TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00594 XX ID T00594 XX DT 15.10.1992 (created); ewi. DT 21.10.2014 (updated); pos. CO Copyright (C), QIAGEN. XX FA RelA-p65-isoform1 XX SY NF-kappaB (p65); NFKB3; Nuclear Factor kappa B p65; Nuclear factor NF-kappa-B p65 subunit; p65; Rel-A; RelA; Transcription factor p65. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004622 RELA; HGNC: RELA. XX CL C0020; Rel; XX SZ 551 AA; 60.2 kDa (cDNA) (calc.), 65 kDa (SDS) XX SQ MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT SQ IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC SQ VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLP SQ HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS SQ QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE SQ KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY SQ DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA SQ VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ SQ GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM SQ DFSALLSQISS XX SC translated from EMBL:M62399 XX FT 16 190 PS50254; REL_2. FT 21 186 PF00554; Rel homology domain (RHD). FT 193 289 SM00429; iptmega2. FT 194 289 PF01833; IPT/TIG domain. FT 216 216 cysteine important for homodimerization [20]. FT 273 276 potential PKA site important for homodimerization [20]. FT 286 551 binding to CBP/p300 [33]. FT 301 304 nuclear localization signal [24]. FT 415 550 transcription activation domain [11]. FT 428 521 trans-activation domain 2 (TA2) [12]. FT 458 483 trans-activation domain 1' (TA1') [12]. FT 521 551 trans-activation domain 1 (TA1) [12]. XX SF four AA residues in the DNA-binding Rel domain mediate a distinct DNA-binding specificity of the RelA-p65-isoform1-p65 (p65) homodimer compared to heterodimers [21]; SF cytoplasmic inhibitors (IkappaB-alpha and -beta) bind to the Rel domain of RelA-p65-isoform1-p65 thus masking the nuclear localization signal [13] [24] [7] [5]; SF the splice variant p65delta cannot dimerize with itself or with p50, but with intact RelA-p65-isoform1-p65, and interacts only weakly with IkappaB-alpha since dimerization is important for inhibitor binding [11] [24]; SF the Rel domain of RelA-p65-isoform1-p65 interacts with leucine zipper structures of c-Fos, c-Jun, C/EBP-beta, and probably also ATF-a and CRE-BP1 [17] [18] [31]; SF it may also interact with the zinc finger domain of Sp1 and the DNA-binding domain of the estrogen receptor (ER), independent of its ligand-bound status [15] [28]; SF the potent trans-activating domain comprises several subdomains, of which TA2 contains another TA1-homologous region, both revealing a highly amphiphilic character when alpha-helically folded, with one side exclusively comprising serine residues [12]; SF moreover, the trans-activating domain contains several acidic modules with a critical core phenylalanine and flanking bulky hydrophobic residues [12]; XX CP ubiquitous. XX FF activator; FF contributes the major transcription activation domain to the NF-kappaB T00590 complex [4]; FF at some sequences, its homodimers may act as transcriptional activators [9] [3]; FF synergistic effects with AP-1 through AP-1 sites as well as through kappaB sites (c-Fos and c-Jun, not JunB or JunD, also not found for NF-kappaB1) [31]; FF synergism with C/EBP family members and with Sp1, e. g. at the HIV-1 LTR [35] [18] [32]; FF in T cells, RelA-p65-isoform1-p65 