TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00123 XX ID T00123 XX DT 15.10.1992 (created); ewi. DT 10.06.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA c-Fos XX SY c-Fos; FBJ osteosarcoma oncogene; p55(c-fos). XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G000218 FOS; HGNC: FOS. XX CL C0008; bZIP; XX SF no homodimerization, probably due to electrostatic repulsion [41]; SF no DNA-binding by its own; SF dimerization with c-Jun enhances DNA-binding efficiency of c-Jun at least 25-fold [3]; SF either leucine of the zipper may be exchanged, but substituting 2 or more abolishes its dimerization capability [9]; SF the leucine zipper causes dimerization specificity among bZIP class members, probably by establishing an optimal pattern of electrostatic and hydrophobic contacts [31] [41]; SF in the heterodimer, c-Fos also contacts the DNA via its basic region [22]; SF upon DNA-binding, the alpha-helix of the zipper motif extends to the basic region forming one long continuous alpha helix [31]; SF c-Fos/c-Jun dimer does not bind to the canonical TGAGTCA in a specific orientation [31]; SF the acidic region is required for interaction with NF-ATp [27]; SF the leucine zipper mediates interaction with RelA [32]; SF the most C-terminally located activating module (FAM5) confers TBP-binding when bound to TATA-containing promoters [34]; XX CP K562 cells treated with t-BHQ (tert-butylhydroquinone) and PMA(Phorbol 12-myristate 13-acetate) [63]; MCF-7 + E2 [66]. XX FF activator or repressor as a heterodimer with c-Jun [33]; FF may negatively regulate transcription interfering with binding of other factors, for example ER [57]; FF negative autoregulation [57]; FF involved in negative regulation of myc; FF enhanced mRNA levels after thrombin treatment after 0.5h [24]; FF numerous regulatory elements in the 5' upstream region confer responses to cAMP [8]; FF positive regulation by serum growth factors [25] [36] [2] [43] [44] [46] [49] [50] [18] [2] [7]; FF positive regulation by estrogens [38]; FF up-regulation by TPA [35] [36] [14]; FF inducible by EGF [52]; FF inducible by GM-CSF [55]; FF inducible by IL-6 [56]; FF up-regulation by antioxidants [45]; FF in cerebellar granular neurons is activated via beta2-adrenoreceptors and second messengers cAMP and Ca2+ [58]; FF c-Fos is a repressor of its own expression, which depends on its leucine zipper but not on DNA-binding [35]; FF both the retinoblastoma suppressor gene product and tumor suppressor p53 inhibit c-fos expression [39] [40]; FF c-fos mRNA degradation is subject to some instability determinants [47] [48]; FF HBV trans-activator pX influences the phosphorylation status of c-Fos thus inducing DNA-binding of the c-Fos:c-Jun heterodimer [29]; FF negative regulation by MyoD upon muscle cell differentiation [26]; XX IN T00167 ATF-2-isoform1; human, Homo sapiens. IN T01303 ATF-4; human, Homo sapiens. IN T00051 ATF; human, Homo sapiens. IN T00131 c-Jun; mouse, Mus musculus. IN T00132 c-Jun; rat, Rattus norvegicus. IN T00133 c-Jun; human, Homo sapiens. IN T00134 c-Jun; chick, Gallus gallus. IN T00135 c-Jun; hamster, Cricetulus sp. IN T00581 C/EBPbeta; human, Homo sapiens. IN T00967 E1A 12S protein; adenovirus. IN T00209 E1A 13S protein; adenovirus type 2. IN T01113 Elf-1; human, Homo sapiens. IN T05220 Evi-1; human, Homo sapiens. IN T27165 Fbl11; human, Homo sapiens. IN T00337 GR-alpha; human, Homo sapiens. IN T01920 GR-beta; human, Homo sapiens. IN T00436 JunB; mouse, Mus musculus. IN T01977 JunB; human, Homo sapiens. IN T00437 JunD; mouse, Mus musculus. IN T03477 MM-1; human, Homo sapiens. IN T01082 NRL; human, Homo sapiens. IN T01427 