AC T00437
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ID T00437
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DT 15.10.1992 (created); ewi.
DT 05.02.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA JunD
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SY Jun-D; JUND1; TRANSCRIPTION FACTOR JUN-D.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G000545 Jund.
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CL C0008; bZIP; 1.1.1.1.3.
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SF relatively poor sequence conservation with human JunD [11];
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CP widespread expression at differing levels [10]; wild type mouse fibroblasts, Nrf1 (F1) and Nrf2 (F2) knockout mouse fibroblasts [17]; FSDC and FSDC + antiCD40 [15].
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FF no detectable transforming activity [7];
FF antagonist to transforming effects of the Ras - c-Jun pathway [12];
FF no inhibition of myogenic effects of MyoD or myogenin [6];
FF expressed at a higher level than c-Jun and JunB in nongrowing cells (3T3) [10];
FF expression is only slightly stimulated by growth factors in late G12 phase [10];
FF resynthesis following quick degradation of nuclear JunD after serum stimulation [12];
FF activation by JunD may depend on PKA and s antagonized by JunB+c-Fos [9];
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IN T00122 c-Fos; mouse, Mus musculus.
IN T00123 c-Fos; human, Homo sapiens.
IN T00124 c-Fos; rat, Rattus norvegicus.
IN T00125 c-Fos; chick, Gallus gallus.
IN T02198 deltaFosB; mouse, Mus musculus.
IN T00291 FosB; mouse, Mus musculus.
IN T00292 Fra-1; mouse, Mus musculus.
IN T01208 Fra-1; rat, Rattus norvegicus.
IN T01990 Fra-2; chick, Gallus gallus.
IN T01991 Fra-2; human, Homo sapiens.
IN T00436 JunB; mouse, Mus musculus.
IN T00437 JunD; mouse, Mus musculus.
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MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M03552 V$JUND_Q6.
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BS R02666.
BS R25217.
BS R02667.
BS R23219.
BS R09882.
BS R22860.
BS R25855.
BS R73762.
BS R73824.
BS R34234.
BS R37586.
BS R37826.
BS R66081.
BS R04079.
BS R04032.
BS R37213.
BS R40188.
BS R02096.
BS R08510.
BS R35834.
BS R13173.
BS R13176.
BS R21509.
BS R23478.
BS R41865.
BS R64219.
BS R01225.
BS R35124.
BS R35353.
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DR TRANSPATH: MO000007835.
DR UniProtKB: P15066;
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RN [1]; RE0000143.
RX PUBMED: 3142691.
RA Nakabeppu Y., Ryder K., Nathans D.
RT DNA Binding Activities of Three Murine Jun Proteins: Stimulation by Fos
RL Cell 55:907-915 (1988).
RN [2]; RE0000396.
RX PUBMED: 2504580.
RA Hirai S.-I., Ryseck R.-P., Mechta F., Bravo R., Yaniv M.
RT Characterization of junD: a new member of the jun proto-oncogene family
RL EMBO J. 8:1433-1439 (1989).
RN [3]; RE0000442.
RX PUBMED: 2511004.
RA Nakabeppu Y., Nathans D.
RT The basic region of Fos mediates specific DNA binding
RL EMBO J. 8:3833-3841 (1989).
RN [4]; RE0000521.
RX PUBMED: 1714380.
RA de Groot R. P., Karperien M., Pals C., Kruijer W.
RT Characterization of the mouse junD promoter - high basal level activity due to an octamer motif
RL EMBO J. 10:2523-2532 (1991).
RN [5]; RE0002365.
RX PUBMED: 3422745.
RA Ryder K., Lau L. F., Nathans D.
RT A gene activated by growth factor is related to the oncogene v-jun
RL Proc. Natl. Acad. Sci. USA 85:1487-1491 (1988).
RN [6]; RE0003225.
RX PUBMED: 1313772.
RA Li L., Chambard J. C., Karin M., Olson E. N.
RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression
RL Genes Dev. 6:676-689 (1992).
RN [7]; RE0004679.
RX PUBMED: 1924349.
RA Castellazzi M., Spyrou G., La Vista N., Dangy J.-P., Piu F., Yaniv M., Brun G.
RT Overexpression of c-jun, junB, or junD affects cell growth differently
RL Proc. Natl. Acad. Sci. USA 88:8890-8894 (1991).
RN [8]; RE0004737.
RX PUBMED: 1945831.
RA Suzuki T., Okuno H., Yoshida T., Endo T., Nishina H., Iba H.
RT Difference in transcriptional regulatory function between c-Fos and Fra-2
RL Nucleic Acids Res. 19:5537-5542 (1991).
RN [9]; RE0004740.
RX PUBMED: 1719551.
RA Kobierski L. A., Chu H. M., Tan Y., Comb M. J.
RT cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins
RL Proc. Natl. Acad. Sci. USA 88:10222-10226 (1991).
RN [10]; RE0004783.
RX PUBMED: 2493644.
RA Ryder K., Lanahan A., Perez-Albuerne E., Nathans D.
RT Jun-D: A third member of the Jun gene family
RL Proc. Natl. Acad. Sci. USA 86:1500-1503 (1989).
RN [11]; RE0004786.
RX PUBMED: 1903194.
RA Berger I., Shaul Y.
RT Structure and function of human jun-D
RL Oncogene 6:561-566 (1991).
RN [12]; RE0004792.
RX PUBMED: 8124713.
RA Pfarr C. M., Mechta F., Spyrou G., Lallemand D., Carillo S., Yaniv M.
RT Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras
RL Cell 76:747-760 (1994).
RN [13]; RE0004882.
RX PUBMED: 1900040.
RA Nakabeppu Y., Nathans D.
RT A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity
RL Cell 64:751-759 (1991).
RN [14]; RE0019485.
RX PUBMED: 2104845.
RA LI L., HU J.-S., OLSON E.N.
RT Different members of the jun proto-oncogene family exhibit distinct patterns of expression in response to type beta transforming growth factor.
RL J. Biol. Chem. 265:1556-1562 (1990).
RN [15]; RE0025717.
RX PUBMED: 11886848.
RA Mann J., Oakley F., Johnson P. W., Mann D. A.
RT CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1.
RL J. Biol. Chem. 277:17125-38 (2002).
RN [16]; RE0036098.
RX PUBMED: 11756554.
RA Young M. R., Nair R., Bucheimer N., Tulsian P., Brown N., Chapp C., Hsu T. C., Colburn N. H.
RT Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently.
RL Mol. Cell. Biol. 22:587-598 (2002).
RN [17]; RE0051710.
RX PUBMED: 15988009.
RA Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J. Y., Lu S. C.
RT Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1.
RL Mol. Cell. Biol. 25:5933-5946 (2005).
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