AC T01924
XX
ID T01924
XX
DT 04.11.1996 (created); ewi.
DT 08.04.2014 (updated); prb.
CO Copyright (C), QIAGEN.
XX
FA NF-kappaB1-isoform1
XX
SY KBF1; NF-kappaB1 (p105); NF-kappaB1 (p110); NFkappaB1 precursor (p105); p105; p110.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006465 Nfkb1.
XX
CL C0020; Rel; 6.1.1.1.1.1.
XX
SZ 971 AA; 105.6 kDa (cDNA) (calc.), 105 kDa (SDS)
XX
SQ MADDDPYGTGQMFHLNTALTHSIFNAELYSPEIPLSTDGPYLQILEQPKQRGFRFRYVCE
SQ GPSHGGLPGASSEKNKKSYPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGV
SQ CTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLAYLQAEG
SQ GGDRQLTDREKEIIRQAAVQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDS
SQ KAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSP
SQ TDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRK
SQ RQKLMPNFSDSFGGGSGAGAGGGGMFGSGGGGGSTGSPGPGYGYSNYGFPPYGGITFHPG
SQ VTKSNAGVTHGTINTKFKNGPKDCAKSDDEESLTLPEKETEGEGPSLPMACTKTEPIALA
SQ STMEDKEQDMGFQDNLFLEKALQLARRHANALFDYAVTGDVKMLLAVQRHLTAVQDENGD
SQ SVLHLAIIHLHAQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRV
SQ GADLSLLDRWGNSVLHLAAKEGHDRILSILLKSRKAAPLIDHPNGEGLNAIHIAVMSNSL
SQ PCLLLLVAAGAEVNAQEQKSGRTPLHLAVEYDNISLAGCLLLEGDAHVDSTTYDGTTPLH
SQ IAAGRGSTRLAALLKAAGADPLVENFEPLYDLDDSWEKAGEDEGVVPGTTPLDMAANWQV
SQ FDILNGKPYEPVFTSDDILPQGDMKQLTEDTRLQLCKLLEIPDPDKNWATLAQKLGLGIL
SQ NNAFRLSPAPSKTLMDNYEVSGGTIKELMEALQQMGYTEAIEVIQAAFRTPATTASSPVT
SQ TAQVHCLPLSSSSTRQHIDELRDSDSVCDSGVETSFRKLSFTESLTGDSPLLSLNKMPHG
SQ YGQEGPIEGKI
XX
SC Swiss-Prot#P25799-1
XX
FT 37 244 
PS50254; REL_2.
FT 42 240 
PF00554; Rel homology domain (RHD).
FT 77 707 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 247 348 
SM00429; iptmega2.
FT 248 348 
PF01833; IPT/TIG domain.
FT 538 568 
SM00248; ANK_2a.
FT 538 576 
PF00023; Ankyrin repeat.
FT 538 746 
PS50297; ANK_REP_REGION.
FT 577 606 
SM00248; ANK_2a.
FT 577 609 
PF00023; Ankyrin repeat.
FT 577 609 PS50088; ANK_REPEAT.
FT 610 640 SM00248; ANK_2a.
FT 610 642 PS50088; ANK_REPEAT.
FT 610 643 PF00023; Ankyrin repeat.
FT 646 675 SM00248; ANK_2a.
FT 646 678 PF00023; Ankyrin repeat.
FT 646 678 PS50088; ANK_REPEAT.
FT 680 710 SM00248; ANK_2a.
FT 680 713 PF00023; Ankyrin repeat.
FT 680 713 PS50088; ANK_REPEAT.
FT 714 743 SM00248; ANK_2a.
FT 714 746 PF00023; Ankyrin repeat.
FT 714 746 PS50088; ANK_REPEAT.
FT 782 971 missing in NF-kappaB1 (p84) [2].
FT 801 888 SM00005; DEATH_4.
FT 813 888 PF00531; Death domain.
FT 861 971 replaced by 661-695 in NF-kappaB1 (p98) [2].
XX
SF precursor of the NF-kappaB p50 T01923 subunit [1];
SF alternative splicing leads to NF-kappaB (p98) and NF-kappaB (p84), the latter lacking most of the C-terminal ankyrin repeats [2];
XX
CP ubiquitous.
XX
FF transcriptionally inert precursor form, exclusively found in the cytoplasm;
FF alternative splice variants NF-kappaB (p98) and NF-kappaB (p84) are found also in the nucleus [2];
FF only NF-kappaB (p98) can act as a transcriptional activator [2];
XX
IN T00168 c-Rel; human, Homo sapiens.
IN T00950 IkappaB-alpha; human, Homo sapiens.
IN T00414 IkappaB-beta; human, Homo sapiens.
IN T00416 IkappaB-beta; chick, Gallus gallus.
IN T00971 IkappaB-beta; mouse, Mus musculus.
IN T09437 NF-kappaB1; mouse, Mus musculus.
IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T).
XX
MX M00194 V$NFKB_Q6.
MX M00774 V$NFKB_Q6_01.
XX
DR TRANSPATH: MO000019360.
DR EMBL: M57999; MMTFDBS.
DR UniProtKB: P25799-1;
XX
RN [1]; RE0000215.
RX PUBMED: 2203532.
RA Ghosh S., Gifford A. M., Riviere L. R., Tempst P., Nolan G. P., Baltimore D.
RT Cloning of the p50 DNA binding subunit of NF-kappaB: homology to rel and dorsal
RL Cell 62:1019-1029 (1990).
RN [2]; RE0004526.
RX PUBMED: 7969179.
RA Grumont R. J., Fecondo J., Gerondakis S.
RT Alternate splicing of murine nfkb1 generates a nuclear isoform of the p50 precursor NF-kappaB1 that can function as a transactivator of NF-kappaB-regulated transcription
RL Mol. Cell. Biol. 14:8460-8470 (1994).
RN [3]; RE0065096.
RX PUBMED: 18180283.
RA Windheim M., Stafford M., Peggie M., Cohen P.
RT Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase.
RL Mol. Cell. Biol. 28:1783-1791 (2008).
RN [4]; RE0065527.
RX PUBMED: 19531803.
RA Wall E. A., Zavzavadjian J. R., Chang M. S., Randhawa B., Zhu X., Hsueh R. C., Liu J., Driver A., Bao X. R., Sternweis P. C., Simon M. I., Fraser I. D.
RT Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105.
RL Sci. Signal. 2:ra28 (2009).
XX
//