AC T00124
XX
ID T00124
XX
DT 15.10.1992 (created); ewi.
DT 26.09.2014 (updated); msr.
CO Copyright (C), QIAGEN.
XX
FA c-Fos
XX
SY c-Fos; FBJ osteosarcoma oncogene.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002143 Fos.
XX
CL C0008; bZIP; 1.1.2.1.1.
XX
SF the apparent molecular weight may increase from 55 kDa to 62 kDa or more due to extensive phosphorylation [26];
SF no homodimerization, no DNA-binding by its own;
SF dimerization with c-Jun enhances DNA-binding efficiency of c-Jun at least 25-fold [8];
SF either leucine of the zipper may be exchanged, but substituting 2 or more abolishes its dimerization capability [8];
SF the leucine zipper confers dimerization specificity among bZIP class members [9];
SF two zipper motifs associate in a parallel arrangement and juxtapose the basic DNA-contacting regions [19];
SF in the heterodimer, c-Fos also contacts the DNA via its basic region [18] [14] [8];
SF the alpha-helical conformation of the zipper region extends to the basic region upon DNA-binding [10];
SF c-Fos/c-Jun heterodimers bend the DNA in the opposite direction than c-Jun homodimers do;
SF the C-TA is rich in acidic residues and comprises two c-Jun homology boxes, HOB1 and HOB2 which synergize but are able to independently activate transcription [27];
SF additional trans-activating modules comprise, e. g., another HOB1 element within the N-terminal part [27] [28];
SF especially this element is silenced by an inhibitory domain between HOB1-N and the basic region [28];
XX
CP PC-12 cells treated with cAMP and PMA [35]; PTZ treated hippocampus and amygdaloid nucleus [37]; estrogen treated or untreated rat hypothalamic nuclear extracts of ovariectomized (OVX) females [38].
XX
FF transcriptional activator and repressor;
FF represses transcription of its own gene and of ANF through the C-terminal domain distinct from the activation domain and through a distinct DNA element [21];
FF numerous regulatory elements in the 5' upstream region confer responses to enhanced cAMP levels, serum growth factors [29] [30] [31] [3];
FF inducible by GM-CSF [34];
FF oxidation of Cys-154 disables DNA-binding of the c-Fos/c-Jun dimer [24];
FF involved in the cAMP dependent regulation of catecholamine neurotransmitter biosynthesis [32];
XX
IN T01303 ATF-4; human, Homo sapiens.
IN T00051 ATF; human, Homo sapiens.
IN T10523 c-Ets-2; human, Homo sapiens.
IN T00131 c-Jun; mouse, Mus musculus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00134 c-Jun; chick, Gallus gallus.
IN T00135 c-Jun; hamster, Cricetulus sp.
IN T00967 E1A 12S protein; adenovirus.
IN T00209 E1A 13S protein; adenovirus type 2.
IN T00436 JunB; mouse, Mus musculus.
IN T06445 JunB; rat, Rattus norvegicus.
IN T00437 JunD; mouse, Mus musculus.
IN T00893 v-Jun; ASV 17, avian sarcoma virus 17.
IN T00902 XBP-1; human, Homo sapiens.
XX
MX M00172 V$AP1FJ_Q2.
MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M07600 V$CFOS_Q4.
MX M03815 V$CFOS_Q6.
XX
BS R03668.
BS R22874.
BS R22885.
BS R16636.
BS R00592.
BS R03059.
BS R38349.
BS R38353.
BS R32189.
BS R29771.
BS R55861.
BS R55862.
BS R31119.
BS R09471.
BS R37949.
BS R22730.
BS R56362.
BS R62140.
BS R34575.
BS R56504.
BS R56650.
BS R28545.
BS R26776.
BS R71399.
BS R26186.
BS R31517.
BS R37444.
BS R31550.
BS R01358.
BS R01491.
BS R01460.
BS R01383.
XX
DR TRANSPATH: MO000024722.
DR TRANSCOMPEL: C00115.
DR UniProtKB: P12841;
XX
RN [1]; RE0000047.
RX PUBMED: 3125983.
RA Rauscher III F. J., Sambucetti L. C., Curran T., Distel R. J., Spiegelman B. M.
RT Common DNA Binding Site for FOS Protein Complexes and Transcription Factor AP-1
RL Cell 52:471-480 (1988).
RN [2]; RE0000239.
RX PUBMED: 1906785.
RA Kerppola T. K., Curran T.
RT Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity
RL Cell 66:317-326 (1991).
RN [3]; RE0000633.
RX PUBMED: 2850967.
RA Sassone-Corsi P., Visvader J., Ferland L., Mellon P. L., Verma I. M.
RT Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element
RL Genes Dev. 2:1529-1538 (1988).
RN [4]; RE0000641.
RX PUBMED: 2467839.
