TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00588 XX ID T00588 XX DT 15.10.1992 (created); ewi. DT 16.04.2015 (updated); asv. CO Copyright (C), QIAGEN. XX FA NF-kappaB XX SY NF-kappaB; NF-kappaB complex; Nuclear Factor kappa B; Nuclear Factor kappa B p50:p65; p50/p65. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX CL C0020; Rel. XX SF constituent complexes may be p50 T01923 homodimers or heterodimers of p50/p65 T01923 T00595, p50/RelB T01923 T01932, or p50/c-Rel T01923 T00169 [27] [28] [30]; XX FF Dectin1 mediates heat inactivated Candida albicans (fungal pathogen) and zymosan induced NF-kappaB activation [36]; FF DNA binding activity of NF-kappaB is increased following the treatment with recombinant human IL-1beta [35]; FF inducible activator, induced by many agents: e. g. TNF, PKA- or PKC-mediated signals and dsRNA [8] [23] [25] [26] [13] [18] [14]; XX IN T00168 c-Rel; human, Homo sapiens. IN T00950 IkappaB-alpha; human, Homo sapiens. IN T00414 IkappaB-beta; human, Homo sapiens. IN T00416 IkappaB-beta; chick, Gallus gallus. IN T00971 IkappaB-beta; mouse, Mus musculus. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). XX MX M00054 V$NFKAPPAB_01. MX M08891 V$NFKB1_Q4. MX M00208 V$NFKB_C. MX M00194 V$NFKB_Q6. MX M00774 V$NFKB_Q6_01. XX BS R05893. BS R05894. BS R05895. BS R05896. BS R05897. BS R05898. BS R05899. BS R05900. BS R05901. BS R05902. BS R05903. BS R05904. BS R05905. BS R05906. BS R05907. BS R05908. BS R05909. BS R05910. BS R05911. BS R05912. BS R05913. BS R05914. BS R05915. BS R05916. BS R05917. BS R05918. BS R05919. BS R05920. BS R05921. BS R05922. BS R05923. BS R05924. BS R05925. BS R05926. BS R05927. BS R05928. BS R05929. BS R05930. BS R05931. BS R05932. BS R20825. BS R20924. BS R02668. BS R20630. BS R24493. BS R01766. BS R26202. BS R19592. BS R00699. BS R00702. BS R25431. BS R29232. BS R29238. BS R00923. BS R24519. BS R14486. BS R25017. BS R73961. BS R30641. BS R14565. BS R24497. BS R36039. BS R35491. BS R32902. BS R17095. BS R32165. BS R30569. BS R26211. BS R00606. BS R60351. BS R60361. BS R27179. BS R38722. BS R38724. BS R14717. BS R24927. BS R22547. BS R33966. BS R33968. BS R18417. BS R28681. BS R59752. BS R73953. BS R74051. BS R00877. BS R25606. BS R14483. BS R26676. BS R74074. BS R27473. BS R27474. BS R02951. BS R24514. BS R30497. BS R23523. BS R01058. BS R01060. BS R01071. BS R01607. BS R13259. BS R08126. BS R08131. BS R26673. BS R21225. BS R24784. BS R34521. BS R29548. BS R29562. BS R32894. BS R22352. BS R22353. BS R14690. BS R14691. BS R01448. BS R14783. BS R14784. BS R14785. BS R25059. BS R25734. BS R33557. BS R35831. BS R02217. BS R04556. BS R01887. BS R29144. XX DR TRANSPATH: MO000019668. DR TRANSCOMPEL: C00183. DR TRANSCOMPEL: C00192. DR TRANSCOMPEL: C00257. DR TRANSCOMPEL: C00258. DR TRANSCOMPEL: C00301. DR TRANSCOMPEL: C00311. DR TRANSCOMPEL: C00337. DR TRANSCOMPEL: C00339. XX RN [1]; RE0000089. RX PUBMED: 3098435. RA Atchison M. L., Perry R. P. RT The Role of the kappa Enhancer and Its Binding Factor NF-kB in the Developmental Regulation of kappa Gene Transcription RL Cell 48:121-128 (1987). RN [2]; RE0000090. RX PUBMED: 3129195. RA Baeuerle P. A., Baltimore D. RT Activation of DNA-Binding Activity in an Apparently Cytoplasmic Precursor of the NF-kB Transcription Factor RL Cell 53:211-217 (1988). RN [3]; RE0000093. RX PUBMED: 2495183. RA Lenardo M. J., Fan C.-M., Maniatis T., Baltimore D. RT The Involvement of NF-kB in beta-Interferon Gene Regulation Reveals Its Role as Widely Inducible Mediator of Signal Transduction RL Cell 57:287-294 (1989). RN [4]; RE0000169. RX PUBMED: 2203533. RA Gilmore T. D. RT NF-kappaB, KBF1, dorsal, and related matters RL Cell 62:841-843 (1990). RN [5]; RE0000174. RX PUBMED: 1988149. RA Lewin B. RT Oncogenic conversion by regulatory changes in transcription factors RL Cell 64:303-312 (1991). RN [6]; RE0000176. RX PUBMED: 2001591. RA Nolan G. P., Gosh S., Liou H.