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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T08711 XX ID T08711 XX DT 17.03.2006 (created); sou. DT 26.05.2016 (updated); vis. CO Copyright (C), QIAGEN. XX FA RelA-p65 XX SY NF-kappaB (p65); NFKB3; Nuclear Factor kappa B p65; Rel-A; RelA; Transcription factor p65. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004622 RELA; HGNC: RELA. XX CL C0020; Rel; 6.1.1.2.1. XX CP K562 cells treated with t-BHQ (tert-butylhydroquinone) and PMA(Phorbol 12-myristate 13-acetate) [22]; HUVEC [43]. XX FF TNF-alpha induction is abrogated by DOX (doxorubicin) [41]; XX IN T04074 brca1; human, Homo sapiens. IN T30638 BRD4; human, Homo sapiens. IN T15118 CBP; Mammalia. IN T18378 CBP; human, Homo sapiens. IN T00100 CDP; human, Homo sapiens. IN T18364 Clock; Mammalia. IN T06040 CtBP2; human, Homo sapiens. IN T05839 DEC2; human, Homo sapiens. IN T06570 Dnmt1; human, Homo sapiens. IN T22508 dpf2-isoform1; human, Homo sapiens. IN T33762 DRIP205; human, Homo sapiens. IN T01542 E2F-1; human, Homo sapiens. IN T09570 E2F-1; Mammalia. IN T17403 E2F-2; Mammalia. IN T17404 E2F-3; Mammalia. IN T09462 Egr-1; human, Homo sapiens. IN T00261 ER-alpha; human, Homo sapiens. IN T05220 Evi-1; human, Homo sapiens. IN T04956 FKLF; human, Homo sapiens. IN T06587 Gfi1; human, Homo sapiens. IN T27186 GILZ-isoform1; human, Homo sapiens. IN T19182 GLEA2; human, Homo sapiens. IN T04106 HDAC1; human, Homo sapiens. IN T28193 HES6; Mammalia. IN T01610 HIF-1alpha; human, Homo sapiens. IN T14419 Id1; human, Homo sapiens. IN T00950 IkappaB-alpha; human, Homo sapiens. IN T08767 IkappaB-alpha; human, Homo sapiens. IN T18455 IkappaB-alpha; Mammalia. IN T00414 IkappaB-beta; human, Homo sapiens. IN T22412 IkappaB-epsilon; human, Homo sapiens. IN T17890 ing4-isoform1; human, Homo sapiens. IN T17025 ing4; human, Homo sapiens. IN T00593 NF-kappaB1-p50; human, Homo sapiens. IN T01925 NF-kappaB1; human, Homo sapiens. IN T15707 NF-kappaB2-p52; human, Homo sapiens. IN T21984 p300; human, Homo sapiens. IN T14055 PARP; human, Homo sapiens. IN T02726 PPARalpha; human, Homo sapiens. IN T16551 RBTN2; human, Homo sapiens. IN T17026 RNF96; human, Homo sapiens. IN T29717 SIRT1; human, Homo sapiens. IN T30703 SIRT1; Mammalia. IN T08326 Sp1; Mammalia. IN T22422 SRC3-xbb2; human, Homo sapiens. IN T00857 TTF-1; human, Homo sapiens. IN T00878 USF2; human, Homo sapiens. IN T08660 YY1; human, Homo sapiens. IN T19456 ZNF277; human, Homo sapiens. XX MX M00052 V$NFKAPPAB65_01. MX M00054 V$NFKAPPAB_01. MX M00774 V$NFKB_Q6_01. MX M04706 V$RELA_02. MX M04811 V$RELA_03. MX M04814 V$RELA_04. MX M04849 V$RELA_05. MX M03563 V$RELA_Q6. XX BS R20825. BS R02921. BS R26202. BS R19592. BS R61153. BS R56830. BS R56831. BS R56846. BS R56841. BS R56833. BS R56844. BS R41748. BS R57626. BS R57628. BS R69104. BS R69105. BS R38574. BS R39203. BS R27918. BS R30510. BS R40311. BS R56879. BS R61726. BS R72669. BS R72670. BS R72671. BS R72672. BS R56363. BS R56364. BS R66891. BS R66893. BS R66894. BS R37334. BS R57003. BS R57006. BS R56894. BS R25550. BS R25553. BS R21071. BS R21072. BS R32966. BS R39660. BS R62607. BS R25011. BS R25318. BS R59335. BS R65616. BS R62771. BS R60747. BS R32905. BS R39495. BS R69819. BS R59482. BS R67066. BS R33333. BS R33335. BS R37622. BS R37626. BS R37631. BS R60309. BS R27591. BS R35327. BS R60171. BS R60172. BS R33602. BS R32146. BS R32147. BS R32148. BS R03340. BS R32145. BS R23158. BS R23160. BS R23162. BS R73825. BS R64997. BS R70893. BS R70894. BS R70895. BS R70896. BS R70897. BS R29232. BS R29238. BS R29912. BS R56884. BS R19559. BS R19561. BS R59980. BS R69855. BS R68147. BS R68149. BS R68151. BS R66705. BS R56624. BS R56626. BS R27973. BS R35205. BS R22943. BS R27700. BS R20329. BS R56892. BS R22435. BS R68579. BS R28359. BS R34970. BS R73757. BS R25932. BS R65270. BS R56860. BS