AC T00131
XX
ID T00131
XX
DT 15.10.1992 (created); ewi.
DT 04.07.2016 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA c-Jun
XX
SY AH119; AP-1; c-Jun; Jun; JunA; p39; proto-oncogene Jun A; transcription factor c-Jun.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G000487 Jun.
XX
CL C0008; bZIP; 1.1.1.1.1.
XX
SF structural properties have been investigated by CD and fluorescence spectroscopy [22] [34];
SF the leucine zipper regions are alpha-helically folded [22];
SF c-Jun/c-Fos heterodimers are much more stable than c-Jun homodimers and thus form preferentially [22] [30] [8];
SF at least three leucine residues and some additional residues of the zipper region are important for dimerization, probably by establishing the optimal pattern of hydrophobic and electrostatic contacts [17] [30] [8];
SF the dissociation constant of the c-Jun/c-Fos heterodimer is 23 nM [34];
SF Jun/Fos exhibits very fast association kinetics and subunit exchange (t1/2 < 10s) [34];
SF the exact relative positioning of zipper and basic region is important for DNA-binding [30];
SF the heterodimer with c-Fos binds 25-fold more efficiently to DNA than the homodimer [30];
SF very fast binding to DNA (t1/2 < 5s) and very low subunit exchange rate in the DNA-bound complex [34];
SF opposite DNA bending by homodimers and by c-Jun/c-Fos heterodimers [28];
SF the leucine zipper region interacts also with the Rel domain of RelA [45];
SF trans-activation and transforming activity correlate within the N-terminal 168 AA [38];
SF delta region may play an essential role in the interaction of c-Jun with a protein kinase [32];
XX
CP ubiquitous; Mouse fibroblasts [62]; RAW264.7, RAW264.7 + LPS, RAW264.7 + IFNgamma [65]; FSDC and FSDC + antiCD40 [50].
XX
FF transcriptional activator, major contributor to trans-activation by AP-1 [31];
FF inhibits myogenesis by direct interaction with MyoD [27];
FF essential "progression factor" during intermediate stages of skin tumor development, subsequent to dysregulated proliferation (similar to JunB, but different from JunD and c-Fos) [43];
FF immediate early gene, activated by serum growth factors, superinduced by cycloheximide [26] [29] [14];
FF repression of serum inducibility of c-jun by adipocyte differentiation [49];
FF inducible by UV through a Raf-1 dependent pathway [42] [44];
FF phosphorylation at Ser-63/Ser-73 by JNK protein kinases increases trans-activation potential [39];
FF and is enhanced by Ha-Ras [25] [36] [37] [40];
FF possibly also involving v-Sis, v-Src, and Raf-1 [25];
FF phosphorylation near the DNA-binding domain by DNA-PK is enhanced, that by CK II, p34cdc2 and in response to PKC is reduced after DNA-binding [41];
XX
IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T01017 ATF-2-isoform2; mouse, Mus musculus.
IN T01313 ATF-3-isoform1; human, Homo sapiens.
IN T01095 ATF-3; rat, Rattus norvegicus.
IN T01303 ATF-4; human, Homo sapiens.
IN T00051 ATF; human, Homo sapiens.
IN T00122 c-Fos; mouse, Mus musculus.
IN T00123 c-Fos; human, Homo sapiens.
IN T00124 c-Fos; rat, Rattus norvegicus.
IN T00125 c-Fos; chick, Gallus gallus.
IN T00131 c-Jun; mouse, Mus musculus.
IN T01318 CBP; mouse, Mus musculus.
IN T01308 CREBPA; human, Homo sapiens.
IN T02198 deltaFosB; mouse, Mus musculus.
IN T00967 E1A 12S protein; adenovirus.
IN T00209 E1A 13S protein; adenovirus type 2.
IN T00291 FosB; mouse, Mus musculus.
IN T00292 Fra-1; mouse, Mus musculus.
