AC T01303
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ID T01303
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DT 22.10.1994 (created); ewi.
DT 27.01.2016 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA ATF-4
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SY activating transcription factor 4; ATF-4; ATF4; C/ATF; CREB-2; hCREB2; TAXREB67; TAXREB67 homolog; TR67; YAVREB67.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002874 ATF4; HGNC: ATF4.
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CL C0008; bZIP; 1.1.6.0.1.
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SF no PKA or PKC phosphorylation sites [3];
SF in contrast to other ATF factors, it does not interact with p50 or p65 subunit of NFkappaB [6];
SF interacts with latency-associated nuclear antigen (LANA T04852) of Kaposi's sarcoma-associated herpesvirus [7];
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CP ubiquitous.
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FF repressor [3];
FF mRNA decreases temporarily after raising the cAMP concentration, but increases with enhanced calcium concentration [5];
FF interaction with LANA T04852 inhibits transactivation ability [7];
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IN T01303 ATF-4; human, Homo sapiens.
IN T00122 c-Fos; mouse, Mus musculus.
IN T00123 c-Fos; human, Homo sapiens.
IN T00124 c-Fos; rat, Rattus norvegicus.
IN T00125 c-Fos; chick, Gallus gallus.
IN T00131 c-Jun; mouse, Mus musculus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00135 c-Jun; hamster, Cricetulus sp.
IN T00104 C/EBPalpha-isoform1; mouse, Mus musculus.
IN T00108 C/EBPalpha-isoform1; rat, Rattus norvegicus.
IN T00105 C/EBPalpha; human, Homo sapiens.
IN T00017 C/EBPbeta-FL; mouse, Mus musculus.
IN T00459 C/EBPbeta-FL; rat, Rattus norvegicus.
IN T00581 C/EBPbeta; human, Homo sapiens.
IN T00171 C/EBPepsilon; rat, Rattus norvegicus.
IN T00216 C/EBPgamma; mouse, Mus musculus.
IN T00292 Fra-1; mouse, Mus musculus.
IN T01208 Fra-1; rat, Rattus norvegicus.
IN T09395 IRF-7; human, Homo sapiens.
IN T01977 JunB; human, Homo sapiens.
IN T04852 LANA; KSHV, Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8).
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MX M00514 V$ATF4_Q2.
MX M07246 V$ATF4_Q5.
MX M01864 V$ATF4_Q6.
MX M00981 V$CREBATF_Q6.
MX M00801 V$CREB_Q3.
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BS R23654.
BS R11477.
BS R55818.
BS R67506.
BS R67508.
BS R35095.
BS R63722.
BS R40996.
BS R34153.
BS R71619.
BS R71621.
BS R34152.
BS R34063.
BS R30029.
BS R39397.
BS R63720.
BS R63721.
BS R68481.
BS R38710.
BS R62881.
BS R62656.
BS R71603.
BS R71605.
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DR TRANSPATH: MO000019140.
DR UniProtKB: P18848; ATF4_HUMAN.
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RN [1]; RE0000666.
RX PUBMED: 2516827.
RA Hai T., Liu F., Coukos W. J., Green M. R.
RT Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
RL Genes Dev. 3:2083-2090 (1989).
RN [2]; RE0000787.
RX PUBMED: 8504929.
RA Vinson C. R., Hai T., Boyd S. M.
RT Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design
RL Genes Dev. 7:1047-1058 (1993).
RN [3]; RE0002560.
RX PUBMED: 1534408.
RA Karpinski B. A., Morle G. D., Huggenvik J., Uhler M. D., Leiden J. M.
RT Molecular cloning of human CREB-2: An ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element
RL Proc. Natl. Acad. Sci. USA 89:4820-4824 (1992).
RN [4]; RE0002561.
RX PUBMED: 1827203.
RA Hai T., Curran T.
RT Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991).
RN [5]; RE0003154.
RX PUBMED: 1847461.
RA Tsujimoto A., Nyunoya H., Morita T., Sato T., Shimotohno K.
RT Isolation of cDNAs for DNA-Binding Proteins Which Specifically Bind to a tax-Responsive Enhancer Element in the Long Terminal Repeat of Human T-Cell Leukemia Virus Type I
RL J. Virol. 65:1420-1426 (1991).
RN [6]; RE0004521.
RX PUBMED: 7692236.
RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., DeRaemy-Schenk A.-M., Chen B. P. C., Hai T., DeLamarter J. F., Whelan J.
RT Cyclic AMP-independent ATF family members interact with NF-kappaB and function in the activation of the E-selectin promoter in response to cytokines
RL Mol. Cell. Biol. 13:7180-7190 (1993).
RN [7]; RE0017064.
RX PUBMED: 11038375.
RA Lim C., Sohn H., Gwack Y., Choe J.
RT Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity
RL J. Gen. Virol. 81:2645-2652 (2000).
RN [8]; RE0032328.
RX PUBMED: 15109498.
RA Yang X., Matsuda K., Bialek P., Jacquot S., Masuoka H. C., Schinke T., Li L., Brancorsini S., Sassone-Corsi P., Townes T. M., Hanauer A., Karsenty G.
RT ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome.
RL Cell 117:387-98 (2004).
RN [9]; RE0070798.
RX PUBMED: 21148039.
RA Liang Q., Deng H., Sun C. W., Townes T. M., Zhu F.
RT Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses.
RL J. Immunol. 186:1001-1010 (2011).
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