AC T01991
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ID T01991
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DT 02.12.1996 (created); hiwi.
DT 11.03.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA Fra-2
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SY Fos related antigen 2; Fos-like antigen 2; FOSL2; Fra2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004688 FOSL2; HGNC: FOSL2.
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CL C0008; bZIP; 1.1.2.1.4.
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SF the heterodimer with c-Jun bends DNA similar as the c-Fos/c-Jun complex, but with a smaller bending angle [1];
SF the heterodimer with CRE-BP1/ATF-2 T00167 induces a bending towards the minor groove which is slightly lower than that caused by c-Fos/CRE-BP1 [1];
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CP widespread; human endometrium from proliferative and secretory phases of the menstrual cycle and human decidua from early pregnancy [7].
CN T cells, B cells (probably) [5].
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FF lacks the C-terminal trans-activation domain of c-Fos and does not exhibit transforming activity [3];
FF may be involved in G0-G1 transition [4];
FF gene is induced by phorbol ester with slower kinetics than c-fos or fra-1 [5];
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IN T00968 ATF-1; human, Homo sapiens.
IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T01113 Elf-1; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T10210 Evi-1; human, Homo sapiens.
IN T02368 HMGIY; human, Homo sapiens.
IN T00437 JunD; mouse, Mus musculus.
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MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M07092 V$FOSL2_02.
MX M08914 V$FRA2_01.
MX M08915 V$FRA2_02.
MX M03870 V$FRA2_Q4_01.
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BS R21775.
BS R62338.
BS R41978.
BS R14540.
BS R26802.
BS R31706.
BS R31708.
BS R41737.
BS R28305.
BS R29092.
BS R30937.
BS R14544.
BS R26674.
BS R72604.
BS R14725.
BS R26758.
BS R39281.
BS R66690.
BS R59837.
BS R26793.
BS R34900.
BS R35944.
BS R60863.
BS R36611.
BS R38461.
BS R29975.
BS R14478.
BS R14480.
BS R21738.
BS R33879.
XX
DR TRANSPATH: MO000026074.
DR TRANSCOMPEL: C00418.
DR UniProtKB: P15408;
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RN [1]; RE0004643.
RX PUBMED: 8355695.
RA Kerppola T. K., Curran T.
RT Selective DNA bending by a variety of bZIP proteins
RL Mol. Cell. Biol. 13:5479-5489 (1993).
RN [2]; RE0004788.
RX PUBMED: 8415709.
RA Kameda T., Akahori A., Sonobe M. H., Suzuki T., Endo T., Iba H.
RT JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2
RL Proc. Natl. Acad. Sci. USA 90:9369-9373 (1993).
RN [3]; RE0004817.
RX PUBMED: 7504176.
RA Wisdom R., Verma I. M.
RT Transformation by Fos proteins requires a C-terminal transactivation domain
RL Mol. Cell. Biol. 13:7429-7438 (1993).
RN [4]; RE0004865.
RX PUBMED: 1406676.
RA Kovary K., Bravo R.
RT Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins
RL Mol. Cell. Biol. 12:5015-5023 (1992).
RN [5]; RE0004893.
RX PUBMED: 2107490.
RA Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R.
RT Isolation of human fos- related genes and their expression during monocyte-macrophage differentiation
RL Oncogene 5:249-255 (1990).
RN [6]; RE0016689.
RX PUBMED: 7648395.
RA Bassuk A. G., Leiden J. M.
RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
RL Immunity 3:223-237 (1995).
RN [7]; RE0034082.
RX PUBMED: 11266514.
RA Watanabe K., Kessler C. A., Bachurski C. J., Kanda Y., Richardson B. D., Stanek J., Handwerger S., Brar A. K.
RT Identification of a decidua-specific enhancer on the human prolactin gene with two critical activator protein 1 (AP-1) binding sites.
RL Mol. Endocrinol. 15:638-53 (2001).
RN [8]; RE0066649.
RX PUBMED: 16984917.
RA Byun H. J., Hong I. K., Kim E., Jin Y. J., Jeoung D. I., Hahn J. H., Kim Y. M., Park S. H., Lee H.
RT A splice variant of CD99 increases motility and MMP-9 expression of human breast cancer cells through the AKT-, ERK-, and JNK-dependent AP-1 activation signaling pathways.
RL J. Biol. Chem. 281:34833-34847 (2006).
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