TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00131 XX ID T00131 XX DT 15.10.1992 (created); ewi. DT 04.07.2016 (updated); ros. CO Copyright (C), QIAGEN. XX FA c-Jun XX SY AH119; AP-1; c-Jun; Jun; JunA; p39; proto-oncogene Jun A; transcription factor c-Jun. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G000487 Jun. XX CL C0008; bZIP; XX SF structural properties have been investigated by CD and fluorescence spectroscopy [22] [34]; SF the leucine zipper regions are alpha-helically folded [22]; SF c-Jun/c-Fos heterodimers are much more stable than c-Jun homodimers and thus form preferentially [22] [30] [8]; SF at least three leucine residues and some additional residues of the zipper region are important for dimerization, probably by establishing the optimal pattern of hydrophobic and electrostatic contacts [17] [30] [8]; SF the dissociation constant of the c-Jun/c-Fos heterodimer is 23 nM [34]; SF Jun/Fos exhibits very fast association kinetics and subunit exchange (t1/2 < 10s) [34]; SF the exact relative positioning of zipper and basic region is important for DNA-binding [30]; SF the heterodimer with c-Fos binds 25-fold more efficiently to DNA than the homodimer [30]; SF very fast binding to DNA (t1/2 < 5s) and very low subunit exchange rate in the DNA-bound complex [34]; SF opposite DNA bending by homodimers and by c-Jun/c-Fos heterodimers [28]; SF the leucine zipper region interacts also with the Rel domain of RelA [45]; SF trans-activation and transforming activity correlate within the N-terminal 168 AA [38]; SF delta region may play an essential role in the interaction of c-Jun with a protein kinase [32]; XX CP ubiquitous; Mouse fibroblasts [62]; RAW264.7, RAW264.7 + LPS, RAW264.7 + IFNgamma [65]; FSDC and FSDC + antiCD40 [50]. XX FF transcriptional activator, major contributor to trans-activation by AP-1 [31]; FF inhibits myogenesis by direct interaction with MyoD [27]; FF essential "progression factor" during intermediate stages of skin tumor development, subsequent to dysregulated proliferation (similar to JunB, but different from JunD and c-Fos) [43]; FF immediate early gene, activated by serum growth factors, superinduced by cycloheximide [26] [29] [14]; FF repression of serum inducibility of c-jun by adipocyte differentiation [49]; FF inducible by UV through a Raf-1 dependent pathway [42] [44]; FF phosphorylation at Ser-63/Ser-73 by JNK protein kinases increases trans-activation potential [39]; FF and is enhanced by Ha-Ras [25] [36] [37] [40]; FF possibly also involving v-Sis, v-Src, and Raf-1 [25]; FF phosphorylation near the DNA-binding domain by DNA-PK is enhanced, that by CK II, p34cdc2 and in response to PKC is reduced after DNA-binding [41]; XX IN T00167 ATF-2-isoform1; human, Homo sapiens. IN T01017 ATF-2-isoform2; mouse, Mus musculus. IN T01313 ATF-3-isoform1; human, Homo sapiens. IN T01095 ATF-3; rat, Rattus norvegicus. IN T01303 ATF-4; human, Homo sapiens. IN T00051 ATF; human, Homo sapiens. IN T00122 c-Fos; mouse, Mus musculus. IN T00123 c-Fos; human, Homo sapiens. IN T00124 c-Fos; rat, Rattus norvegicus. IN T00125 c-Fos; chick, Gallus gallus. IN T00131 c-Jun; mouse, Mus musculus. IN T01318 CBP; mouse, Mus musculus. IN T01308 CREBPA; human, Homo sapiens. IN T02198 deltaFosB; mouse, Mus musculus. IN T00967 E1A 12S protein; adenovirus. IN T00209 E1A 13S protein; adenovirus type 2. IN T00291 FosB; mouse, Mus musculus. IN T00292 Fra-1; mouse, Mus musculus. IN T01208 Fra-1; rat, Rattus norvegicus. IN