AC T00123
XX
ID T00123
XX
DT 15.10.1992 (created); ewi.
DT 10.06.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA c-Fos
XX
SY c-Fos; FBJ osteosarcoma oncogene; p55(c-fos).
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G000218 FOS; HGNC: FOS.
XX
CL C0008; bZIP; 1.1.2.1.1.
XX
SF no homodimerization, probably due to electrostatic repulsion [41];
SF no DNA-binding by its own;
SF dimerization with c-Jun enhances DNA-binding efficiency of c-Jun at least 25-fold [3];
SF either leucine of the zipper may be exchanged, but substituting 2 or more abolishes its dimerization capability [9];
SF the leucine zipper causes dimerization specificity among bZIP class members, probably by establishing an optimal pattern of electrostatic and hydrophobic contacts [31] [41];
SF in the heterodimer, c-Fos also contacts the DNA via its basic region [22];
SF upon DNA-binding, the alpha-helix of the zipper motif extends to the basic region forming one long continuous alpha helix [31];
SF c-Fos/c-Jun dimer does not bind to the canonical TGAGTCA in a specific orientation [31];
SF the acidic region is required for interaction with NF-ATp [27];
SF the leucine zipper mediates interaction with RelA [32];
SF the most C-terminally located activating module (FAM5) confers TBP-binding when bound to TATA-containing promoters [34];
XX
CP K562 cells treated with t-BHQ (tert-butylhydroquinone) and PMA(Phorbol 12-myristate 13-acetate) [63]; MCF-7 + E2 [66].
XX
FF activator or repressor as a heterodimer with c-Jun [33];
FF may negatively regulate transcription interfering with binding of other factors, for example ER [57];
FF negative autoregulation [57];
FF involved in negative regulation of myc;
FF enhanced mRNA levels after thrombin treatment after 0.5h [24];
FF numerous regulatory elements in the 5' upstream region confer responses to cAMP [8];
FF positive regulation by serum growth factors [25] [36] [2] [43] [44] [46] [49] [50] [18] [2] [7];
FF positive regulation by estrogens [38];
FF up-regulation by TPA [35] [36] [14];
FF inducible by EGF [52];
FF inducible by GM-CSF [55];
FF inducible by IL-6 [56];
FF up-regulation by antioxidants [45];
FF in cerebellar granular neurons is activated via beta2-adrenoreceptors and second messengers cAMP and Ca2+ [58];
FF c-Fos is a repressor of its own expression, which depends on its leucine zipper but not on DNA-binding [35];
FF both the retinoblastoma suppressor gene product and tumor suppressor p53 inhibit c-fos expression [39] [40];
FF c-fos mRNA degradation is subject to some instability determinants [47] [48];
FF HBV trans-activator pX influences the phosphorylation status of c-Fos thus inducing DNA-binding of the c-Fos:c-Jun heterodimer [29];
FF negative regulation by MyoD upon muscle cell differentiation [26];
XX
IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T01303 ATF-4; human, Homo sapiens.
IN T00051 ATF; human, Homo sapiens.
IN T00131 c-Jun; mouse, Mus musculus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00134 c-Jun; chick, Gallus gallus.
IN T00135 c-Jun; hamster, Cricetulus sp.
IN T00581 C/EBPbeta; human, Homo sapiens.
IN T00967 E1A 12S protein; adenovirus.
IN T00209 E1A 13S protein; adenovirus type 2.
IN T01113 Elf-1; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T27165 Fbl11; human, Homo sapiens.
IN T00337 GR-alpha; human, Homo sapiens.
IN T01920 GR-beta; human, Homo sapiens.
IN T00436 JunB; mouse, Mus musculus.
IN T01977 JunB; human, Homo sapiens.
IN T00437 JunD; mouse, Mus musculus.
IN T03477 MM-1; human, Homo sapiens.
IN T01082 NRL; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T04878 Ref-1; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T00878 USF2; human, Homo sapiens.
IN T02115 USF2; rat, Rattus norvegicus.
IN T00893 v-Jun; ASV 17, avian sarcoma virus 17.
IN T00902 XBP-1; human, Homo sapiens.
IN T19456 ZNF277; human, Homo sapiens.
XX
MX M00172 V$AP1FJ_Q2.
MX M00517 V$AP1_01.
MX M02280 V$AP1_02.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M07600 V$CFOS_Q4.
MX M03815 V$CFOS_Q6.
MX M04693 V$FOS_02.
