TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00134 XX ID T00134 XX DT 15.10.1992 (created); ewi. DT 02.03.2008 (updated); sou. CO Copyright (C), QIAGEN. XX FA c-Jun XX SY AP-1; c-Jun; Jun; JunA; proto-oncogene c-Jun; transcription factor c-Jun. XX OS chick, Gallus gallus OC eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes; neognathae; galliformes; phasianidae XX GE G053771 JUN. XX CL C0008; bZIP; XX SF the leucine zipper of c-Jun interacts with the HLH domain of MyoD [14]; XX CP ubiquitous. XX FF activator, contributes to the transcriptional activation by the AP-1 complex [1]; FF weaker activator than v-Jun due to the regulatory delta region, which acts in a cell-specific manner [1] [16]; FF coactivation of ERE (ovalbumin) with c-Fos and estrogen receptor; FF the direct interaction with MyoD causes inhibition of myogenesis [14]; FF target of a signalling cascade starting with Ha-Ras and resulting in c-Jun phosphorylation on Ser-59 and Ser-69 by JNK protein kinases [17] [18]; FF interaction with Jif-1 (identical with ribosomal protein L10) occurs in a mutually exclusive manner with c-Fos [19]; XX IN T00167 ATF-2-isoform1; human, Homo sapiens. IN T01017 ATF-2-isoform2; mouse, Mus musculus. IN T01313 ATF-3-isoform1; human, Homo sapiens. IN T01095 ATF-3; rat, Rattus norvegicus. IN T00051 ATF; human, Homo sapiens. IN T00122 c-Fos; mouse, Mus musculus. IN T00123 c-Fos; human, Homo sapiens. IN T00124 c-Fos; rat, Rattus norvegicus. IN T00125 c-Fos; chick, Gallus gallus. IN T00134 c-Jun; chick, Gallus gallus. IN T01308 CREBPA; human, Homo sapiens. IN T02198 deltaFosB; mouse, Mus musculus. IN T00967 E1A 12S protein; adenovirus. IN T00209 E1A 13S protein; adenovirus type 2. IN T00291 FosB; mouse, Mus musculus. IN T00292 Fra-1; mouse, Mus musculus. IN T01208 Fra-1; rat, Rattus norvegicus. IN T01990 Fra-2; chick, Gallus gallus. IN T00333 GR; rat, Rattus norvegicus. IN T01128 MyoD; chick, Gallus gallus. IN T00888 v-Fos; FBR MuLV, FBR murine osteosarcoma virus. XX MX M00172 V$AP1FJ_Q2. MX M00517 V$AP1_01. MX M00924 V$AP1_Q2_01. MX M00926 V$AP1_Q4_01. MX M00925 V$AP1_Q6_01. MX M03541 V$CJUN_Q6. MX M00041 V$CREBP1CJUN_01. XX BS R00678. XX DR TRANSPATH: MO000001263. DR UniProtKB: P18870; XX RN [1]; RE0000124. RX PUBMED: 2510934. RA Bohmann D., Tjian R. RT Biochemical analysis of transcriptional activation by Jun: Differential activity of c- and v-Jun RL Cell 59:709-717 (1989). RN [2]; RE0000157. RX PUBMED: 1846781. RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [3]; RE0000158. RX PUBMED: 1900458. RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [4]; RE0000166. RX PUBMED: 2124518. RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [5]; RE0000662. RX PUBMED: 2498163. RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [6]; RE0001155. RX PUBMED: 2536818. RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [7]; RE0001453. RX PUBMED: 2115122. RA Gius D., Cao X., Rauscher III F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are Independent Functions: The C Terminus Represses Immediate-Early Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). RN [8]; RE0001460. RX PUBMED: 2501665. RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [9]; RE0001940. RX PUBMED: 2518690. RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner RL New Biol. 1:35-43 (1989). RN [10]; RE0001941. RX PUBMED: 1963081. RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription RL New Biol. 2:351-361 (1990). RN [11]; RE0002299. RX PUBMED: 2492109. RA Sharma A., Bos T. J., Pekkala-Flagan A., Vogt P. K., Lee A. S. RT Interaction of cellular factors related to the Jun oncoprotein with the promoter of a replication-dependent hamster histone H3.2 gene RL Proc. Natl. Acad. Sci. USA 86:491-495 (1989). RN [12]; RE0002407. RX PUBMED: 3174663. RA Saffen D. W., Cole A. J., Worley P. F., Christy B. A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [13]; RE0002408. RX PUBMED: 2453058. RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [14]; RE0003418. RX PUBMED: 1310896. RA Bengal E., Ransone L., Scharfmann R., Dwarki V. J., Tapscott S. J., Weintraub H., Verma I. M. RT Functional antagonism between c-Jun and MyoD proteins: a direct physical association RL Cell 68:507-519 (1992). RN [15]; RE0004653. RX PUBMED: 2577867. RA Nishimura T., Vogt P. K. RT The avian cellular homolog of the oncogene jun RL Oncogene 3:659-663 (1988). RN [16]; RE0004660. RX PUBMED: 1309952. RA Havarstein L. S., Morgan I. M., Wong W.-Y., Vogt P. K. RT Mutations in the Jun Delta region suggest an inverse correlation between transformation and transcriptional activation RL Proc. Natl. Acad. Sci. USA 89:618-622 (1992). RN [17]; RE0004706. RX PUBMED: 1906140. RA Baichwal V. R., Park A., Tjian R. RT v-Src and EJ Ras alleviate repression of c-jun by a cell-specific inhibitor RL Nature 352:165-168 (1991). RN [18]; RE0004714. RX PUBMED: 8224842. RA Hibi M., Lin A., Smeal T., Minden A., Karin M. RT Idnetification of an oncoprotin- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain RL Genes Dev. 7:2135-2148 (1993). RN [19]; RE0004717. RX PUBMED: 8341691. RA Monteclaro F. S., Vogt P. K. RT A Jun-binding protein related to a putative tumor suppressor RL Proc. Natl. Acad. Sci. USA 90:6726-6730 (1993). RN [20]; RE0052166. RX PUBMED: 9427647. RA May G. H., Funk M., Black E. J., Clark W., Hussain S., Woodgett J. R., Gillespie D. A. RT An oncogenic mutation uncouples the v-Jun oncoprotein from positive regulation by the SAPK/JNK pathway in vivo. RL Curr. Biol. 8:117-120 (1998). XX //