R19572. BS R35058. BS R34717. BS R24757. BS R66737. BS R27927. BS R30655. BS R30369. BS R30650. BS R29952. BS R28669. BS R35342. BS R66266. BS R01634. BS R03553. BS R25017. BS R30979. BS R35449. BS R02909. BS R30143. BS R66728. BS R29805. BS R34823. BS R24123. BS R25474. BS R25475. BS R61845. BS R39330. BS R60527. BS R60528. BS R60529. BS R31357. BS R66346. BS R73718. BS R39356. BS R39357. BS R64354. BS R29732. BS R37557. BS R39916. BS R35961. BS R73819. BS R37554. BS R29088. BS R31641. BS R31643. BS R64535. BS R73743. BS R69147. BS R62619. BS R56352. BS R56353. BS R64532. BS R63990. BS R56345. BS R56346. BS R19783. BS R61229. BS R65534. BS R30683. BS R40081. BS R35143. BS R25405. BS R37736. BS R56896. BS R28216. BS R66747. BS R68249. BS R68253. BS R27455. BS R27108. BS R31072. BS R64619. BS R29578. BS R24815. BS R32640. BS R19739. BS R19741. BS R19742. BS R27453. BS R35969. BS R40952. BS R40702. BS R40734. BS R40743. BS R40744. BS R11382. BS R37884. BS R37885. BS R32364. BS R41595. BS R22506. BS R64893. BS R65350. BS R65351. BS R62694. BS R62696. BS R35448. BS R66698. BS R66699. BS R66701. BS R37632. BS R37636. BS R37640. BS R39068. BS R65966. BS R57300. BS R57301. BS R26906. BS R27891. BS R34802. BS R30908. BS R30966. BS R34834. BS R67504. BS R67507. BS R01349. BS R32736. BS R57945. BS R57950. BS R69492. BS R34710. BS R37951. BS R56876. BS R56885. BS R69261. BS R69262. BS R73357. BS R38700. BS R42205. BS R71694. BS R71695. BS R71697. BS R62490. BS R63242. BS R42030. BS R29217. BS R29223. BS R56877. BS R56878. BS R26907. BS R29852. BS R62539. BS R62543. BS R56886. BS R30054. BS R66742. BS R66749. BS R24873. BS R59995. BS R61067. BS R61068. BS R73153. BS R37715. BS R64783. BS R71773. BS R72271. BS R72272. BS R72273. BS R39956. BS R60584. BS R56865. BS R56872. BS R56881. BS R26754. BS R35547. BS R65334. BS R67205. BS R67207. BS R57770. BS R56665. BS R22751. BS R22752. BS R32472. BS R01058. BS R55836. BS R30716. XX DR TRANSPATH: MO000079319. DR TRANSCOMPEL: C00577. DR UniProtKB: Q04206; XX RN [1]; RE0013471. RX PUBMED: 9135156. RA Whiteside S. T., Epinat J. C., Rice N. R., Israel A. RT I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. RL EMBO J. 16:1413-1426 (1997). RN [2]; RE0021997. RX PUBMED: 9751059. RA Cohen L., Henzel W. J., Baeuerle P. A. RT IKAP is a scaffold protein of the IkappaB kinase complex RL Nature 395:292-296 (1998). RN [3]; RE0030415. RX PUBMED: 12842894. RA Sakurai H., Suzuki S., Kawasaki N., Nakano H., Okazaki T., Chino A., Doi T., Saiki I. RT Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. RL J. Biol. Chem. 278:36916-23 (2003). RN [4]; RE0031419. RX PUBMED: 12972430. RA Viatour P., Legrand-Poels S., van Lint C., Warnier M., Merville M. P., Gielen J., Piette J., Bours V., Chariot A. RT Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3. RL J. Biol. Chem. 278:46541-8 (2003). RN [5]; RE0032702. RX PUBMED: 12419817. RA Jiang X., Takahashi N., Matsui N., Tetsuka T., Okamoto T. RT The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536. RL J. Biol. Chem. 278:919-26 (2003). RN [6]; RE0033324. RX PUBMED: 14976190. RA Catley M. C., Cambridge L. M., Nasuhara Y., Ito K., Chivers J. E., Beaton A., Holden N. S., Bergmann M. W., Barnes P. J., Newton R. RT Inhibitors of protein kinase C (PKC) prevent activated transcription: role of events downstream of NF-kappaB DNA binding. RL J. Biol. Chem. 279:18457-66 (2004). RN [7]; RE0046041. RX PUBMED: 12040027. RA Islam K. N., Mendelson C. R. RT Potential role of nuclear factor kappaB and reactive oxygen species in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells RL Mol. Endocrinol. 