T00333 GR; rat, Rattus norvegicus. IN T02315 KRC; mouse, Mus musculus. IN T02505 MEF-2D-isoform muscle; mouse, Mus musculus. IN T02506 MEF-2D-isoform non-muscle; mouse, Mus musculus. IN T27821 MTA-1; mouse, Mus musculus. IN T00526 MyoD; mouse, Mus musculus. IN T01438 NRL; mouse, Mus musculus. IN T02415 pitx1; mouse, Mus musculus. IN T32110 SIRT1; mouse, Mus musculus. IN T01576 STAT4; mouse, Mus musculus. IN T00888 v-Fos; FBR MuLV, FBR murine osteosarcoma virus. XX MX M00172 V$AP1FJ_Q2. MX M00517 V$AP1_01. MX M00924 V$AP1_Q2_01. MX M00926 V$AP1_Q4_01. MX M00925 V$AP1_Q6_01. MX M03541 V$CJUN_Q6. MX M00041 V$CREBP1CJUN_01. XX BS R03540. BS R20934. BS R22911. BS R25003. BS R25123. BS R23219. BS R62498. BS R62516. BS R39734. BS R02734. BS R01037. BS R58113. BS R22860. BS R72631. BS R24999. BS R25855. BS R62244. BS R24062. BS R03186. BS R14470. BS R24500. BS R01564. BS R35990. BS R64892. BS R19553. BS R73762. BS R60265. BS R67450. BS R67451. BS R26288. BS R34234. BS R41409. BS R04064. BS R67555. BS R69088. BS R72586. BS R68078. BS R62217. BS R61623. BS R37826. BS R62456. BS R29786. BS R19522. BS R14477. BS R24866. BS R28401. BS R64625. BS R41850. BS R41853. BS R41856. BS R41859. BS R04079. BS R01067. BS R73704. BS R14160. BS R66843. BS R38541. BS R38546. BS R02096. BS R08510. BS R24785. BS R24787. BS R24790. BS R64548. BS R26630. BS R13176. BS R21509. BS R56972. BS R23478. BS R41865. BS R65566. BS R65567. BS R65568. BS R14663. BS R31129. BS R61168. BS R16979. BS R01225. BS R73909. BS R33767. BS R74039. BS R18402. BS R26259. BS R26264. BS R26504. XX DR TRANSPATH: MO000001268. DR TRANSCOMPEL: C00081. DR TRANSCOMPEL: C00082. DR TRANSCOMPEL: C00139. DR TRANSCOMPEL: C00144. DR TRANSCOMPEL: C00294. DR TRANSCOMPEL: C00571. DR UniProtKB: P05627; XX RN [1]; RE0000106. RX PUBMED: 3135941. RA Sassone-Corsi P., Lamph W. W., Kamps M., Verma I. M. RT fos-associated cellular p39 is related to nuclear transcription factor AP-1 RL Cell 54:553-560 (1988). RN [2]; RE0000143. RX PUBMED: 3142691. RA Nakabeppu Y., Ryder K., Nathans D. RT DNA Binding Activities of Three Murine Jun Proteins: Stimulation by Fos RL Cell 55:907-915 (1988). RN [3]; RE0000157. RX PUBMED: 1846781. RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [4]; RE0000158. RX PUBMED: 1900458. RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [5]; RE0000166. RX PUBMED: 2124518. RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [6]; RE0000247. RX PUBMED: 2169353. RA Schuele R., Rangarajan P., Kliewer S., Ransone L. J., Bolado J., Yang N., Verma I. M., Evans R. M. RT Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor RL Cell 62:1217-1226 (1990). RN [7]; RE0000521. RX PUBMED: 1714380. RA de Groot R. P., Karperien M., Pals C., Kruijer W. RT Characterization of the mouse junD promoter - high basal level activity due to an octamer motif RL EMBO J. 10:2523-2532 (1991). RN [8]; RE0000636. RX PUBMED: 2501150. RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M. RT Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins RL Genes Dev. 3:770-781 (1989). RN [9]; RE0000662. RX PUBMED: 2498163. RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E. RT Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction RL Genes Dev. 3:304-313 (1989). RN [10]; RE0001155. RX PUBMED: 2536818. RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [11]; RE0001453. RX PUBMED: 2115122. RA Gius D., Cao X., Rauscher III F. J., Cohen D. R., Curran T., Sukhatme V. P. RT Transcriptional Activation