TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00168 XX ID T00168 XX DT 15.10.1992 (created); ewi. DT 12.06.2015 (updated); hna. CO Copyright (C), QIAGEN. XX FA c-Rel XX SY c-Rel; HIVEN86A; Nuclear Factor kappa B c-Rel; p68; p82(hc-rel). XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004960 REL; HGNC: REL. XX CL C0020; Rel; XX SF overlapping DNA-binding specificity with NF-kappaB T00590; SF exclusive binding to, e. g., intronic enhancer of IFN-gamma gene (AGGGATTT) [11]; SF trans-activation through physical interaction with TBP [13]; XX CP (HeLa); UT-7/TPO, Megakaryocytes [17]; HUVEC [18]. XX FF potent activator as homo- or heterodimer with RelA T00594 [10] [15]; FF may also repress trans-activation by induced RelA [9]; FF relA gene is activated by RelA, but repressed by c-Rel itself [9]; FF DNA-binding by c-Rel is induced by HTLV-I Tax which abrogates the negative feed-back regulation [9] [12]; XX IN T00168 c-Rel; human, Homo sapiens. IN T00416 IkappaB-beta; chick, Gallus gallus. IN T00971 IkappaB-beta; mouse, Mus musculus. IN T22412 IkappaB-epsilon; human, Homo sapiens. IN T01924 NF-kappaB1-isoform1; mouse, Mus musculus. IN T00593 NF-kappaB1-p50; human, Homo sapiens. IN T01925 NF-kappaB1; human, Homo sapiens. IN T01927 NF-kappaB2-p100; human, Homo sapiens. IN T00394 NF-kappaB2-p52; human, Homo sapiens. IN T00587 NF-kappaB; rat, Rattus norvegicus. IN T00588 NF-kappaB; mouse, Mus musculus. IN T00590 NF-kappaB; human, Homo sapiens. IN T01929 p100; chick, Gallus gallus. IN T00594 RelA-p65-isoform1; human, Homo sapiens. IN T00595 RelA-p65; mouse, Mus musculus. IN T00794 TBP; human, Homo sapiens. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). XX MX M00053 V$CREL_01. MX M03545 V$CREL_Q6. XX BS R61153. BS R04704. BS R00699. BS R02173. BS R39203. BS R30510. BS R40311. BS R14436. BS R21071. BS R37622. BS R37626. BS R37631. BS R60309. BS R35327. BS R74080. BS R35458. BS R72343. BS R39859. BS R00923. BS R14486. BS R14492. BS R00940. BS R00943. BS R29952. BS R03673. BS R30935. BS R35342. BS R24123. BS R25474. BS R25475. BS R60487. BS R73764. BS R63623. BS R68249. BS R68253. BS R66698. BS R66699. BS R66701. BS R37632. BS R37636. BS R37640. BS R57945. BS R57950. BS R26907. BS R14565. BS R72342. BS R14483. BS R65612. BS R02951. BS R01058. XX DR TRANSPATH: MO000019368. DR TRANSCOMPEL: C00168. DR TRANSCOMPEL: C00344. DR TRANSCOMPEL: C00345. DR TRANSCOMPEL: C00349. DR UniProtKB: Q04864; REL_HUMAN. XX RN [1]; RE0000100. RX PUBMED: 2836068. RA Boehnlein E., Lowenthal J. W., Siekevitz M., Ballard D. W., Franza B. R., Greene W. C. RT The Same Inducible Nuclear Protein Regulates Mitogen Activation of Both the Interleukin-2 Receptor-Alpha Gene and Type 1 HIV RL Cell 53:827-836 (1988). RN [2]; RE0000216. RX PUBMED: 2225078. RA Ballard D. W., Walker W. H., Doerre S., Sista P., Molitor J. A., Dixon E. P., Peffer N. J., Hannink M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). RN [3]; RE0001791. RX PUBMED: 2825023. RA Franza jr B. R., Josephs S. F., Gilman M. Z., Ryan W., Clarkson B. RT Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay RL Nature 330:391-395 (1987). RN [4]; RE0002417. RX PUBMED: 2263603. RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [5]; RE0002922. RX PUBMED: 1406630. RA Kunsch C., Ruben S. M., Rosen C. A. RT Selection of optimal kappaB/Rel DNA-binding motifs: interaction of both subunits of NF-kappaB with DNA is required for transcriptional activation RL Mol. Cell. Biol. 12:4412-4421 (1992). RN [6]; RE0004480. RX PUBMED: 3016517. RA Brownell