-C., Tempst P., Baltimore D. RT DNA binding and IkappaB inhibition of the cloned p65 subunit of NF-kappaB, a rel-related polypeptide RL Cell 64:961-969 (1991). RN [7]; RE0000216. RX PUBMED: 2225078. RA Ballard D. W., Walker W. H., Doerre S., Sista P., Molitor J. A., Dixon E. P., Peffer N. J., Hannink M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). RN [8]; RE0000285. RX PUBMED: 3076097. RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB transcription factor involves dissociation of an apparently cytoplasmic NF-kappaB/inhibitor complex RL Cold Spring Harb. Symp. Quant. Biol. 53:789-798 (1988). RN [9]; RE0000372. RX PUBMED: 3141147. RA Wirth T., Baltimore D. RT Nuclear factor NF-kB can interact functionally with its cognate binding site to provide lymphoid-specific promoter function RL EMBO J. 7:3109-3113 (1988). RN [10]; RE0000458. RX PUBMED: 2050119. RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [11]; RE0000517. RX PUBMED: 1675604. RA Logeat F., Israel N., Ten R., Blank V., Le Bail O., Kourilsky P., Israel A. RT Inhibition of transcription factors belonging to the rel/NF-kappaB family by a transdominant negative mutant RL EMBO J. 10:1827-1832 (1991). RN [12]; RE0000658. RX PUBMED: 2116989. RA Hagman J., Rudin Ch. M., Haasch D., Chaplin D., Storb U. RT A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NFkB RL Genes Dev. 4:987-992 (1990). RN [13]; RE0000978. RX PUBMED: 2176217. RA Hohmann H.-P., Brockhaus M., Baeuerle P. A., Remy R., Kolbeck R., van Loon A. P. G. M. RT Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappaB RL J. Biol. Chem. 265:22409-22417 (1990). RN [14]; RE0001296. RX PUBMED: 2542770. RA Shirakawa F., Chedid M., Suttles J., Pollok B. A., Mizel S. B. RT Interleukin 1 and Cyclic AMP Induce k Immunoglobulin Light-Chain Expression vis Activation of an NF-kB-Like DNA-Binding Protein RL Mol. Cell. Biol. 9:959-964 (1989). RN [15]; RE0001309. RX PUBMED: 2496303. RA Blanar M. A., Burkly L. C., Flavell R. A. RT NF-kB Binds within a Region Required for B-Cell-Specific Expression of the Major Histocompatibility Complex Class II Gene E RL Mol. Cell. Biol. 9:844-846 (1989). RN [16]; RE0001422. RX PUBMED: 2405250. RA Shimizu H., Mitomo K., Watanabe T., Okamoto S., Yamamoto K.-I. RT Involvment of a NK-kB-Like Transcription Factor in the Activation of the Interleukin-6 Gene by Inflammatory Lymphokines RL Mol. Cell. Biol. 10:561-568 (1990). RN [17]; RE0001505. RX PUBMED: 1922027. RA Baldwin jr A. S., Azizkhan J. C., Jensen D. E., Beg A. A., Coodly L. R. RT Induction of NF-kappaB DNA-binding activity during G0-to-G1 transition in mouse fibroblasts RL Mol. Cell. Biol. 11:4943-4951 (1991). RN [18]; RE0001632. RX PUBMED: 2548081. RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 9:2424-2430 (1991). RN [19]; RE0001807. RX PUBMED: 2157987. RA Ghosh S., Baltimore D. RT Activation in vitro of NF-kappaB by phosphorylation of its inhibitor IkappaB RL Nature 344:678-682 (1990). RN [20]; RE0002002. RX PUBMED: 2830597. RA Hromas R., Pauli U., Marcuzzi A., Lafrenz D., Nick H., Stein J., Stein G., van Ness B. RT Inducible DNA-protein interactions of the murine kappa immunoglobulin enhancer in intact cells: comparison with in vitro interactions RL Nucleic Acids Res. 16:953-967 (1988). RN [21]; RE0002417. RX PUBMED: 2263603. RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [22]; RE0002609. RX PUBMED: 3143155. RA Briskin M., Kuwabara M. D., Sigman D. S., Wall R. RT Induction of kappa transcription by interferon-gamma without activation of NF-kappaB RL Science 242:1036-1037 (1988). RN [23]; RE0004441. RX PUBMED: 8449662. RA Grilli M., Chiu J. J.