TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00968 XX ID T00968 XX DT 29.06.1993 (created); ewi. DT 16.05.2014 (updated); jmh. CO Copyright (C), QIAGEN. XX FA ATF-1 XX SY activating transcription factor 1; ATF1; EWS-ATF1; FUS/ATF-1; TREB-36; TREB36. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G005792 ATF1; HGNC: ATF1. XX CL C0008; bZIP; XX SF CRE-binding as homodimer or as CREB-heterodimer [4]; SF probably the basic region interacts with the viral regulator Tax [13]; SF no significant bending of the bound DNA [11]; SF for interaction with correctly spaced half-sites DNA elements, Lys-239 is important (here, c-Jun-like factors possess a hydrophobic or acidic side chain) [12]; SF no homolog to the alpha-domain of CREB; XX CP ubiquitous [10]; 184A1N4, MCF7, MDA231, MCF10A, HBL100, T47D [17]. XX FF activator; FF may also inhibit activity of some unrelated factors; FF mediates response to enhanced calcium or cAMP concentrations, but to a distinct extent [4]; FF does not support gene activation by E1A, in contrast to CRE-BP1/ATF-2 [2]; XX IN T00968 ATF-1; human, Homo sapiens. IN T04074 brca1; human, Homo sapiens. IN T15204 brca1; Mammalia. IN T00163 CREB-A; human, Homo sapiens. IN T00166 CREB-B; human, Homo sapiens. IN T00164 CREB1; rat, Rattus norvegicus. IN T01385 CREB1; cattle, Bos taurus. IN T00989 CREB; mouse, Mus musculus. IN T01127 CREB; pig, Sus scrofa. IN T01307 CREB; hamster, Cricetulus sp. IN T01380 CREB; mink, Mustela vison. IN T01991 Fra-2; human, Homo sapiens. IN T00793 Tax; HTLV-I, human T-cell lymphotropic virus type I. XX MX M07034 V$ATF1_Q3. MX M00691 V$ATF1_Q6. MX M01861 V$ATF1_Q6_01. MX M00981 V$CREBATF_Q6. MX M00801 V$CREB_Q3. XX BS R00343. BS R16162. BS R02126. BS R25014. BS R31372. BS R12540. BS R25010. BS R59341. BS R59342. BS R59343. BS R59344. BS R59347. BS R59348. BS R20975. BS R13381. BS R41356. BS R04356. BS R26041. BS R16776. BS R61834. BS R36325. BS R31350. BS R31351. BS R27588. BS R32731. BS R32733. BS R24882. BS R39945. BS R29836. BS R34433. BS R38316. BS R19543. BS R14781. BS R29660. BS R35571. BS R33868. BS R34122. BS R21486. BS R30422. BS R30423. BS R30425. BS R34843. BS R21507. BS R20819. BS R20821. BS R25046. BS R00777. BS R00779. BS R56813. BS R00963. BS R13230. BS R24961. BS R01358. XX DR TRANSPATH: MO000001471. DR UniProtKB: P18846; XX RN [1]; RE0000062. RX PUBMED: 3416354. RA Horikoshi M., Hai T., Lin Y.-S., Green M. R., Roeder R. G. RT Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex RL Cell 54:1033-1042 (1988). RN [2]; RE0000186. RX PUBMED: 2142019. RA Liu F., Green M. R. R. RT A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein RL Cell 61:1217-1224 (1990). RN [3]; RE0000666. RX PUBMED: 2516827. RA Hai T., Liu F., Coukos W. J., Green M. R. RT Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers RL Genes Dev. 3:2083-2090 (1989). RN [4]; RE0001106. RX PUBMED: 1655749. RA Rehfuss R. P., Walton K. M., Loriaux M. M., Goodman R. H. RT The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A RL J. Biol. Chem. 266:18431-18434 (1991). RN [5]; RE0001663. RX PUBMED: 1831536. RA Jones C., Lee K. A. W. RT E1A-mediated activation of the adenovirus E4 promoter can occur independently of the cellular transcription factor E4F RL Mol. Cell. Biol. 11:4297-4305 (1991). RN [6]; RE0002228. RX PUBMED: 8332500. RA Lemaigre F. P., Ace C. I., Green M. R. RT The cAMP response element binding protein, CREB, is a potent inhibitor of diverse transcriptional activators RL Nucleic Acids Res. 21:2907-2911 (1993). RN [7]; RE0002270. RX PUBMED: 2835770. RA Lin Y.-S., Green M. R. RT Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters RL Proc. Natl. Acad. Sci. USA 85:3396-3400 (1988). RN [8]; RE0002647. RX PUBMED: 1646483. RA Sheng M., Thompson M. A., Greenberg M. E. RT CREB: A Ca2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases RL Science 252:1427-1430 (1991). RN [9]; RE0003152. RX PUBMED: 2960975. RA Lee K.A.W., Hai T.-Y., Raman L.S., Thimmappaya B., Hurst H.C., Jones N.C., Green M.R. RT A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promotors RL Proc. Natl. Acad. Sci. USA 84:8355-8359 (1987). RN [10]; RE0003157. RX PUBMED: 2196176. RA Yoshimura T., Fujisawa J.-I., Yoshida M. RT Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain RL EMBO J. 9:2537-2542 (1990). RN [11]; RE0004643. RX PUBMED: 8355695. RA Kerppola T. K., Curran T. RT Selective DNA bending by a variety of bZIP proteins RL Mol. Cell. Biol. 13:5479-5489 (1993). RN [12]; RE0004872. RX PUBMED: 7630732. RA Kim J., Struhl K. RT Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains RL Nucleic Acids Res. 23:2531-2537 (1995). RN [13]; RE0005255. RX PUBMED: 7637811. RA Perini G., Wagner S., Green M. R. RT Recognition of bZIP proteins by the human T-cell leukemia virus transactivator Tax RL Nature 376:602-605 (1995). RN [14]; RE0043216. RX PUBMED: 12414794. RA Gupta P., Prywes R. RT ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression RL J. Biol. Chem. 277:50550-6 (2002). RN [15]; RE0048396. RX PUBMED: 16818466. RA Presnell S. R., Zhang L., Ramilo C. A., Chan H. W., Lutz C. T. RT Functional redundancy of transcription factor-binding sites in the killer cell Ig-like receptor (KIR) gene promoter. RL Int. Immunol. 18:1221-1232 (2006). RN [16]; RE0050340. RX PUBMED: 10945975. RA Houvras Y., Benezra M., Zhang H., Manfredi J. J., Weber B. L., Licht J. D. RT BRCA1 physically and functionally interacts with ATF1. RL J. Biol. Chem. 275:36230-36237 (2000). RN [17]; RE0053607. RX PUBMED: 12027462. RA Dong Y., Asch H. L., Ying A., Asch B. B. RT Molecular mechanism of transcriptional repression of gelsolin in human breast cancer cells. RL Exp. Cell Res. 276:328-336 (2002). RN [18]; RE0063969. RX PUBMED: 19428786. RA Hutchinson A. J., Chou C. L., Israel D. D., Xu W., Regan J. W. RT Activation of EP2 prostanoid receptors in human glial cell lines stimulates the secretion of BDNF. RL Neurochem. Int. 54:439-446 (2009). XX //