p300; human, Homo sapiens. IN T21984 p300; human, Homo sapiens. IN T04878 Ref-1; human, Homo sapiens. IN T00594 RelA-p65-isoform1; human, Homo sapiens. IN T00878 USF2; human, Homo sapiens. IN T02115 USF2; rat, Rattus norvegicus. IN T00893 v-Jun; ASV 17, avian sarcoma virus 17. IN T00902 XBP-1; human, Homo sapiens. IN T19456 ZNF277; human, Homo sapiens. XX MX M00172 V$AP1FJ_Q2. MX M00517 V$AP1_01. MX M02280 V$AP1_02. MX M00924 V$AP1_Q2_01. MX M00926 V$AP1_Q4_01. MX M00925 V$AP1_Q6_01. MX M07600 V$CFOS_Q4. MX M03815 V$CFOS_Q6. MX M04693 V$FOS_02. MX M04802 V$FOS_03. MX M07090 V$FOS_06. MX M08763 V$FOS_07. MX M08946 V$FOS_08. MX M08947 V$FOS_09. XX BS R02666. BS R03082. BS R22897. BS R25004. BS R02667. BS R29956. BS R00199. BS R71961. BS R71962. BS R71963. BS R60543. BS R70646. BS R70685. BS R70687. BS R37581. BS R02420. BS R26587. BS R38918. BS R25009. BS R27031. BS R27990. BS R68064. BS R62977. BS R62914. BS R39186. BS R24143. BS R61972. BS R26710. BS R22661. BS R04127. BS R61832. BS R29741. BS R26886. BS R14540. BS R16117. BS R68203. BS R68212. BS R23022. BS R20615. BS R41829. BS R41830. BS R37082. BS R35817. BS R71654. BS R26802. BS R31706. BS R31708. BS R41737. BS R28305. BS R29092. BS R03522. BS R25249. BS R30937. BS R29953. BS R30031. BS R72007. BS R25803. BS R26674. BS R72604. BS R36379. BS R14786. BS R03105. BS R03104. BS R64459. BS R67678. BS R72325. BS R72326. BS R72327. BS R72328. BS R72329. BS R72330. BS R72331. BS R72363. BS R26793. BS R00235. BS R09882. BS R26528. BS R28553. BS R25054. BS R34900. BS R01037. BS R26884. BS R18404. BS R32816. BS R22366. BS R35944. BS R19727. BS R19728. BS R11383. BS R01258. BS R36611. BS R08494. BS R64946. BS R25000. BS R70424. BS R38461. BS R59490. BS R27963. BS R32291. BS R29975. BS R62946. BS R67340. BS R31558. BS R67305. BS R67309. BS R31592. BS R60945. BS R01564. BS R17130. BS R37726. BS R02454. BS R14971. BS R23242. BS R03386. BS R14160. BS R60089. BS R01285. BS R30931. XX DR TRANSPATH: MO000018137. DR TRANSCOMPEL: C00495. DR UniProtKB: P01100; FOS_HUMAN. DR PDB: 1fos. XX RN [1]; RE0000047. RX PUBMED: 3125983. RA Rauscher III F. J., Sambucetti L. C., Curran T., Distel R. J., Spiegelman B. M. RT Common DNA Binding Site for FOS Protein Complexes and Transcription Factor AP-1 RL Cell 52:471-480 (1988). RN [2]; RE0000067. RX PUBMED: 3524858. RA Treisman R. RT Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors RL Cell 46:567-574 (1986). RN [3]; RE0000144. RX PUBMED: 3142692. RA Halazonetis T. D., Georgopoulos K., Greenberg M. E., Leder P. RT c-jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities RL Cell 55:917-924 (1988). RN [4]; RE0000157. RX PUBMED: 1846781. RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett G. R., Karin M., Hunter T. RT Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity RL Cell 64:573-584 (1991). RN [5]; RE0000158. RX PUBMED: 1900458. RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [6]; RE0000166. RX PUBMED: 2124518. RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [7]; RE0000496. RX PUBMED: 2176154. RA Wagner B. J., Hayes T. E., Hoban C. J., Cochran B. H. RT The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter RL EMBO J. 9:4477-4484 (1990). RN [8]; RE0000633. RX PUBMED: 2850967. RA Sassone-Corsi P., Visvader J., Ferland L., Mellon P. L., Verma I. M. RT Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element RL Genes Dev. 2:1529-1538 (1988). RN [9]; RE0000636. RX PUBMED: 2501150. RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M. RT Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins RL Genes Dev. 3:770-781 (1989). RN [10]; RE0000652. RX PUBMED: 2498162. RA Hay