AC T09570
XX
ID T09570
XX
DT 10.03.2005 (created); nvo.
DT 18.02.2016 (updated); jmh.
CO Copyright (C), QIAGEN.
XX
FA E2F-1
XX
SY adenovirus E2 gene binding Factor 1; E2F transcription factor 1; E2F-1; PBR3; PRB-binding protein E2F-1; RBAP-1; RBB3; RBBP3; Retinoblastoma-associated protein 1; Retinoblastoma-binding protein 3.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
FF Treatment with opioid agonist [59];
XX
IN T04074 brca1; human, Homo sapiens.
IN T10891 C/EBPepsilon; Mammalia.
IN T00100 CDP; human, Homo sapiens.
IN T16691 DP-1; Mammalia.
IN T23419 MCT-isoform1; human, Homo sapiens.
IN T25811 p107-isoform1; human, Homo sapiens.
IN T08321 p53-isoform1; human, Homo sapiens.
IN T15350 PARP; Mammalia.
IN T08513 pRb; human, Homo sapiens.
IN T25008 pRb; Mammalia.
IN T08711 RelA-p65; human, Homo sapiens.
IN T10397 RelA-p65; Mammalia.
IN T14323 Skp2; Mammalia.
IN T08326 Sp1; Mammalia.
IN T14175 TBP; Mammalia.
IN T05140 trrap; human, Homo sapiens.
XX
MX M01250 V$E2F1_01.
MX M01251 V$E2F1_02.
MX M00428 V$E2F1_Q3.
MX M00938 V$E2F1_Q3_01.
MX M00430 V$E2F1_Q4.
MX M07250 V$E2F1_Q4_01.
MX M08874 V$E2F1_Q4_02.
MX M00431 V$E2F1_Q6.
MX M00024 V$E2F_01.
MX M00050 V$E2F_02.
MX M00516 V$E2F_03.
MX M00803 V$E2F_Q2.
MX M00918 V$E2F_Q3_01.
MX M00919 V$E2F_Q4_01.
MX M00939 V$E2F_Q4_02.
MX M08875 V$E2F_Q4_03.
MX M00920 V$E2F_Q6_01.
XX
BS R15444.
BS R22101.
BS R37123.
BS R37124.
BS R70785.
BS R70786.
BS R30885.
BS R20183.
BS R65339.
BS R39910.
BS R31205.
BS R41169.
BS R41170.
BS R41173.
BS R04382.
BS R70467.
BS R63513.
BS R25467.
BS R25527.
BS R63494.
BS R26152.
BS R70636.
BS R62190.
BS R30955.
BS R35946.
BS R35947.
BS R35949.
BS R67974.
BS R59741.
BS R66414.
BS R66426.
BS R62195.
BS R62196.
BS R71032.
BS R71034.
BS R58893.
BS R67203.
BS R58894.
BS R62193.
BS R66376.
BS R66380.
BS R36890.
BS R66455.
BS R66456.
BS R66457.
BS R60672.
BS R25793.
BS R71215.
BS R69742.
BS R71271.
BS R63281.
BS R63283.
BS R63284.
BS R22115.
BS R64240.
BS R64241.
BS R64244.
XX
DR TRANSPATH: MO000046814.
DR TRANSCOMPEL: C00514.
XX
RN [1]; RE0003302.
RX PUBMED: 8405995.
RA Helin K., Wu C. L., Fattaey A. R., Lees J. A., Dynlacht B. D., Ngwu C., Harlow E.
RT Heterodimerization of the transcription factors E2F1 and DP-1 leads to cooperative trans-activation
RL Genes Dev. 7:1850-1861 (1993).
RN [2]; RE0012785.
RX PUBMED: 8657142.
RA Lin S.-Y., Black A. R., Kostic D., Pajovic S., Hoover C. N., Azizkhan J. C.
RT Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction
RL Mol. Cell. Biol. 16:1668-1675 (1996).
RN [3]; RE0015891.
RX PUBMED: 10753885.
RA Marzio G., Wagener C., Gutierrez M. I., Cartwright P., Helin K., Giacca M.
RT E2F family members are differentially regulated by reversible acetylation.
RL J. Biol. Chem. 275:10887-10892 (2000).
RN [4]; RE0021259.
RX PUBMED: 11568180.
RA Strachan G. D., Rallapalli R., Pucci B., Lafond T. P., Hall D. J.