IN T01208 Fra-1; rat, Rattus norvegicus.
IN T00333 GR; rat, Rattus norvegicus.
IN T02315 KRC; mouse, Mus musculus.
IN T02505 MEF-2D-isoform muscle; mouse, Mus musculus.
IN T02506 MEF-2D-isoform non-muscle; mouse, Mus musculus.
IN T27821 MTA-1; mouse, Mus musculus.
IN T00526 MyoD; mouse, Mus musculus.
IN T01438 NRL; mouse, Mus musculus.
IN T02415 pitx1; mouse, Mus musculus.
IN T32110 SIRT1; mouse, Mus musculus.
IN T01576 STAT4; mouse, Mus musculus.
IN T00888 v-Fos; FBR MuLV, FBR murine osteosarcoma virus.
XX
MX M00172 V$AP1FJ_Q2.
MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M03541 V$CJUN_Q6.
MX M00041 V$CREBP1CJUN_01.
XX
BS R03540.
BS R20934.
BS R22911.
BS R25003.
BS R25123.
BS R23219.
BS R62498.
BS R62516.
BS R39734.
BS R02734.
BS R01037.
BS R58113.
BS R22860.
BS R72631.
BS R24999.
BS R25855.
BS R62244.
BS R24062.
BS R03186.
BS R14470.
BS R24500.
BS R01564.
BS R35990.
BS R64892.
BS R19553.
BS R73762.
BS R60265.
BS R67450.
BS R67451.
BS R26288.
BS R34234.
BS R41409.
BS R04064.
BS R67555.
BS R69088.
BS R72586.
BS R68078.
BS R62217.
BS R61623.
BS R37826.
BS R62456.
BS R29786.
BS R19522.
BS R14477.
BS R24866.
BS R28401.
BS R64625.
BS R41850.
BS R41853.
BS R41856.
BS R41859.
BS R04079.
BS R01067.
BS R73704.
BS R14160.
BS R66843.
BS R38541.
BS R38546.
BS R02096.
BS R08510.
BS R24785.
BS R24787.
BS R24790.
BS R64548.
BS R26630.
BS R13176.
BS R21509.
BS R56972.
BS R23478.
BS R41865.
BS R65566.
BS R65567.
BS R65568.
BS R14663.
BS R31129.
BS R61168.
BS R16979.
BS R01225.
BS R73909.
BS R33767.
BS R74039.
BS R18402.
BS R26259.
BS R26264.
BS R26504.
XX
DR TRANSPATH: MO000001268.
DR TRANSCOMPEL: C00081.
DR TRANSCOMPEL: C00082.
DR TRANSCOMPEL: C00139.
DR TRANSCOMPEL: C00144.
DR TRANSCOMPEL: C00294.
DR TRANSCOMPEL: C00571.
DR UniProtKB: P05627;
XX
RN [1]; RE0000106.
RX PUBMED: 3135941.
RA Sassone-Corsi P., Lamph W. W., Kamps M., Verma I. M.
RT fos-associated cellular p39 is related to nuclear transcription factor AP-1
RL Cell 54:553-560 (1988).
RN [2]; RE0000143.
RX PUBMED: 3142691.
RA Nakabeppu Y., Ryder K., Nathans D.
RT DNA Binding Activities of Three Murine Jun Proteins: Stimulation by Fos
RL Cell 55:907-915 (1988).
RN [3]; RE0000157.
RX PUBMED: 1846781.
RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett G. R., Karin M., Hunter T.
RT Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
RL Cell 64:573-584 (1991).
RN [4]; RE0000158.
RX PUBMED: 1900458.
RA Auwerx J., Sassone-Corsi P.
RT IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation
RL Cell 64:983-993 (1991).
RN [5]; RE0000166.
RX PUBMED: 2124518.
RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P.
RT Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex
RL Cell 63:1267-1276 (1990).
RN [6]; RE0000247.
RX PUBMED: 2169353.