16:1428-40 (2002). RN [8]; RE0046561. RX PUBMED: 11468175. RA Ayroldi E., Migliorati G., Bruscoli S., Marchetti C., Zollo O., Cannarile L., D'Adamio F., Riccardi C. RT Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB RL Blood 98:743-53 (2001). RN [9]; RE0047693. RX PUBMED: 15489227. RA Buss H., Dorrie A., Schmitz M. L., Hoffmann E., Resch K., Kracht M. RT Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. RL J. Biol. Chem. 279:55633-55643 (2004). RN [10]; RE0048086. RX PUBMED: 11526476. RA Heppner C., Bilimoria K. Y., Agarwal S. K., Kester M., Whitty L. J., Guru S. C., Chandrasekharappa S. C., Collins F. S., Spiegel A. M., Marx S. J., Burns A. L. RT The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation. RL Oncogene 20:4917-4925 (2001). RN [11]; RE0048186. RX PUBMED: 15383283. RA Wu R. C., Qin J., Yi P., Wong J., Tsai S. Y., Tsai M. J., O'Malley B. W. RT Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. RL Mol. Cell 15:937-949 (2004). RN [12]; RE0048413. RX PUBMED: 16728495. RA Zeold A., Doleschall M., Haffner M. C., Capelo L. P., Menyhert J., Liposits Z., da Silva W. S., Bianco A. C., Kacskovics I., Fekete C., Gereben B. RT Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene. RL Endocrinology 147:4419-4429 (2006). RN [13]; RE0048827. RX PUBMED: 15913553. RA Becker T. M., Rizos H., de la Pena A., Leclercq I. A., Woodruff S., Kefford R. F., Mann G. J. RT Impaired inhibition of NF-kappaB activity by melanoma-associated p16INK4a mutations. RL Biochem. Biophys. Res. Commun. 332:873-879 (2005). RN [14]; RE0049054. RX PUBMED: 10671503. RA Chapman N. R., Perkins N. D. RT Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1. RL J. Biol. Chem. 275:4719-4725 (2000). RN [15]; RE0049372. RX PUBMED: 11336543. RA Zhu N., Ware C. F., Lai M. M. RT Hepatitis C virus core protein enhances FADD-mediated apoptosis and suppresses TRADD signaling of tumor necrosis factor receptor. RL Virology 283:178-187 (2001). RN [16]; RE0049828. RX PUBMED: 16204234. RA Hassa P. O., Haenni S. S., Buerki C., Meier N. I., Lane W. S., Owen H., Gersbach M., Imhof R., Hottiger M. O. RT Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. RL J. Biol. Chem. 280:40450-40464 (2005). RN [17]; RE0049976. RX PUBMED: 17434128. RA Huang W. C., Ju T. K., Hung M. C., Chen C. C. RT Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. RL Mol. Cell 26:75-87 (2007). RN [18]; RE0050028. RX PUBMED: 14690596. RA Ryo A., Suizu F., Yoshida Y., Perrem K., Liou Y. C., Wulf G., Rottapel R., Yamaoka S., Lu K. P. RT Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. RL Mol. Cell 12:1413-1426 (2003). RN [19]; RE0050192. RX PUBMED: 15592525. RA Jun J. I., Chung C. W., Lee H. J., Pyo J. O., Lee K. N., Kim N. S., Kim Y. S., Yoo H. S., Lee T. H., Kim E., Jung Y. K. RT Role of FLASH in caspase-8-mediated activation of NF-kappaB: dominant-negative function of FLASH mutant in NF-kappaB signaling pathway. RL Oncogene 24:688-696 (2005). RN [20]; RE0050802. RX PUBMED: 12700228. RA Benezra M., Chevallier N., Morrison D. J., MacLachlan T. K., El-Deiry W. S., Licht J. D. RT BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit. RL J. Biol. Chem. 278:26333-26341 (2003). RN [21]; RE0051619. RX PUBMED: 15951441. RA Hu W. H., Pendergast J. S., Mo X. M., Brambilla R., Bracchi-Ricard V., Li F., Walters W. M., Blits B., He L., Schaal S. M., Bethea J. R. RT NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation. RL J. Biol. Chem. 280:29233-29241 (2005). RN [22]; RE0051628. RX PUBMED: 15640523. RA Arinze I. J., Kawai Y. RT Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements. RL J. Biol. Chem. 280:9786-9795 (2005). RN [23]; RE0051641. RX PUBMED: 15208311. RA Hu W. H., Mo X. M., Walters W. M., Brambilla R., Bethea J. R. RT TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation. RL J. Biol. Chem. 279:35975-35983 (2004). RN [24]; RE0051660. RX PUBMED: 16046471. RA Schwabe R. F., Sakurai H. RT IKKbeta phosphorylates p65 at S468 in transactivaton domain 2. RL FASEB J. 19:1758-1760 (2005). RN [25]; RE0051716. RX PUBMED: 12748188. RA