AC T00134
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ID T00134
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DT 15.10.1992 (created); ewi.
DT 02.03.2008 (updated); sou.
CO Copyright (C), QIAGEN.
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FA c-Jun
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SY AP-1; c-Jun; Jun; JunA; proto-oncogene c-Jun; transcription factor c-Jun.
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OS chick, Gallus gallus
OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae
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GE G053771 JUN.
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CL C0008; bZIP; 1.1.1.1.1.
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SF the leucine zipper of c-Jun interacts with the HLH domain of MyoD [14];
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CP ubiquitous.
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FF activator, contributes to the transcriptional activation by the AP-1 complex [1];
FF weaker activator than v-Jun due to the regulatory delta region, which acts in a cell-specific manner [1] [16];
FF coactivation of ERE (ovalbumin) with c-Fos and estrogen receptor;
FF the direct interaction with MyoD causes inhibition of myogenesis [14];
FF target of a signalling cascade starting with Ha-Ras and resulting in c-Jun phosphorylation on Ser-59 and Ser-69 by JNK protein kinases [17] [18];
FF interaction with Jif-1 (identical with ribosomal protein L10) occurs in a mutually exclusive manner with c-Fos [19];
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IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T01017 ATF-2-isoform2; mouse, Mus musculus.
IN T01313 ATF-3-isoform1; human, Homo sapiens.
IN T01095 ATF-3; rat, Rattus norvegicus.
IN T00051 ATF; human, Homo sapiens.
IN T00122 c-Fos; mouse, Mus musculus.
IN T00123 c-Fos; human, Homo sapiens.
IN T00124 c-Fos; rat, Rattus norvegicus.
IN T00125 c-Fos; chick, Gallus gallus.
IN T00134 c-Jun; chick, Gallus gallus.
IN T01308 CREBPA; human, Homo sapiens.
IN T02198 deltaFosB; mouse, Mus musculus.
IN T00967 E1A 12S protein; adenovirus.
IN T00209 E1A 13S protein; adenovirus type 2.
IN T00291 FosB; mouse, Mus musculus.
IN T00292 Fra-1; mouse, Mus musculus.
IN T01208 Fra-1; rat, Rattus norvegicus.
IN T01990 Fra-2; chick, Gallus gallus.
IN T00333 GR; rat, Rattus norvegicus.
IN T01128 MyoD; chick, Gallus gallus.
IN T00888 v-Fos; FBR MuLV, FBR murine osteosarcoma virus.
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MX M00172 V$AP1FJ_Q2.
MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M03541 V$CJUN_Q6.
MX M00041 V$CREBP1CJUN_01.
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BS R00678.
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DR TRANSPATH: MO000001263.
DR UniProtKB: P18870;
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RN [1]; RE0000124.
RX PUBMED: 2510934.
RA Bohmann D., Tjian R.
RT Biochemical analysis of transcriptional activation by Jun: Differential activity of c- and v-Jun
RL Cell 59:709-717 (1989).
RN [2]; RE0000157.
RX PUBMED: 1846781.
RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett G. R., Karin M., Hunter T.
RT Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
RL Cell 64:573-584 (1991).
RN [3]; RE0000158.
RX PUBMED: 1900458.
RA Auwerx J., Sassone-Corsi P.
RT IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation
RL Cell 64:983-993 (1991).
RN [4]; RE0000166.
RX PUBMED: 2124518.
RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P.
RT Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex
RL Cell 63:1267-1276 (1990).
RN [5]; RE0000662.
RX PUBMED: 2498163.
RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E.
RT Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction
RL Genes Dev. 3:304-313 (1989).
RN [6]; RE0001155.
RX PUBMED: 2536818.
RA Yamaguchi Y., Satake M., Ito Y.
RT Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene
RL J. Virol. 63:1040-1048 (1989).
RN [7]; RE0001453.
RX PUBMED: 2115122.
RA Gius D., Cao X., Rauscher III F. J., Cohen D. R., Curran T., Sukhatme V. P.
RT Transcriptional Activation and Repression by Fos Are Independent Functions: The C Terminus Represses Immediate-Early Gene Expression via CArG Elements
RL Mol. Cell. Biol. 10:4243-4255 (1990).
RN [8]; RE0001460.
RX PUBMED: 2501665.
RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R.
RT Expression of raf oncogenes activates the PEA1 transcription factor motif
RL Mol. Cell. Biol. 9:2247-2250 (1989).
RN [9]; RE0001940.
RX PUBMED: 2518690.
RA Angel P., Smeal T., Meek J., Karin M.
RT jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner
RL New Biol. 1:35-43 (1989).
RN [10]; RE0001941.
RX PUBMED: 1963081.
RA Yang-Yen H.-F., Chiu R., Karin M.
RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription
RL New Biol. 2:351-361 (1990).
RN [11]; RE0002299.
RX PUBMED: 2492109.
RA Sharma A., Bos T. J., Pekkala-Flagan A., Vogt P. K., Lee A. S.
RT Interaction of cellular factors related to the Jun oncoprotein with the promoter of a replication-dependent hamster histone H3.2 gene
RL Proc. Natl. Acad. Sci. USA 86:491-495 (1989).
RN [12]; RE0002407.
RX PUBMED: 3174663.
RA Saffen D. W., Cole A. J., Worley P. F., Christy B. A., Ryder K., Baraban J. M.
RT Convulsant-induced increase in transcription factor messenger RNAs in rat brain
RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988).
RN [13]; RE0002408.
RX PUBMED: 2453058.
RA Piette J., Hirai S.-I., Yaniv M.
RT Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts
RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988).
RN [14]; RE0003418.
RX PUBMED: 1310896.
RA Bengal E., Ransone L., Scharfmann R., Dwarki V. J., Tapscott S. J., Weintraub H., Verma I. M.
RT Functional antagonism between c-Jun and MyoD proteins: a direct physical association
RL Cell 68:507-519 (1992).
RN [15]; RE0004653.
RX PUBMED: 2577867.
RA Nishimura T., Vogt P. K.
RT The avian cellular homolog of the oncogene jun
RL Oncogene 3:659-663 (1988).
RN [16]; RE0004660.
RX PUBMED: 1309952.
RA Havarstein L. S., Morgan I. M., Wong W.-Y., Vogt P. K.
RT Mutations in the Jun Delta region suggest an inverse correlation between transformation and transcriptional activation
RL Proc. Natl. Acad. Sci. USA 89:618-622 (1992).
RN [17]; RE0004706.
RX PUBMED: 1906140.
RA Baichwal V. R., Park A., Tjian R.
RT v-Src and EJ Ras alleviate repression of c-jun by a cell-specific inhibitor
RL Nature 352:165-168 (1991).
RN [18]; RE0004714.
RX PUBMED: 8224842.
RA Hibi M., Lin A., Smeal T., Minden A., Karin M.
RT Idnetification of an oncoprotin- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
RL Genes Dev. 7:2135-2148 (1993).
RN [19]; RE0004717.
RX PUBMED: 8341691.
RA Monteclaro F. S., Vogt P. K.
RT A Jun-binding protein related to a putative tumor suppressor
RL Proc. Natl. Acad. Sci. USA 90:6726-6730 (1993).
RN [20]; RE0052166.
RX PUBMED: 9427647.
RA May G. H., Funk M., Black E. J., Clark W., Hussain S., Woodgett J. R., Gillespie D. A.
RT An oncogenic mutation uncouples the v-Jun oncoprotein from positive regulation by the SAPK/JNK pathway in vivo.
RL Curr. Biol. 8:117-120 (1998).
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