RT A transcriptionally inactive E2F-1 targets the MDM family of proteins for proteolytic degradation
RL J. Biol. Chem. 276:45677-45685 (2001).
RN [5]; RE0026482.
RX PUBMED: 10848600.
RA Vairo G., Soos T. J., Upton T. M., Zalvide J., DeCaprio J. A., Ewen M. E., Koff A., Adams J. M.
RT Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation
RL Mol. Cell. Biol. 20:4745-53 (2000).
RN [6]; RE0027396.
RX PUBMED: 10734134.
RA Nicolas E., Morales V., Magnaghi-Jaulin L., Harel-Bellan A., Richard-Foy H., Trouche D.
RT RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein.
RL J. Biol. Chem. 275:9797-804 (2000).
RN [7]; RE0028283.
RX PUBMED: 11331592.
RA Hsu S. I., Yang C. M., Sim K. G., Hentschel D. M., O'Leary E., Bonventre J. V.
RT TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.
RL EMBO J. 20:2273-85 (2001).
RN [8]; RE0029518.
RX PUBMED: 12101225.
RA Ryo A., Liou Y. C., Wulf G., Nakamura M., Lee S. W., Lu K. P.
RT PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.
RL Mol. Cell. Biol. 22:5281-95 (2002).
RN [9]; RE0031299.
RX PUBMED: 12411495.
RA Schlisio S., Halperin T., Vidal M., Nevins J. R.
RT Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.
RL EMBO J. 21:5775-86 (2002).
RN [10]; RE0031304.
RX PUBMED: 12438297.
RA Chen M., Capps C., Willerson J. T., Zoldhelyi P.
RT E2F-1 regulates nuclear factor-kappaB activity and cell adhesion: potential antiinflammatory activity of the transcription factor E2F-1.
RL Circulation 106:2707-13 (2002).
RN [11]; RE0031417.
RX PUBMED: 14576193.
RA Kishore R., Luedemann C., Bord E., Goukassian D., Losordo D. W.
RT Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signal transduction pathways.
RL Circ. Res. 93:932-40 (2003).
RN [12]; RE0031451.
RX PUBMED: 14681231.
RA Shen W. H., Yin Y., Broussard S. R., McCusker R. H., Freund G. G., Dantzer R., Kelley K. W.
RT Tumor necrosis factor alpha inhibits cyclin A expression and retinoblastoma hyperphosphorylation triggered by insulin-like growth factor-I induction of new E2F-1 synthesis.
RL J. Biol. Chem. 279:7438-46 (2004).
RN [13]; RE0031478.
RX PUBMED: 15024084.
RA Rogoff H. A., Pickering M. T., Frame F. M., Debatis M. E., Sanchez Y., Jones S., Kowalik T. F.
RT Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.
RL Mol. Cell. Biol. 24:2968-77 (2004).
RN [14]; RE0036213.
RX PUBMED: 14593116.
RA Kuwako K., Taniura H., Yoshikawa K.
RT Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor
RL J. Biol. Chem. 279:1703-12 (2004).
RN [15]; RE0036673.
RX PUBMED: 12629508.
RA Wells J., Yan P. S., Cechvala M., Huang T., Farnham P. J.
RT Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase
RL Oncogene 22:1445-60 (2003).
RN [16]; RE0036836.
RX PUBMED: 8931991.
RA Weir L., Chen D.
RT Characterization of the nonmuscle myosin heavy chain IIB promoter: regulation by E2F
RL Gene Expr. 6:45-57 (1996).
RN [17]; RE0036840.
RX PUBMED: 14990995.
RA Yoshida K., Inoue I.
RT Regulation of Geminin and Cdt1 expression by E2F transcription factors
RL Oncogene 23:3802-12 (2004).
RN [18]; RE0036841.
RX PUBMED: 10783144.
RA Fanciulli M., Bruno T., Di Padova M., De Angelis R., Iezzi S., Iacobini C., Floridi A., Passananti C.
RT Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb
RL FASEB J. 14:904-12 (2000).
RN [19]; RE0036850.
RX PUBMED: 8892111.
RA Miyajima M., Nornes H. O., Sato K., Neuman T.
RT Overexpression of E2F1 in astrocytes leads to neoplastic transformation and changes in expression of retinoblastoma family members
RL J. Neurosci. Res. 46:108-13 (1996).
RN [20]; RE0036859.