-S., Lenardo M. J. RT NF-kappaB and Rel: Participants in a multiform transcriptional regulatory system RL Int. Rev. Cytol. 143:1-62 (1993). RN [24]; RE0004492. RX PUBMED: 8196632. RA Zhang Q., Didonato J. A., Karin M., McKeithan T. W. RT BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappaB proteins RL Mol. Cell. Biol. 14:3915-3926 (1994). RN [25]; RE0004500. RX PUBMED: 8336714. RA Diaz-Meco M. T., Berra E., Municio M. M., Sanz L., Lozano J., Dominguez I., Diaz-Golpe V., Lain De Lera M. T., Alcami J., Paya C. V., Arenzana-Seisdedos F., Virelizier J.-L., Moscat J. RT A dominant negative protein kinase C zeta subspecies blocks NF- kappaB activation RL Mol. Cell. Biol. 13:4770-4775 (1993). RN [26]; RE0004511. RX PUBMED: 3096580. RA Sen R., Baltimore D. RT Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappaB by a posttranslational mechanism RL Cell 47:921-928 (1986). RN [27]; RE0004518. RX PUBMED: 1577272. RA Fujita T., Nolan G. P., Ghosh S., Baltimore D. RT Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappaB RL Genes Dev. 6:775-787 (1992). RN [28]; RE0004522. RX PUBMED: 7692309. RA Lernbecher T., Mueller U., Wirth T. RT Distinct NF-kappaB/Rel transcription factors are responsible for tissue-specific and inducible gene activation RL Nature 365:767-770 (1993). RN [29]; RE0004530. RX PUBMED: 7926758. RA Klug C. A., Gerety S. J., Shah P. C., Chen Y.-Y., Rice N. R., Rosenberg N., Singh H. RT The v-abl tyrosine kinase negatively regulates NF-kappaB/Rel factors and blocks kappa gene transcription in pre-B lymphocytes RL Genes Dev. 8:678-687 (1994). RN [30]; RE0004531. RX PUBMED: 8197184. RA Miyamoto S., Schmitt M. J., Verma I. M. RT Qualitative changes in the subunit composition of kappa-binding complexes during murine B-cell differentiation RL Proc. Natl. Acad. Sci. USA 91:5056-5060 (1994). RN [31]; RE0053934. RX PUBMED: 12794154. RA Mogensen T. H., Melchjorsen J., Hollsberg P., Paludan S. R. RT Activation of NF-kappa B in virus-infected macrophages is dependent on mitochondrial oxidative stress and intracellular calcium: downstream involvement of the kinases TGF-beta-activated kinase 1, mitogen-activated kinase/extracellular signal-regulated kinase kinase 1, and I kappa B kinase. RL J. Immunol. 170:6224-6233 (2003). RN [32]; RE0065206. RX PUBMED: 18571728. RA Xu H., An H., Hou J., Han C., Wang P., Yu Y., Cao X. RT Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages. RL Mol. Immunol. 45:3545-3552 (2008). RN [33]; RE0068120. RX PUBMED: 19124758. RA Goodridge H. S., Shimada T., Wolf A. J., Hsu Y. M., Becker C. A., Lin X., Underhill D. M. RT Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. RL J. Immunol. 182:1146-1154 (2009). RN [34]; RE0069996. RX PUBMED: 16356855. RA Sommer K., Guo B., Pomerantz J. L., Bandaranayake A. D., Moreno-Garcia M. E., Ovechkina Y. L., Rawlings D. J. RT Phosphorylation of the CARMA1 linker controls NF-kappaB activation. RL Immunity 23:561-574 (2005). RN [35]; RE0052261. RX PUBMED: 16085472. RA Persson E., Voznesensky O. S., Huang Y. F., Lerner U. H. RT Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts. RL Bone 37:513-529 (2005). RN [36]; RE0067372. RX PUBMED: 20538615. RA Bi L., Gorjestani S., Wu W., Hsu Y. M., Zhu J., Ariizumi K., Lin X. RT CARD9 mediates Dectin-2-induced IKK ubiquitination leading to activation of NF-kappaB in response to the stimulation by the hyphal form of Candida albicans. RL J. Biol. Chem. 285:25969-25977 (2010). XX //