AC T00588
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ID T00588
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DT 15.10.1992 (created); ewi.
DT 16.04.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA NF-kappaB
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SY NF-kappaB; NF-kappaB complex; Nuclear Factor kappa B; Nuclear Factor kappa B p50:p65; p50/p65.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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CL C0020; Rel.
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SF constituent complexes may be p50 T01923 homodimers or heterodimers of p50/p65 T01923 T00595, p50/RelB T01923 T01932, or p50/c-Rel T01923 T00169 [27] [28] [30];
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FF Dectin1 mediates heat inactivated Candida albicans (fungal pathogen) and zymosan induced NF-kappaB activation [36];
FF DNA binding activity of NF-kappaB is increased following the treatment with recombinant human IL-1beta [35];
FF inducible activator, induced by many agents: e. g. TNF, PKA- or PKC-mediated signals and dsRNA [8] [23] [25] [26] [13] [18] [14];
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IN T00168 c-Rel; human, Homo sapiens.
IN T00950 IkappaB-alpha; human, Homo sapiens.
IN T00414 IkappaB-beta; human, Homo sapiens.
IN T00416 IkappaB-beta; chick, Gallus gallus.
IN T00971 IkappaB-beta; mouse, Mus musculus.
IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T).
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MX M00054 V$NFKAPPAB_01.
MX M08891 V$NFKB1_Q4.
MX M00208 V$NFKB_C.
MX M00194 V$NFKB_Q6.
MX M00774 V$NFKB_Q6_01.
XX
BS R05893.
BS R05894.
BS R05895.
BS R05896.
BS R05897.
BS R05898.
BS R05899.
BS R05900.
BS R05901.
BS R05902.
BS R05903.
BS R05904.
BS R05905.
BS R05906.
BS R05907.
BS R05908.
BS R05909.
BS R05910.
BS R05911.
BS R05912.
BS R05913.
BS R05914.
BS R05915.
BS R05916.
BS R05917.
BS R05918.
BS R05919.
BS R05920.
BS R05921.
BS R05922.
BS R05923.
BS R05924.
BS R05925.
BS R05926.
BS R05927.
BS R05928.
BS R05929.
BS R05930.
BS R05931.
BS R05932.
BS R20825.
BS R20924.
BS R02668.
BS R20630.
BS R24493.
BS R01766.
BS R26202.
BS R19592.
BS R00699.
BS R00702.
BS R25431.
BS R29232.
BS R29238.
BS R00923.
BS R24519.
BS R14486.
BS R25017.
BS R73961.
BS R30641.
BS R14565.
BS R24497.
BS R36039.
BS R35491.
BS R32902.
BS R17095.
BS R32165.
BS R30569.
BS R26211.
BS R00606.
BS R60351.
BS R60361.
BS R27179.
BS R38722.
BS R38724.
BS R14717.
BS R24927.
BS R22547.
BS R33966.
BS R33968.
BS R18417.
BS R28681.
BS R59752.
BS R73953.
BS R74051.
BS R00877.
BS R25606.
BS R14483.
BS R26676.
BS R74074.
BS R27473.
BS R27474.
BS R02951.
BS R24514.
BS R30497.
BS R23523.
BS R01058.
BS R01060.
BS R01071.
BS R01607.
BS R13259.
BS R08126.
BS R08131.
BS R26673.
BS R21225.
BS R24784.
BS R34521.
BS R29548.
BS R29562.
BS R32894.
BS R22352.
BS R22353.
BS R14690.
BS R14691.
BS R01448.
BS R14783.
BS R14784.
BS R14785.
BS R25059.
BS R25734.
BS R33557.
BS R35831.
BS R02217.
BS R04556.
BS R01887.
BS R29144.
XX
DR TRANSPATH: MO000019668.
DR TRANSCOMPEL: C00183.
DR TRANSCOMPEL: C00192.
DR TRANSCOMPEL: C00257.
DR TRANSCOMPEL: C00258.
DR TRANSCOMPEL: C00301.
DR TRANSCOMPEL: C00311.
DR TRANSCOMPEL: C00337.
DR TRANSCOMPEL: C00339.
XX
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RX PUBMED: 3098435.
RA Atchison M. L., Perry R. P.
RT The Role of the kappa Enhancer and Its Binding Factor NF-kB in the Developmental Regulation of kappa Gene Transcription
RL Cell 48:121-128 (1987).
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RA Baeuerle P. A., Baltimore D.