N., Takimoto M., Bishop J. M. RT A FOS protein is present in a complex that binds a negative regulator of MYC RL Genes Dev. 3:293-303 (1989). RN [11]; RE0000891. RX PUBMED: 2498322. RA Takimoto M., Quinn J. P., Farina A. R., Staudt L. M., Levens D. RT fos/jun and Octamer-binding Protein Interact with a Common Site in a Negative Element of the Human c-myc Gene RL J. Biol. Chem. 264:8982-8999 (1989). RN [12]; RE0001012. RX PUBMED: 1847391. RA Fink J. S., Verhave M., Walton K., Mandel G., Goodman R. H. RT Cyclic AMP- and phorbol ester-induced transcriptional activation are mediated by the same enhancer element in the human vasoactive intestinal peptide gene RL J. Biol. Chem. 266:3882-3887 (1991). RN [13]; RE0001155. RX PUBMED: 2536818. RA Yamaguchi Y., Satake M., Ito Y. RT Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene RL J. Virol. 63:1040-1048 (1989). RN [14]; RE0001250. RX PUBMED: 3119989. RA Fisch T. M., Prywes R., Roeder R. G. RT c-fos Sequences Necessary for Basal Expression and Induction by Epidermal Growth Factor, 12-O-Tetradecanoyl Phorbol-13-Acetate, and the Calcium Ionophore RL Mol. Cell. Biol. 7:3490-3502 (1987). RN [15]; RE0001940. RX PUBMED: 2518690. RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner RL New Biol. 1:35-43 (1989). RN [16]; RE0001941. RX PUBMED: 1963081. RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription RL New Biol. 2:351-361 (1990). RN [17]; RE0002170. RX PUBMED: 1906606. RA Buttice G., Quinones S., Kurkinen M. RT The AP-1 site is required for basal expression but is not necessary for TPA-response of the human stromelysin gene RL Nucleic Acids Res. 19:3723-3731 (1991). RN [18]; RE0002284. RX PUBMED: 3029776. RA Hayes T. E., Kitchen A. M., Cochran B. H. RT Inducible binding of a factor to the c-fos regulatory region RL Proc. Natl. Acad. Sci. USA 84:1272-1276 (1987). RN [19]; RE0002481. RX PUBMED: 1709740. RA Ono S. J., Bazil V., Levi B.-Z., Ozato K., Strominger J. L. RT Transcription of a subset of human class II major histocompatibility complex genes is regulated by a nucleoprotein complex that contains c-fos or an antigenically related protein RL Proc. Natl. Acad. Sci. USA 88:4304-4308 (1991). RN [20]; RE0002552. RX PUBMED: 6574479. RA van Straaten F., Mueller R., Curran T., van Beveren C., Verma I. M. RT Complete nucleotide sequence of a human c-onc gene: Deduced amino acid sequence of the human c-fos proten RL Proc. Natl. Acad. Sci. USA 80:3183-3187 (1983). RN [21]; RE0002591. RX PUBMED: 2964084. RA Franza jr B. R., Rauscher III F. J., Josephs S. F., Curran T. RT The Fos-complex and Fos-related antigens recognize sequence elements that contain AP-2 binding sites RL Science 239:1150-1153 (1988). RN [22]; RE0002619. RX PUBMED: 2494701. RA Turner R., Tjian R. RT Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers RL Science 243:1689-1694 (1989). RN [23]; RE0002630. RX PUBMED: 2825349. RA Bohmann D., Bos T. J., Admon A., Nishimura T., Vogt P. K., Tjian R. RT Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1 RL Science 238:1386-1392 (1987). RN [24]; RE0002956. RX PUBMED: 1328861. RA Trejo J., Chambard J.