MX M04802 V$FOS_03.
MX M07090 V$FOS_06.
MX M08763 V$FOS_07.
MX M08946 V$FOS_08.
MX M08947 V$FOS_09.
XX
BS R02666.
BS R03082.
BS R22897.
BS R25004.
BS R02667.
BS R29956.
BS R00199.
BS R71961.
BS R71962.
BS R71963.
BS R60543.
BS R70646.
BS R70685.
BS R70687.
BS R37581.
BS R02420.
BS R26587.
BS R38918.
BS R25009.
BS R27031.
BS R27990.
BS R68064.
BS R62977.
BS R62914.
BS R39186.
BS R24143.
BS R61972.
BS R26710.
BS R22661.
BS R04127.
BS R61832.
BS R29741.
BS R26886.
BS R14540.
BS R16117.
BS R68203.
BS R68212.
BS R23022.
BS R20615.
BS R41829.
BS R41830.
BS R37082.
BS R35817.
BS R71654.
BS R26802.
BS R31706.
BS R31708.
BS R41737.
BS R28305.
BS R29092.
BS R03522.
BS R25249.
BS R30937.
BS R29953.
BS R30031.
BS R72007.
BS R25803.
BS R26674.
BS R72604.
BS R36379.
BS R14786.
BS R03105.
BS R03104.
BS R64459.
BS R67678.
BS R72325.
BS R72326.
BS R72327.
BS R72328.
BS R72329.
BS R72330.
BS R72331.
BS R72363.
BS R26793.
BS R00235.
BS R09882.
BS R26528.
BS R28553.
BS R25054.
BS R34900.
BS R01037.
BS R26884.
BS R18404.
BS R32816.
BS R22366.
BS R35944.
BS R19727.
BS R19728.
BS R11383.
BS R01258.
BS R36611.
BS R08494.
BS R64946.
BS R25000.
BS R70424.
BS R38461.
BS R59490.
BS R27963.
BS R32291.
BS R29975.
BS R62946.
BS R67340.
BS R31558.
BS R67305.
BS R67309.
BS R31592.
BS R60945.
BS R01564.
BS R17130.
BS R37726.
BS R02454.
BS R14971.
BS R23242.
BS R03386.
BS R14160.
BS R60089.
BS R01285.
BS R30931.
XX
DR TRANSPATH: MO000018137.
DR TRANSCOMPEL: C00495.
DR UniProtKB: P01100; FOS_HUMAN.
DR PDB: 1fos.
XX
RN [1]; RE0000047.
RX PUBMED: 3125983.
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RT Common DNA Binding Site for FOS Protein Complexes and Transcription Factor AP-1
RL Cell 52:471-480 (1988).
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RA Treisman R.
RT Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors
RL Cell 46:567-574 (1986).
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RA Halazonetis T. D., Georgopoulos K., Greenberg M. E., Leder P.
RT c-jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities
RL Cell 55:917-924 (1988).
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RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett G. R., Karin M., Hunter T.
RT Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
RL Cell 64:573-584 (1991).
RN [5]; RE0000158.
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RA Auwerx J., Sassone-Corsi P.
RT IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation
RL Cell 64:983-993 (1991).
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RT Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex
RL Cell 63:1267-1276 (1990).
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RT The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
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RT Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element
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RT Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins
RL Genes Dev. 3:770-781 (1989).
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RT A FOS protein is present in a complex that binds a negative regulator of MYC
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RT fos/jun and Octamer-binding Protein Interact with a Common Site in a Negative Element of the Human c-myc Gene
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RT Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene
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RT c-fos Sequences Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate, and the Calcium Ionophore
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RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription
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RT Transcription of a subset of human class II major histocompatibility complex genes is regulated by a nucleoprotein complex that contains c-fos or an antigenically related protein
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RT Complete nucleotide sequence of a human c-onc gene: Deduced amino acid sequence of the human c-fos proten
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RT Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers
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RT Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
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RT Functional Analysis of an Isolated fos Promotor Element with AP-1 Site Homology Reveals Cell Type-Specific Transcriptional Properties
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RT Repression of c-fos promoter by MyoD on muscle cell differentiation
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RT Fos-associated protein p39 is the product of the jun proto-oncogene
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RT Induction of the DNA-binding activity of c-Jun/c-Fos heterodimers by the hepatitis B virus transactivator pX
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RT Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
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RT Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA
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RT Cross-coupling of the NF-6B p65 and Fos/Jun transcription factors produces potentiated biological function
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RT Both Jun and Fos contribute to transcription activation by the heterodimer
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RT c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein
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RT Autoregulation of fos: the dyad symmetry element as the major target of repression
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RT An AP1-binding site in the c-fos gene can mediate induction by epidermal growth factor and 12-O-tetradecanoyl phorbol-13-acetate
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RT Gene regulation by tyrosine kinases: src protein activates various promoters, including c-fos
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RT Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor
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RT Negative regulation of human c-fos expression by the retinoblastoma gene product
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RT Repression of the basal c-fos promoter by wild-type p53
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RT The serum response element and an AP-1/ATF sequence immediately downstream co-operate in the regulation of c-fos transcription
RL Cell Prolif. 25:205-215 (1992).