Asamitsu K., Tetsuka T., Kanazawa S., Okamoto T. RT RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. RL J. Biol. Chem. 278:26879-26887 (2003). RN [26]; RE0051818. RX PUBMED: 18178962. RA Gao N., Asamitsu K., Hibi Y., Ueno T., Okamoto T. RT AKIP1 augments NF-kappa B-dependent gene expression by promoting the nuclear retention and phosphorylation of p65. RL J. Biol. Chem. 283:7834-7843 (2008). RN [27]; RE0051828. RX PUBMED: 18035048. RA Kwon O., Kim K. A., He L., Jung M., Jeong S. J., Ahn J. S., Kim B. Y. RT Complex formation of p65/RelA with nuclear Akt1 for enhanced transcriptional activation of NF-kappaB. RL Biochem. Biophys. Res. Commun. 365:771-776 (2008). RN [28]; RE0051862. RX PUBMED: 17196614. RA Owen H. R., Elser M., Cheung E., Gersbach M., Kraus W. L., Hottiger M. O. RT MYBBP1a is a novel repressor of NF-kappaB. RL J. Mol. Biol. 366:725-736 (2007). RN [29]; RE0051864. RX PUBMED: 17000776. RA Liu Y., Smith P. W., Jones D. R. RT Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis. RL Mol. Cell. Biol. 26:8683-8696 (2006). RN [30]; RE0051899. RX PUBMED: 18056395. RA Lakshmanan U., Porter A. G. RT Caspase-4 interacts with TNF receptor-associated factor 6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 (macrophage-inflammatory protein-1 ). RL J. Immunol. 179:8480-8490 (2007). RN [31]; RE0051930. RX PUBMED: 17644309. RA Yamaguchi T., Miki Y., Yoshida K. RT Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress. RL Cell. Signal. 19:2088-2097 (2007). RN [32]; RE0051949. RX PUBMED: 16382138. RA Hoberg J. E., Popko A. E., Ramsey C. S., Mayo M. W. RT IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. RL Mol. Cell. Biol. 26:457-471 (2006). RN [33]; RE0051974. RX PUBMED: 15494311. RA Hoberg J. E., Yeung F., Mayo M. W. RT SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival. RL Mol. Cell 16:245-255 (2004). RN [34]; RE0052155. RX PUBMED: 15152190. RA Yeung F., Hoberg J. E., Ramsey C. S., Keller M. D., Jones D. R., Frye R. A., Mayo M. W. RT Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. RL EMBO J. 23:2369-2380 (2004). RN [35]; RE0052363. RX PUBMED: 15625114. RA Lau D., Mollnau H., Eiserich J. P., Freeman B. A., Daiber A., Gehling U. M., Brummer J., Rudolph V., Munzel T., Heitzer T., Meinertz T., Baldus S. RT Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins. RL Proc. Natl. Acad. Sci. USA 102:431-436 (2005). RN [36]; RE0052381. RX PUBMED: 17595324. RA Choudhary S., Lu M., Cui R., Brasier A. R. RT Involvement of a novel Rac/RhoA guanosine triphosphatase-nuclear factor-kappaB inducing kinase signaling pathway mediating angiotensin II-induced RelA transactivation. RL Mol. Endocrinol. 21:2203-2217 (2007). RN [37]; RE0053061. RX PUBMED: 17296604. RA Johnson J., Albarani V., Nguyen M., Goldman M., Willems F., Aksoy E. RT Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis. RL J. Biol. Chem. 282:15022-15032 (2007). RN [38]; RE0053154. RX PUBMED: 17991436. RA Hochrainer K., Racchumi G., Anrather J. RT Hypo-phosphorylation leads to nuclear retention of NF-kappaB p65 due to impaired IkappaBalpha gene synthesis. RL FEBS Lett. 581:5493-5499 (2007). RN [39]; RE0053206. RX PUBMED: 17183367. RA Maine G. N., Mao X., Komarck C. M., Burstein E. RT COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. RL EMBO J. 26:436-447 (2007). RN [40]; RE0053386. RX PUBMED: 18383035. RA Gregory D. J., Godbout M., Contreras I., Forget G., Olivier M. RT A novel form of NF-kappaB is induced by Leishmania infection: involvement in macrophage gene expression. RL Eur. J. Immunol. 38:1071-1081 (2008). RN [41]; RE0053436. RX PUBMED: 16483679. RA Cao W., Ma S. L., Tang J., Shi J., Lu Y. RT A combined treatment TNF-alpha/doxorubicin alleviates the resistance of MCF-7/Adr cells to cytotoxic treatment. RL Biochim. Biophys. Acta 1763:182-187 (2006). RN [42]; RE0053439. RX PUBMED: 17468759. RA Tanaka T., Grusby M. J., Kaisho T. RT PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. RL Nat. Immunol. 