-C., Karin M., Brown J. H. RT Biphasic increase in c-jun mRNA is required for induction of AP-1-mediated gene transcription: Differential effects of muscarinic and thrombin receptor activation RL Mol. Cell. Biol. 12:4742- 4750 (1992). RN [25]; RE0003133. RX PUBMED: 2147223. RA Velcich A., Ziff E. B. RT Functional Analysis of an Isolated fos Promotor Element with AP-1 Site Homology Reveals Cell Type-Specific Transcriptional Properties RL Mol. Cell. Biol. 10:6273-6282 (1990). RN [26]; RE0003231. RX PUBMED: 8386804. RA Trouche D., Grigoriev M., Lenormand J. L., Robin P., Leibovitch S. A., Sassone-Corsi P., Harel-Bellan A. RT Repression of c-fos promoter by MyoD on muscle cell differentiation RL Nature 363:79-82 (1993). RN [27]; RE0004631. RX PUBMED: 7935406. RA Yaseen N. R., Park J., Kerppola T., Curran T., Sharma S. RT A central role for Fos in human B- and T-cell NFAT (nuclear factor of activated T cells): an acidic region is required for in vitro assembly RL Mol. Cell. Biol. 14:6886-6895 (1994). RN [28]; RE0004649. RX PUBMED: 3130660. RA Rauscher III F. J., Cohen D. R., Curran T., Bos T. J., Vogt P. K., Bohmann D., Tjian R., Franza jr B. R. RT Fos-associated protein p39 is the product of the jun proto-oncogene RL Science 240:1010-1016 (1988). RN [29]; RE0004673. RX PUBMED: 7507209. RA Natoli G., Avantaggiati M. L., Chirillo P., Costanzo A., Artini M., Balsano C., Levrero M. RT Induction of the DNA-binding activity of c-Jun/c-Fos heterodimers by the hepatitis B virus transactivator pX RL Mol. Cell. Biol. 14:989-998 (1994). RN [30]; RE0004709. RX PUBMED: 1380454. RA Xanthoudakis S., Curran T. RT Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme RL EMBO J. 11:3323-3335 (1992). RN [31]; RE0004731. RX PUBMED: 7816143. RA Glover J. N. M., Harrison S. C. RT Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA RL Nature 373:257-261 (1995). RN [32]; RE0004732. RX PUBMED: 8404856. RA Stein B., Baldwin jr A. S., Ballard D. W., Greene W. C., Angel P., Herrlich P. RT Cross-coupling of the NF-6B p65 and Fos/Jun transcription factors produces potentiated biological function RL EMBO J. 12:3879-3891 (1993). RN [33]; RE0004812. RX PUBMED: 2108402. RA Hirai S.-I., Bourachot D., Yaniv M. RT Both Jun and Fos contribute to transcription activation by the heterodimer RL Oncogene 5:39-46 (1990). RN [34]; RE0004824. RX PUBMED: 8065335. RA Metz R., Bannister A. J., Sutherland J. A., Hagemeier C., O'Rourke E. C., Cook A., Bravo R., Kouzarides T. RT c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein RL Mol. Cell. Biol. 14:6021-6029 (1994). RN [35]; RE0004838. RX PUBMED: 2511006. RA Koenig H., Ponta H., Rahmsdorf U., Buescher M., Schoenthal A., Rahmsdorf H. J., Herrlich P. RT Autoregulation of fos: the dyad symmetry element as the major target of repression RL EMBO J. 8:2559-2566 (1989). RN [36]; RE0004840. RX PUBMED: 2498646. RA Fisch T. M., Prywes R., Roeder R. G. RT An AP1-binding site in the c-fos gene can mediate induction by epidermal growth factor and 12-O-tetradecanoyl phorbol-13-acetate RL Mol. Cell. Biol. 9:1327-1331 (1989). RN [37]; RE0004841. RX PUBMED: 2474755. RA Fujii M., Shalloway D., Verma I. M. RT Gene regulation by tyrosine kinases: src protein activates various promoters, including c-fos RL Mol. Cell. Biol. 9:2493-2499 (1989). RN [38]; RE0004844. RX PUBMED: 2119495. RA Weisz A., Rosales R. RT Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor RL Nucleic Acids Res. 18:5097-5106 (1990). RN [39]; RE0004845. RX PUBMED: 2117257. RA Robbins P. D., Horowitz J. M., Mulligan R. C. RT Negative regulation of human c-fos expression by the retinoblastoma gene product RL Nature 346:668-671 (1990). RN [40]; RE0004848. RX PUBMED: 1508692. RA Kley N., Chung R. Y., Say S., Loeffler J. P., Seizinger B. R. RT Repression of the basal c-fos promoter by wild-type p53 RL Nucleic Acids Res. 20:4083-4087 (1992). RN [41]; RE0004849. RX PUBMED: 1739975. RA OShea E. K., Rutkowski R., Kim P. S. RT Mechanism of specificity in the Fos-Jun oncoprotein heterodimer RL Cell 68:699-708 (1992). RN [42]; RE0004850. RX PUBMED: 1596533. RA Morgan I. M., Birnie G. D. RT The serum response element and an AP-1/ATF sequence immediately downstream co-operate in the regulation of c-fos transcription RL Cell Prolif. 