT 380 440 
PS50071; HOMEOBOX_2.
FT 380 442 
PS50550; POU_HOMEODOMAIN.
FT 382 444 
SM00389; HOX_1.
FT 383 439 
PF00046; Homeobox domain.
FT 693 746 
replaced by 693-701 in Oct-1C [1].
XX
SF at least 3 splice variants are encoded by the murine oct-1 gene [1];
SF mouse Oct-1B is the homolog of 'the' human Oct-1 (743 AA) [1];
SF compared to the human homolog, mouse Oct-1 isoforms exhibit four AA exchanges within helix 1 and 2 making its sequence more similar to (human) Oct-2 and thus causing a much weaker interaction with VP16 [1] [2];
XX
IN T00894 Vmw65; HSV-1, herpes simplex virus type 1.
XX
MX M00135 V$OCT1_01.
MX M00136 V$OCT1_02.
MX M00137 V$OCT1_03.
MX M00138 V$OCT1_04.
MX M00161 V$OCT1_05.
MX M00162 V$OCT1_06.
MX M00248 V$OCT1_07.
MX M01354 V$OCT1_08.
MX M00342 V$OCT1_B.
MX M00930 V$OCT1_Q5_01.
MX M00195 V$OCT1_Q6.
MX M00210 V$OCT_C.
MX M00795 V$OCT_Q6.
MX M07059 V$POU2F1_Q4_01.
MX M03561 V$POU2F1_Q6.
XX
BS R03333.
BS R03334.
BS R03335.
BS R00810.
BS R02824.
BS R00303.
BS R00304.
BS R00305.
BS R00306.
BS R00864.
BS R00870.
BS R00872.
BS R01884.
BS R01885.
BS R01886.
BS R02225.
BS R04602.
BS R01933.
XX
DR TRANSPATH: MO000025984.
DR EMBL: X68363;
DR UniProtKB: P25425-2;
XX
RN [1]; RE0004185.
RX PUBMED: 8441632.
RA Suzuki N., Peter W., Ciesiolka T., Gruss P., Schoeler H. R.
RT Mouse Oct-1 contains a composite homeodomain of human Oct-1 and Oct-2
RL Nucleic Acids Res. 21:245-252 (1993).
RN [2]; RE0004213.
RX PUBMED: 8422989.
RA Cleary M. A., Stern S., Tanaka M., Herr W.
RT Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment
RL Genes Dev. 7:72-83 (1993).
XX
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