is phosphorylated by a 43 kDa protein kinase associated with the NF-kappaB/IkappaB complex [14]; FF subsequent release of RelA-p65-isoform1-p65 permits nuclear translocation [16]; FF PKC-mediated phosphorylation and trans-activation through TA2 [12]; FF constitutive phosphorylation of TA1 [12]; FF PKA-mediated phosphorylation decreases nuclear translocation of RelA-p65-isoform1-p65, presumably by decreasing the rate of IkappaB degradation [23]; FF the splice variant p65delta suppresses NF-kappaB activity and exhibits transforming properties [26]; XX IN T01795 AhR; human, Homo sapiens. IN T00167 ATF-2-isoform1; human, Homo sapiens. IN T00052 ATFa-isoform6; human, Homo sapiens. IN T00123 c-Fos; human, Homo sapiens. IN T00133 c-Jun; human, Homo sapiens. IN T00168 c-Rel; human, Homo sapiens. IN T00581 C/EBPbeta; human, Homo sapiens. IN T02214 CBP-isoform1; human, Homo sapiens. IN T18378 CBP; human, Homo sapiens. IN T00176 CTF-1; human, Homo sapiens. IN T06570 Dnmt1; human, Homo sapiens. IN T27826 Dnmt1; mouse, Mus musculus. IN T08705 Egr-4; human, Homo sapiens. IN T00261 ER-alpha; human, Homo sapiens. IN T17961 Gfi1; Mammalia. IN T05076 GR; human, Homo sapiens. IN T00950 IkappaB-alpha; human, Homo sapiens. IN T18455 IkappaB-alpha; Mammalia. IN T00414 IkappaB-beta; human, Homo sapiens. IN T00416 IkappaB-beta; chick, Gallus gallus. IN T00971 IkappaB-beta; mouse, Mus musculus. IN T17890 ing4-isoform1; human, Homo sapiens. IN T17025 ing4; human, Homo sapiens. IN T08251 LRF; human, Homo sapiens. IN T00593 NF-kappaB1-p50; human, Homo sapiens. IN T17520 NF-kappaB1; Mammalia. IN T01927 NF-kappaB2-p100; human, Homo sapiens. IN T01930 NF-kappaB2-p49; human, Homo sapiens. IN T00394 NF-kappaB2-p52; human, Homo sapiens. IN T01929 p100; chick, Gallus gallus. IN T23075 p100; Mammalia. IN T09322 p160MBP-isoform1; human, Homo sapiens. IN T01427 p300; human, Homo sapiens. IN T23091 p300; Mammalia. IN T01523 RelA-p65-delta; human, Homo sapiens. IN T00594 RelA-p65-isoform1; human, Homo sapiens. IN T22169 RTA; KSHV, Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8). IN T08433 RXR-alpha; human, Homo sapiens. IN T17974 TAFII105; human, Homo sapiens. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). XX MX M00052 V$NFKAPPAB65_01. MX M00054 V$NFKAPPAB_01. MX M00774 V$NFKB_Q6_01. MX M03563 V$RELA_Q6. XX BS R02921. BS R14659. BS R32490. BS R14640. BS R14431. BS R14460. BS R08088. BS R00923. BS R13472. BS R13473. BS R13474. BS R14486. BS R00943. BS R01634. BS R02909. BS R30143. BS R38274. BS R22655. BS R22555. BS R22558. BS R14438. BS R32007. BS R32013. BS R32008. BS R32009. BS R32010. BS R32012. BS R17059. BS R17060. BS R17061. BS R17062. BS R17063. BS R11382. BS R16684. BS R22506. BS R22617. BS R17119. BS R17121. BS R73911. BS R20680. BS R22635. BS R22543. BS R14565. BS R13476. BS R13477. BS R36035. BS R30535. BS R74083. BS R00879. BS R01744. BS R01058. BS R01065. BS R22553. BS R08104. BS R04703. BS R13306. BS R14448. BS R14449. BS R04905. XX DR TRANSPATH: MO000019363. DR TRANSCOMPEL: C00098. DR TRANSCOMPEL: C00100. DR TRANSCOMPEL: C00101. DR TRANSCOMPEL: C00148. DR TRANSCOMPEL: C00155. DR TRANSCOMPEL: C00338. DR TRANSCOMPEL: C00340. DR TRANSCOMPEL: C00343. DR TRANSCOMPEL: C00348. DR TRANSCOMPEL: C00406. DR TRANSCOMPEL: C00414. DR EMBL: L01459; HSNFKBX. DR EMBL: L19067; DR EMBL: M62399; DR EMBL: Z22948; DR EMBL: Z22949; HSP65B. DR EMBL: Z22950; HSP65C. DR