TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00793 XX ID T00793 XX DT 09.12.1992 (created); ewi. DT 25.02.2010 (updated); jtr. CO Copyright (C), QIAGEN. XX FA Tax XX SY Tax. XX OS HTLV-I, human T-cell lymphotropic virus type I OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; retroviridae; oncovirinae; type C oncovirus group; mammalian type C oncoviruses XX SF at least 1 zinc finger motif of C2CH-type [4]; SF capable of dimerization via its zinc finger motif(s) [4]; XX FF activator of viral and cellular genes [5]; FF does not bind to DNA directly but interacts through protein-protein contacts with DNA-binding TFs [5]; FF promotes dimerization of bZIP transcription factors [3]; FF dimerization may be important for optimal function [5]; FF enhances DNA-binding by NF-kappaB(p50), NF-kappaB(p65), Sp1, SRF (without entering the complex) [7]; FF JunB has been reported to inhibit Tax-dependent transcription, whereas ATF-3 induces it in a manner additionally enhanced by PKA [6]; FF in contrast, CREB, c-Fos, c-Jun, and JunD have no effect on Tax-mediated transcription [6]; FF enhances DNA binding by C/EBP-beta and by PU.1 in monocytic cells [8]; XX IN T00968 ATF-1; human, Homo sapiens. IN T01304 ATF-1; mouse, Mus musculus. IN T00167 ATF-2-isoform1; human, Homo sapiens. IN T00163 CREB-A; human, Homo sapiens. IN T00164 CREB1; rat, Rattus norvegicus. IN T02272 HEB1-p67; human, Homo sapiens. IN T01940 NF-kappaB1-isoform5; mouse, Mus musculus. IN T06148 p/CAF; human, Homo sapiens. XX MX M00114 V$TAXCREB_01. MX M00115 V$TAXCREB_02. XX BS R04240. BS R04241. BS R04242. BS R00777. BS R00779. BS R00780. BS R02069. BS R03997. BS R04456. BS R04578. BS R04579. XX DR TRANSPATH: MO000025177. XX RN [1]; RE0000902. RX PUBMED: 2768259. RA Giam C.-Z., Xu Y.-L. RT HTLV-I Tax Gene Product Activates Transcription via Pre-existing Cellular Factors and cAMP Responsive Element RL J. Biol. Chem. 264:15236-15241 (1989). RN [2]; RE0002562. RX PUBMED: 8202541. RA Adya N., Zhao L.-J., Huang W., Boros I., Giam C.-Z. RT Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB RL Proc. Natl. Acad. Sci. USA 91:5642-5646 (1994). RN [3]; RE0002710. RX PUBMED: 8211160. RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [4]; RE0006584. RX PUBMED: 9478126. RA MacKay J. P., Crossley M. RT Zinc fingers are sticking together RL Trends Biochem. Sci. 23:1-4 (1998). RN [5]; RE0006586. RX PUBMED: 9016568. RA Jin D.-Y., Jeang K.-T. RT HTLV-I Tax self-association in optimal trans-activation function RL Nucleic Acids Res. 25:379-387 (1997). RN [6]; RE0006674. RX PUBMED: 8007991. RA Low K. G., Chu H.-M., Tan Y., Schwartz P. M., Daniels G. M., Melner M. H., Comb M. J. RT Novel interactions between human T-cell leukemia virus type I Tax and activating transcription factor 3 at a cyclic AMP-responsive element RL Mol. Cell. Biol. 14:4958-4974 (1994). RN [7]; RE0007087. RX PUBMED: 8346248. RA Armstrong A. P., Franklin A. A., Uittenbogaard M. N., Giebler H. A., Nyborg J. K. RT Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors RL Proc. Natl. Acad. Sci. USA 90:7303-7307 (1993). RN [8]; RE0023161. RX PUBMED: 9376596. RA Tsukada J., Misago M., Serino Y., Ogawa R., Murakami S., Nakanishi M., Tonai S., Kominato Y., Morimoto I., Auron P. E., Eto S. RT Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1. RL Blood 90:3142-3153 (1997). XX //