TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00971 XX ID T00971 XX DT 30.06.1993 (created); ewi. DT 10.01.2011 (updated); din. CO Copyright (C), QIAGEN. XX FA IkappaB-beta XX SY IkappaB-beta; IkB; IKB-beta; IKBB; inhibitor kappaB beta; MGC36057; Nfkbib; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G014471 Nfkbib. XX CL C0020; Rel; XX SF association with c-Rel and RelA has been proven in vitro and in vivo [4]; SF pI(calc) = 4.6 [4]; SF pI(exp) = 4.8-5.0 [5]; SF no interaction with NF-kappaB1 (p50) [4]; XX CP testis (very high levels), spleen, lower in brain, heart, liver, lung [4]. XX FF inhibitor of NF-kappaB, c-Rel and v-Rel [2] [4]; FF expression of IkappaB-beta is not upregulated by NF-kappaB, TPA, or TNF-alpha [4]; FF LPS and IL-1 decrease IkappaB-beta levels [4]; FF rapid degradation a by chymotrypsin-like protease [4]; FF binding to NF-kappaB can be suppressed by PKA, PKC, or phosphatase treatment [5]; XX IN T00168 c-Rel; human, Homo sapiens. IN T00169 c-Rel; mouse, Mus musculus. IN T01154 c-Rel; chick, Gallus gallus. IN T01924 NF-kappaB1-isoform1; mouse, Mus musculus. IN T01925 NF-kappaB1; human, Homo sapiens. IN T09437 NF-kappaB1; mouse, Mus musculus. IN T00587 NF-kappaB; rat, Rattus norvegicus. IN T00588 NF-kappaB; mouse, Mus musculus. IN T00590 NF-kappaB; human, Homo sapiens. IN T00594 RelA-p65-isoform1; human, Homo sapiens. IN T00595 RelA-p65; mouse, Mus musculus. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). XX DR TRANSPATH: MO000021813. DR UniProtKB: Q60778; XX RN [1]; RE0000458. RX PUBMED: 2050119. RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [2]; RE0000762. RX PUBMED: 1907941. RA Kerr L. D., Inoue J.-I., Davis N., Link E., Baeuerle P. A., Bose jr H. R., Verma I. M. RT The Rel-associated pp40 protein prevents DNA binding of Rel and NF-kappaB: relationship with IkappaBbeta and regulation by phosphorylation RL Genes Dev. 5:1464-1476 (1991). RN [3]; RE0002688. RX PUBMED: 1891714. RA Davis N., Ghosh S., Simmons D. L., Tempst P., Liou H.-C., Baltimore D., Bose jr H. R. RT Rel-associated pp40: An inhibitor of the Rel family of transcription factors RL Science 253:1268-1271 (1991). RN [4]; RE0004550. RX PUBMED: 7867065. RA Thompson J. E., Phillips R. J., Erdjument-Bromage H., Tempst P., Ghosh S. RT IkappaB-beta regulates the persistent response in a biphasic activation of NF-kappaB RL Cell 80:573-582 (1995). RN [5]; RE0004614. RX PUBMED: 1309735. RA Link E., Kerr L. D., Schreck R., Zabel U., Vermat I., Baeuerle P. A. RT Purified IkappaB-beta is inactivated upon dephosphorylation RL J. Biol. Chem. 267:239-246 (1992). RN [6]; RE0013471. RX PUBMED: 9135156. RA Whiteside S. T., Epinat J. C., Rice N. R., Israel A. RT I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. RL EMBO J. 16:1413-1426 (1997). RN [7]; RE0030779. RX PUBMED: 12556537. RA Muller J. R., Siebenlist U. RT Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways. RL J. Biol. Chem. 278:12006-12 (2003). RN [8]; RE0053165. RX PUBMED: 17878357. RA Kang Y. J., Kusler B., Otsuka M., Hughes M., Suzuki N., Suzuki S., Yeh W. C., Akira S., Han J., Jones P. P. RT Calcineurin negatively regulates TLR-mediated activation pathways. RL J. Immunol. 179:4598-4607 (2007). RN [9]; RE0053543. RX PUBMED: 10940917. RA Mattner J., Schindler H., Diefenbach A., Rollinghoff M., Gresser I., Bogdan C. RT Regulation of type 2 nitric oxide synthase by type 1 interferons in macrophages infected with Leishmania major. RL Eur. J. Immunol. 30:2257-2267 (2000). RN [10]; RE0055632. RX PUBMED: 19201871. RA Bode K. A., Schmitz F., Vargas L., Heeg K., Dalpke A. H. RT Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction. RL J. Immunol. 182:2176-2184 (2009). RN [11]; RE0064492. RX PUBMED: 12920017. RA Guthridge M. A., Barry E. F., Felquer F. A., McClure B. J., Stomski F. C., Ramshaw H., Lopez A. F. RT The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kappaB and induction of bcl-2. RL Blood 103:820-827 (2004). RN [12]; RE0065317. RX PUBMED: 19414785. RA Park J. E., Kim Y. I., Yi A. K. RT Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway. RL J. Immunol. 182:6316-6327 (2009). XX //