AC T02145
XX
ID T02145
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DT 26.05.1997 (created); hiwi.
DT 29.11.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Gcn5p
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SY ADA4; GCN5; GCN5p; SWI9.
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OS yeast, Saccharomyces cerevisiae
OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
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GE G004230 GCN5.
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HO HAT A (Tetrahymena) [6].
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SZ 439 AA; 51.1 kDa (cDNA) (calc.).
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SQ MVTKHQIEEDHLDGATTDPEVKRVKLENNVEEIQPEQAETNKQEGTDKENKGKFEKETER
SQ IGGSEVVTDVEKGIVKFEFDGVEYTFKERPSVVEENEGKIEFRVVNNDNTKENMMVLTGL
SQ KNIFQKQLPKMPKEYIARLVYDRSHLSMAVIRKPLTVVGGITYRPFDKREFAEIVFCAIS
SQ STEQVRGYGAHLMNHLKDYVRNTSNIKYFLTYADNYAIGYFKKQGFTKEITLDKSIWMGY
SQ IKDYEGGTLMQCSMLPRIRYLDAGKILLLQEAALRRKIRTISKSHIVRPGLEQFKDLNNI
SQ KPIDPMTIPGLKEAGWTPEMDALAQRPKRGPHDAAIQNILTELQNHAAAWPFLQPVNKEE
SQ VPDYYDFIKEPMDLSTMEIKLESNKYQKMEDFIYDARLVFNNCRMYNGENTSYYKYANRL
SQ EKFFNNKVKEIPEYSHLID
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SC Swiss-Prot#Q03330
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FT 25 317 
PF00478; IMP dehydrogenase / GMP reductase doma.
FT 149 227 
PF00583; Acetyltransferase (GNAT) family.
FT 325 433 
SM00297; bromo_6.
FT 332 419 
PF00439; Bromodomain.
FT 344 414 
PS50014; BROMODOMAIN_2.
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SF the bromo domain is important for the function of Gcn5p [3];
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FF coactivator / adaptor (as complex with ADA2) of certain acidic activation domains [2] [5];
FF may have to cooperate with ADA3 [4];
FF required for cell-cycle-regulated histone acetylation at the HO upstream regulatory region [7];
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IN T02144 Ada2p; yeast, Saccharomyces cerevisiae.
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DR EMBL: X68628;
DR EMBL: Z73037;
DR UniProtKB: Q03330;
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RN [1]; RE0005636.
RX PUBMED: 7642611.
RA Barlev N. A., Candau R., Wang L., Darpino P., Silverman N., Berger S. L.
RT Characterization of physical interactions of the putative transcriptional adaptor, ADA2, with acidic activation domains and TATA-binding protein
RL J. Biol. Chem. 270:19337-19344 (1995).
RN [2]; RE0005637.
RX PUBMED: 1638630.
RA Berger S. L., Pina B., Silverman N., Marcus G. A., Agapite J., Regier J. L., Triezenberg S. J., Guarente L.
RT Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains
RL Cell 70:251-265 (1992).
RN [3]; RE0005638.
RX PUBMED: 7957049.
RA Marcus G. A., Silverman N., Berger S. L., Horiuchi J., Guarente L.
RT Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors
RL EMBO J. 13:4807-4815 (1994).
RN [4]; RE0005639.
RX PUBMED: 7972120.
RA Silverman N., Agapite J., Guarente L.
RT Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription
RL Proc. Natl. Acad. Sci. USA 91:11665-11668 (1994).
RN [5]; RE0005640.
RX PUBMED: 1396595.
RA Georgakopoulos T., Thireos G.
RT Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription
RL EMBO J. 11:4145-4152 (1992).
RN [6]; RE0017889.
RX PUBMED: 8601308.
RA Brownell J. E., Zhou J., Ranalli T., Kobayashi R., Edmondson D. G., Roth S. Y., Allis C. D.
RT Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.
RL Cell 84:843-851 (1996).
RN [7]; RE0017890.
RX PUBMED: 10364158.
RA Krebs J. E., Kuo M. H., Allis C. D., Peterson C. L.
RT Cell cycle-regulated histone acetylation required for expression of the yeast HO gene.
RL Genes Dev. 13:1412-1421 (1999).
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