and Repression by Fos Are Independent Functions: The C Terminus Represses Immediate-Early Gene Expression via CArG Elements RL Mol. Cell. Biol. 10:4243-4255 (1990). RN [12]; RE0001460. RX PUBMED: 2501665. RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [13]; RE0001770. RX PUBMED: 2974122. RA Kouzarides T., Ziff E. RT The role of the leucine zipper in the fos-jun interaction RL Nature 336:646-651 (1988). RN [14]; RE0001834. RX PUBMED: 2457172. RA Lamph W. W., Wamsley P., Sassone-Corsi P., Verma I. M. RT Induction of proto-oncogene JUN/AP-1 by serum and TPA RL Nature 334:629 (1988). RN [15]; RE0001940. RX PUBMED: 2518690. RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner RL New Biol. 1:35-43 (1989). RN [16]; RE0001941. RX PUBMED: 1963081. RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription RL New Biol. 2:351-361 (1990). RN [17]; RE0002182. RX PUBMED: 1901988. RA Schuermann M., Hunter J. B., Henning G., Mueller R. RT Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization RL Nucleic Acids Res. 19:739-746 (1991). RN [18]; RE0002247. RX PUBMED: 1832215. RA Maguire K., Shi X.-P., Horikoshi N., Rappaport J., Rosenberg M., Weinmann R. RT Interactions between adenovirus E1A and members of the AP-1 family of cellular transcription factors RL Oncogene 6:1417-1422 (1991). RN [19]; RE0002407. RX PUBMED: 3174663. RA Saffen D. W., Cole A. J., Worley P. F., Christy B. A., Ryder K., Baraban J. M. RT Convulsant-induced increase in transcription factor messenger RNAs in rat brain RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988). RN [20]; RE0002408. RX PUBMED: 2453058. RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [21]; RE0002543. RX PUBMED: 1902565. RA Hsu J. C., Laz T., Mohn K. L., Taub R. RT Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991). RN [22]; RE0002698. RX PUBMED: 2503872. RA O'Shea E. K., Rutkowski R., Stafford III W. F., Kim P. S. RT Preferential heterodimer formation by isolated leucine zippers from Fos and Jun RL Science 245:646-648 (1989). RN [23]; RE0002710. RX PUBMED: 8211160. RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [24]; RE0002917. RX PUBMED: 8264639. RA Kataoka K., Noda M., Nishizawa M. RT Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun RL Mol. Cell. Biol. 14:700-712 (1994). RN [25]; RE0002997. RX PUBMED: 1630458. RA Smeal T., Binetruy B., Mercola D., Grover-Bardwick A., Heidecker G., Rapp U. R., Karin M. RT Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73 RL Mol. Cell. Biol. 12:3507-3513 (1992). RN [26]; RE0003142. RX PUBMED: 3136397. RA Ryseck R.-P., Hirai S.I., Yaniv M., Bravo R. RT Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts RL Nature 334:535-537 (1988). RN [27]; RE0003225. RX PUBMED: 1313772. RA Li L., Chambard J. C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [28]; RE0004643. RX PUBMED: 8355695. RA Kerppola T. K., Curran T. RT Selective DNA bending by a variety of bZIP proteins RL Mol. Cell. Biol. 13:5479-5489 (1993). RN [29]; RE0004650. RX PUBMED: 3186736. RA Ryder K., Nathans D. RT Induction of protooncogene c-jun by serum growth factors RL Proc. Natl. Acad. Sci. USA 85:8464-8467 (1988). RN [30]; RE0004654. RX PUBMED: 2516828. RA Smeal T., Angel P., Meek J., Karin M. RT Different requirements for formation of Jun:Jun and Jun:Fos complexes RL Genes Dev. 3:2091-2100 (1989). RN [31]; RE0004659. RX PUBMED: 1904542. RA Abate C., Luk D., Curran T. RT Transcriptional regulation by Fos and Jun in vitro: Interaction among