AC T00168
XX
ID T00168
XX
DT 15.10.1992 (created); ewi.
DT 12.06.2015 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA c-Rel
XX
SY c-Rel; HIVEN86A; Nuclear Factor kappa B c-Rel; p68; p82(hc-rel).
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004960 REL; HGNC: REL.
XX
CL C0020; Rel; 6.1.1.2.3.
XX
SF overlapping DNA-binding specificity with NF-kappaB T00590;
SF exclusive binding to, e. g., intronic enhancer of IFN-gamma gene (AGGGATTT) [11];
SF trans-activation through physical interaction with TBP [13];
XX
CP (HeLa); UT-7/TPO, Megakaryocytes [17]; HUVEC [18].
XX
FF potent activator as homo- or heterodimer with RelA T00594 [10] [15];
FF may also repress trans-activation by induced RelA [9];
FF relA gene is activated by RelA, but repressed by c-Rel itself [9];
FF DNA-binding by c-Rel is induced by HTLV-I Tax which abrogates the negative feed-back regulation [9] [12];
XX
IN T00168 c-Rel; human, Homo sapiens.
IN T00416 IkappaB-beta; chick, Gallus gallus.
IN T00971 IkappaB-beta; mouse, Mus musculus.
IN T22412 IkappaB-epsilon; human, Homo sapiens.
IN T01924 NF-kappaB1-isoform1; mouse, Mus musculus.
IN T00593 NF-kappaB1-p50; human, Homo sapiens.
IN T01925 NF-kappaB1; human, Homo sapiens.
IN T01927 NF-kappaB2-p100; human, Homo sapiens.
IN T00394 NF-kappaB2-p52; human, Homo sapiens.
IN T00587 NF-kappaB; rat, Rattus norvegicus.
IN T00588 NF-kappaB; mouse, Mus musculus.
IN T00590 NF-kappaB; human, Homo sapiens.
IN T01929 p100; chick, Gallus gallus.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T00595 RelA-p65; mouse, Mus musculus.
IN T00794 TBP; human, Homo sapiens.
IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T).
XX
MX M00053 V$CREL_01.
MX M03545 V$CREL_Q6.
XX
BS R61153.
BS R04704.
BS R00699.
BS R02173.
BS R39203.
BS R30510.
BS R40311.
BS R14436.
BS R21071.
BS R37622.
BS R37626.
BS R37631.
BS R60309.
BS R35327.
BS R74080.
BS R35458.
BS R72343.
BS R39859.
BS R00923.
BS R14486.
BS R14492.
BS R00940.
BS R00943.
BS R29952.
BS R03673.
BS R30935.
BS R35342.
BS R24123.
BS R25474.
BS R25475.
BS R60487.
BS R73764.
BS R63623.
BS R68249.
BS R68253.
BS R66698.
BS R66699.
BS R66701.
BS R37632.
BS R37636.
BS R37640.
BS R57945.
BS R57950.
BS R26907.
BS R14565.
BS R72342.
BS R14483.
BS R65612.
BS R02951.
BS R01058.
XX
DR TRANSPATH: MO000019368.
DR TRANSCOMPEL: C00168.
DR TRANSCOMPEL: C00344.
DR TRANSCOMPEL: C00345.
DR TRANSCOMPEL: C00349.
DR UniProtKB: Q04864; REL_HUMAN.
XX
RN [1]; RE0000100.
RX PUBMED: 2836068.
RA Boehnlein E., Lowenthal J. W., Siekevitz M., Ballard D. W., Franza B. R., Greene W. C.
RT The Same Inducible Nuclear Protein Regulates Mitogen Activation of Both the Interleukin-2 Receptor-Alpha Gene and Type 1 HIV
RL Cell 53:827-836 (1988).
RN [2]; RE0000216.
RX PUBMED: 2225078.
RA Ballard D. W., Walker W. H., Doerre S., Sista P., Molitor J. A., Dixon E. P., Peffer N. J., Hannink M., Greene W. C.
RT The v-rel oncogene encodes a kappaB enhancer binding protein that inhibits NF-kappaB function
RL Cell 63:803-814 (1990).
RN [3]; RE0001791.
RX PUBMED: 2825023.
RA Franza jr B. R., Josephs S. F., Gilman M. Z., Ryan W., Clarkson B.
RT Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay
RL Nature 330:391-395 (1987).
RN [4]; RE0002417.
RX PUBMED: 2263603.
RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C.
RT NF-kappaB: a family of inducible and differentially expressed enhancer-binding proteins in human T cells
RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990).
RN [5]; RE0002922.
RX PUBMED: 1406630.
RA Kunsch C., Ruben S. M., Rosen C. A.
