AC T00971
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ID T00971
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DT 30.06.1993 (created); ewi.
DT 10.01.2011 (updated); din.
CO Copyright (C), QIAGEN.
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FA IkappaB-beta
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SY IkappaB-beta; IkB; IKB-beta; IKBB; inhibitor kappaB beta; MGC36057; Nfkbib; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014471 Nfkbib.
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CL C0020; Rel; 6.1.2.1.2.
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SF association with c-Rel and RelA has been proven in vitro and in vivo [4];
SF pI(calc) = 4.6 [4];
SF pI(exp) = 4.8-5.0 [5];
SF no interaction with NF-kappaB1 (p50) [4];
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CP testis (very high levels), spleen, lower in brain, heart, liver, lung [4].
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FF inhibitor of NF-kappaB, c-Rel and v-Rel [2] [4];
FF expression of IkappaB-beta is not upregulated by NF-kappaB, TPA, or TNF-alpha [4];
FF LPS and IL-1 decrease IkappaB-beta levels [4];
FF rapid degradation a by chymotrypsin-like protease [4];
FF binding to NF-kappaB can be suppressed by PKA, PKC, or phosphatase treatment [5];
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IN T00168 c-Rel; human, Homo sapiens.
IN T00169 c-Rel; mouse, Mus musculus.
IN T01154 c-Rel; chick, Gallus gallus.
IN T01924 NF-kappaB1-isoform1; mouse, Mus musculus.
IN T01925 NF-kappaB1; human, Homo sapiens.
IN T09437 NF-kappaB1; mouse, Mus musculus.
IN T00587 NF-kappaB; rat, Rattus norvegicus.
IN T00588 NF-kappaB; mouse, Mus musculus.
IN T00590 NF-kappaB; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T00595 RelA-p65; mouse, Mus musculus.
IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T).
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DR TRANSPATH: MO000021813.
DR UniProtKB: Q60778;
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RN [1]; RE0000458.
RX PUBMED: 2050119.
RA Urban M. B., Schreck R., Baeuerle P. A.
RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit
RL EMBO J. 10:1817-1825 (1991).
RN [2]; RE0000762.
RX PUBMED: 1907941.
RA Kerr L. D., Inoue J.-I., Davis N., Link E., Baeuerle P. A., Bose jr H. R., Verma I. M.
RT The Rel-associated pp40 protein prevents DNA binding of Rel and NF-kappaB: relationship with IkappaBbeta and regulation by phosphorylation
RL Genes Dev. 5:1464-1476 (1991).
RN [3]; RE0002688.
RX PUBMED: 1891714.
RA Davis N., Ghosh S., Simmons D. L., Tempst P., Liou H.-C., Baltimore D., Bose jr H. R.
RT Rel-associated pp40: An inhibitor of the Rel family of transcription factors
RL Science 253:1268-1271 (1991).
RN [4]; RE0004550.
RX PUBMED: 7867065.
RA Thompson J. E., Phillips R. J., Erdjument-Bromage H., Tempst P., Ghosh S.
RT IkappaB-beta regulates the persistent response in a biphasic activation of NF-kappaB
RL Cell 80:573-582 (1995).
RN [5]; RE0004614.
RX PUBMED: 1309735.
RA Link E., Kerr L. D., Schreck R., Zabel U., Vermat I., Baeuerle P. A.
RT Purified IkappaB-beta is inactivated upon dephosphorylation
RL J. Biol. Chem. 267:239-246 (1992).
RN [6]; RE0013471.
RX PUBMED: 9135156.
RA Whiteside S. T., Epinat J. C., Rice N. R., Israel A.
RT I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
RL EMBO J. 16:1413-1426 (1997).
RN [7]; RE0030779.
RX PUBMED: 12556537.
RA Muller J. R., Siebenlist U.
RT Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways.
RL J. Biol. Chem. 278:12006-12 (2003).
RN [8]; RE0053165.
RX PUBMED: 17878357.
RA Kang Y. J., Kusler B., Otsuka M., Hughes M., Suzuki N., Suzuki S., Yeh W. C., Akira S., Han J., Jones P. P.
RT Calcineurin negatively regulates TLR-mediated activation pathways.
RL J. Immunol. 179:4598-4607 (2007).
RN [9]; RE0053543.
RX PUBMED: 10940917.
RA Mattner J., Schindler H., Diefenbach A., Rollinghoff M., Gresser I., Bogdan C.
RT Regulation of type 2 nitric oxide synthase by type 1 interferons in macrophages infected with Leishmania major.
RL Eur. J. Immunol. 30:2257-2267 (2000).
RN [10]; RE0055632.
RX PUBMED: 19201871.
RA Bode K. A., Schmitz F., Vargas L., Heeg K., Dalpke A. H.
RT Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction.
RL J. Immunol. 182:2176-2184 (2009).
RN [11]; RE0064492.
RX PUBMED: 12920017.
RA Guthridge M. A., Barry E. F., Felquer F. A., McClure B. J., Stomski F. C., Ramshaw H., Lopez A. F.
RT The phosphoserine-585-dependent pathway of the GM-CSF/IL-3/IL-5 receptors mediates hematopoietic cell survival through activation of NF-kappaB and induction of bcl-2.
RL Blood 103:820-827 (2004).
RN [12]; RE0065317.
RX PUBMED: 19414785.
RA Park J. E., Kim Y. I., Yi A. K.
RT Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway.
RL J. Immunol. 182:6316-6327 (2009).
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