RA Schuele R., Rangarajan P., Kliewer S., Ransone L. J., Bolado J., Yang N., Verma I. M., Evans R. M.
RT Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
RL Cell 62:1217-1226 (1990).
RN [7]; RE0000521.
RX PUBMED: 1714380.
RA de Groot R. P., Karperien M., Pals C., Kruijer W.
RT Characterization of the mouse junD promoter - high basal level activity due to an octamer motif
RL EMBO J. 10:2523-2532 (1991).
RN [8]; RE0000636.
RX PUBMED: 2501150.
RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M.
RT Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins
RL Genes Dev. 3:770-781 (1989).
RN [9]; RE0000662.
RX PUBMED: 2498163.
RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E.
RT Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction
RL Genes Dev. 3:304-313 (1989).
RN [10]; RE0001155.
RX PUBMED: 2536818.
RA Yamaguchi Y., Satake M., Ito Y.
RT Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene
RL J. Virol. 63:1040-1048 (1989).
RN [11]; RE0001453.
RX PUBMED: 2115122.
RA Gius D., Cao X., Rauscher III F. J., Cohen D. R., Curran T., Sukhatme V. P.
RT Transcriptional Activation and Repression by Fos Are Independent Functions: The C Terminus Represses Immediate-Early Gene Expression via CArG Elements
RL Mol. Cell. Biol. 10:4243-4255 (1990).
RN [12]; RE0001460.
RX PUBMED: 2501665.
RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R.
RT Expression of raf oncogenes activates the PEA1 transcription factor motif
RL Mol. Cell. Biol. 9:2247-2250 (1989).
RN [13]; RE0001770.
RX PUBMED: 2974122.
RA Kouzarides T., Ziff E.
RT The role of the leucine zipper in the fos-jun interaction
RL Nature 336:646-651 (1988).
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RX PUBMED: 2457172.
RA Lamph W. W., Wamsley P., Sassone-Corsi P., Verma I. M.
RT Induction of proto-oncogene JUN/AP-1 by serum and TPA
RL Nature 334:629 (1988).
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RX PUBMED: 2518690.
RA Angel P., Smeal T., Meek J., Karin M.
RT jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner
RL New Biol. 1:35-43 (1989).
RN [16]; RE0001941.
RX PUBMED: 1963081.
RA Yang-Yen H.-F., Chiu R., Karin M.
RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription
RL New Biol. 2:351-361 (1990).
RN [17]; RE0002182.
RX PUBMED: 1901988.
RA Schuermann M., Hunter J. B., Henning G., Mueller R.
RT Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization
RL Nucleic Acids Res. 19:739-746 (1991).
RN [18]; RE0002247.
RX PUBMED: 1832215.
RA Maguire K., Shi X.-P., Horikoshi N., Rappaport J., Rosenberg M., Weinmann R.
RT Interactions between adenovirus E1A and members of the AP-1 family of cellular transcription factors
RL Oncogene 6:1417-1422 (1991).
RN [19]; RE0002407.
RX PUBMED: 3174663.
RA Saffen D. W., Cole A. J., Worley P. F., Christy B. A., Ryder K., Baraban J. M.
RT Convulsant-induced increase in transcription factor messenger RNAs in rat brain
RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988).
RN [20]; RE0002408.
RX PUBMED: 2453058.
RA Piette J., Hirai S.-I., Yaniv M.
RT Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts
RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988).
RN [21]; RE0002543.
RX PUBMED: 1902565.
RA Hsu J. C., Laz T., Mohn K. L., Taub R.
RT Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver
RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991).
RN [22]; RE0002698.
RX PUBMED: 2503872.
RA O'Shea E. K., Rutkowski R., Stafford III W. F., Kim P. S.
RT Preferential heterodimer formation by isolated leucine zippers from Fos and Jun
RL Science 245:646-648 (1989).
RN [23]; RE0002710.
RX PUBMED: 8211160.