RT Selection of optimal kappaB/Rel DNA-binding motifs: interaction of both subunits of NF-kappaB with DNA is required for transcriptional activation
RL Mol. Cell. Biol. 12:4412-4421 (1992).
RN [6]; RE0004480.
RX PUBMED: 3016517.
RA Brownell E., Brien S. J., Nash W. G., Rice N.
RT Genetic characterization of human c-rel sequences
RL Mol. Cell. Biol. 5:2826-2831 (1985).
RN [7]; RE0004507.
RX PUBMED: 7925300.
RA Naumann M., Scheidereit C.
RT Activation of NF-6B in vivo is regulated by multiple phosphorylations
RL EMBO J. 13:4597-4607 (1994).
RN [8]; RE0004559.
RX PUBMED: 1740106.
RA Hansen S. K., Nerlov C., Zabel U., Verde P., Johnsen M., Baeuerle P., Blasi F.
RT A novel complex between the p65 subunit of NF-kappaB and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene
RL EMBO J. 11:205-213 (1992).
RN [9]; RE0004565.
RX PUBMED: 7935451.
RA Sun S.-C., Elwood J., Beraud C., Greene W. C.
RT Human T-cell leukemia virus type I Tax activation of NF-kappaB/Rel involves phosphorylation and degradation of IkappaBalpha and RelA (p65)-mediated induction of the c-rel gene
RL Mol. Cell. Biol. 14:7377-7384 (1994).
RN [10]; RE0004574.
RX PUBMED: 1903456.
RA Richardson P. M., Gilmore T. D.
RT vRel is an inactive member of the Rel family of transcriptional activating proteins
RL J. Virol. 65:3122-3130 (1991).
RN [11]; RE0004575.
RX PUBMED: 1542667.
RA Sica A., Tan T.-H., Rice N. R., Kretzschmar M., Ghosh P., Young H. A.
RT The c-rel protooncogene product c-Rel but not NF-6B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response gene
RL Proc. Natl. Acad. Sci. USA 89:1740-1744 (1992).
RN [12]; RE0004576.
RX PUBMED: 8455941.
RA Crenon I., Beraud C., Simard P., Montagne J., Veschambre P., Jalinot P.
RT The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2Ralpha kappaB enhancer include the product of the c-rel proto-oncogene
RL Oncogene 8:867-875 (1993).
RN [13]; RE0004577.
RX PUBMED: 8413585.
RA Kerr L. D., Ransone L. J., Wamsley P., Schmitt M. J., Boyer T. G., Zhou Q., Berk A. J., Verma I. M.
RT Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappaB
RL Nature 365:412-419 (1993).
RN [14]; RE0004580.
RX PUBMED: 8430069.
RA Doerre S., Sista P., Sun S.-C., Ballard D. W., Greene W. C.
RT The c-rel protooncogene product represses NF-kappaB p65-mediated transcriptional activation of the long terminal repeat of type 1 human immunodeficiency virus
RL Proc. Natl. Acad. Sci. USA 90:1023-1027 (1993).
RN [15]; RE0004581.
RX PUBMED: 8139561.
RA Hansen S. K., Baeuerle P. A., Blasi F.
RT Purification, reconstitution, and IkappaB association of the c-RelBp65 (RelA) complex, a strong activator of transcription
RL Mol. Cell. Biol. 14:2593-2603 (1994).
RN [16]; RE0013471.
RX PUBMED: 9135156.
RA Whiteside S. T., Epinat J. C., Rice N. R., Israel A.
RT I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
RL EMBO J. 16:1413-1426 (1997).
RN [17]; RE0029138.
RX PUBMED: 11756417.
RA Kirito K., Watanabe T., Sawada K., Endo H., Ozawa K., Komatsu N.
RT Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways.
RL J. Biol. Chem. 277:8329-37 (2002).
RN [18]; RE0053454.
RX PUBMED: 17675290.
RA Wang J., Mahmud S. A., Bitterman P. B., Huo Y., Slungaard A.
RT Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes.
RL J. Biol. Chem. 282:28408-28418 (2007).
RN [19]; RE0054190.
RX PUBMED: 12820969.
RA Saccani S., Pantano S., Natoli G.
RT Modulation of NF-kappaB activity by exchange of dimers.
RL Mol. Cell 11:1563-1574 (2003).
RN [20]; RE0065087.
RX PUBMED: 17652082.
RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B.
RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
RL J. Biol. Chem. 282:27229-27238 (2007).
RN [21]; RE0069524.
RX PUBMED: 19880579.
RA Chang J. W., Koike T., Iwashima M.
RT hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation.
RL Int. Immunol. 21:1351-1361 (2009).
XX
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