TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01977 XX ID T01977 XX DT 29.11.1996 (created); hiwi. DT 04.06.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA JunB XX SY (G0S3); TRANSCRIPTION FACTOR JUN-B. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G006329 JUNB; HGNC: JUNB. XX CL C0008; bZIP; XX SF due to 4 AA exchanges, JunB binds with a differential affinity single and to multimerized binding sites [6]; SF binds DNA as a homodimer or heterodimer with c-Fos, Fra-1, Fra-2; XX FF activator [11] [6]; FF activator through multiple DNA elements only [6]; FF like c-Jun, it inhibits myogenic differentiation by interfering with MyoD and myogenin [3]; FF together with Fra-1, it constitute the AP-1 component of NFAT-1 [4]; FF immediate early gene, activated by serum growth factors [1]; FF absent from quiescent T cells, induced during T cell activation [4]; FF enhanced mRNA levels after thrombin treatment maximum after 0.5-1h [2]; FF interaction with SMAD-3 T04096 and SMAD-4 T04292 on SMAD-binding site [9]; FF DNA binding is markedly enhanced after treatment of cells with TPA [11]; XX IN T01303 ATF-4; human, Homo sapiens. IN T18808 B-ATF; human, Homo sapiens. IN T04074 brca1; human, Homo sapiens. IN T15204 brca1; Mammalia. IN T00123 c-Fos; human, Homo sapiens. IN T02214 CBP-isoform1; human, Homo sapiens. IN T01113 Elf-1; human, Homo sapiens. IN T05220 Evi-1; human, Homo sapiens. IN T10210 Evi-1; human, Homo sapiens. IN T01462 Fra-1; human, Homo sapiens. IN T02368 HMGIY; human, Homo sapiens. IN T01977 JunB; human, Homo sapiens. IN T01427 p300; human, Homo sapiens. XX MX M00517 V$AP1_01. MX M00924 V$AP1_Q2_01. MX M00926 V$AP1_Q4_01. MX M00925 V$AP1_Q6_01. MX M07103 V$JUNB_01. MX M08926 V$JUNB_02. MX M08927 V$JUNB_03. MX M03551 V$JUNB_Q6. XX BS R36254. BS R66333. BS R60543. BS R37577. BS R37580. BS R37581. BS R30618. BS R68064. BS R36308. BS R26709. BS R26886. BS R14540. BS R39947. BS R35816. BS R29689. BS R29093. BS R30939. BS R39833. BS R72604. BS R72687. BS R31611. BS R14724. BS R14725. BS R36379. BS R66690. BS R59836. BS R26793. BS R09882. BS R60850. BS R40652. BS R32816. BS R22860. BS R08494. BS R39479. BS R38461. BS R27962. BS R13178. BS R29975. BS R14478. BS R14480. BS R32295. BS R21760. BS R21763. BS R21747. BS R33800. BS R31616. BS R05017. BS R05020. XX DR TRANSPATH: MO000007830. DR TRANSCOMPEL: C00418. DR UniProtKB: P17275; XX RN [1]; RE0002365. RX PUBMED: 3422745. RA Ryder K., Lau L. F., Nathans D. RT A gene activated by growth factor is related to the oncogene v-jun RL Proc. Natl. Acad. Sci. USA 85:1487-1491 (1988). RN [2]; RE0002956. RX PUBMED: 1328861. RA Trejo J., Chambard J.-C., Karin M., Brown J. H. RT Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: Differential effects of muscarinic and thrombin receptor activation RL Mol. Cell. Biol. 12:4742- 4750 (1992). RN [3]; RE0003225. RX PUBMED: 1313772. RA Li L., Chambard J. C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [4]; RE0004628. RX PUBMED: 8441422. RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B. RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB RL Mol. Cell. Biol. 13:1911-1919 (1993). RN [5]; RE0004707. RX PUBMED: 2513129. RA Schuette J., Viallet J., Nau M., Segal S., Fedorko J., Minna J. RT jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun RL Cell 59:987-997 (1989). RN [6]; RE0004735. RX PUBMED: 2513128. RA Chiu R., Angel P., Karin M. RT Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun RL Cell 59:979-986 (1989). RN [7]; RE0004784. RX PUBMED: 2112242. RA Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R. RT Isolation of human cDNA clones of jun-related genes, jun-B and jun-D RL Nucleic Acids Res. 18:3047-3048 (1990). RN [8]; RE0013940. RX PUBMED: 10454570. RA Cirillo G., Casalino L., Vallone D., Caracciolo A., De Cesare D., Verde P. RT Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate RL Mol. Cell. Biol. 19:6340-6252 (1999). RN [9]; RE0016071. RX PUBMED: 10220381. RA Liberati N. T., Datto M. B., Frederick J. P., Shen X., Wong C., Rougier-Chapman E. M., Wang X. F. RT Smads bind directly to the Jun family of AP-1 transcription factors. RL Proc. Natl. Acad. Sci. USA 96:4844-4849 (1999). RN [10]; RE0016689. RX PUBMED: 7648395. RA Bassuk A. G., Leiden J. M. RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells. RL Immunity 3:223-237 (1995). RN [11]; RE0023779. RX PUBMED: 13679379. RA Adiseshaiah P., Papaiahgari S. R., Vuong H., Kalvakolanu D. V., Reddy S. P. RT Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells. RL J. Biol. Chem. 278:47423-47433 (2003). RN [12]; RE0035951. RX PUBMED: 8570175. RA Dorsey M. J., Tae H. J., Sollenberger K. G., Mascarenhas N. T., Johansen L. M., Taparowsky E. J. RT B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. RL Oncogene 11:2255-2265 (1995). RN [13]; RE0046981. RX PUBMED: 11828324. RA Fang D., Elly C., Gao B., Fang N., Altman Y., Joazeiro C., Hunter T., Copeland N., Jenkins N., Liu Y. C. RT Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation RL Nat. Immunol. 3:281-7 (2002). RN [14]; RE0048037. RX PUBMED: 12080089. RA Hu Y. F., Li R. RT JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction. RL Genes Dev. 16:1509-1517 (2002). RN [15]; RE0066800. RX PUBMED: 20220142. RA Por E., Byun H. J., Lee E. J., Lim J. H., Jung S. Y., Park I., Kim Y. M., Jeoung D. I., Lee H. RT The cancer/testis antigen CAGE with oncogenic potential stimulates cell proliferation by up-regulating cyclins D1 and E in an AP-1- and E2F-dependent manner. RL J. Biol. Chem. 285:14475-14485 (2010). RN [16]; RE0067497. RX PUBMED: 15530426. RA Zhao H., Nakajima R., Kunimoto H., Sasaki T., Kojima H., Nakajima K. RT Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation. RL Biochem. Biophys. Res. Commun. 325:541-548 (2004). XX //