RA Wagner S., Green M. R.
RT HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization
RL Science 262:395-399 (1993).
RN [24]; RE0002917.
RX PUBMED: 8264639.
RA Kataoka K., Noda M., Nishizawa M.
RT Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun
RL Mol. Cell. Biol. 14:700-712 (1994).
RN [25]; RE0002997.
RX PUBMED: 1630458.
RA Smeal T., Binetruy B., Mercola D., Grover-Bardwick A., Heidecker G., Rapp U. R., Karin M.
RT Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73
RL Mol. Cell. Biol. 12:3507-3513 (1992).
RN [26]; RE0003142.
RX PUBMED: 3136397.
RA Ryseck R.-P., Hirai S.I., Yaniv M., Bravo R.
RT Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
RL Nature 334:535-537 (1988).
RN [27]; RE0003225.
RX PUBMED: 1313772.
RA Li L., Chambard J. C., Karin M., Olson E. N.
RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression
RL Genes Dev. 6:676-689 (1992).
RN [28]; RE0004643.
RX PUBMED: 8355695.
RA Kerppola T. K., Curran T.
RT Selective DNA bending by a variety of bZIP proteins
RL Mol. Cell. Biol. 13:5479-5489 (1993).
RN [29]; RE0004650.
RX PUBMED: 3186736.
RA Ryder K., Nathans D.
RT Induction of protooncogene c-jun by serum growth factors
RL Proc. Natl. Acad. Sci. USA 85:8464-8467 (1988).
RN [30]; RE0004654.
RX PUBMED: 2516828.
RA Smeal T., Angel P., Meek J., Karin M.
RT Different requirements for formation of Jun:Jun and Jun:Fos complexes
RL Genes Dev. 3:2091-2100 (1989).
RN [31]; RE0004659.
RX PUBMED: 1904542.
RA Abate C., Luk D., Curran T.
RT Transcriptional regulation by Fos and Jun in vitro: Interaction among multiple activator and regulator domains
RL Mol. Cell. Biol. 11:3624-3632 (1991).
RN [32]; RE0004663.
RX PUBMED: 1324919.
RA Adler V., Polotskaya A., Wagner F., Kraft A. S.
RT Affinity-purified j-Jun amino-terminal protein kinases requires serine/threonine phosphorylation for activity
RL J. Biol. Chem. 267:17001-17005 (1992).
RN [33]; RE0004665.
RX PUBMED: 8382609.
RA van Dam H., Duyndam M., Rottier R., Bosch A., de Vries-Smits L., Herrlich P., Zantema A., Angel P., van der Eb A. J.
RT Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amin acid adenovirus E1A protein
RL EMBO J. 12:479-487 (1993).
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RX PUBMED: 8041795.
RA Patel L. R., Curran T., Kerppola T. K.
RT Energy transfer analysis of Fos-Jun dimerization and DNA binding
RL Proc. Natl. Acad. Sci. USA 91:7360-7364 (1994).
RN [35]; RE0004669.
RX PUBMED: 7937838.
RA Srinivas S., Schoenthal A., Eckhart W.
RT Polymomavirus middle-sizes tumor antigen modulates c-Jun phosphorylation and transcriptional activity
RL Proc. Natl. Acad. Sci. USA 91:10064-10068 (1994).
RN [36]; RE0004675.
RX PUBMED: 7935449.
RA Cano E., Hazzalin C. A., Mahadevan L. C.
RT Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun
RL Mol. Cell. Biol. 14:7352-7362 (1994).
RN [37]; RE0004678.
RX PUBMED: 1903181.
RA Binetruy B., Smeal T., Karin M.
RT Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
RL Nature 351:122-127 (1991).
RN [38]; RE0004679.
RX PUBMED: 1924349.
RA Castellazzi M., Spyrou G., La Vista N., Dangy J.-P., Piu F., Yaniv M., Brun G.
