AC T01977
XX
ID T01977
XX
DT 29.11.1996 (created); hiwi.
DT 04.06.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA JunB
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SY (G0S3); TRANSCRIPTION FACTOR JUN-B.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006329 JUNB; HGNC: JUNB.
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CL C0008; bZIP; 1.1.1.1.2.
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SF due to 4 AA exchanges, JunB binds with a differential affinity single and to multimerized binding sites [6];
SF binds DNA as a homodimer or heterodimer with c-Fos, Fra-1, Fra-2;
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FF activator [11] [6];
FF activator through multiple DNA elements only [6];
FF like c-Jun, it inhibits myogenic differentiation by interfering with MyoD and myogenin [3];
FF together with Fra-1, it constitute the AP-1 component of NFAT-1 [4];
FF immediate early gene, activated by serum growth factors [1];
FF absent from quiescent T cells, induced during T cell activation [4];
FF enhanced mRNA levels after thrombin treatment maximum after 0.5-1h [2];
FF interaction with SMAD-3 T04096 and SMAD-4 T04292 on SMAD-binding site [9];
FF DNA binding is markedly enhanced after treatment of cells with TPA [11];
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IN T01303 ATF-4; human, Homo sapiens.
IN T18808 B-ATF; human, Homo sapiens.
IN T04074 brca1; human, Homo sapiens.
IN T15204 brca1; Mammalia.
IN T00123 c-Fos; human, Homo sapiens.
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T01113 Elf-1; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T10210 Evi-1; human, Homo sapiens.
IN T01462 Fra-1; human, Homo sapiens.
IN T02368 HMGIY; human, Homo sapiens.
IN T01977 JunB; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
XX
MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M07103 V$JUNB_01.
MX M08926 V$JUNB_02.
MX M08927 V$JUNB_03.
MX M03551 V$JUNB_Q6.
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BS R36254.
BS R66333.
BS R60543.
BS R37577.
BS R37580.
BS R37581.
BS R30618.
BS R68064.
BS R36308.
BS R26709.
BS R26886.
BS R14540.
BS R39947.
BS R35816.
BS R29689.
BS R29093.
BS R30939.
BS R39833.
BS R72604.
BS R72687.
BS R31611.
BS R14724.
BS R14725.
BS R36379.
BS R66690.
BS R59836.
BS R26793.
BS R09882.
BS R60850.
BS R40652.
BS R32816.
BS R22860.
BS R08494.
BS R39479.
BS R38461.
BS R27962.
BS R13178.
BS R29975.
BS R14478.
BS R14480.
BS R32295.
BS R21760.
BS R21763.
BS R21747.
BS R33800.
BS R31616.
BS R05017.
BS R05020.
XX
DR TRANSPATH: MO000007830.
DR TRANSCOMPEL: C00418.
DR UniProtKB: P17275;
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RN [1]; RE0002365.
RX PUBMED: 3422745.
RA Ryder K., Lau L. F., Nathans D.
RT A gene activated by growth factor is related to the oncogene v-jun
RL Proc. Natl. Acad. Sci. USA 85:1487-1491 (1988).
RN [2]; RE0002956.
RX PUBMED: 1328861.
RA Trejo J., Chambard J.-C., Karin M., Brown J. H.
RT Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: Differential effects of muscarinic and thrombin receptor activation
RL Mol. Cell. Biol. 12:4742- 4750 (1992).
RN [3]; RE0003225.
RX PUBMED: 1313772.
RA Li L., Chambard J. C., Karin M., Olson E. N.
RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression
RL Genes Dev. 6:676-689 (1992).
RN [4]; RE0004628.
RX PUBMED: 8441422.
RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B.
RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB
RL Mol. Cell. Biol. 13:1911-1919 (1993).
RN [5]; RE0004707.
RX PUBMED: 2513129.
RA Schuette J., Viallet J., Nau M., Segal S., Fedorko J., Minna J.
RT jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun
RL Cell 59:987-997 (1989).
RN [6]; RE0004735.
RX PUBMED: 2513128.
RA Chiu R., Angel P., Karin M.
RT Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun
RL Cell 59:979-986 (1989).
RN [7]; RE0004784.
RX PUBMED: 2112242.
RA Nomura N., Ide M., Sasamoto S., Matsui M., Date T., Ishizaki R.
RT Isolation of human cDNA clones of jun-related genes, jun-B and jun-D
RL Nucleic Acids Res. 18:3047-3048 (1990).
RN [8]; RE0013940.
RX PUBMED: 10454570.
RA Cirillo G., Casalino L., Vallone D., Caracciolo A., De Cesare D., Verde P.
RT Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate
RL Mol. Cell. Biol. 19:6340-6252 (1999).
RN [9]; RE0016071.
RX PUBMED: 10220381.
RA Liberati N. T., Datto M. B., Frederick J. P., Shen X., Wong C., Rougier-Chapman E. M., Wang X. F.
RT Smads bind directly to the Jun family of AP-1 transcription factors.
RL Proc. Natl. Acad. Sci. USA 96:4844-4849 (1999).
RN [10]; RE0016689.
RX PUBMED: 7648395.
RA Bassuk A. G., Leiden J. M.
RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
RL Immunity 3:223-237 (1995).
RN [11]; RE0023779.
RX PUBMED: 13679379.
RA Adiseshaiah P., Papaiahgari S. R., Vuong H., Kalvakolanu D. V., Reddy S. P.
RT Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells.
RL J. Biol. Chem. 278:47423-47433 (2003).
RN [12]; RE0035951.
RX PUBMED: 8570175.
RA Dorsey M. J., Tae H. J., Sollenberger K. G., Mascarenhas N. T., Johansen L. M., Taparowsky E. J.
RT B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family.
RL Oncogene 11:2255-2265 (1995).
RN [13]; RE0046981.
RX PUBMED: 11828324.
RA Fang D., Elly C., Gao B., Fang N., Altman Y., Joazeiro C., Hunter T., Copeland N., Jenkins N., Liu Y. C.
RT Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation
RL Nat. Immunol. 3:281-7 (2002).
RN [14]; RE0048037.
RX PUBMED: 12080089.
RA Hu Y. F., Li R.
RT JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.
RL Genes Dev. 16:1509-1517 (2002).
RN [15]; RE0066800.
RX PUBMED: 20220142.
RA Por E., Byun H. J., Lee E. J., Lim J. H., Jung S. Y., Park I., Kim Y. M., Jeoung D. I., Lee H.
RT The cancer/testis antigen CAGE with oncogenic potential stimulates cell proliferation by up-regulating cyclins D1 and E in an AP-1- and E2F-dependent manner.
RL J. Biol. Chem. 285:14475-14485 (2010).
RN [16]; RE0067497.
RX PUBMED: 15530426.
RA Zhao H., Nakajima R., Kunimoto H., Sasaki T., Kojima H., Nakajima K.
RT Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation.
RL Biochem. Biophys. Res. Commun. 325:541-548 (2004).
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