EMBL: Z22951; HSP65D. DR EMBL: Z22952; HSP65E. DR EMBL: Z22953; HSP65F. DR EMBL: Z22954; HSP65G. DR UniProtKB: Q04206-1; XX RN [1]; RE0000091. RX PUBMED: 2184941. RA Zabel U., Bauerle P. A. RT Purified human IkappaB can rapidly dissociate the complex of the NF-kappaB transcription factor with its cognate DNA RL Cell 61:255-265 (1990). RN [2]; RE0000285. RX PUBMED: 3076097. RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB transcription factor involves dissociation of an apparently cytoplasmic NF-kappaB/inhibitor complex RL Cold Spring Harb. Symp. Quant. Biol. 53:789-798 (1988). RN [3]; RE0000458. RX PUBMED: 2050119. RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [4]; RE0000506. RX PUBMED: 1935902. RA Schmitz M. L., Baeuerle P. A. RT The p65 subunit is responsible for the strong transcription activating potential of NF-kappaB RL EMBO J. 10:3805-3817 (1991). RN [5]; RE0000609. RX PUBMED: 2691328. RA Baeuerle P., Baltimore D. RT A 65-kD subunit of active NF-kappaB is required for inhibition of NF-kappaB by IkappaB RL Genes Dev. 3:1689-1698 (1989). RN [6]; RE0000629. RX PUBMED: 2558054. RA Errede B., Ammerer G. RT STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes RL Genes Dev. 3:1349-1361 (1989). RN [7]; RE0000726. RX PUBMED: 2125960. RA Urban M. B., Baeuerle P. A. RT The 65-kD subunit of NF-kappaB is a receptor for IkappaB and a modulator of DNA-binding specificity RL Genes Dev. 4:1975-1984 (1990). RN [8]; RE0001632. RX PUBMED: 2548081. RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 9:2424-2430 (1991). RN [9]; RE0002682. RX PUBMED: 2006423. RA Ruben S. M., Dillon P. J., Schreck R., Henkel T., Chen C.-H., Maher M., Baeuerle P. A., Rosen C. A. RT Isolation of a rel-related human cDNA that potentially encodes the p65-kD subunit of NF-kappaB RL Science 251:1490-1493 (1991). RN [10]; RE0002922. RX PUBMED: 1406630. RA Kunsch C., Ruben S. M., Rosen C. A. RT Selection of optimal kappaB/Rel DNA-binding motifs: interaction of both subunits of NF-kappaB with DNA is required for transcriptional activation RL Mol. Cell. Biol. 12:4412-4421 (1992). RN [11]; RE0003105. RX PUBMED: 1732726. RA Ruben S. M., Narayanan R., Klement J. F., Chen C.-H., Rosen C. A. RT Functional characterization of the NF-kappaB p65 transcriptional activator and an alternatively spliced derivate RL Mol. Cell. Biol. 12:444-454 (1992). RN [12]; RE0003823. RX PUBMED: 7797554. RA Schmitz M. L., dos Santos Silva M. A., Baeuerle P. A. RT Transactivation domain 2 (TA2) of p65 NF-kappaB RL J. Biol. Chem. 270:15576-15584 (1995). RN [13]; RE0004487. RX PUBMED: 7679069. RA Zabel U., Henkel T., dos Santos Silva M., Baeuerle P. A. 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RT Cyclic AMP-independent ATF family members interact with NF-kappaB and function in the activation of the E-selectin promoter in response to cytokines RL Mol. Cell. Biol. 13:7180-7190 (1993). RN [18]; RE0004524. RX PUBMED: 8321203. RA Stein B., Cogswell P. C., Baldwin jr A. S. RT Functional and physical associations between NF-kappaB and C/EBP family members: a Rel domain-bZIP interaction RL Mol. Cell. Biol. 13:3964-3974 (1993). RN [19]; RE0004541. RX PUBMED: 8441377. RA Duckett C. S., Perkins N. D., Kowalik T. F., Schmid R. M., Huang E.