RT Activation of DNA-Binding Activity in an Apparently Cytoplasmic Precursor of the NF-kB Transcription Factor
RL Cell 53:211-217 (1988).
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RA Lenardo M. J., Fan C.-M., Maniatis T., Baltimore D.
RT The Involvement of NF-kB in beta-Interferon Gene Regulation Reveals Its Role as Widely Inducible Mediator of Signal Transduction
RL Cell 57:287-294 (1989).
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RX PUBMED: 2203533.
RA Gilmore T. D.
RT NF-kappaB, KBF1, dorsal, and related matters
RL Cell 62:841-843 (1990).
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RA Lewin B.
RT Oncogenic conversion by regulatory changes in transcription factors
RL Cell 64:303-312 (1991).
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RX PUBMED: 2001591.
RA Nolan G. P., Gosh S., Liou H.-C., Tempst P., Baltimore D.
RT DNA binding and IkappaB inhibition of the cloned p65 subunit of NF-kappaB, a rel-related polypeptide
RL Cell 64:961-969 (1991).
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RA Ballard D. W., Walker W. H., Doerre S., Sista P., Molitor J. A., Dixon E. P., Peffer N. J., Hannink M., Greene W. C.
RT The v-rel oncogene encodes a kappaB enhancer binding protein that inhibits NF-kappaB function
RL Cell 63:803-814 (1990).
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RX PUBMED: 3076097.
RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D.
RT Phorbol-ester-induced activation of the NF-kappaB transcription factor involves dissociation of an apparently cytoplasmic NF-kappaB/inhibitor complex
RL Cold Spring Harb. Symp. Quant. Biol. 53:789-798 (1988).
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RA Wirth T., Baltimore D.
RT Nuclear factor NF-kB can interact functionally with its cognate binding site to provide lymphoid-specific promoter function
RL EMBO J. 7:3109-3113 (1988).
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RA Urban M. B., Schreck R., Baeuerle P. A.
RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit
RL EMBO J. 10:1817-1825 (1991).
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RA Logeat F., Israel N., Ten R., Blank V., Le Bail O., Kourilsky P., Israel A.
RT Inhibition of transcription factors belonging to the rel/NF-kappaB family by a transdominant negative mutant
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RA Hagman J., Rudin Ch. M., Haasch D., Chaplin D., Storb U.
RT A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NFkB
RL Genes Dev. 4:987-992 (1990).
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RA Hohmann H.-P., Brockhaus M., Baeuerle P. A., Remy R., Kolbeck R., van Loon A. P. G. M.
RT Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappaB
RL J. Biol. Chem. 265:22409-22417 (1990).
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RX PUBMED: 2542770.
RA Shirakawa F., Chedid M., Suttles J., Pollok B. A., Mizel S. B.
RT Interleukin 1 and Cyclic AMP Induce k Immunoglobulin Light-Chain Expression vis Activation of an NF-kB-Like DNA-Binding Protein
RL Mol. Cell. Biol. 9:959-964 (1989).
RN [15]; RE0001309.
RX PUBMED: 2496303.
RA Blanar M. A., Burkly L. C., Flavell R. A.
RT NF-kB Binds within a Region Required for B-Cell-Specific Expression of the Major Histocompatibility Complex Class II Gene E
RL Mol. Cell. Biol. 9:844-846 (1989).
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RX PUBMED: 2405250.
RA Shimizu H., Mitomo K., Watanabe T., Okamoto S., Yamamoto K.-I.
RT Involvment of a NK-kB-Like Transcription Factor in the Activation of the Interleukin-6 Gene by Inflammatory Lymphokines
RL Mol. Cell. Biol. 10:561-568 (1990).
RN [17]; RE0001505.
RX PUBMED: 1922027.
RA Baldwin jr A. S., Azizkhan J. C., Jensen D. E., Beg A. A., Coodly L. R.
RT Induction of NF-kappaB DNA-binding activity during G0-to-G1 transition in mouse fibroblasts
RL Mol. Cell. Biol. 11:4943-4951 (1991).
RN [18]; RE0001632.
RX PUBMED: 2548081.
RA Shirakawa F., Mizel S. B.
RT In vitro activation and nuclear translocation of NF-kappaB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C
RL Mol. Cell. Biol. 9:2424-2430 (1991).
RN [19]; RE0001807.
RX PUBMED: 2157987.
RA Ghosh S., Baltimore D.
RT Activation in vitro of NF-kappaB by phosphorylation of its inhibitor IkappaB
RL Nature 344:678-682 (1990).