8:584-591 (2007). RN [43]; RE0053454. RX PUBMED: 17675290. RA Wang J., Mahmud S. A., Bitterman P. B., Huo Y., Slungaard A. RT Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. RL J. Biol. Chem. 282:28408-28418 (2007). RN [44]; RE0053529. RX PUBMED: 10655476. RA Huang T. T., Kudo N., Yoshida M., Miyamoto S. RT A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes. RL Proc. Natl. Acad. Sci. USA 97:1014-1019 (2000). RN [45]; RE0053645. RX PUBMED: 18045535. RA Wan F., Anderson D. E., Barnitz R. A., Snow A., Bidere N., Zheng L., Hegde V., Lam L. T., Staudt L. M., Levens D., Deutsch W. A., Lenardo M. J. RT Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. RL Cell 131:927-939 (2007). RN [46]; RE0053748. RX PUBMED: 12871932. RA Demarchi F., Bertoli C., Sandy P., Schneider C. RT Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability. RL J. Biol. Chem. 278:39583-39590 (2003). RN [47]; RE0053839. RX PUBMED: 16407239. RA Mattioli I., Geng H., Sebald A., Hodel M., Bucher C., Kracht M., Schmitz M. L. RT Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon. RL J. Biol. Chem. 281:6175-6183 (2006). RN [48]; RE0053894. RX PUBMED: 17307160. RA Lin C. C., Chiang L. L., Lin C. H., Shih C. H., Liao Y. T., Hsu M. J., Chen B. C. RT Transforming growth factor-beta1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells. RL Eur. J. Pharmacol. 560:101-109 (2007). RN [49]; RE0053911. RX PUBMED: 18424438. RA Joo J. H., Jetten A. M. RT NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway. RL J. Biol. Chem. 283:16391-16399 (2008). RN [50]; RE0053976. RX PUBMED: 15708970. RA Hauer J., Puschner S., Ramakrishnan P., Simon U., Bongers M., Federle C., Engelmann H. RT TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. RL Proc. Natl. Acad. Sci. USA 102:2874-2879 (2005). RN [51]; RE0054060. RX PUBMED: 12789342. RA Yamamoto Y., Verma U. N., Prajapati S., Kwak Y. T., Gaynor R. B. RT Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. RL Nature 423:655-659 (2003). RN [52]; RE0054072. RX PUBMED: 11687592. RA Solan N. J., Miyoshi H., Carmona E. M., Bren G. D., Paya C. V. RT RelB cellular regulation and transcriptional activity are regulated by p100. RL J. Biol. Chem. 277:1405-1418 (2002). RN [53]; RE0054190. RX PUBMED: 12820969. RA Saccani S., Pantano S., Natoli G. RT Modulation of NF-kappaB activity by exchange of dimers. RL Mol. Cell 11:1563-1574 (2003). RN [54]; RE0054529. RX PUBMED: 17785851. RA Liu G., Tsuruta Y., Gao Z., Park Y. J., Abraham E. RT Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity. RL J. Immunol. 179:4125-4134 (2007). RN [55]; RE0054543. RX PUBMED: 17317104. RA Jamaluddin M., Wang S., Boldogh I., Tian B., Brasier A. R. RT TNF-alpha-induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway. RL Cell. Signal. 19:1419-1433 (2007). RN [56]; RE0054588. RX PUBMED: 17548605. RA Mandrekar P., Jeliazkova V., Catalano D., Szabo G. RT Acute alcohol exposure exerts anti-inflammatory effects by inhibiting IkappaB kinase activity and p65 phosphorylation in human monocytes. RL J. Immunol. 178:7686-7693 (2007). RN [57]; RE0055135. RX PUBMED: 18542057. RA Araki K., Kawauchi K., Tanaka N. RT IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors. RL Oncogene 27:5696-5705 (2008). RN [58]; RE0055188. RX PUBMED: 17921324. RA Cortez D. M., Feldman M. D., Mummidi S., Valente A. J., Steffensen B., Vincenti M., Barnes J. L., Chandrasekar B. RT IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation. RL Am. J. Physiol. Heart Circ. Physiol. 