AC T08767
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ID T08767
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DT 29.03.2006 (created); sou.
DT 27.06.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA IkappaB-alpha
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SY human inhibitor kappaB-alpha; I-kappa-B-alpha; IkappaB-alpha; IKBA; MAD-3; MAD3; NF-kappa-B inhibitor alpha; NFKBI; NFKBIA.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002981 NFKBIA; HGNC: NFKBIA.
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CL C0020; Rel.
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SZ 317 AA; 35.6 kDa (cDNA) (calc.), 36-38 kDa (SDS)
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SQ MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVP
SQ RGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVI
SQ TNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATN
SQ YNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG
SQ ADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE
SQ DELPYDDCVFGGQRLTL
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SC translated from EMBL:M69043
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FT 73 103 
SM00248; ANK_2a.
FT 73 109 
PF00023; Ankyrin repeat.
FT 73 256 
PS50297; ANK_REP_REGION.
FT 110 139 
SM00248; ANK_2a.
FT 110 142 
PF00023; Ankyrin repeat.
FT 110 142 
PS50088; ANK_REPEAT.
FT 143 172 
SM00248; ANK_2a.
FT 143 175 
PF00023; Ankyrin repeat.
FT 182 211 
SM00248; ANK_2a.
FT 182 214 
PF00023; Ankyrin repeat.
FT 182 214 PS50088; ANK_REPEAT.
FT 216 245 SM00248; ANK_2a.
FT 216 248 PF00023; Ankyrin repeat.
FT 216 248 PS50088; ANK_REPEAT.
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IN T10538 (RelA-p65)2; mouse, Mus musculus.
IN T21852 HDAC1; Mammalia.
IN T08251 LRF; human, Homo sapiens.
IN T08711 RelA-p65; human, Homo sapiens.
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DR TRANSPATH: MO000079655.
DR EMBL: M69043;
DR UniProtKB: P25963;
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RN [1]; RE0031419.
RX PUBMED: 12972430.
RA Viatour P., Legrand-Poels S., van Lint C., Warnier M., Merville M. P., Gielen J., Piette J., Bours V., Chariot A.
RT Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3.
RL J. Biol. Chem. 278:46541-8 (2003).
RN [2]; RE0047618.
RX PUBMED: 15917220.
RA Lee D. K., Kang J. E., Park H. J., Kim M. H., Yim T. H., Kim J. M., Heo M. K., Kim K. Y., Kwon H. J., Hur M. W.
RT FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.
RL J. Biol. Chem. 280:27783-27791 (2005).
RN [3]; RE0049538.
RX PUBMED: 12909638.
RA Waris G., Livolsi A., Imbert V., Peyron J. F., Siddiqui A.
RT Hepatitis C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease.
RL J. Biol. Chem. 278:40778-40787 (2003).
RN [4]; RE0051415.
RX PUBMED: 10669746.
RA Castrillo A., Diaz-Guerra M. J., Hortelano S., Martin-Sanz P., Bosca L.
RT Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages.
RL Mol. Cell. Biol. 20:1692-1698 (2000).
RN [5]; RE0053529.
RX PUBMED: 10655476.
RA Huang T. T., Kudo N., Yoshida M., Miyamoto S.
RT A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes.
RL Proc. Natl. Acad. Sci. USA 97:1014-1019 (2000).
RN [6]; RE0060983.
RX PUBMED: 16920985.
RA Lin C. H., Cheng H. W., Hsu M. J., Chen M. C., Lin C. C., Chen B. C.
RT c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells.
RL J. Immunol. 177:3427-3438 (2006).
RN [7]; RE0065288.
RX PUBMED: 19289499.
RA Copetti T., Bertoli C., Dalla E., Demarchi F., Schneider C.
RT p65/RelA modulates BECN1 transcription and autophagy.
RL Mol. Cell. Biol. 29:2594-2608 (2009).
RN [8]; RE0065739.
RX PUBMED: 17548520.
RA Reiley W. W., Jin W., Lee A. J., Wright A., Wu X., Tewalt E. F., Leonard T. O., Norbury C. C., Fitzpatrick L., Zhang M., Sun S. C.
RT Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses.
RL J. Exp. Med. 204:1475-1485 (2007).
RN [9]; RE0071050.
RX PUBMED: 15007072.
RA Chen B. C., Chang Y. S., Kang J. C., Hsu M. J., Sheu J. R., Chen T. L., Teng C. M., Lin C. H.
RT Peptidoglycan induces nuclear factor-kappaB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages.
RL J. Biol. Chem. 279:20889-20897 (2004).
RN [10]; RE0071600.
RX PUBMED: 18436238.
RA Trinh D. V., Zhu N., Farhang G., Kim B. J., Huxford T.
RT The nuclear I kappaB protein I kappaB zeta specifically binds NF-kappaB p50 homodimers and forms a ternary complex on kappaB DNA.
RL J. Mol. Biol. 379:122-135 (2008).
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