AC T02144
XX
ID T02144
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DT 26.05.1997 (created); hiwi.
DT 29.11.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Ada2p
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SY ADA2; ADA2p.
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OS yeast, Saccharomyces cerevisiae
OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
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GE G004229 ADA2.
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HO Ada2p (human).
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SZ 434 AA; 50.6 kDa (cDNA) (calc.).
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SQ MSNKFHCDVCSADCTNRVRVSCAICPEYDLCVPCFSQGSYTGKHRPYHDYRIIETNSYPI
SQ LCPDWGADEELQLIKGAQTLGLGNWQDIADHIGSRGKEEVKEHYLKYYLESKYYPIPDIT
SQ QNIHVPQDEFLEQRRHRIESFRERPLEPPRKPMASVPSCHEVQGFMPGRLEFETEFENEA
SQ EGPVKDMVFEPDDQPLDIELKFAILDIYNSRLTTRAEKKRLLFENHLMDYRKLQAIDKKR
SQ SKEAKELYNRIKPFARVMTAQDFEEFSKDILEELHCRARIQQLQEWRSNGLTTLEAGLKY
SQ ERDKQARISSFEKFGASTAASLSEGNSRYRSNSAHRSNAEYSQNYSENGGRKKNMTISDI
SQ QHAPDYALLSNDEQQLCIQLKILPKPYLVLKEVMFRELLKTGGNLSKSACRELLNIDPIK
SQ ANRIYDFFQSQNWM
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SC Swiss-Prot#Q02336
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FT 1 46 
PF00569; Zinc finger, ZZ type.
FT 1 46 
SM00291; zz_5.
FT 1 48 
PS50135; ZF_ZZ_2.
FT 61 110 
SM00717; sant.
FT 62 108 
PF00249; Myb-like DNA-binding domain.
FT 65 95 
c-Myb (30-60) homology region [2].
FT 65 108 
PS50090; MYB_3.
FT 349 434 
PF04433; SWIRM domain.
FT 349 434 
PS50934; SWIRM.
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SF similarity with a single Myb-like tryptophan repeat [2];
SF N-terminal part interacts directly with the acidic trans-activation domain of Vmw65 T00894 [1];
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FF coactivator / adaptor (as complex with GCN5 T02145) for certain acidic activation domains [2] [5];
FF may have to cooperate with ADA3 [4];
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IN T02145 Gcn5p; yeast, Saccharomyces cerevisiae.
IN T00894 Vmw65; HSV-1, herpes simplex virus type 1.
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DR EMBL: M95396;
DR EMBL: U33007;
DR UniProtKB: Q02336;
DR UniProtKB: Q02354;
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RN [1]; RE0005636.
RX PUBMED: 7642611.
RA Barlev N. A., Candau R., Wang L., Darpino P., Silverman N., Berger S. L.
RT Characterization of physical interactions of the putative transcriptional adaptor, ADA2, with acidic activation domains and TATA-binding protein
RL J. Biol. Chem. 270:19337-19344 (1995).
RN [2]; RE0005637.
RX PUBMED: 1638630.
RA Berger S. L., Pina B., Silverman N., Marcus G. A., Agapite J., Regier J. L., Triezenberg S. J., Guarente L.
RT Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains
RL Cell 70:251-265 (1992).
RN [3]; RE0005638.
RX PUBMED: 7957049.
RA Marcus G. A., Silverman N., Berger S. L., Horiuchi J., Guarente L.
RT Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors
RL EMBO J. 13:4807-4815 (1994).
RN [4]; RE0005639.
RX PUBMED: 7972120.
RA Silverman N., Agapite J., Guarente L.
RT Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription
RL Proc. Natl. Acad. Sci. USA 91:11665-11668 (1994).
RN [5]; RE0005640.
RX PUBMED: 1396595.
RA Georgakopoulos T., Thireos G.
RT Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription
RL EMBO J. 11:4145-4152 (1992).
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