AC T00436
XX
ID T00436
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DT 15.10.1992 (created); ewi.
DT 04.07.2016 (updated); ros.
CO Copyright (C), QIAGEN.
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FA JunB
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SY Jun-B.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002553 Junb.
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CL C0008; bZIP; 1.1.1.1.2.
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SF due to 4 AA exchanges, JunB binds with a 10-fold lower affinity to single DNA elements than c-Jun [12] [14];
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CP FSDC and FSDC + antiCD40 [23].
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FF activator through multiple DNA elements only [12] [14];
FF activator as a heterodimer with Fra-1 [8];
FF JunB:Fra-1 heterodimer binds to DNA cooperatively with NFAT-1 and forms a ternary complex [8];
FF increases myeloid differentiation in contrast to c-Jun [15];
FF like c-Jun, it inhibits myogenic differentiation by interfering with MyoD and myogenin [7];
FF together with c-Fos, it antagonizes cAMP-dependent activation by JunD [16];
FF acts as a progression factor during intermediate stages of skin tumor development [11];
FF immediate early gene, activated by serum growth factors [4];
FF repression of serum inducibility of the junB gene by adipocyte differentiation [22];
FF not stimulated by Ha-Ras [9];
FF enhanced via the PKA and PKC signal transduction pathways [3];
FF expression of the junB gene in suprachiasmatic nuclei of the hypothalamus is regulated by light and thus depends on the circadian rhythm [18];
FF absent from quiescent T cells, induced during T cell activation [8];
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IN T01095 ATF-3; rat, Rattus norvegicus.
IN T00122 c-Fos; mouse, Mus musculus.
IN T00123 c-Fos; human, Homo sapiens.
IN T00124 c-Fos; rat, Rattus norvegicus.
IN T00125 c-Fos; chick, Gallus gallus.
IN T02198 deltaFosB; mouse, Mus musculus.
IN T00291 FosB; mouse, Mus musculus.
IN T00292 Fra-1; mouse, Mus musculus.
IN T01208 Fra-1; rat, Rattus norvegicus.
IN T01990 Fra-2; chick, Gallus gallus.
IN T00436 JunB; mouse, Mus musculus.
IN T00437 JunD; mouse, Mus musculus.
IN T02505 MEF-2D-isoform muscle; mouse, Mus musculus.
IN T02506 MEF-2D-isoform non-muscle; mouse, Mus musculus.
IN T10542 p300; mouse, Mus musculus.
IN T23091 p300; Mammalia.
XX
MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M03551 V$JUNB_Q6.
XX
BS R25217.
BS R23219.
BS R00592.
BS R09882.
BS R25855.
BS R34245.
BS R66081.
BS R62456.
BS R19522.
BS R14477.
BS R72705.
BS R41850.
BS R41853.
BS R41856.
BS R41859.
BS R05079.
BS R04079.
BS R72704.
BS R04032.
BS R14160.
BS R35834.
BS R13173.
BS R21509.
BS R23478.
BS R72702.
BS R61168.
BS R20314.
BS R59154.
BS R23477.
BS R29892.
XX
DR TRANSPATH: MO000024923.
DR TRANSCOMPEL: C00499.
DR UniProtKB: P09450;
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RN [1]; RE0000143.
RX PUBMED: 3142691.
RA Nakabeppu Y., Ryder K., Nathans D.
RT DNA Binding Activities of Three Murine Jun Proteins: Stimulation by Fos
RL Cell 55:907-915 (1988).
RN [2]; RE0000421.
RX PUBMED: 2498083.
RA Zerial M., Toschi L., Ryseck R.-P., Schuermann M., Mueller R., Bravo R.
RT The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity
RL EMBO J. 8:805-813 (1989).
RN [3]; RE0002091.
RX PUBMED: 1708123.
RA de Groot R. P., Auwerx J., Karperien M., Staels B., Kruijer W.
RT Activation of junB by PKC and PKA signal transduction through a novel cis-acting element
RL Nucleic Acids Res. 19:775-781 (1991).
RN [4]; RE0002365.
RX PUBMED: 3422745.
RA Ryder K., Lau L. F., Nathans D.
RT A gene activated by growth factor is related to the oncogene v-jun
RL Proc. Natl. Acad. Sci. USA 85:1487-1491 (1988).
RN [5]; RE0002543.
RX PUBMED: 1902565.
RA Hsu J. C., Laz T., Mohn K. L., Taub R.
RT Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver
RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991).
RN [6]; RE0002619.
RX PUBMED: 2494701.
RA Turner R., Tjian R.
RT Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers
RL Science 243:1689-1694 (1989).
RN [7]; RE0003225.
RX PUBMED: 1313772.
RA Li L., Chambard J. C., Karin M., Olson E. N.
RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression
RL Genes Dev. 6:676-689 (1992).
RN [8]; RE0004628.
RX PUBMED: 8441422.
RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B.
RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB
RL Mol. Cell. Biol. 13:1911-1919 (1993).
RN [9]; RE0004678.
RX PUBMED: 1903181.
RA Binetruy B., Smeal T., Karin M.
RT Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
RL Nature 351:122-127 (1991).
RN [10]; RE0004679.
RX PUBMED: 1924349.
RA Castellazzi M., Spyrou G., La Vista N., Dangy J.-P., Piu F., Yaniv M., Brun G.