RT Overexpression of c-jun, junB, or junD affects cell growth differently
RL Proc. Natl. Acad. Sci. USA 88:8890-8894 (1991).
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RX PUBMED: 1922387.
RA Pulverer B. J., Kyriakis J. M., Avruch J., Nikolakaki E., Woodgett J. R.
RT Phosphorylation of c-jun mediated by MAP kinases
RL Nature 353:670-674 (1991).
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RX PUBMED: 1906140.
RA Baichwal V. R., Park A., Tjian R.
RT v-Src and EJ Ras alleviate repression of c-jun by a cell-specific inhibitor
RL Nature 352:165-168 (1991).
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RX PUBMED: 8341696.
RA Abate C., Baker S. J., Lees-Miller S. P., Anderson C. W., Marshak D. R., Curran T.
RT Dimerization and DNA binding alter phosphorylation of Fos and Jun
RL Proc. Natl. Acad. Sci. USA 90:6766-6770 (1993).
RN [42]; RE0004720.
RX PUBMED: 1561239.
RA Stein B., Angel P., van Dam H., Ponta H., Herrlich P., van der Eb A., Rahmsdorf H. J.
RT Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response
RL Photochem. Photobiol. 55:409-415 (1992).
RN [43]; RE0004721.
RX PUBMED: 1459456.
RA Bossy-Wetzel E., Bravo R., Hanahan D.
RT Transcription factors JunB and c-Jun are selectively up-regulated and functionally implicated in fibrosarcoma development
RL Genes Dev. 6:2340-2351 (1992).
RN [44]; RE0004722.
RX PUBMED: 8384549.
RA Radler-Pohl A., Sachsenmaier C., Gebel S., Auer H.-P., Bruder J. T., Rapp U., Angel P., Rahmsdorf H. J., Herrlich P.
RT UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase
RL EMBO J. 12:1005-1012 (1993).
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RX PUBMED: 8404856.
RA Stein B., Baldwin jr A. S., Ballard D. W., Greene W. C., Angel P., Herrlich P.
RT Cross-coupling of the NF-6B p65 and Fos/Jun transcription factors produces potentiated biological function
RL EMBO J. 12:3879-3891 (1993).
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RX PUBMED: 8028671.
RA Arias J., Alberts A. S., Brindle P., Claret F. X., Smeal T., Karin M., Feramisco J., Montminy M.
RT Activation of cAMP and mitogen responsive genes relies in a common nuclear factor
RL Nature 370:226-229 (1994).
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RX PUBMED: 1900040.
RA Nakabeppu Y., Nathans D.
RT A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity
RL Cell 64:751-759 (1991).
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RX PUBMED: 1905017.
RA Yen J., Wisdom R. M., Tratner I., Verma I. M.
RT An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins
RL Proc. Natl. Acad. Sci. USA 88:5077-5081 (1991).
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RX PUBMED: 8197114.
RA Wang H., Scott R. E.
RT Adipocyte differentiation selectively represses the serum inducibility of c-jun and junB by reversible transcription-dependent mechanisms
RL Proc. Natl. Acad. Sci. USA 91:4649-4653 (1994).
RN [50]; RE0025717.
RX PUBMED: 11886848.
RA Mann J., Oakley F., Johnson P. W., Mann D. A.
RT CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1.
RL J. Biol. Chem. 277:17125-38 (2002).
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RX PUBMED: 11477071.
RA Teyssier C., Belguise K., Galtier F., Chalbos D.
RT Characterization of the physical interaction between estrogen receptor alpha and JUN proteins.
RL J. Biol. Chem. 276:36361-9 (2001).
RN [52]; RE0042645.
RX PUBMED: 12791272.
RA Zenz R., Scheuch H., Martin P., Frank C., Eferl R., Kenner L., Sibilia M., Wagner E. F.
RT c-Jun regulates eyelid closure and skin tumor development through EGFR signaling
RL Dev. Cell 4:879-89 (2003).
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RX PUBMED: 10788439.