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RT Cell-specific regulation of oncogene-responsive sequences of the c-fos promoter
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RT The serum response element can mediate induction of c-fos by growth hormone
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RT H2O2 and antioxidants have opposite effects on activation of NF-6B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
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RT Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter
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RT Determinants that contribute to cytoplasmic stability of human c-fos and $-globin mRNAs are located at several sites in each mRNA
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RT The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways
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RA Sadowski H. B., Gilman M. Z.
RT Cell-free activation of a DNA-binding protein by epidermal growth factor
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RA Treisman R.
RT -
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RA Lee W. M. F., Lin C., Curran T.
RT Activation of the transforming potential of the human fos proto-oncogene requires message stabilizatiob and results in increased amounts of partially modified fos protein
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RT Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor
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RT Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate
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RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
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RT Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor.
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RT Independent and cooperative activation of chromosomal c-fos promoter by STAT3.
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RA Ambrosino C., Cicatiello L., Cobellis G., Addeo R., Sica V., Bresciani F., Weisz A.
RT Functional antagonism between the estrogen receptor and Fos in the regulation of c-fos protooncogene transcription.
RL Mol. Endocrinol. 7:1472-1483 (1993).
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RA Barthel F., Loeffler J. P.
RT Beta 2-adrenoreceptors stimulate c-fos transcription through multiple cyclic AMP- and Ca(2+)-responsive elements in cerebellar granular neurons.
RL J. Neurochem 64:41-51 (1995).
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RX PUBMED: 15615716.
RA Hoffmann E., Thiefes A., Buhrow D., Dittrich-Breiholz O., Schneider H., Resch K., Kracht M.
RT MEK1-dependent delayed expression of FRA-1 counteracts c-FOS and p65 NF-kB-mediated interleukin-8 transcription in response to cytokines or growth factors.
RL J. Biol. Chem. 280:9706-9718 (2004).
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RA Graus-Porta D., Beerli R. R., Hynes N. E.
RT Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling
RL Mol. Cell. Biol. 15:1182-91 (1995).
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RA Tanos T., Marinissen M. J., Leskow F. C., Hochbaum D., Martinetto H., Gutkind J. S., Coso O. A.
RT Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light.
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RA Bossis G., Malnou C. E., Farras R., Andermarcher E., Hipskind R., Rodriguez M., Schmidt D., Muller S., Jariel-Encontre I., Piechaczyk M.
RT Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.
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RA Arinze I. J., Kawai Y.
RT Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements.
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RA Quan T., He T., Voorhees J. J., Fisher G. J.
RT Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts.
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RA Gervais M., Dugourd C., Muller L., Ardidie C., Canton B., Loviconi L., Corvol P., Chneiweiss H., Monnot C.
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RA Cortez D. M., Feldman M. D., Mummidi S., Valente A. J., Steffensen B., Vincenti M., Barnes J. L., Chandrasekar B.
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RA Pazdrak K., Young T. W., Stafford S., Olszewska-Pazdrak B., Straub C., Starosta V., Brasier A., Kurosky A.
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RA Hu X., Paik P. K., Chen J., Yarilina A., Kockeritz L., Lu T. T., Woodgett J. R., Ivashkiv L. B.
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RA Buch T. R., Biebermann H., Kalwa H., Pinkenburg O., Hager D., Barth H., Aktories K., Breit A., Gudermann T.
RT G13-dependent activation of MAPK by thyrotropin.
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RT A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans
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RA Kolev V., Mandinova A., Guinea-Viniegra J., Hu B., Lefort K., Lambertini C., Neel V., Dummer R., Wagner E. F., Dotto G. P.
RT EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.
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RT Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.
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