RT Overexpression of c-jun, junB, or junD affects cell growth differently
RL Proc. Natl. Acad. Sci. USA 88:8890-8894 (1991).
RN [11]; RE0004721.
RX PUBMED: 1459456.
RA Bossy-Wetzel E., Bravo R., Hanahan D.
RT Transcription factors JunB and c-Jun are selectively up-regulated and functionally implicated in fibrosarcoma development
RL Genes Dev. 6:2340-2351 (1992).
RN [12]; RE0004735.
RX PUBMED: 2513128.
RA Chiu R., Angel P., Karin M.
RT Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun
RL Cell 59:979-986 (1989).
RN [13]; RE0004737.
RX PUBMED: 1945831.
RA Suzuki T., Okuno H., Yoshida T., Endo T., Nishina H., Iba H.
RT Difference in transcriptional regulatory function between c-Fos and Fra-2
RL Nucleic Acids Res. 19:5537-5542 (1991).
RN [14]; RE0004738.
RX PUBMED: 8383624.
RA Deng T., Karin M.
RT JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers
RL Genes Dev. 7:479-490 (1993).
RN [15]; RE0004739.
RX PUBMED: 8423806.
RA Lord K. A., Abdollahi A., Hoffman-Liebermann B., Liebermann D. A.
RT Proto-oncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation
RL Mol. Cell. Biol. 13:841-851 (1993).
RN [16]; RE0004740.
RX PUBMED: 1719551.
RA Kobierski L. A., Chu H. M., Tan Y., Comb M. J.
RT cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins
RL Proc. Natl. Acad. Sci. USA 88:10222-10226 (1991).
RN [17]; RE0004743.
RX PUBMED: 1630451.
RA Apel I., Yu C. L., Wang T., Dobry C., van Antwerp M. E., Jove R., Prochownik E. V.
RT Regulation of the junB gene by v-src
RL Mol. Cell. Biol. 12:3356-3364 (1992).
RN [18]; RE0004744.
RX PUBMED: 1549784.
RA Kornhauser J. M., Nelson D. E., May K. E., Takahashi J. S.
RT Regulation of jun-B mesenger RNA and AP-1 activity by light and a circadian clock
RL Science 255:1581-1585 (1992).
RN [19]; RE0004882.
RX PUBMED: 1900040.
RA Nakabeppu Y., Nathans D.
RT A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity
RL Cell 64:751-759 (1991).
RN [20]; RE0007516.
RX PUBMED: 8392062.
RA Fujihara M., Muroi M., Muroi Y., Ito N., Suzuki T.
RT Mechanism of lipopolysaccharide-triggered junB activation in a mouse macrophage-like cell line (J774)
RL J. Biol. Chem. 268:14898-14905 (1993).
RN [21]; RE0007916.
RX PUBMED: 1542584.
RA Kawakami Z., Kitabayishi I., Matsuoka T., Gachelin G., Yokoyama K.
RT Conserved structural motifs among mammalian junB genes
RL Nucleic Acids Res. 20:914 (1992).
RN [22]; RE0009126.
RX PUBMED: 8197114.
RA Wang H., Scott R. E.
RT Adipocyte differentiation selectively represses the serum inducibility of c-jun and junB by reversible transcription-dependent mechanisms
RL Proc. Natl. Acad. Sci. USA 91:4649-4653 (1994).
RN [23]; RE0025717.
RX PUBMED: 11886848.
RA Mann J., Oakley F., Johnson P. W., Mann D. A.
RT CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1.
RL J. Biol. Chem. 277:17125-38 (2002).
RN [24]; RE0047321.
RX PUBMED: 10788439.
RA Muller S., Berger M., Lehembre F., Seeler J. S., haupt Y., Dejean A.
RT c-Jun and p53 activity is modulated by SUMO-1 modification.
RL J. Biol. Chem. 275:13321-13329 (2000).
RN [25]; RE0048379.
RX PUBMED: 15699140.
RA Wang Z. Y., Sato H., Kusam S., Sehra S., Toney L. M., Dent A. L.
RT Regulation of IL-10 gene expression in Th2 cells by Jun proteins.
RL J. Immunol. 174:2098-2105 (2005).
RN [26]; RE0048805.
RX PUBMED: 15308641.
RA Narayanan K., Srinivas R., Peterson M. C., Ramachandran A., Hao J., Thimmapaya B., Scherer P. E., George A.
RT Transcriptional regulation of dentin matrix protein 1 by JunB and p300 during osteoblast differentiation.
RL J. Biol. Chem. 279:44294-44302 (2004).
RN [27]; RE0051710.
RX PUBMED: 15988009.
RA Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J. Y., Lu S. C.
RT Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1.
RL Mol. Cell. Biol. 25:5933-5946 (2005).
RN [28]; RE0065826.
RX PUBMED: 18653705.
RA Wang Y., Fortin J., Lamba P., Bonomi M., Persani L., Roberson M. S., Bernard D. J.
RT Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone beta-promoter activity.
RL Endocrinology 149:5577-5591 (2008).
RN [29]; RE0073070.
RX PUBMED: 15781469.
RA Xin H., Xu X., Li L., Ning H., Rong Y., Shang Y., Wang Y., Fu X. Y., Chang Z.
RT CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.
RL J. Biol. Chem. 280:20842-20850 (2005).
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