-S., Baldwin jr A. S., Nabel G. J. RT Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an IkappaB-alpha (MAD-3) RL Mol. Cell. Biol. 13:1315-1322 (1993). RN [20]; RE0004543. RX PUBMED: 8246997. RA Ganchi P. A., Sun S. C., Greene W. C., Ballard D. W. RT A novel NF-kappaB complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization RL Mol. Cell. Biol. 13:7826-7835 (1993). RN [21]; RE0004544. RX PUBMED: 8321192. RA Coleman T. A., Kunsch C., Maher M., Ruben S. M., Rosen C. A. RT Acquisition of NFKB1-selective DNA binding by substitution of four amino acid residues from NFKB1 into RelA RL Mol. Cell. Biol. 13:3850-3859 (1993). RN [22]; RE0004546. RX PUBMED: 7935437. RA Blair W. S., Bogerd H. P., Madore S. J., Cullen B. R. RT Mutational analysis of the transcription activation domain of RelA: identification of a highly synergistic minimal acidic activation module RL Mol. Cell. Biol. 14:7226-7234 (1994). RN [23]; RE0004548. RX PUBMED: 7744006. RA Neumann M., Grieshammer T., Chuvpilo S., Kneitz B., Lohoff M., Schimpl A., Franza jr B. R., Serfling E. RT ReIA/p65 is a molecular target for the immunosuppressive action of protein kinase A RL EMBO J. 14:1991-2004 (1995). RN [24]; RE0004549. RX PUBMED: 1340770. RA Beg A. A., Ruben S. M., Scheinman R. I., Rosen C. A., Baldwin jr A. S. 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USA 90:9901-9905 (1993). RN [28]; RE0004557. RX PUBMED: 7935378. RA Perkins N. D., Agranoff A. B., Pascal E., Nabel G. J. RT An interaction the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation RL Mol. Cell. Biol. 14:6570-6583 (1994). RN [29]; RE0004558. RX PUBMED: 1542686. RA Ballard D. W., Dixon E. P., Peffer N. J., Bogerd H., Doerre S., Stein B., Greene W. C. RT The 65-kDa subunit of human NF-kappaB functions as a potent transcriptional activator and a target for v-Rel-mediated repression RL Proc. Natl. Acad. Sci. USA 89:1875-1879 (1992). RN [30]; RE0004559. RX PUBMED: 1740106. RA Hansen S. K., Nerlov C., Zabel U., Verde P., Johnsen M., Baeuerle P., Blasi F. RT A novel complex between the p65 subunit of NF-kappaB and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene RL EMBO J. 11:205-213 (1992). RN [31]; RE0004732. RX PUBMED: 8404856. RA Stein B., Baldwin jr A. S., Ballard D. W., Greene W. 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Biol. 20:2326-2333 (2000). RN [35]; RE0023683. RX PUBMED: 14514692. RA Papin S., Cazeneuve C., Duquesnoy P., Jeru I., Sahali D., Amselem S. RT The tumor necrosis factor alpha-dependent activation of the human mediterranean fever (MEFV) promoter is mediated by a synergistic interaction between C/EBP beta and NF kappaB p65. RL J. Biol. Chem. 278:48839-48847 (2003). RN [36]; RE0030415. RX PUBMED: 12842894. RA Sakurai H., Suzuki S., Kawasaki N., Nakano H., Okazaki T., Chino A., Doi T., Saiki I. RT Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. RL J. Biol. Chem. 278:36916-23 (2003). RN [37]; RE0035136. RX PUBMED: 14527995. RA Martone R., Euskirchen G., Bertone P., Hartman S., Royce T. E., Luscombe N. M., Rinn J. L., Nelson F. K., Miller P., Gerstein M., Weissman S., Snyder M. RT Distribution of NF-kappaB-binding sites across human chromosome 22. RL Proc. Natl. Acad. Sci. 