AC T01017
XX
ID T01017
XX
DT 19.02.1994 (created); ewi.
DT 05.08.2009 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA ATF-2-isoform2
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SY activating transcription factor 2; ATF-2 (rat); ATF2; CRE-BP1; CRE-BP2; mXBP/CRE-BP2; XBP.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009504 Atf2.
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CL C0008; bZIP.
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SZ 389 AA; 42.3 kDa (cDNA) (calc.).
XX
SQ MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKN
SQ CEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPL
SQ PHPESTTSDEKLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVK
SQ GHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQNTSGRRRRAANEDPDEKRR
SQ KFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHK
SQ DCPVTAMQKKSGYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSV
SQ LTQMADQSTEPALSQIVMAPPSQAQPSGS
XX
SC Swiss-Prot#P16951-2
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FT 31 358 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 202 266 
PF00170; bZIP transcription factor.
FT 202 266 
SM00338; brlzneu.
FT 204 267 
PS50217; BZIP.
XX
SF splice variants: CRE-BP1 T02056, CRE-BP3 T02036;
SF heterodimerizes with c-Jun, but not with c-Fos [1];
SF heterodimer binds to CREs, but not to AP-1 sites [1];
SF lacks the N-terminal zinc finger motif found in human CRE-BP1 [2];
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CP brain, T cells [2].
CN kidney, liver, heart, thymus, spleen [2].
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FF potent activator [2];
FF regulation by PKA or PKC unclear;
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IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T02056 ATF-2-isoform1; mouse, Mus musculus.
IN T01017 ATF-2-isoform2; mouse, Mus musculus.
IN T00131 c-Jun; mouse, Mus musculus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00134 c-Jun; chick, Gallus gallus.
IN T00135 c-Jun; hamster, Cricetulus sp.
XX
MX M07312 V$ATF2_Q6.
MX M00981 V$CREBATF_Q6.
MX M00041 V$CREBP1CJUN_01.
MX M00040 V$CREBP1_01.
MX M00179 V$CREBP1_Q2.
MX M00801 V$CREB_Q3.
XX
BS R00356.
BS R14470.
BS R01067.
BS R01941.
BS R15965.
BS R02096.
XX
DR TRANSPATH: MO000001476.
DR EMBL: M31629;
DR EMBL: S76659; S76659.
DR UniProtKB: P16951-2;
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RN [1]; RE0001241.
RX PUBMED: 2138707.
RA Ivashkiv L. B., Liou H.-C., Kara C. J., Lamph W. W., Verma I. M., Glimcher L. H.
RT mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic AMP, but not to the 12-O-tetradecanoylphorbol-13-acetate, response element
RL Mol. Cell. Biol. 10:1609-1621 (1990).
RN [2]; RE0005262.
RX PUBMED: 1531087.
RA Georgopoulos K., Morgan B. A., Moore D. D.
RT Functionally distinct isoforms of the CRE-BP DNA-binding protein mediate activity of a T-cell-specific enhancer
RL Mol. Cell. Biol. 12:747-757 (1992).
RN [3]; RE0013954.
RX PUBMED: 9409785.
RA D'Orazio D., Besser D., Marksitzer R., Kunz C., Hume D. A., Kiefer B., Nagamine Y.
RT Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2
RL Gene 201:179-187 (1997).
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