TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01303 XX ID T01303 XX DT 22.10.1994 (created); ewi. DT 27.01.2016 (updated); jmh. CO Copyright (C), QIAGEN. XX FA ATF-4 XX SY activating transcription factor 4; ATF-4; ATF4; C/ATF; CREB-2; hCREB2; TAXREB67; TAXREB67 homolog; TR67; YAVREB67. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002874 ATF4; HGNC: ATF4. XX CL C0008; bZIP; XX SF no PKA or PKC phosphorylation sites [3]; SF in contrast to other ATF factors, it does not interact with p50 or p65 subunit of NFkappaB [6]; SF interacts with latency-associated nuclear antigen (LANA T04852) of Kaposi's sarcoma-associated herpesvirus [7]; XX CP ubiquitous. XX FF repressor [3]; FF mRNA decreases temporarily after raising the cAMP concentration, but increases with enhanced calcium concentration [5]; FF interaction with LANA T04852 inhibits transactivation ability [7]; XX IN T01303 ATF-4; human, Homo sapiens. IN T00122 c-Fos; mouse, Mus musculus. IN T00123 c-Fos; human, Homo sapiens. IN T00124 c-Fos; rat, Rattus norvegicus. IN T00125 c-Fos; chick, Gallus gallus. IN T00131 c-Jun; mouse, Mus musculus. IN T00132 c-Jun; rat, Rattus norvegicus. IN T00133 c-Jun; human, Homo sapiens. IN T00135 c-Jun; hamster, Cricetulus sp. IN T00104 C/EBPalpha-isoform1; mouse, Mus musculus. IN T00108 C/EBPalpha-isoform1; rat, Rattus norvegicus. IN T00105 C/EBPalpha; human, Homo sapiens. IN T00017 C/EBPbeta-FL; mouse, Mus musculus. IN T00459 C/EBPbeta-FL; rat, Rattus norvegicus. IN T00581 C/EBPbeta; human, Homo sapiens. IN T00171 C/EBPepsilon; rat, Rattus norvegicus. IN T00216 C/EBPgamma; mouse, Mus musculus. IN T00292 Fra-1; mouse, Mus musculus. IN T01208 Fra-1; rat, Rattus norvegicus. IN T09395 IRF-7; human, Homo sapiens. IN T01977 JunB; human, Homo sapiens. IN T04852 LANA; KSHV, Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8). XX MX M00514 V$ATF4_Q2. MX M07246 V$ATF4_Q5. MX M01864 V$ATF4_Q6. MX M00981 V$CREBATF_Q6. MX M00801 V$CREB_Q3. XX BS R23654. BS R11477. BS R55818. BS R67506. BS R67508. BS R35095. BS R63722. BS R40996. BS R34153. BS R71619. BS R71621. BS R34152. BS R34063. BS R30029. BS R39397. BS R63720. BS R63721. BS R68481. BS R38710. BS R62881. BS R62656. BS R71603. BS R71605. XX DR TRANSPATH: MO000019140. DR UniProtKB: P18848; ATF4_HUMAN. XX RN [1]; RE0000666. RX PUBMED: 2516827. RA Hai T., Liu F., Coukos W. J., Green M. R. RT Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers RL Genes Dev. 3:2083-2090 (1989). RN [2]; RE0000787. RX PUBMED: 8504929. RA Vinson C. R., Hai T., Boyd S. M. RT Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design RL Genes Dev. 7:1047-1058 (1993). RN [3]; RE0002560. RX PUBMED: 1534408. RA Karpinski B. A., Morle G. D., Huggenvik J., Uhler M. D., Leiden J. M. RT Molecular cloning of human CREB-2: An ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element RL Proc. Natl. Acad. Sci. USA 89:4820-4824 (1992). RN [4]; RE0002561. RX PUBMED: 1827203. RA Hai T., Curran T. RT Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991). RN [5]; RE0003154. RX PUBMED: 1847461. RA Tsujimoto A., Nyunoya H., Morita T., Sato T., Shimotohno K. RT Isolation of cDNAs for DNA-Binding Proteins Which Specifically Bind to a tax-Responsive Enhancer Element in the Long Terminal Repeat of Human T-Cell Leukemia Virus Type I RL J. Virol. 65:1420-1426 (1991). RN [6]; RE0004521. RX PUBMED: 7692236. RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., DeRaemy-Schenk A.-M., Chen B. P. C., Hai T., DeLamarter J. F., Whelan J. RT Cyclic AMP-independent ATF family members interact with NF-kappaB and function in the activation of the E-selectin promoter in response to cytokines RL Mol. Cell. Biol. 13:7180-7190 (1993). RN [7]; RE0017064. RX PUBMED: 11038375. RA Lim C., Sohn H., Gwack Y., Choe J. RT Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity RL J. Gen. Virol. 81:2645-2652 (2000). RN [8]; RE0032328. RX PUBMED: 15109498. RA Yang X., Matsuda K., Bialek P., Jacquot S., Masuoka H. C., Schinke T., Li L., Brancorsini S., Sassone-Corsi P., Townes T. M., Hanauer A., Karsenty G. RT ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. RL Cell 117:387-98 (2004). RN [9]; RE0070798. RX PUBMED: 21148039. RA Liang Q., Deng H., Sun C. W., Townes T. M., Zhu F. RT Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses. RL J. Immunol. 186:1001-1010 (2011). XX //