multiple activator and regulator domains RL Mol. Cell. Biol. 11:3624-3632 (1991). RN [32]; RE0004663. RX PUBMED: 1324919. RA Adler V., Polotskaya A., Wagner F., Kraft A. S. RT Affinity-purified j-Jun amino-terminal protein kinases requires serine/threonine phosphorylation for activity RL J. Biol. Chem. 267:17001-17005 (1992). RN [33]; RE0004665. RX PUBMED: 8382609. RA van Dam H., Duyndam M., Rottier R., Bosch A., de Vries-Smits L., Herrlich P., Zantema A., Angel P., van der Eb A. J. RT Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amin acid adenovirus E1A protein RL EMBO J. 12:479-487 (1993). RN [34]; RE0004668. RX PUBMED: 8041795. RA Patel L. R., Curran T., Kerppola T. K. RT Energy transfer analysis of Fos-Jun dimerization and DNA binding RL Proc. Natl. Acad. Sci. USA 91:7360-7364 (1994). RN [35]; RE0004669. RX PUBMED: 7937838. RA Srinivas S., Schoenthal A., Eckhart W. RT Polymomavirus middle-sizes tumor antigen modulates c-Jun phosphorylation and transcriptional activity RL Proc. Natl. Acad. Sci. USA 91:10064-10068 (1994). RN [36]; RE0004675. RX PUBMED: 7935449. RA Cano E., Hazzalin C. A., Mahadevan L. C. RT Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun RL Mol. Cell. Biol. 14:7352-7362 (1994). RN [37]; RE0004678. RX PUBMED: 1903181. RA Binetruy B., Smeal T., Karin M. RT Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain RL Nature 351:122-127 (1991). RN [38]; RE0004679. RX PUBMED: 1924349. RA Castellazzi M., Spyrou G., La Vista N., Dangy J.-P., Piu F., Yaniv M., Brun G. RT Overexpression of c-jun, junB, or junD affects cell growth differently RL Proc. Natl. Acad. Sci. USA 88:8890-8894 (1991). RN [39]; RE0004680. RX PUBMED: 1922387. RA Pulverer B. J., Kyriakis J. M., Avruch J., Nikolakaki E., Woodgett J. R. RT Phosphorylation of c-jun mediated by MAP kinases RL Nature 353:670-674 (1991). RN [40]; RE0004706. RX PUBMED: 1906140. RA Baichwal V. R., Park A., Tjian R. RT v-Src and EJ Ras alleviate repression of c-jun by a cell-specific inhibitor RL Nature 352:165-168 (1991). RN [41]; RE0004713. RX PUBMED: 8341696. RA Abate C., Baker S. J., Lees-Miller S. P., Anderson C. W., Marshak D. R., Curran T. RT Dimerization and DNA binding alter phosphorylation of Fos and Jun RL Proc. Natl. Acad. Sci. USA 90:6766-6770 (1993). RN [42]; RE0004720. RX PUBMED: 1561239. RA Stein B., Angel P., van Dam H., Ponta H., Herrlich P., van der Eb A., Rahmsdorf H. J. RT Ultraviolet-radiation induced c-jun gene transcription: two AP-1 like binding sites mediate the response RL Photochem. Photobiol. 55:409-415 (1992). RN [43]; RE0004721. RX PUBMED: 1459456. RA Bossy-Wetzel E., Bravo R., Hanahan D. RT Transcription factors JunB and c-Jun are selectively up-regulated and functionally implicated in fibrosarcoma development RL Genes Dev. 6:2340-2351 (1992). RN [44]; RE0004722. RX PUBMED: 8384549. RA Radler-Pohl A., Sachsenmaier C., Gebel S., Auer H.-P., Bruder J. T., Rapp U., Angel P., Rahmsdorf H. J., Herrlich P. RT UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase RL EMBO J. 12:1005-1012 (1993). RN [45]; RE0004732. RX PUBMED: 8404856. RA Stein B., Baldwin jr A. S., Ballard D. W., Greene W. C., Angel P., Herrlich P. RT Cross-coupling of the NF-6B p65 and Fos/Jun transcription factors produces potentiated biological function RL EMBO J. 12:3879-3891 (1993). RN [46]; RE0004733. RX PUBMED: 8028671. RA Arias J., Alberts A. S., Brindle P., Claret F. X., Smeal T., Karin M., Feramisco J., Montminy M. RT Activation of cAMP and mitogen