RN [20]; RE0002002.
RX PUBMED: 2830597.
RA Hromas R., Pauli U., Marcuzzi A., Lafrenz D., Nick H., Stein J., Stein G., van Ness B.
RT Inducible DNA-protein interactions of the murine kappa immunoglobulin enhancer in intact cells: comparison with in vitro interactions
RL Nucleic Acids Res. 16:953-967 (1988).
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RX PUBMED: 2263603.
RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C.
RT NF-kappaB: a family of inducible and differentially expressed enhancer-binding proteins in human T cells
RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990).
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RX PUBMED: 3143155.
RA Briskin M., Kuwabara M. D., Sigman D. S., Wall R.
RT Induction of kappa transcription by interferon-gamma without activation of NF-kappaB
RL Science 242:1036-1037 (1988).
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RX PUBMED: 8449662.
RA Grilli M., Chiu J. J.-S., Lenardo M. J.
RT NF-kappaB and Rel: Participants in a multiform transcriptional regulatory system
RL Int. Rev. Cytol. 143:1-62 (1993).
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RX PUBMED: 8196632.
RA Zhang Q., Didonato J. A., Karin M., McKeithan T. W.
RT BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappaB proteins
RL Mol. Cell. Biol. 14:3915-3926 (1994).
RN [25]; RE0004500.
RX PUBMED: 8336714.
RA Diaz-Meco M. T., Berra E., Municio M. M., Sanz L., Lozano J., Dominguez I., Diaz-Golpe V., Lain De Lera M. T., Alcami J., Paya C. V., Arenzana-Seisdedos F., Virelizier J.-L., Moscat J.
RT A dominant negative protein kinase C zeta subspecies blocks NF- kappaB activation
RL Mol. Cell. Biol. 13:4770-4775 (1993).
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RA Sen R., Baltimore D.
RT Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappaB by a posttranslational mechanism
RL Cell 47:921-928 (1986).
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RA Fujita T., Nolan G. P., Ghosh S., Baltimore D.
RT Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappaB
RL Genes Dev. 6:775-787 (1992).
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RA Lernbecher T., Mueller U., Wirth T.
RT Distinct NF-kappaB/Rel transcription factors are responsible for tissue-specific and inducible gene activation
RL Nature 365:767-770 (1993).
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RA Klug C. A., Gerety S. J., Shah P. C., Chen Y.-Y., Rice N. R., Rosenberg N., Singh H.
RT The v-abl tyrosine kinase negatively regulates NF-kappaB/Rel factors and blocks kappa gene transcription in pre-B lymphocytes
RL Genes Dev. 8:678-687 (1994).
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RA Miyamoto S., Schmitt M. J., Verma I. M.
RT Qualitative changes in the subunit composition of kappa-binding complexes during murine B-cell differentiation
RL Proc. Natl. Acad. Sci. USA 91:5056-5060 (1994).
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RA Mogensen T. H., Melchjorsen J., Hollsberg P., Paludan S. R.
RT Activation of NF-kappa B in virus-infected macrophages is dependent on mitochondrial oxidative stress and intracellular calcium: downstream involvement of the kinases TGF-beta-activated kinase 1, mitogen-activated kinase/extracellular signal-regulated kinase kinase 1, and I kappa B kinase.
RL J. Immunol. 170:6224-6233 (2003).
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RA Xu H., An H., Hou J., Han C., Wang P., Yu Y., Cao X.
RT Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages.
RL Mol. Immunol. 45:3545-3552 (2008).
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RA Goodridge H. S., Shimada T., Wolf A. J., Hsu Y. M., Becker C. A., Lin X., Underhill D. M.
RT Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.
RL J. Immunol. 182:1146-1154 (2009).
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RX PUBMED: 16356855.
RA Sommer K., Guo B., Pomerantz J. L., Bandaranayake A. D., Moreno-Garcia M. E., Ovechkina Y. L., Rawlings D. J.
RT Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
RL Immunity 23:561-574 (2005).
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RA Persson E., Voznesensky O. S., Huang Y. F., Lerner U. H.
RT Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts.
RL Bone 37:513-529 (2005).
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RA Bi L., Gorjestani S., Wu W., Hsu Y. M., Zhu J., Ariizumi K., Lin X.
RT CARD9 mediates Dectin-2-induced IKK ubiquitination leading to activation of NF-kappaB in response to the stimulation by the hyphal form of Candida albicans.
RL J. Biol. Chem. 285:25969-25977 (2010).
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