25:205-215 (1992). RN [43]; RE0004851. RX PUBMED: 1922053. RA Gutman A., Wasylyk C., Wasylyk B. RT Cell-specific regulation of oncogene-responsive sequences of the c-fos promoter RL Mol. Cell. Biol. 11:5381-5387 (1991). RN [44]; RE0004855. RX PUBMED: 8341690. RA Meyer D. J., Stephenson E. W., Johnson L., Cochran B. H., Schwartz J. RT The serum response element can mediate induction of c-fos by growth hormone RL Proc. Natl. Acad. Sci. USA 90:6721-6725 (1993). RN [45]; RE0004856. RX PUBMED: 8491191. RA Meyer M., Schreck R., Baeuerle P. A. RT H2O2 and antioxidants have opposite effects on activation of NF-6B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor RL EMBO J. 12:2005-2015 (1993). RN [46]; RE0004857. RX PUBMED: 8402883. RA Fu X.-Y., Zhang J.-J. RT Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter RL Cell 74:1135-1145 (1993). RN [47]; RE0004863. RX PUBMED: 3211141. RA Kabnick K. S., Housman D. E. RT Determinants that contribute to cytoplasmic stability of human c-fos and $-globin mRNAs are located at several sites in each mRNA RL Mol. Cell. Biol. 8:3244-3250 (1988). RN [48]; RE0004864. RX PUBMED: 2496006. RA Shyu A.-B., Greenberg M. E., Belasco J. G. RT The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways RL Genes Dev. 3:60-72 (1989). RN [49]; RE0004871. RX PUBMED: 7680434. RA Sadowski H. B., Gilman M. Z. RT Cell-free activation of a DNA-binding protein by epidermal growth factor RL Nature 362:79-83 (1993). RN [50]; RE0004875. RX PUBMED: 2414012. RA Treisman R. RT - RL Cell 42:889-902 (1985). RN [51]; RE0005236. RX PUBMED: 3149716. RA Lee W. M. F., Lin C., Curran T. RT Activation of the transforming potential of the human fos proto-oncogene requires message stabilizatiob and results in increased amounts of partially modified fos protein RL Mol. Cell. Biol. 8:5521-5527 (1988). RN [52]; RE0011817. RX PUBMED: 8524316. RA Leaman D. W., Pisharody S., Flickinger T. W., Commane M. A., Schlessinger J., Kerr I. M., Levy D. E., Stark G. S. RT Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor RL Mol. Cell. Biol. 16:369-375 (1996). RN [53]; RE0013940. RX PUBMED: 10454570. RA Cirillo G., Casalino L., Vallone D., Caracciolo A., De Cesare D., Verde P. RT Role of distinct mitogen-activated protein kinase pathways and cooperation between Ets-2, ATF-2, and Jun family members in human urokinase-type plasminogen activator gene induction by interleukin-1 and tetradecanoyl phorbol acetate RL Mol. Cell. Biol. 19:6340-6252 (1999). RN [54]; RE0016689. RX PUBMED: 7648395. RA Bassuk A. G., Leiden J. M. RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells. RL Immunity 3:223-237 (1995). RN [55]; RE0025195. RX PUBMED: 8874187. RA Rajotte D., Sadowski H. B., Haman A., Gopalbhai K., Meloche S., Liu L., Krystal G., Hoang T. RT Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor. RL Blood 88:2906-2916 (1996). RN [56]; RE0025196. RX PUBMED: 12600988. RA Yang E., Lerner L., Besser D., Darnell JE J. r. RT Independent and cooperative activation of chromosomal c-fos promoter by STAT3. RL J. Biol. Chem. 278:15794-15799 (2003). RN [57]; RE0025293. RX PUBMED: 8114761. RA Ambrosino C., Cicatiello L., Cobellis G., Addeo R., Sica V., Bresciani F., Weisz A. RT Functional antagonism between the estrogen receptor and Fos in the regulation of c-fos protooncogene transcription. RL Mol. Endocrinol. 