RA Rauscher III F. J., Voulalas P. J., Franza jr B. R., Curran T.
RT Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro
RL Genes Dev. 2:1687-1699 (1988).
RN [5]; RE0000652.
RX PUBMED: 2498162.
RA Hay N., Takimoto M., Bishop J. M.
RT A FOS protein is present in a complex that binds a negative regulator of MYC
RL Genes Dev. 3:293-303 (1989).
RN [6]; RE0000662.
RX PUBMED: 2498163.
RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E.
RT Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction
RL Genes Dev. 3:304-313 (1989).
RN [7]; RE0001453.
RX PUBMED: 2115122.
RA Gius D., Cao X., Rauscher III F. J., Cohen D. R., Curran T., Sukhatme V. P.
RT Transcriptional Activation and Repression by Fos Are Independent Functions: The C Terminus Represses Immediate-Early Gene Expression via CArG Elements
RL Mol. Cell. Biol. 10:4243-4255 (1990).
RN [8]; RE0001770.
RX PUBMED: 2974122.
RA Kouzarides T., Ziff E.
RT The role of the leucine zipper in the fos-jun interaction
RL Nature 336:646-651 (1988).
RN [9]; RE0001771.
RX PUBMED: 2505081.
RA Kouzarides T., Ziff E.
RT Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding
RL Nature 340:568-571 (1989).
RN [10]; RE0001901.
RX PUBMED: 2120592.
RA Patel L., Abate C., Curan T.
RT Altered protein conformation on DNA binding by Fos and Jun
RL Nature 347:572-574 (1990).
RN [11]; RE0001940.
RX PUBMED: 2518690.
RA Angel P., Smeal T., Meek J., Karin M.
RT jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner
RL New Biol. 1:35-43 (1989).
RN [12]; RE0001941.
RX PUBMED: 1963081.
RA Yang-Yen H.-F., Chiu R., Karin M.
RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription
RL New Biol. 2:351-361 (1990).
RN [13]; RE0002247.
RX PUBMED: 1832215.
RA Maguire K., Shi X.-P., Horikoshi N., Rappaport J., Rosenberg M., Weinmann R.
RT Interactions between adenovirus E1A and members of the AP-1 family of cellular transcription factors
RL Oncogene 6:1417-1422 (1991).
RN [14]; RE0002325.
RX PUBMED: 2105492.
RA Abate C., Luk D., Gentz R., Rauscher III F. J., Curran T.
RT Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: Both Fos and Jun contact DNA directly
RL Proc. Natl. Acad. Sci. USA 87:1032-1036 (1990).
RN [15]; RE0002407.
RX PUBMED: 3174663.
RA Saffen D. W., Cole A. J., Worley P. F., Christy B. A., Ryder K., Baraban J. M.
RT Convulsant-induced increase in transcription factor messenger RNAs in rat brain
RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988).
RN [16]; RE0002481.
RX PUBMED: 1709740.
RA Ono S. J., Bazil V., Levi B.-Z., Ozato K., Strominger J. L.
RT Transcription of a subset of human class II major histocompatibility complex genes is regulated by a nucleoprotein complex that contains c-fos or an antigenically related protein
RL Proc. Natl. Acad. Sci. USA 88:4304-4308 (1991).
RN [17]; RE0002561.
RX PUBMED: 1827203.
RA Hai T., Curran T.
RT Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991).
RN [18]; RE0002619.
RX PUBMED: 2494701.
RA Turner R., Tjian R.
RT Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers
RL Science 243:1689-1694 (1989).
RN [19]; RE0002620.
RX PUBMED: 2494702.
RA Gentz R., Rauscher III F. J., Abate C., Curan T.
RT Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains
RL Science 243:1695-1699 (1989).
RN [20]; RE0002772.
RX PUBMED: 2114014.
RA Naranjo J. R., Mellstroem B., Auwerx J., Mollinedo F., Sassone-Corsi P.
RT Unusual c-fos induction upon chromaffin PC12 differentiation by sodium butyrate: loss of fos autoregulatory function
RL Nucleic Acids Res. 18:3605-3610 (1990).
RN [21]; RE0003084.
RX PUBMED: 1530876.
RA Kovacic-Milivojevic B., Gardner D. G.
RT Divergent regulation of the human atrial natriuretic peptide gene by c-jun and c-fos
RL Mol. Cell. Biol. 12:292-301 (1992).
RN [22]; RE0003438.
RX PUBMED: 8336713.
RA Kim J., Tontonoz P., Spiegelman B.
RT ADD: a novel helix-loop-helix protein associated with adipocyte determination and differentiation
RL Mol. Cell. Biol. 13:4753-4759 (1993).
RN [23]; RE0004648.
RX PUBMED: 1406655.
RA Hsu J. C., Bravo R., Taub R.
RT Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration
RL Mol. Cell. Biol. 12:4654-4665 (1991).
