AC T00793
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ID T00793
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DT 09.12.1992 (created); ewi.
DT 25.02.2010 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA Tax
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SY Tax.
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OS HTLV-I, human T-cell lymphotropic virus type I
OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; retroviridae; oncovirinae; type C oncovirus group; mammalian type C oncoviruses
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SF at least 1 zinc finger motif of C2CH-type [4];
SF capable of dimerization via its zinc finger motif(s) [4];
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FF activator of viral and cellular genes [5];
FF does not bind to DNA directly but interacts through protein-protein contacts with DNA-binding TFs [5];
FF promotes dimerization of bZIP transcription factors [3];
FF dimerization may be important for optimal function [5];
FF enhances DNA-binding by NF-kappaB(p50), NF-kappaB(p65), Sp1, SRF (without entering the complex) [7];
FF JunB has been reported to inhibit Tax-dependent transcription, whereas ATF-3 induces it in a manner additionally enhanced by PKA [6];
FF in contrast, CREB, c-Fos, c-Jun, and JunD have no effect on Tax-mediated transcription [6];
FF enhances DNA binding by C/EBP-beta and by PU.1 in monocytic cells [8];
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IN T00968 ATF-1; human, Homo sapiens.
IN T01304 ATF-1; mouse, Mus musculus.
IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T00163 CREB-A; human, Homo sapiens.
IN T00164 CREB1; rat, Rattus norvegicus.
IN T02272 HEB1-p67; human, Homo sapiens.
IN T01940 NF-kappaB1-isoform5; mouse, Mus musculus.
IN T06148 p/CAF; human, Homo sapiens.
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MX M00114 V$TAXCREB_01.
MX M00115 V$TAXCREB_02.
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BS R04240.
BS R04241.
BS R04242.
BS R00777.
BS R00779.
BS R00780.
BS R02069.
BS R03997.
BS R04456.
BS R04578.
BS R04579.
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DR TRANSPATH: MO000025177.
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RN [1]; RE0000902.
RX PUBMED: 2768259.
RA Giam C.-Z., Xu Y.-L.
RT HTLV-I Tax Gene Product Activates Transcription via Pre-existing Cellular Factors and cAMP Responsive Element
RL J. Biol. Chem. 264:15236-15241 (1989).
RN [2]; RE0002562.
RX PUBMED: 8202541.
RA Adya N., Zhao L.-J., Huang W., Boros I., Giam C.-Z.
RT Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB
RL Proc. Natl. Acad. Sci. USA 91:5642-5646 (1994).
RN [3]; RE0002710.
RX PUBMED: 8211160.
RA Wagner S., Green M. R.
RT HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization
RL Science 262:395-399 (1993).
RN [4]; RE0006584.
RX PUBMED: 9478126.
RA MacKay J. P., Crossley M.
RT Zinc fingers are sticking together
RL Trends Biochem. Sci. 23:1-4 (1998).
RN [5]; RE0006586.
RX PUBMED: 9016568.
RA Jin D.-Y., Jeang K.-T.
RT HTLV-I Tax self-association in optimal trans-activation function
RL Nucleic Acids Res. 25:379-387 (1997).
RN [6]; RE0006674.
RX PUBMED: 8007991.
RA Low K. G., Chu H.-M., Tan Y., Schwartz P. M., Daniels G. M., Melner M. H., Comb M. J.
RT Novel interactions between human T-cell leukemia virus type I Tax and activating transcription factor 3 at a cyclic AMP-responsive element
RL Mol. Cell. Biol. 14:4958-4974 (1994).
RN [7]; RE0007087.
RX PUBMED: 8346248.
RA Armstrong A. P., Franklin A. A., Uittenbogaard M. N., Giebler H. A., Nyborg J. K.
RT Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors
RL Proc. Natl. Acad. Sci. USA 90:7303-7307 (1993).
RN [8]; RE0023161.
RX PUBMED: 9376596.
RA Tsukada J., Misago M., Serino Y., Ogawa R., Murakami S., Nakanishi M., Tonai S., Kominato Y., Morimoto I., Auron P. E., Eto S.
RT Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1.
RL Blood 90:3142-3153 (1997).
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