293:H3356-65 (2007). RN [59]; RE0055271. RX PUBMED: 17068485. RA Lebre M. C., van der Aar A. M., van Baarsen L., van Capel T. M., Schuitemaker J. H., Kapsenberg M. L., de Jong E. C. RT Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. RL J. Invest. Dermatol 127:331-341 (2007). RN [60]; RE0055337. RX PUBMED: 17311279. RA Liang K. C., Lee C. W., Lin W. N., Lin C. C., Wu C. B., Luo S. F., Yang C. M. RT Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells. RL J. Cell. Physiol. 211:759-770 (2007). RN [61]; RE0055339. RX PUBMED: 18336852. RA Lin C. C., Tseng H. W., Hsieh H. L., Lee C. W., Wu C. Y., Cheng C. Y., Yang C. M. RT Tumor necrosis factor-alpha induces MMP-9 expression via p42/p44 MAPK, JNK, and nuclear factor-kappaB in A549 cells. RL Toxicol. Appl. Pharmacol. 229:386-398 (2008). RN [62]; RE0058894. RX PUBMED: 11753650. RA Bren G. D., Solan N. J., Miyoshi H., Pennington K. N., Pobst L. J., Paya C. V. RT Transcription of the RelB gene is regulated by NF-kappaB. RL Oncogene 20:7722-7733 (2001). RN [63]; RE0060125. RX PUBMED: 15905523. RA Mattioli B., Straface E., Quaranta M. G., Giordani L., Viora M. RT Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. RL J. Immunol. 174:6820-6828 (2005). RN [64]; RE0060983. RX PUBMED: 16920985. RA Lin C. H., Cheng H. W., Hsu M. J., Chen M. C., Lin C. C., Chen B. C. RT c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells. RL J. Immunol. 177:3427-3438 (2006). RN [65]; RE0063965. RX PUBMED: 18694960. RA Moschonas A., Kouraki M., Knox P. G., Thymiakou E., Kardassis D., Eliopoulos A. G. RT CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. RL Mol. Cell. Biol. 28:6208-6222 (2008). RN [66]; RE0064195. RX PUBMED: 16318585. RA Ganster R. W., Guo Z., Shao L., Geller D. A. RT Differential effects of TNF-alpha and IFN-gamma on gene transcription mediated by NF-kappaB-Stat1 interactions. RL J. Interferon Cytokine Res. 25:707-719 (2005). RN [67]; RE0064604. RX PUBMED: 18252806. RA Grund E. M., Kagan D., Tran C. A., Zeitvogel A., Starzinski-Powitz A., Nataraja S., Palmer S. S. RT Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells. RL Mol. Pharmacol. 73:1394-1404 (2008). RN [68]; RE0064666. RX PUBMED: 19592490. RA Wort S. J., Ito M., Chou P. C., Mc Master S. K., Badiger R., Jazrawi E., de Souza P., Evans T. W., Mitchell J. A., Pinhu L., Ito K., Adcock I. M. RT Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites. RL J. Biol. Chem. 284:24297-24305 (2009). RN [69]; RE0064761. RX PUBMED: 17827154. RA Sun J. M., Chen H. Y., Davie J. R. RT Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. RL J. Biol. Chem. 282:33227-33236 (2007). RN [70]; RE0065066. RX PUBMED: 18362142. RA Kao C. Y., Kim C., Huang F., Wu R. RT Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium. RL J. Biol. Chem. 283:15309-15318 (2008). RN [71]; RE0065080. RX PUBMED: 19527497. RA Yanagisawa S., Koarai A., Sugiura H., Ichikawa T., Kanda M., Tanaka R., Akamatsu K., Hirano T., Matsunaga K., Minakata Y., Ichinose M. RT Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects. RL Respir. Res. 10:50 (2009). RN [72]; RE0065087. RX PUBMED: 17652082. RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B. RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation. RL J. Biol. Chem. 282:27229-27238 (2007). RN [73]; RE0065165. RX PUBMED: 16272323. RA Kao C. Y., Huang F., Chen Y., Thai P., Wachi S., Kim C., Tam L., Wu R. RT Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway. RL J. Immunol. 175:6676-6685 (2005). RN [74]; RE0065182. RX PUBMED: 19377466. RA Chew J., Biswas S., Shreeram S., Humaidi M., Wong E. T., Dhillion M. K., Teo H., Hazra A., Fang C. C., Lopez-Collazo E., Bulavin D. V., Tergaonkar V. RT WIP1 phosphatase is a negative regulator of NF-kappaB signalling. RL Nat. Cell Biol. 11:659-666 (2009). RN [75]; RE0065231. RX PUBMED: 17108260. RA Keslacy S., Tliba O., Baidouri H., Amrani Y. RT Inhibition of tumor necrosis factor-alpha-inducible inflammatory genes by interferon-gamma is associated with altered nuclear factor-kappaB transactivation and enhanced histone deacetylase activity. RL Mol. Pharmacol. 