responsive genes relies in a common nuclear factor RL Nature 370:226-229 (1994). RN [47]; RE0004882. RX PUBMED: 1900040. RA Nakabeppu Y., Nathans D. RT A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity RL Cell 64:751-759 (1991). RN [48]; RE0004883. RX PUBMED: 1905017. RA Yen J., Wisdom R. M., Tratner I., Verma I. M. RT An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins RL Proc. Natl. Acad. Sci. USA 88:5077-5081 (1991). RN [49]; RE0009126. RX PUBMED: 8197114. RA Wang H., Scott R. E. RT Adipocyte differentiation selectively represses the serum inducibility of c-jun and junB by reversible transcription-dependent mechanisms RL Proc. Natl. Acad. Sci. USA 91:4649-4653 (1994). RN [50]; RE0025717. RX PUBMED: 11886848. RA Mann J., Oakley F., Johnson P. W., Mann D. A. RT CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1. RL J. Biol. Chem. 277:17125-38 (2002). RN [51]; RE0031549. RX PUBMED: 11477071. RA Teyssier C., Belguise K., Galtier F., Chalbos D. RT Characterization of the physical interaction between estrogen receptor alpha and JUN proteins. RL J. Biol. Chem. 276:36361-9 (2001). RN [52]; RE0042645. RX PUBMED: 12791272. RA Zenz R., Scheuch H., Martin P., Frank C., Eferl R., Kenner L., Sibilia M., Wagner E. F. RT c-Jun regulates eyelid closure and skin tumor development through EGFR signaling RL Dev. Cell 4:879-89 (2003). RN [53]; RE0047321. RX PUBMED: 10788439. RA Muller S., Berger M., Lehembre F., Seeler J. S., haupt Y., Dejean A. RT c-Jun and p53 activity is modulated by SUMO-1 modification. RL J. Biol. Chem. 275:13321-13329 (2000). RN [54]; RE0047551. RX PUBMED: 14707112. RA Oukka M., Wein M. N., Glimcher L. H. RT Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells. RL J. Exp. Med. 199:15-24 (2004). RN [55]; RE0047640. RX PUBMED: 15226417. RA Jeong K. H., Chin W. W., Kaiser U. B. RT Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA. RL Mol. Cell. Biol. 24:6127-6139 (2004). RN [56]; RE0047797. RX PUBMED: 15923621. RA Mialon A., Sankinen M., Soderstrom H., Junttila T. T., Holmstrom T., Koivusalo R., Papageorgiou A. C., Johnson R. S., Hietanen S., Elenius K., Westermarck J. RT DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. RL Mol. Cell. Biol. 25:5040-5051 (2005). RN [57]; RE0048292. RX PUBMED: 15314150. RA Shuman J. D., Sebastian T., Kaldis P., Copeland T. D., Zhu S., Smart R. C., Johnson P. F. RT Cell cycle-dependent phosphorylation of C/EBPbeta mediates oncogenic cooperativity between C/EBPbeta and H-RasV12. RL Mol. Cell. Biol. 24:7380-7391 (2004). RN [58]; RE0048379. RX PUBMED: 15699140. RA Wang Z. Y., Sato H., Kusam S., Sehra S., Toney L. M., Dent A. L. RT Regulation of IL-10 gene expression in Th2 cells by Jun proteins. RL J. Immunol. 174:2098-2105 (2005). RN [59]; RE0048408. RX PUBMED: 16854466. RA Martin C. B., Ingersoll S. A., Martin B. K. RT Transcriptional control of the C3a receptor gene in glial cells: Dependence upon AP-1 but not Ets. RL Mol. Immunol. 44:703-712 (2007). RN [60]; RE0051324. RX PUBMED: 14532268. RA Perez-Sala D., Cernuda-Morollon E., Canada F. J. RT Molecular basis for the direct inhibition of AP-1 DNA binding by 15-deoxy-Delta 12,14-prostaglandin J2. RL J. Biol. Chem. 278:51251-51260 (2003). RN [61]; RE0051515. RX PUBMED: 17158449. RA Besse A., Lamothe B., Campos A. D., Webster W. K., Maddineni U., Lin S. C., Wu H., Darnay B. G. RT TAK1-dependent signaling requires functional interaction with TAB2/TAB3. RL J. Biol. Chem. 282:3918-3928 (2007). RN [62]; RE0051710. RX