AC T08251
XX
ID T08251
XX
DT 04.11.2005 (created); elf.
DT 16.04.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA LRF
XX
SY Factor binding IST protein 1; Factor that binds to inducer of short transcripts protein 1; FBI-1; FBI1; HIV-1 1st-binding protein 1; Leukemia/lymphoma related factor; Lrf; TIP21; TTF-I interacting peptide 21; ZBTB7; zinc finger and BTB domain containing 7; Zinc finger and BTB domain containing protein 7.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G021445 ZBTB7A; HGNC: ZBTB7A.
XX
CL C0058; CH+BTB/POZ.
XX
SZ 584 AA; 61.4 kDa (cDNA) (calc.).
XX
SQ MAGGVDGPIGIPFPDHSSDILSGLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFK
SQ KLFTSGAVVDQQNVYEIDFVSAEALTALMDFAYTATLTVSTANVGDILSAARLLEIPAVS
SQ HVCADLLDRQILAADAGADAGQLDLVDQIDQRNLLRAKEYLEFFQSNPMNSLPPAAAAAA
SQ ASFPWSAFGASDDDLDATKEAVAAAVAAVAAGDCNGLDFYGPGPPAERPPTGDGDEGDSN
SQ PGLWPERDEDAPTGGLFPPPVAPPAATQNGHYGRGGEEEAASLSEAAPEPGDSPGFLSGA
SQ AEGEDGDGPDVDGLAASTLLQQMMSSVGRAGAAAGDSDEESRADDKGVMDYYLKYFSGAH
SQ DGDVYPAWSQKVEKKIRAKAFQKCPICEKVIQGAGKLPRHIRTHTGEKPYECNICKVRFT
SQ RQDKLKVHMRKHTGEKPYLCQQCGAAFAHNYDLKNHMRVHTGLRPYQCDSCCKTFVRSDH
SQ LHRHLKKDGCNGVPSRRGRKPRVRGGAPDPSPGATATPGAPAQPSSPDARRNGQEKHFKD
SQ EDEDEDVASPDGLGRLNVAGAGGGGDSGGGPGAATDGNFTAGLA
XX
SC translated from EMBL:AF097916
XX
FT 1 120 
POZ domain [3].
FT 24 131 
PF00651; BTB/POZ domain.
FT 34 101 
PS50097; BTB.
FT 34 131 
SM00225; BTB_4.
FT 83 432 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 376 489 
zinc finger (C2H2 type) [3].
FT 382 404 
SM00355; c2h2final6.
FT 382 409 
PS50157; ZINC_FINGER_C2H2_2.
FT 410 432 
PF00096; zf-C2H2.
FT 410 432 
SM00355; c2h2final6.
FT 410 437 PS50157; ZINC_FINGER_C2H2_2.
FT 438 460 PF00096; zf-C2H2.
FT 438 460 SM00355; c2h2final6.
FT 438 465 PS50157; ZINC_FINGER_C2H2_2.
FT 466 486 SM00355; c2h2final6.
FT 466 490 PF00096; zf-C2H2.
FT 466 501 PS50157; ZINC_FINGER_C2H2_2.
FT 490 503 NLS (nuclear localization sequence) [3].
XX
SF BTB/POZ-domain protein at the N-terminus, a protein-protein interaction domain, and zinc fingers at the C-terminus [1];
XX
FF modulates HIV-1 Tat trans-activation and represses transcription of some cellular genes [1];
XX
IN T08767 IkappaB-alpha; human, Homo sapiens.
IN T00414 IkappaB-beta; human, Homo sapiens.
IN T31905 KR3; Mammalia.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
XX
MX M01100 V$LRF_Q2.
MX M07387 V$LRF_Q3.
MX M04617 V$LRF_Q6.
XX
BS R18501.
BS R18502.
BS R18483.
BS R18484.
BS R18486.
BS R18487.
BS R18488.
BS R18489.
BS R18490.
BS R18491.
BS R18492.
BS R18493.
BS R18494.
BS R18495.
BS R18496.
BS R18497.
BS R18500.
BS R18499.
BS R18482.
BS R18481.
BS R18480.
BS R18479.
BS R18478.
BS R18477.
BS R28003.
BS R28239.
BS R28240.
BS R27849.
BS R18503.
BS R18504.
BS R18505.
BS R67233.
BS R67235.
BS R28122.
BS R28125.
BS R28127.
BS R28128.
BS R28139.
BS R28140.
BS R67227.
BS R67231.
BS R18506.
BS R18507.
BS R18508.
BS R18509.
XX
DR TRANSPATH: MO000056499.
DR EMBL: AF097916; AF097916.
DR UniProtKB: O95365; ZBTB7_HUMAN.
XX
RN [1]; RE0035544.
RX PUBMED: 12750370.
RA Pessler F., Hernandez N.
RT Flexible DNA binding of the BTB/POZ-domain protein FBI-1.
RL J. Biol. Chem. 278:29327-29335 (2003).
RN [2]; RE0047618.
RX PUBMED: 15917220.
RA Lee D. K., Kang J. E., Park H. J., Kim M. H., Yim T. H., Kim J. M., Heo M. K., Kim K. Y., Kwon H. J., Hur M. W.
RT FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.
RL J. Biol. Chem. 280:27783-27791 (2005).
RN [3]; RE0063003.
RX PUBMED: 12004059.
RA Lee D. K., Suh D., Edenberg H. J., Hur M. W.
RT POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.
RL J. Biol. Chem. 277:26761-26768 (2002).
XX
//