TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00436 XX ID T00436 XX DT 15.10.1992 (created); ewi. DT 04.07.2016 (updated); ros. CO Copyright (C), QIAGEN. XX FA JunB XX SY Jun-B. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002553 Junb. XX CL C0008; bZIP; XX SF due to 4 AA exchanges, JunB binds with a 10-fold lower affinity to single DNA elements than c-Jun [12] [14]; XX CP FSDC and FSDC + antiCD40 [23]. XX FF activator through multiple DNA elements only [12] [14]; FF activator as a heterodimer with Fra-1 [8]; FF JunB:Fra-1 heterodimer binds to DNA cooperatively with NFAT-1 and forms a ternary complex [8]; FF increases myeloid differentiation in contrast to c-Jun [15]; FF like c-Jun, it inhibits myogenic differentiation by interfering with MyoD and myogenin [7]; FF together with c-Fos, it antagonizes cAMP-dependent activation by JunD [16]; FF acts as a progression factor during intermediate stages of skin tumor development [11]; FF immediate early gene, activated by serum growth factors [4]; FF repression of serum inducibility of the junB gene by adipocyte differentiation [22]; FF not stimulated by Ha-Ras [9]; FF enhanced via the PKA and PKC signal transduction pathways [3]; FF expression of the junB gene in suprachiasmatic nuclei of the hypothalamus is regulated by light and thus depends on the circadian rhythm [18]; FF absent from quiescent T cells, induced during T cell activation [8]; XX IN T01095 ATF-3; rat, Rattus norvegicus. IN T00122 c-Fos; mouse, Mus musculus. IN T00123 c-Fos; human, Homo sapiens. IN T00124 c-Fos; rat, Rattus norvegicus. IN T00125 c-Fos; chick, Gallus gallus. IN T02198 deltaFosB; mouse, Mus musculus. IN T00291 FosB; mouse, Mus musculus. IN T00292 Fra-1; mouse, Mus musculus. IN T01208 Fra-1; rat, Rattus norvegicus. IN T01990 Fra-2; chick, Gallus gallus. IN T00436 JunB; mouse, Mus musculus. IN T00437 JunD; mouse, Mus musculus. IN T02505 MEF-2D-isoform muscle; mouse, Mus musculus. IN T02506 MEF-2D-isoform non-muscle; mouse, Mus musculus. IN T10542 p300; mouse, Mus musculus. IN T23091 p300; Mammalia. XX MX M00517 V$AP1_01. MX M00924 V$AP1_Q2_01. MX M00926 V$AP1_Q4_01. MX M00925 V$AP1_Q6_01. MX M03551 V$JUNB_Q6. XX BS R25217. BS R23219. BS R00592. BS R09882. BS R25855. BS R34245. BS R66081. BS R62456. BS R19522. BS R14477. BS R72705. BS R41850. BS R41853. BS R41856. BS R41859. BS R05079. BS R04079. BS R72704. BS R04032. BS R14160. BS R35834. BS R13173. BS R21509. BS R23478. BS R72702. BS R61168. BS R20314. BS R59154. BS R23477. BS R29892. XX DR TRANSPATH: MO000024923. DR TRANSCOMPEL: C00499. DR UniProtKB: P09450; XX RN [1]; RE0000143. RX PUBMED: 3142691. RA Nakabeppu Y., Ryder K., Nathans D. RT DNA Binding Activities of Three Murine Jun Proteins: Stimulation by Fos RL Cell 55:907-915 (1988). RN [2]; RE0000421. RX PUBMED: 2498083. RA Zerial M., Toschi L., Ryseck R.-P., Schuermann M., Mueller R., Bravo R. RT The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity RL EMBO J. 8:805-813 (1989). RN [3]; RE0002091. RX PUBMED: 1708123. RA de Groot R. P., Auwerx J., Karperien M., Staels B., Kruijer W. RT Activation of junB by PKC and PKA signal transduction through a novel cis-acting element RL Nucleic Acids Res. 19:775-781 (1991). RN [4]; RE0002365. RX PUBMED: 3422745. RA Ryder K., Lau L. F., Nathans D. RT A gene activated by growth factor is related to the oncogene v-jun RL Proc. Natl. Acad. Sci. USA 85:1487-1491 (1988). RN [5]; RE0002543. RX PUBMED: 1902565. RA Hsu J. C., Laz T., Mohn K. L., Taub R. RT Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991). RN [6]; RE0002619. RX PUBMED: 2494701. RA Turner R., Tjian R. RT Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers RL Science 243:1689-1694 (1989). RN [7]; RE0003225. RX PUBMED: 1313772. RA Li L., Chambard J. C., Karin M., Olson E. N. RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression RL Genes Dev. 6:676-689 (1992). RN [8]; RE0004628. RX PUBMED: 8441422. RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B. RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB RL Mol. Cell. Biol. 13:1911-1919 (1993). RN [9]; RE0004678. RX PUBMED: 1903181. RA Binetruy B., Smeal T., Karin M. RT Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain RL Nature 351:122-127 (1991). RN [10]; RE0004679. RX PUBMED: 1924349. RA Castellazzi M., Spyrou G., La Vista N., Dangy J.