AC T01940
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ID T01940
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DT 05.11.1996 (created); ewi.
DT 21.01.2010 (updated); pum.
CO Copyright (C), QIAGEN.
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FA NF-kappaB1-isoform5
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SY p105 carboxy-terminal region; p105 CTR; p105/pdI; p70; p70IkappaB-gamma.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006465 Nfkb1.
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CL C0020; Rel.
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SZ 607 AA; 64.8 kDa (cDNA) (calc.), 70 kDa (SDS) [3]
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SQ MPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPGVTKS
SQ NAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALASTME
SQ DKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLH
SQ LAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRVGADL
SQ SLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSLPCLL
SQ LLVAAGAEVNAQEQKSGRTPLHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAG
SQ RGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQVFDIL
SQ NGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGILNNAF
SQ RLSPAPSKTLMDNYEVSGGTIKELMEALQQMGYTEAIEVIQAAFRTPATTASSPVTTAQV
SQ HCLPLSSSSTRQHIDELRDSDSVCDSGVETSFRKLSFTESLTGDSPLLSLNKMPHGYGQE
SQ GPIEGKI
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SC translated from EMBL #S89033
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FT 72 384 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 174 204 
SM00248; ANK_2a.
FT 174 212 
PF00023; Ankyrin repeat.
FT 174 382 
PS50297; ANK_REP_REGION.
FT 213 242 
SM00248; ANK_2a.
FT 213 245 
PF00023; Ankyrin repeat.
FT 213 245 
PS50088; ANK_REPEAT.
FT 246 276 
SM00248; ANK_2a.
FT 246 278 
PS50088; ANK_REPEAT.
FT 246 279 
PF00023; Ankyrin repeat.
FT 282 311 SM00248; ANK_2a.
FT 282 314 PF00023; Ankyrin repeat.
FT 282 314 PS50088; ANK_REPEAT.
FT 316 346 SM00248; ANK_2a.
FT 316 349 PF00023; Ankyrin repeat.
FT 316 349 PS50088; ANK_REPEAT.
FT 350 379 SM00248; ANK_2a.
FT 350 382 PF00023; Ankyrin repeat.
FT 350 382 PS50088; ANK_REPEAT.
FT 437 524 SM00005; DEATH_4.
FT 449 524 PF00531; Death domain.
FT 573 576 PKA phosphorylation site [2].
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SF identical to the C-terminal half of the NF-kappaB1 (p105) precursor [3];
SF transcript may arise from an alternative transcription start site directing translation initiation to Met-365 of the p105 precursor [3];
SF splice variants NF-kappaB1-isoform51 and -gamma2 differ in their C-terminal sequences and lack the PKA phosphorylation site [1] [2];
SF in addition to the ankyrin repeats, the acidic region is required for NF-kappaB interaction;
SF the seventh ankyrin repeat has auxiliary function [1];
SF in contrast to IkappaB-alpha, NF-kappaB1-isoform5 interacts with the p50 subunit unless the first ankyrin repeat is deleted [1];
SF the ankyrin repeats also interact with viral Tax [4];
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CP lymphoid cells (predominantly) [3].
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FF inhibitor of DNA-binding of NF-kappaB1 (p50) homodimers and c-Rel [3] [5];
FF controversial results on the effects on p50/p65 heterodimers [1] [3] [5];
FF prevents nuclear translocation and suppresses trans-activation by, e. g., c-Rel [3];
FF dissociates p50/DNA complexes [5];
FF gamma1 and -2 isoforms specifically act on the NF-kappaB1 (p50) subunit [1];
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IN T01923 p50; mouse, Mus musculus.
IN T00793 Tax; HTLV-I, human T-cell lymphotropic virus type I.
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MX M00194 V$NFKB_Q6.
MX M00774 V$NFKB_Q6_01.
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DR TRANSPATH: MO000019317.
DR EMBL: S89033; S89033.
DR UniProtKB: P25799-5;
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RN [1]; RE0004615.
RX PUBMED: 8183915.
RA Grumont R. J., Gerondakis S.
RT Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappaB gene generates IkappaBgamma isoforms with different inhibitory activities
RL Proc. Natl. Acad. Sci. USA 91:4367-4371 (1994).
RN [2]; RE0004640.
RX PUBMED: 8398903.
RA Gerondakis S., Morrice N., Richadson I. B., Wettenhall R., Fecondo J., Grumont R. J.
RT The activity of a 70 kilodalton I kappa B molecule identical to the carboxyl terminus of the p105 NF-kappa B precursor is modulated by protein kinase A
RL Cell Growth Differ. 4:617-627 (1993).
RN [3]; RE0004750.
RX PUBMED: 1339305.
RA Inoue J.-I., Kerr L. D., Kakizuka A., Verma I. M.
RT IkappaBgamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappaB: A new member of the IkappaB family
RL Cell 68:1109-1120 (1992).
RN [4]; RE0004751.
RX PUBMED: 8170951.
RA Hirai H., Suzuki T., Fujisawa J.-I., Inoue J.-I., Yoshida M.
RT Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappaB and induces nuclear translocation of transcription factor NF-kappaB proteins for transcriptional activation
RL Proc. Natl. Acad. Sci. USA 91:3584-3588 (1994).
RN [5]; RE0004752.
RX PUBMED: 1639070.
RA Liou H.-C., Nolan G. P., Ghosh S., Fujita T., Baltimore D.
RT The NF-kappaB p50 precursor, p105, contains an internal IkappaB-like inhibitor that preferentially inhibits p50
RL EMBO J. 11:3003-3009 (1992).
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