E., Brien S. J., Nash W. G., Rice N. RT Genetic characterization of human c-rel sequences RL Mol. Cell. Biol. 5:2826-2831 (1985). RN [7]; RE0004507. RX PUBMED: 7925300. RA Naumann M., Scheidereit C. RT Activation of NF-6B in vivo is regulated by multiple phosphorylations RL EMBO J. 13:4597-4607 (1994). RN [8]; RE0004559. RX PUBMED: 1740106. RA Hansen S. K., Nerlov C., Zabel U., Verde P., Johnsen M., Baeuerle P., Blasi F. RT A novel complex between the p65 subunit of NF-kappaB and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene RL EMBO J. 11:205-213 (1992). RN [9]; RE0004565. RX PUBMED: 7935451. RA Sun S.-C., Elwood J., Beraud C., Greene W. C. RT Human T-cell leukemia virus type I Tax activation of NF-kappaB/Rel involves phosphorylation and degradation of IkappaBalpha and RelA (p65)-mediated induction of the c-rel gene RL Mol. Cell. Biol. 14:7377-7384 (1994). RN [10]; RE0004574. RX PUBMED: 1903456. RA Richardson P. M., Gilmore T. D. RT vRel is an inactive member of the Rel family of transcriptional activating proteins RL J. Virol. 65:3122-3130 (1991). RN [11]; RE0004575. RX PUBMED: 1542667. RA Sica A., Tan T.-H., Rice N. R., Kretzschmar M., Ghosh P., Young H. A. RT The c-rel protooncogene product c-Rel but not NF-6B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response gene RL Proc. Natl. Acad. Sci. USA 89:1740-1744 (1992). RN [12]; RE0004576. RX PUBMED: 8455941. RA Crenon I., Beraud C., Simard P., Montagne J., Veschambre P., Jalinot P. RT The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2Ralpha kappaB enhancer include the product of the c-rel proto-oncogene RL Oncogene 8:867-875 (1993). RN [13]; RE0004577. RX PUBMED: 8413585. RA Kerr L. D., Ransone L. J., Wamsley P., Schmitt M. J., Boyer T. G., Zhou Q., Berk A. J., Verma I. M. RT Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappaB RL Nature 365:412-419 (1993). RN [14]; RE0004580. RX PUBMED: 8430069. RA Doerre S., Sista P., Sun S.-C., Ballard D. W., Greene W. C. RT The c-rel protooncogene product represses NF-kappaB p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus RL Proc. Natl. Acad. Sci. USA 90:1023-1027 (1993). RN [15]; RE0004581. RX PUBMED: 8139561. RA Hansen S. K., Baeuerle P. A., Blasi F. RT Purification, reconstitution, and IkappaB association of the c-RelBp65 (RelA) complex, a strong activator of transcription RL Mol. Cell. Biol. 14:2593-2603 (1994). RN [16]; RE0013471. RX PUBMED: 9135156. RA Whiteside S. T., Epinat J. C., Rice N. R., Israel A. RT I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. RL EMBO J. 16:1413-1426 (1997). RN [17]; RE0029138. RX PUBMED: 11756417. RA Kirito K., Watanabe T., Sawada K., Endo H., Ozawa K., Komatsu N. RT Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways. RL J. Biol. Chem. 277:8329-37 (2002). RN [18]; RE0053454. RX PUBMED: 17675290. RA Wang J., Mahmud S. A., Bitterman P. B., Huo Y., Slungaard A. RT Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. RL J. Biol. Chem. 282:28408-28418 (2007). RN [19]; RE0054190. RX PUBMED: 12820969. RA Saccani S., Pantano S., Natoli G. RT Modulation of NF-kappaB activity by exchange of dimers. RL Mol. Cell 11:1563-1574 (2003). RN [20]; RE0065087. RX PUBMED: 17652082. RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B. RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation. RL J. Biol. Chem. 282:27229-27238 (2007). RN [21]; RE0069524. RX PUBMED: 19880579. RA Chang J. W., Koike T., Iwashima M. RT hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation. RL Int. Immunol. 21:1351-1361 (2009). XX //