TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01923 XX ID T01923 XX DT 04.11.1996 (created); ewi. DT 18.07.2014 (updated); jmh. CO Copyright (C), QIAGEN. XX FA p50 XX SY 243/NFA-kappaB; H2TF1; KBF1; NF-kappaB (p50); NF-kappaB1; p50. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0020; Rel. XX SF synthesized as a 105 kDa precursor T01924 from which the N-terminal half comprising the Rel domain is released as mature p50 by proteolytic clipping [5]; SF binds to DNA as homo- or heteromer T00588 with, e. g., RelA/p65 or c-Rel [22]; SF the DNA-binding Rel domain comprises two beta-barrel domains the loops of which constitute an extensive DNA contacting surface [17]; SF using a symmetric decameric binding site (GGGAATTCCC), a short alpha-helical segment performs minor groove contacts in a region where augmenting interaction with HMG I(Y) have been observed [17]; XX CP ubiquitous. XX FF transcriptionally inert DNA-binding subunit of holo-NF-kappaB T00588; FF trans-activating induced heterodimers with RelA/p65 T00595 [21]; FF hetero-dimerization with Bcl-3 [18]; FF at some elements, however, p50 may exert a constitutive activating function [19]; FF bound to this sequence, p50 adopts a chymotrypsin-resistant conformation [19]; FF constitutive activating complexes in spleen B-cells and thymocytes consist of p50/RelB heterodimers [21]; FF in pre-B cells, mainly p50/p65 heterodimers are induced, whereas in mature B cells, p50/c-Rel heterodimers predominate [22]; FF constitutive NF-kappaB activity in B-cells partly due to enhanced protease activity degrading IkappaB [15]; FF upstream signal transducers for p50 phosphorylation and, presumably, activation may be Raf, Src, H-Ras, Mos [20]; XX IN T01928 Bcl-3; human, Homo sapiens. IN T23418 HDAC1; mouse, Mus musculus. IN T01940 NF-kappaB1-isoform5; mouse, Mus musculus. IN T01941 NF-kappaB1-isoform6; mouse, Mus musculus. IN T01942 NF-kappaB1-isoform7; mouse, Mus musculus. IN T01923 p50; mouse, Mus musculus. IN T00595 RelA-p65; mouse, Mus musculus. IN T01932 RelB; mouse, Mus musculus. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). XX MX M00194 V$NFKB_Q6. MX M00774 V$NFKB_Q6_01. MX M03557 V$P50_Q6. XX BS R02591. BS R02668. BS R01766. BS R24928. BS R02167. BS R00699. BS R20691. BS R00923. BS R14486. BS R27927. BS R14565. BS R02189. BS R01095. BS R17095. BS R24927. BS R30627. BS R62926. BS R00877. BS R14483. BS R28386. BS R29918. BS R01057. BS R01058. BS R01060. BS R02336. BS R01071. BS R37830. BS R37831. BS R31355. BS R14616. BS R38713. BS R29344. BS R33510. BS R33513. BS R22667. BS R61241. BS R14690. BS R14691. BS R01448. BS R14783. BS R25734. BS R02217. BS R01887. XX DR TRANSPATH: MO000019358. XX RN [1]; RE0000090. RX PUBMED: 3129195. RA Baeuerle P. A., Baltimore D. RT Activation of DNA-Binding Activity in an Apparently Cytoplasmic Precursor of the NF-kB Transcription Factor RL Cell 53:211-217 (1988). RN [2]; RE0000169. RX PUBMED: 2203533. RA Gilmore T. D. RT NF-kappaB, KBF1, dorsal, and related matters RL Cell 62:841-843 (1990). RN [3]; RE0000174. RX PUBMED: 1988149. RA Lewin B. RT Oncogenic conversion by regulatory changes in transcription factors RL Cell 64:303-312 (1991). RN [4]; RE0000176. RX PUBMED: 2001591. RA Nolan G. P., Gosh S., Liou H.