RA Muller S., Berger M., Lehembre F., Seeler J. S., haupt Y., Dejean A.
RT c-Jun and p53 activity is modulated by SUMO-1 modification.
RL J. Biol. Chem. 275:13321-13329 (2000).
RN [54]; RE0047551.
RX PUBMED: 14707112.
RA Oukka M., Wein M. N., Glimcher L. H.
RT Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.
RL J. Exp. Med. 199:15-24 (2004).
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RX PUBMED: 15226417.
RA Jeong K. H., Chin W. W., Kaiser U. B.
RT Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA.
RL Mol. Cell. Biol. 24:6127-6139 (2004).
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RX PUBMED: 15923621.
RA Mialon A., Sankinen M., Soderstrom H., Junttila T. T., Holmstrom T., Koivusalo R., Papageorgiou A. C., Johnson R. S., Hietanen S., Elenius K., Westermarck J.
RT DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation.
RL Mol. Cell. Biol. 25:5040-5051 (2005).
RN [57]; RE0048292.
RX PUBMED: 15314150.
RA Shuman J. D., Sebastian T., Kaldis P., Copeland T. D., Zhu S., Smart R. C., Johnson P. F.
RT Cell cycle-dependent phosphorylation of C/EBPbeta mediates oncogenic cooperativity between C/EBPbeta and H-RasV12.
RL Mol. Cell. Biol. 24:7380-7391 (2004).
RN [58]; RE0048379.
RX PUBMED: 15699140.
RA Wang Z. Y., Sato H., Kusam S., Sehra S., Toney L. M., Dent A. L.
RT Regulation of IL-10 gene expression in Th2 cells by Jun proteins.
RL J. Immunol. 174:2098-2105 (2005).
RN [59]; RE0048408.
RX PUBMED: 16854466.
RA Martin C. B., Ingersoll S. A., Martin B. K.
RT Transcriptional control of the C3a receptor gene in glial cells: Dependence upon AP-1 but not Ets.
RL Mol. Immunol. 44:703-712 (2007).
RN [60]; RE0051324.
RX PUBMED: 14532268.
RA Perez-Sala D., Cernuda-Morollon E., Canada F. J.
RT Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-Delta 12,14-prostaglandin J2.
RL J. Biol. Chem. 278:51251-51260 (2003).
RN [61]; RE0051515.
RX PUBMED: 17158449.
RA Besse A., Lamothe B., Campos A. D., Webster W. K., Maddineni U., Lin S. C., Wu H., Darnay B. G.
RT TAK1-dependent signaling requires functional interaction with TAB2/TAB3.
RL J. Biol. Chem. 282:3918-3928 (2007).
RN [62]; RE0051710.
RX PUBMED: 15988009.
RA Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J. Y., Lu S. C.
RT Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1.
RL Mol. Cell. Biol. 25:5933-5946 (2005).
RN [63]; RE0052377.
RX PUBMED: 16901783.
RA Guo W., Pylayeva Y., Pepe A., Yoshioka T., Muller W. J., Inghirami G., Giancotti F. G.
RT Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.
RL Cell 126:489-502 (2006).
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RX PUBMED: 15548667.
RA Yeiser E. C., Rutkoski N. J., Naito A., Inoue J., Carter B. D.
RT Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice.
RL J. Neurosci. 24:10521-10529 (2004).
RN [65]; RE0053512.
RX PUBMED: 10975835.
RA Kim Y. M., Im J. Y., Han S. H., Kang H. S., Choi I.
RT IFN-gamma up-regulates IL-18 gene expression via IFN consensus sequence-binding protein and activator protein-1 elements in macrophages.
RL J. Immunol. 165:3198-3205 (2000).
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RX PUBMED: 16807249.
RA Qiao L., MacDougald O. A., Shao J.
RT CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase.
RL J. Biol. Chem. 281:24390-24397 (2006).
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RX PUBMED: 16818236.
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RT Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.
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