RN [24]; RE0004656.
RX PUBMED: 2118682.
RA Abate C., Patel L., Rauscher III F. J., Curran T.
RT Redox regulation of Fos and Jun DNA-binding activity in vitro
RL Science 249:1157-1161 (1990).
RN [25]; RE0004658.
RX PUBMED: 1957173.
RA Kerppola T. K., Curran T.
RT DNA bending by Fos and Jun: the flexible hinge model
RL Science 254:1210-1214 (1991).
RN [26]; RE0004810.
RX PUBMED: 4035354.
RA Curran T., Morgan J. I.
RT Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines
RL Science 229:1265-1268 (1985).
RN [27]; RE0004818.
RX PUBMED: 1516835.
RA Sutherland J. A., Cook A., Bannister A. J., Kouzarides T.
RT Conserved motifs in Fos and Jun define a new class of activation domain
RL Genes Dev. 6:1810-1819 (1992).
RN [28]; RE0004823.
RX PUBMED: 7828584.
RA Brown H. J., Sutherland J. A., Cook A., Bannister A. J., Kouzarides T.
RT An inhibitor domain in c-Fos regulates activation domains containing the HOB1 motif
RL EMBO J. 14:124-131 (1995).
RN [29]; RE0004842.
RX PUBMED: 2404011.
RA Fukumoto Y., Kaibuchi K., Oku N., Hori Y., Takai Y.
RT Activation of the serum-response element by the activated c-Ha-ras protein in a manner independent of protein kinase C and cAMP-dependent protein kinase
RL J. Biol. Chem. 265:774-780 (1990).
RN [30]; RE0004843.
RX PUBMED: 2104799.
RA Gauthier-Rouviere C., Fernandez A., Lamb N. J. C.
RT ras-induced c-fos expression and proliferation in living rat fibroblasts involves C-kinase activation and the serum response element pathway
RL EMBO J. 9:171-180 (1990).
RN [31]; RE0004871.
RX PUBMED: 7680434.
RA Sadowski H. B., Gilman M. Z.
RT Cell-free activation of a DNA-binding protein by epidermal growth factor
RL Nature 362:79-83 (1993).
RN [32]; RE0015224.
RX PUBMED: 9341190.
RA Swanson D. J., Zellmer E., Lewis E. J.
RT The homeodomain protein Arix interacts synergistically with cyclic AMP to regulate expression of neurotransmitter biosynthetic genes
RL J. Biol. Chem. 272:27382-27392 (1997).
RN [33]; RE0016714.
RX PUBMED: 9334186.
RA Basuyaux J. P., Ferreira E., Stehelin D., Buttice G.
RT The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner.
RL J. Biol. Chem. 272:26188-26195 (1997).
RN [34]; RE0025195.
RX PUBMED: 8874187.
RA Rajotte D., Sadowski H. B., Haman A., Gopalbhai K., Meloche S., Liu L., Krystal G., Hoang T.
RT Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor.
RL Blood 88:2906-2916 (1996).
RN [35]; RE0026138.
RX PUBMED: 9727025.
RA Swanson D. J., Zellmer E., Lewis E. J.
RT AP1 proteins mediate the cAMP response of the dopamine beta-hydroxylase gene.
RL J. Biol. Chem. 273:24065-74 (1998).
RN [36]; RE0035966.
RX PUBMED: 8710853.
RA Wang W., Chevray P. M., Nathans D.
RT Mammalian Sug1 and c-Fos in the nuclear 26S proteasome.
RL Proc. Natl. Acad. Sci. USA 93:8236-8240 (1996).
RN [37]; RE0051328.
RX PUBMED: 8774943.
RA Asanuma M., Nishibayashi S., Kondo Y., Iwata E., Tsuda M., Ogawa N.
RT Effects of single cyclosporin A pretreatment on pentylenetetrazol-induced convulsion and on TRE-binding activity in the rat brain.
RL Mol. Brain Res. 33:29-36 (1995).
RN [38]; RE0051430.
RX PUBMED: 9645966.
RA Zhu Y. S., Pfaff D. W.
RT Differential regulation of AP-1 DNA binding activity in rat hypothalamus and pituitary by estrogen.
RL Mol. Brain Res. 55:115-125 (1998).
RN [39]; RE0066154.
RX PUBMED: 19940926.
RA Hanada R., Leibbrandt A., Hanada T., Kitaoka S., Furuyashiki T., Fujihara H., Trichereau J., Paolino M., Qadri F., Plehm R., Klaere S., Komnenovic V., Mimata H., Yoshimatsu H., Takahashi N., von Haeseler A., Bader M., Kilic S. S., Ueta Y., Pifl C., Narumiya S., Penninger J. M.
RT Central control of fever and female body temperature by RANKL/RANK.
RL Nature 462:505-509 (2009).
XX
//