AC T01208
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ID T01208
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DT 15.10.1992 (created); bkl.
DT 30.05.2016 (updated); ros.
CO Copyright (C), QIAGEN.
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FA Fra-1
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SY FOSL1; Fra-1; FraI.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001545 Fosl1.
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CL C0008; bZIP; 1.1.2.1.3.
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SF phosphorylation;
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CP hippocampus, hypothalamus, striatum, midbrain and brainstem [7].
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FF the AP-1 component of NFAT-1 is a heterodimer of Fra-1 and JunB [5];
FF induced in T cells during activation [5];
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IN T01303 ATF-4; human, Homo sapiens.
IN T00051 ATF; human, Homo sapiens.
IN T00131 c-Jun; mouse, Mus musculus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00134 c-Jun; chick, Gallus gallus.
IN T00135 c-Jun; hamster, Cricetulus sp.
IN T00436 JunB; mouse, Mus musculus.
IN T00437 JunD; mouse, Mus musculus.
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MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M01267 V$FRA1_Q5.
MX M02095 V$FRA1_Q6.
MX M03869 V$FRA1_Q6_01.
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BS R01037.
BS R13430.
BS R21762.
BS R37949.
BS R22730.
BS R28545.
BS R26776.
BS R01358.
BS R01491.
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DR TRANSPATH: MO000025498.
DR UniProtKB: P10158;
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RN [1]; RE0000656.
RX PUBMED: 2497053.
RA Cohen D. R., Ferreira P. C. P., Gentz R., Franza B. R., Curran T.
RT The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes
RL Genes Dev. 3:172-184 (1989).
RN [2]; RE0001698.
RX PUBMED: 3133553.
RA Cohen D. R., Curran T.
RT fra-1: a serum-inducible, cellular immediate-early gene that encodes a Fos-related antigen
RL Mol. Cell. Biol. 8:2063-2069 (1988).
RN [3]; RE0001770.
RX PUBMED: 2974122.
RA Kouzarides T., Ziff E.
RT The role of the leucine zipper in the fos-jun interaction
RL Nature 336:646-651 (1988).
RN [4]; RE0002561.
RX PUBMED: 1827203.
RA Hai T., Curran T.
RT Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991).
RN [5]; RE0004628.
RX PUBMED: 8441422.
RA Boise L., Petryniak B., Mao X., June C. H., Wang C.-Y., Lindsten T., Bravo R., Kovary K., Leiden J., Thompson C. B.
RT The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB
RL Mol. Cell. Biol. 13:1911-1919 (1993).
RN [6]; RE0036098.
RX PUBMED: 11756554.
RA Young M. R., Nair R., Bucheimer N., Tulsian P., Brown N., Chapp C., Hsu T. C., Colburn N. H.
RT Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently.
RL Mol. Cell. Biol. 22:587-598 (2002).
RN [7]; RE0051794.
RX PUBMED: 10825388.
RA Won J. S., Lee J. K., Song D. K., Huh S. O., Jung J. S., Kim Y. H., Choi M. R., Suh H. W.
RT Cycloheximide increases proenkephalin and tyrosine hydroxylase gene expression in rat adrenal medulla.
RL Mol. Pharmacol. 57:1173-1181 (2000).
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