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K., Kang J. E., Park H. J., Kim M. H., Yim T. H., Kim J. M., Heo M. K., Kim K. Y., Kwon H. J., Hur M. W. RT FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB. RL J. Biol. Chem. 280:27783-27791 (2005). RN [43]; RE0047668. RX PUBMED: 15465828. RA Buss H., Dorrie A., Schmitz M. L., Frank R., Livingstone M., Resch K., Kracht M. RT Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity. RL J. Biol. Chem. 279:49571-49574 (2004). RN [44]; RE0047688. RX PUBMED: 10075655. RA Na S. Y., Kang B. Y., Chung S. W., Han S. J., Ma X., Trinchieri G., Im S. Y., Lee J. W., Kim T. S. RT Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB. RL J. Biol. Chem. 274:7674-7680 (1999). RN [45]; RE0048131. RX PUBMED: 7823959. RA Scheinman R. I., Gualberto A., Jewell C. M., Cidlowski J. A., Baldwin AS J. r. RT Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. RL Mol. Cell. Biol. 15:943-953 (1995). RN [46]; RE0050028. RX PUBMED: 14690596. RA Ryo A., Suizu F., Yoshida Y., Perrem K., Liou Y. C., Wulf G., Rottapel R., Yamaoka S., Lu K. P. RT Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. RL Mol. Cell 12:1413-1426 (2003). RN [47]; RE0051641. RX PUBMED: 15208311. RA Hu W. H., Mo X. M., Walters W. M., Brambilla R., Bethea J. R. RT TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation. RL J. Biol. Chem. 279:35975-35983 (2004). RN [48]; RE0051660. RX PUBMED: 16046471. RA Schwabe R. F., Sakurai H. RT IKKbeta phosphorylates p65 at S468 in transactivaton domain 2. RL FASEB J. 19:1758-1760 (2005). RN [49]; RE0051716. RX PUBMED: 12748188. RA Asamitsu K., Tetsuka T., Kanazawa S., Okamoto T. RT RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. RL J. Biol. Chem. 278:26879-26887 (2003). RN [50]; RE0051727. RX PUBMED: 15140884. RA Jang H. D., Yoon K., Shin Y. J., Kim J., Lee S. Y. RT PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit. RL J. Biol. Chem. 279:24873-24880 (2004). RN [51]; RE0051862. RX PUBMED: 17196614. RA Owen H. R., Elser M., Cheung E., Gersbach M., Kraus W. L., Hottiger M. O. RT MYBBP1a is a novel repressor of NF-kappaB. RL J. Mol. Biol. 366:725-736 (2007). RN [52]; RE0051864. RX PUBMED: 17000776. RA Liu Y., Smith P. W., Jones D. R. RT Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis. RL Mol. Cell. Biol. 26:8683-8696 (2006). RN [53]; RE0051949. RX PUBMED: 16382138. RA Hoberg J. E., Popko A. E., Ramsey C. S., Mayo M. W. RT IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. RL Mol. Cell. Biol. 26:457-471 (2006). RN [54]; RE0053839. RX PUBMED: 16407239. RA Mattioli I., Geng H., Sebald A., Hodel M., Bucher C., Kracht M., Schmitz M. L. RT Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon. RL J. Biol. Chem. 281:6175-6183 (2006). RN [55]; RE0054072. RX PUBMED: 11687592. RA Solan N. J., Miyoshi H., Carmona E. M., Bren G. D., Paya C. V. RT RelB cellular regulation and transcriptional activity are regulated by p100. RL J. Biol. Chem. 277:1405-1418 (2002). RN [56]; RE0054543. RX PUBMED: 17317104. RA Jamaluddin M., Wang S., Boldogh I., Tian B., Brasier A. R. RT TNF-alpha-induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway. RL Cell. Signal. 19:1419-1433 (2007). RN [57]; RE0065182. RX PUBMED: 19377466. RA Chew J., Biswas S., Shreeram S., Humaidi M., Wong E. T., Dhillion M. K., Teo H., Hazra A., Fang C. C., Lopez-Collazo E., Bulavin D. V., Tergaonkar V. RT WIP1 phosphatase is a negative regulator of NF-kappaB signalling. RL Nat. Cell Biol. 11:659-666 (2009). RN [58]; RE0071069. RX PUBMED: 20167866. RA Lee I. T., Lee C. W., Tung W. H., Wang S. W., Lin C. C., Shu J. C., Yang C. M. RT Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses. RL Am. J. Pathol. 176:1671-1684 (2010). XX //