71:609-618 (2007). RN [76]; RE0065287. RX PUBMED: 19820695. RA Lamb A., Yang X. D., Tsang Y. H., Li J. D., Higashi H., Hatakeyama M., Peek R. M., Blanke S. R., Chen L. F. RT Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. RL EMBO Rep. 10:1242-1249 (2009). RN [77]; RE0065288. RX PUBMED: 19289499. RA Copetti T., Bertoli C., Dalla E., Demarchi F., Schneider C. RT p65/RelA modulates BECN1 transcription and autophagy. RL Mol. Cell. Biol. 29:2594-2608 (2009). RN [78]; RE0065762. RX PUBMED: 16005433. RA Lee J., Im Y. H., Jung H. H., Kim J. H., Park J. O., Kim K., Kim W. S., Ahn J. S., Jung C. W., Park Y. S., Kang W. K., Park K. RT Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells. RL Biochem. Biophys. Res. Commun. 334:313-318 (2005). RN [79]; RE0065817. RX PUBMED: 17932106. RA Nettles K. W., Gil G., Nowak J., Metivier R., Sharma V. B., Greene G. L. RT CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor. RL Mol. Endocrinol. 22:263-272 (2008). RN [80]; RE0066175. RX PUBMED: 12169689. RA Rani M. R., Hibbert L., Sizemore N., Stark G. R., Ransohoff R. M. RT Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene. RL J. Biol. Chem. 277:38456-38461 (2002). RN [81]; RE0066266. RX PUBMED: 20007970. RA Lowe J. M., Cha H., Yang Q., Fornace AJ J. r. RT Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase. RL J. Biol. Chem. 285:5249-5257 (2010). RN [82]; RE0066377. RX PUBMED: 12107827. RA Nickoloff B. J., Qin J. Z., Chaturvedi V., Denning M. F., Bonish B., Miele L. RT Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. RL Cell Death Differ. 9:842-855 (2002). RN [83]; RE0066709. RX PUBMED: 18028425. RA Zhao X., Nozell S., Ma Z., Benveniste E. N. RT The interferon-stimulated gene factor 3 complex mediates the inhibitory effect of interferon-beta on matrix metalloproteinase-9 expression. RL FEBS J. 274:6456-6468 (2007). RN [84]; RE0066728. RX PUBMED: 19656324. RA Garcin G., Le Gallic L., Stoebner P. E., Guezennec A., Guesnet J., Lavabre-Bertrand T., Martinez J., Meunier L. RT Constitutive expression of MC1R in HaCaT keratinocytes inhibits basal and UVB-induced TNF-alpha production. RL Photochem. Photobiol. 85:1440-1450 (2009). RN [85]; RE0067414. RX PUBMED: 20526368. RA Oberbach A., Schlichting N., Bluher M., Kovacs P., Till H., Stolzenburg J. U., Neuhaus J. RT Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections. RL PLoS ONE 5:e10882 (2010). RN [86]; RE0067452. RX PUBMED: 18362147. RA Bijli K. M., Fazal F., Minhajuddin M., Rahman A. RT Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65. RL J. Biol. Chem. 283:14674-14684 (2008). RN [87]; RE0067904. RX PUBMED: 19533666. RA Cho S. G., Li D., Stafford L. J., Luo J., Rodriguez-Villanueva M., Wang Y., Liu M. RT KiSS1 suppresses TNFalpha-induced breast cancer cell invasion via an inhibition of RhoA-mediated NF-kappaB activation. RL J. Cell. Biochem. 107:1139-1149 (2009). RN [88]; RE0068049. RX PUBMED: 19956541. RA Chhikara M., Wang S., Kern S. J., Ferreyra G. A., Barb J. J., Munson P. J., Danner R. L. RT Carbon monoxide blocks lipopolysaccharide-induced gene expression by interfering with proximal TLR4 to NF-kappaB signal transduction in human monocytes. RL PLoS ONE 4:e8139 (2009). RN [89]; RE0068547. RX PUBMED: 18684960. RA Kalali B. N., Kollisch G., Mages J., Muller T., Bauer S., Wagner H., Ring J., Lang R., Mempel M., Ollert M. RT Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling. RL J. Immunol. 