7:1472-1483 (1993). RN [58]; RE0025297. RX PUBMED: 7798940. RA Barthel F., Loeffler J. P. RT Beta 2-adrenoreceptors stimulate c-fos transcription through multiple cyclic AMP- and Ca(2+)-responsive elements in cerebellar granular neurons. RL J. Neurochem 64:41-51 (1995). RN [59]; RE0025428. RX PUBMED: 15615716. RA Hoffmann E., Thiefes A., Buhrow D., Dittrich-Breiholz O., Schneider H., Resch K., Kracht M. RT MEK1-dependent delayed expression of FRA-1 counteracts c-FOS and p65 NF-kB-mediated interleukin-8 transcription in response to cytokines or growth factors. RL J. Biol. Chem. 280:9706-9718 (2004). RN [60]; RE0045740. RX PUBMED: 7532277. RA Graus-Porta D., Beerli R. R., Hynes N. E. RT Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling RL Mol. Cell. Biol. 15:1182-91 (1995). RN [61]; RE0047989. RX PUBMED: 15708845. RA Tanos T., Marinissen M. J., Leskow F. C., Hochbaum D., Martinetto H., Gutkind J. S., Coso O. A. RT Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. RL J. Biol. Chem. 280:18842-18852 (2005). RN [62]; RE0049305. RX PUBMED: 16055710. RA Bossis G., Malnou C. E., Farras R., Andermarcher E., Hipskind R., Rodriguez M., Schmidt D., Muller S., Jariel-Encontre I., Piechaczyk M. RT Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. RL Mol. Cell. Biol. 25:6964-6979 (2005). RN [63]; RE0051628. RX PUBMED: 15640523. RA Arinze I. J., Kawai Y. RT Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements. RL J. Biol. Chem. 280:9786-9795 (2005). RN [64]; RE0052184. RX PUBMED: 15579469. RA Quan T., He T., Voorhees J. J., Fisher G. J. RT Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts. RL J. Biol. Chem. 280:8079-8085 (2005). RN [65]; RE0053862. RX PUBMED: 16822839. RA Gervais M., Dugourd C., Muller L., Ardidie C., Canton B., Loviconi L., Corvol P., Chneiweiss H., Monnot C. RT Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15. RL Mol. Biol. Cell 17:3940-3951 (2006). RN [66]; RE0053886. RX PUBMED: 14684847. RA Petz L. N., Ziegler Y. S., Schultz J. R., Nardulli A. M. RT Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site. RL Mol. Endocrinol. 18:521-532 (2004). RN [67]; RE0055188. RX PUBMED: 17921324. RA Cortez D. M., Feldman M. D., Mummidi S., Valente A. J., Steffensen B., Vincenti M., Barnes J. L., Chandrasekar B. RT IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation. RL Am. J. Physiol. Heart Circ. Physiol. 293:H3356-65 (2007). RN [68]; RE0055780. RX PUBMED: 18322230. RA Pazdrak K., Young T. W., Stafford S., Olszewska-Pazdrak B., Straub C., Starosta V., Brasier A., Kurosky A. RT Cross-talk between ICAM-1 and granulocyte-macrophage colony-stimulating factor receptor signaling modulates eosinophil survival and activation. RL J. Immunol. 180:4182-4190 (2008). RN [69]; RE0062522. RX PUBMED: 16713974. RA Hu X., Paik P. K., Chen J., Yarilina A., Kockeritz L., Lu T. T., Woodgett J. R., Ivashkiv L. B. RT IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. RL Immunity 24:563-574 (2006). RN [70]; RE0064127. RX PUBMED: 18445595. RA Buch T. R., Biebermann H., Kalwa H., Pinkenburg O., Hager D., Barth H., Aktories K., Breit A., Gudermann T. RT G13-dependent activation of MAPK by thyrotropin. RL J. Biol. Chem. 283:20330-20341 (2008). RN [71]; RE0065279. RX PUBMED: 19729838. RT A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans RL J. Clin. Invest. 119:3127-3137 (2009). RN [72]; RE0066431. RX PUBMED: 18604200. RA Kolev V., Mandinova A., Guinea-Viniegra J., Hu B., Lefort K., Lambertini C., Neel V., Dummer R., Wagner E. F., Dotto G. P. RT EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. RL Nat. Cell Biol. 10:902-911 (2008). RN [73]; RE0066497. RX PUBMED: 19531493. RA Cottrell G. S., Padilla B. E., Amadesi S., Poole D. P., Murphy J. E., Hardt M., Roosterman D., Steinhoff M., Bunnett N. W. RT Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. RL J. Biol. Chem. 284:22411-22425 (2009). XX //