-P., Piu F., Yaniv M., Brun G. RT Overexpression of c-jun, junB, or junD affects cell growth differently RL Proc. Natl. Acad. Sci. USA 88:8890-8894 (1991). RN [11]; RE0004721. RX PUBMED: 1459456. RA Bossy-Wetzel E., Bravo R., Hanahan D. RT Transcription factors JunB and c-Jun are selectively up-regulated and functionally implicated in fibrosarcoma development RL Genes Dev. 6:2340-2351 (1992). RN [12]; RE0004735. RX PUBMED: 2513128. RA Chiu R., Angel P., Karin M. RT Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun RL Cell 59:979-986 (1989). RN [13]; RE0004737. RX PUBMED: 1945831. RA Suzuki T., Okuno H., Yoshida T., Endo T., Nishina H., Iba H. RT Difference in transcriptional regulatory function between c-Fos and Fra-2 RL Nucleic Acids Res. 19:5537-5542 (1991). RN [14]; RE0004738. RX PUBMED: 8383624. RA Deng T., Karin M. RT JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers RL Genes Dev. 7:479-490 (1993). RN [15]; RE0004739. RX PUBMED: 8423806. RA Lord K. A., Abdollahi A., Hoffman-Liebermann B., Liebermann D. A. RT Proto-oncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation RL Mol. Cell. Biol. 13:841-851 (1993). RN [16]; RE0004740. RX PUBMED: 1719551. RA Kobierski L. A., Chu H. M., Tan Y., Comb M. J. RT cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins RL Proc. Natl. Acad. Sci. USA 88:10222-10226 (1991). RN [17]; RE0004743. RX PUBMED: 1630451. RA Apel I., Yu C. L., Wang T., Dobry C., van Antwerp M. E., Jove R., Prochownik E. V. RT Regulation of the junB gene by v-src RL Mol. Cell. Biol. 12:3356-3364 (1992). RN [18]; RE0004744. RX PUBMED: 1549784. RA Kornhauser J. M., Nelson D. E., May K. E., Takahashi J. S. RT Regulation of jun-B mesenger RNA and AP-1 activity by light and a circadian clock RL Science 255:1581-1585 (1992). RN [19]; RE0004882. RX PUBMED: 1900040. RA Nakabeppu Y., Nathans D. RT A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity RL Cell 64:751-759 (1991). RN [20]; RE0007516. RX PUBMED: 8392062. RA Fujihara M., Muroi M., Muroi Y., Ito N., Suzuki T. RT Mechanism of lipopolysaccharide-triggered junB activation in a mouse macrophage-like cell line (J774) RL J. Biol. Chem. 268:14898-14905 (1993). RN [21]; RE0007916. RX PUBMED: 1542584. RA Kawakami Z., Kitabayishi I., Matsuoka T., Gachelin G., Yokoyama K. RT Conserved structural motifs among mammalian junB genes RL Nucleic Acids Res. 20:914 (1992). RN [22]; RE0009126. RX PUBMED: 8197114. RA Wang H., Scott R. E. RT Adipocyte differentiation selectively represses the serum inducibility of c-jun and junB by reversible transcription-dependent mechanisms RL Proc. Natl. Acad. Sci. USA 91:4649-4653 (1994). RN [23]; RE0025717. RX PUBMED: 11886848. RA Mann J., Oakley F., Johnson P. W., Mann D. A. RT CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1. RL J. Biol. Chem. 277:17125-38 (2002). RN [24]; RE0047321. RX PUBMED: 10788439. RA Muller S., Berger M., Lehembre F., Seeler J. S., haupt Y., Dejean A. RT c-Jun and p53 activity is modulated by SUMO-1 modification. RL J. Biol. Chem. 275:13321-13329 (2000). RN [25]; RE0048379. RX PUBMED: 15699140. RA Wang Z. Y., Sato H., Kusam S., Sehra S., Toney L. M., Dent A. L. RT Regulation of IL-10 gene expression in Th2 cells by Jun proteins. RL J. Immunol. 174:2098-2105 (2005). RN [26]; RE0048805. RX PUBMED: 15308641. RA Narayanan K., Srinivas R., Peterson M. C., Ramachandran A., Hao J., Thimmapaya B., Scherer P. E., George A. RT Transcriptional regulation of dentin matrix protein 1 by JunB and p300 during osteoblast differentiation. RL J. Biol. Chem. 279:44294-44302 (2004). RN [27]; RE0051710. RX PUBMED: 15988009. RA Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J. Y., Lu S. C. RT Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. RL Mol. Cell. Biol. 25:5933-5946 (2005). RN [28]; RE0065826. RX PUBMED: 18653705. RA Wang Y., Fortin J., Lamba P., Bonomi M., Persani L., Roberson M. S., Bernard D. J. RT Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone beta-promoter activity. RL Endocrinology 149:5577-5591 (2008). RN [29]; RE0073070. RX PUBMED: 15781469. RA Xin H., Xu X., Li L., Ning H., Rong Y., Shang Y., Wang Y., Fu X. Y., Chang Z. RT CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation. RL J. Biol. Chem. 280:20842-20850 (2005). XX //