PUBMED: 15988009. RA Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J. Y., Lu S. C. RT Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. RL Mol. Cell. Biol. 25:5933-5946 (2005). RN [63]; RE0052377. RX PUBMED: 16901783. RA Guo W., Pylayeva Y., Pepe A., Yoshioka T., Muller W. J., Inghirami G., Giancotti F. G. RT Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. RL Cell 126:489-502 (2006). RN [64]; RE0053003. RX PUBMED: 15548667. RA Yeiser E. C., Rutkoski N. J., Naito A., Inoue J., Carter B. D. RT Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice. RL J. Neurosci. 24:10521-10529 (2004). RN [65]; RE0053512. RX PUBMED: 10975835. RA Kim Y. M., Im J. Y., Han S. H., Kang H. S., Choi I. RT IFN-gamma up-regulates IL-18 gene expression via IFN consensus sequence-binding protein and activator protein-1 elements in macrophages. RL J. Immunol. 165:3198-3205 (2000). RN [66]; RE0053554. RX PUBMED: 16807249. RA Qiao L., MacDougald O. A., Shao J. RT CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase. RL J. Biol. Chem. 281:24390-24397 (2006). RN [67]; RE0053674. RX PUBMED: 16818236. RA Lu C., Zhu F., Cho Y. Y., Tang F., Zykova T., Ma W. Y., Bode A. M., Dong Z. RT Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. RL Mol. Cell 23:121-132 (2006). RN [68]; RE0054578. RX PUBMED: 12770554. RA Willaime-Morawek S., Brami-Cherrier K., Mariani J., Caboche J., Brugg B. RT C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis. RL Neuroscience 119:387-397 (2003). RN [69]; RE0054833. RX PUBMED: 17690092. RA Lou H., Kaplowitz N. RT Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. RL J. Biol. Chem. 282:29470-29481 (2007). RN [70]; RE0061057. RX PUBMED: 17105733. RA Gough D. J., Sabapathy K., Ko E. Y., Arthur H. A., Schreiber R. D., Trapani J. A., Clarke C. J., Johnstone R. W. RT A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes. RL J. Biol. Chem. 282:938-946 (2007). RN [71]; RE0064837. RX PUBMED: 18567579. RA Otero J. E., Dai S., Foglia D., Alhawagri M., Vacher J., Pasparakis M., Abu-Amer Y. RT Defective osteoclastogenesis by IKKbeta-null precursors is a result of receptor activator of NF-kappaB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation. RL J. Biol. Chem. 283:24546-24553 (2008). RN [72]; RE0065005. RX PUBMED: 18192274. RA Kiryu-Seo S., Kato R., Ogawa T., Nakagomi S., Nagata K., Kiyama H. RT Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons. RL J. Biol. Chem. 283:6988-6996 (2008). RN [73]; RE0065236. RX PUBMED: 16260493. RA Shim J. H., Xiao C., Paschal A. E., Bailey S. T., Rao P., Hayden M. S., Lee K. Y., Bussey C., Steckel M., Tanaka N., Yamada G., Akira S., Matsumoto K., Ghosh S. RT TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. RL Genes Dev. 19:2668-2681 (2005). RN [74]; RE0065565. RX PUBMED: 19131506. RA Salisbury T. B., Binder A. K., Grammer J. C., Nilson J. H. RT GnRH-regulated expression of Jun and JUN target genes in gonadotropes requires a functional interaction between TCF/LEF family members and beta-catenin. RL Mol. Endocrinol. 23:402-411 (2009). RN [75]; RE0065826. RX PUBMED: 18653705. RA Wang Y., Fortin J., Lamba P., Bonomi M., Persani L., Roberson M. S., Bernard D. J. RT Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone beta-promoter activity. RL Endocrinology 149:5577-5591 (2008). RN [76]; RE0066070. RX PUBMED: 19243219. RA Bossuyt W., Kazanjian A., De Geest N., Van Kelst S., De Hertogh G., Geboes K., Boivin G. 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