181:2694-2704 (2008). RN [90]; RE0068737. RX PUBMED: 18006661. RA Funderburg N., Lederman M. M., Feng Z., Drage M. G., Jadlowsky J., Harding C. V., Weinberg A., Sieg S. F. RT Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2. RL Proc. Natl. Acad. Sci. USA 104:18631-18635 (2007). RN [91]; RE0068876. RX PUBMED: 19687304. RA Nishimura M., Shin M. S., Singhirunnusorn P., Suzuki S., Kawanishi M., Koizumi K., Saiki I., Sakurai H. RT TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling. RL Mol. Cell. Biol. 29:5529-5539 (2009). RN [92]; RE0069152. RX PUBMED: 17145842. RA Lin Y. C., Shun C. T., Wu M. S., Chen C. C. RT A novel anticancer effect of thalidomide: inhibition of intercellular adhesion molecule-1-mediated cell invasion and metastasis through suppression of nuclear factor-kappaB. RL Clin. Cancer Res. 12:7165-7173 (2006). RN [93]; RE0069246. RX PUBMED: 20470398. RA Miyamoto R., Ito T., Nomura S., Amakawa R., Amuro H., Katashiba Y., Ogata M., Murakami N., Shimamoto K., Yamazaki C., Hoshino K., Kaisho T., Fukuhara S. RT Inhibitor of IkappaB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells. RL Arthritis Res. Ther. 12:R87 (2010). RN [94]; RE0069976. RX PUBMED: 17447895. RA Matsuo S., Yamazaki S., Takeshige K., Muta T. RT Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation. RL Biochem. J. 405:605-615 (2007). RN [95]; RE0070131. RX PUBMED: 20696840. RA Culver C., Sundqvist A., Mudie S., Melvin A., Xirodimas D., Rocha S. RT Mechanism of hypoxia-induced NF-kappaB. RL Mol. Cell. Biol. 30:4901-4921 (2010). RN [96]; RE0070256. RX PUBMED: 17717293. RA Dandapat A., Hu C., Sun L., Mehta J. L. RT Small concentrations of oxLDL induce capillary tube formation from endothelial cells via LOX-1-dependent redox-sensitive pathway. RL Arterioscler. Thromb. Vasc. Biol. 27:2435-2442 (2007). RN [97]; RE0070710. RX PUBMED: 19452449. RA Sakamoto N., Ishibashi T., Sugimoto K., Sawamura T., Sakamoto T., Inoue N., Saitoh S., Kamioka M., Uekita H., Ohkawara H., Suzuki K., Teramoto T., Maruyama Y., Takeishi Y. RT Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells. RL J. Cell. Physiol. 220:706-715 (2009). RN [98]; RE0070804. RX PUBMED: 21098220. RA Lou X., Sun S., Chen W., Zhou Y., Huang Y., Liu X., Shan Y., Wang C. RT Negative feedback regulation of NF-kappaB action by CITED2 in the nucleus. RL J. Immunol. 186:539-548 (2011). RN [99]; RE0070896. RX PUBMED: 20876301. RA Lai Y. J., Lin V. T., Zheng Y., Benveniste E. N., Lin F. T. RT The adaptor protein TRIP6 antagonizes Fas-induced apoptosis but promotes its effect on cell migration. RL Mol. Cell. Biol. 30:5582-5596 (2010). RN [100]; RE0070954. RX PUBMED: 20460684. RA Tando T., Ishizaka A., Watanabe H., Ito T., Iida S., Haraguchi T., Mizutani T., Izumi T., Isobe T., Akiyama T., Inoue J., Iba H. RT Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. RL J. Biol. Chem. 285:21951-21960 (2010). RN [101]; RE0071171. RX PUBMED: 16007092. RA Martin M., Rehani K., Jope R. S., Michalek S. M. RT Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. RL Nat. Immunol. 6:777-784 (2005). RN [102]; RE0071233. RX PUBMED: 18451326. RA Devaraj S., Torok N., Dasu M. R., Samols D., Jialal I. RT Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loop. RL Arterioscler. Thromb. Vasc. Biol. 28:1368-1374 (2008). RN [103]; RE0071251. RX PUBMED: 19706536. RA Brenner D., Brechmann M., Rohling S., Tapernoux M., Mock T., Winter D., Lehmann W. D., Kiefer F., Thome M., Krammer P. H., Arnold R. RT Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells. RL Proc. Natl. Acad. Sci. USA 106:14508-14513 (2009). RN [104]; RE0071528. RX PUBMED: 20410276. RA Yoboua F., Martel A., Duval A., Mukawera E., Grandvaux N. RT Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta. RL J. Virol. 84:7267-7277 (2010). RN [105]; RE0071992. RX PUBMED: 19265123. RA Dai P., Jeong S. Y., Yu Y., Leng T., Wu W., Xie L., Chen X. RT Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. RL J. Immunol. 182:3450-3460 (2009). RN [106]; RE0072651. RX PUBMED: 21455180. RA Tokunaga F., Nakagawa T., Nakahara M., Saeki Y., Taniguchi M., Sakata S., Tanaka K., Nakano H., Iwai K. RT SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex. RL Nature 471:633-636 (2011). XX //