-C., Tempst P., Baltimore D. RT DNA binding and IkappaB inhibition of the cloned p65 subunit of NF-kappaB, a rel-related polypeptide RL Cell 64:961-969 (1991). RN [5]; RE0000215. RX PUBMED: 2203532. RA Ghosh S., Gifford A. M., Riviere L. R., Tempst P., Nolan G. P., Baltimore D. RT Cloning of the p50 DNA binding subunit of NF-kappaB: homology to rel and dorsal RL Cell 62:1019-1029 (1990). RN [6]; RE0000372. RX PUBMED: 3141147. RA Wirth T., Baltimore D. RT Nuclear factor NF-kB can interact functionally with its cognate binding site to provide lymphoid-specific promoter function RL EMBO J. 7:3109-3113 (1988). RN [7]; RE0000384. RX PUBMED: 3322806. RA Yano O., Kanellopoulos J., Kieran M., Le Bail O., Israel A., Kourilsky P. RT Purification of KBF1, a common factor binding to both H-2 and beta2-microglobulin enhancers RL EMBO J. 6:3317-3324 (1987). RN [8]; RE0000453. RX PUBMED: 2583102. RA Lenardo M., Rustgi A. K., Schievella A. R., Bernards R. RT Suppression of MHC class I gene expression by N-myc through enhancer inactivation RL EMBO J. 8:3351-3355 (1989). RN [9]; RE0000658. RX PUBMED: 2116989. RA Hagman J., Rudin Ch. M., Haasch D., Chaplin D., Storb U. RT A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NFkB RL Genes Dev. 4:987-992 (1990). RN [10]; RE0001474. RX PUBMED: 2196446. RA Henseling U., Schmidt W., Schoeler H. R., Gruss P., Hatzopoulos A. K. RT A transcription factor interacting with the class I gene enhancer is inactive in tumorigenic cell lines which suppress major histocompatibility complex class I genes RL Mol. Cell. Biol. 10:4100-4109 (1990). RN [11]; RE0001632. RX PUBMED: 2548081. RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 9:2424-2430 (1991). RN [12]; RE0002064. RX PUBMED: 2668878. RA Israel A., Yano O., Logeat F., Kieran M., Kourilsky P. RT Two purified factors bind to the same sequence in the enhancer of mouse MHC class I genes: one of them is a positive regulator induced upon differentiation of teratocarcinoma cells RL Nucleic Acids Res. 17:5245 (1989). RN [13]; RE0002491. RX PUBMED: 2247438. RA Rustgi A. K., van't Veer L., Bernards R. RT Two genes encode factors with NF-kappaB- and H2TF1-like DNA-binding properties RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990). RN [14]; RE0002609. RX PUBMED: 3143155. RA Briskin M., Kuwabara M. D., Sigman D. S., Wall R. RT Induction of kappa transcription by interferon-gamma without activation of NF-kappaB RL Science 242:1036-1037 (1988). RN [15]; RE0004491. RX PUBMED: 8164680. RA Miyamoto S., Chiao P. J., Verma I. M. RT Enhanced IkappaBalpha degradation is responsible for constitutive NF-kappaB activity in mature murine B-cell lines RL Mol. Cell. Biol. 14:3276-3282 (1994). RN [16]; RE0004492. RX PUBMED: 8196632. RA Zhang Q., Didonato J. A., Karin M., McKeithan T. W. RT BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappaB proteins RL Mol. Cell. Biol. 14:3915-3926 (1994). RN [17]; RE0004504. RX PUBMED: 7530332. RA Ghosh G., van Duyne G., Ghosh S., Sigler P. B. RT Structure of NF-kappaB p50 homodimer bound to a kappaB site RL Nature 373:303-310 (1995). RN [18]; RE0004510. RX PUBMED: 8330739. RA Fujita T., Nolan G. P., Liou H.-C., Scott M. L., Baltimore D. RT The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappaB p50 homodimers RL Genes Dev. 7:1354-1363 (1993). RN [19]; RE0004518. RX PUBMED: 1577272. RA Fujita T., Nolan G. P., Ghosh S., Baltimore D. RT Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappaB RL Genes Dev. 6:775-787 (1992). RN [20]; RE0004520. RX PUBMED: 8255780. RA Bruder J. T., Heidecker G., Tan T.-H., Derse D., Rapp U. R. RT Oncogene activation of HIV-LTR-driven expression via the NF-kappaB binding sites RL Nucleic Acids Res. 21:5229-5234 (1993). RN [21]; RE0004522. RX PUBMED: 7692309. RA Lernbecher T., Mueller U., Wirth T. RT Distinct NF-kappaB/Rel transcription factors are responsible for tissue-specific and inducible gene activation RL Nature 365:767-770 (1993). RN [22]; RE0004531. RX PUBMED: 8197184. RA Miyamoto S., Schmitt M. J., Verma I. M. RT Qualitative changes in the subunit composition of kappa-binding complexes during murine B-cell differentiation RL Proc. Natl. Acad. Sci. USA 91:5056-5060 (1994). RN [23]; RE0052059. RX PUBMED: 11931769. RA Zhong H., May M. J., Jimi E., Ghosh S. RT The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. RL Mol. Cell 9:625-636 (2002). XX //