RX PUBMED: 10613832.
RA Higashitsuji H., Itoh K., Nagao T., Dawson S., Nonoguchi K., Kido T., Mayer R. J., Arii S., Fujita J.
RT Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas
RL Nat. Med. 6:96-9 (2000).
RN [21]; RE0036872.
RX PUBMED: 12665581.
RA Gao G., Bracken A. P., Burkard K., Pasini D., Classon M., Attwooll C., Sagara M., Imai T., Helin K., Zhao J.
RT NPAT expression is regulated by E2F and is essential for cell cycle progression
RL Mol. Cell. Biol. 23:2821-33 (2003).
RN [22]; RE0036886.
RX PUBMED: 11173543.
RA Hayashi K., Yokozaki H., Naka K., Yasui W., Lotan R., Tahara E.
RT Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines
RL Jpn. J. Cancer Res. 92:42-50 (2001).
RN [23]; RE0036898.
RX PUBMED: 12619038.
RA Khwaja F., Djakiew D.
RT Inhibition of cell-cycle effectors of proliferation in bladder tumor epithelial cells by the p75NTR tumor suppressor
RL Mol. Carcinog. 36:153-60 (2003).
RN [24]; RE0036905.
RX PUBMED: 12554697.
RA Zhu Y., Jin K., Mao X. O., Greenberg D. A.
RT Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression
RL FASEB J. 17:186-93 (2003).
RN [25]; RE0036906.
RX PUBMED: 14684851.
RA Carey J. L., Sasur L. M., Kawakubo H., Gupta V., Christian B., Bailey P. M., Maheswaran S.
RT Mutually antagonistic effects of androgen and activin in the regulation of prostate cancer cell growth
RL Mol. Endocrinol. 18:696-707 (2004).
RN [26]; RE0036947.
RX PUBMED: 10417394.
RA von Harsdorf R., Hauck L., Mehrhof F., Wegenka U., Cardoso M. C., Dietz R.
RT E2F-1 overexpression in cardiomyocytes induces downregulation of p21CIP1 and p27KIP1 and release of active cyclin-dependent kinases in the presence of insulin-like growth factor I
RL Circ. Res. 85:128-36 (1999).
RN [27]; RE0036948.
RX PUBMED: 10100985.
RA Ravi R. K., Thiagalingam A., Weber E., McMahon M., Nelkin B. D., Mabry M.
RT Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells
RL Am. J. Respir. Cell Mol. Biol. 20:543-9 (1999).
RN [28]; RE0036952.
RX PUBMED: 9766653.
RA Li Z. R., Hromchak R., Mudipalli A., Bloch A.
RT Tumor suppressor proteins as regulators of cell differentiation
RL Cancer Res. 58:4282-7 (1998).
RN [29]; RE0037255.
RX PUBMED: 12370749.
RA Mitlianga P. G., Gomez-Manzano C., Kyritsis A. P., Fueyo J.
RT Overexpression of E2F-1 leads to bax-independent cell death in human glioma cells
RL Int. J. Oncol. 21:1015-20 (2002).
RN [30]; RE0037296.
RX PUBMED: 12718877.
RA Baudino T. A., Maclean K. H., Brennan J., Parganas E., Yang C., Aslanian A., Lees J. A., Sherr C. J., Roussel M. F., Cleveland J. L.
RT Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss
RL Mol. Cell 11:905-14 (2003).
RN [31]; RE0037297.
RX PUBMED: 9422723.
RA Taniura H., Taniguchi N., Hara M., Yoshikawa K.
RT Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1
RL J. Biol. Chem. 273:720-8 (1998).
RN [32]; RE0037323.
RX PUBMED: 12697828.
RA Liu K., Lin F. T., Ruppert J. M., Lin W. C.
RT Regulation of E2F1 by BRCT domain-containing protein TopBP1
RL Mol. Cell. Biol. 23:3287-304 (2003).
RN [33]; RE0037324.
RX PUBMED: 12717439.
RA Stevens C., Smith L., La Thangue N. B.
RT Chk2 activates E2F-1 in response to DNA damage
RL Nat. Cell Biol. 5:401-9 (2003).
RN [34]; RE0037327.
RX PUBMED: 11313881.
RA Kalma Y., Marash L., Lamed Y., Ginsberg D.
RT Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2
RL Oncogene 20:1379-87 (2001).
RN [35]; RE0037330.
RX PUBMED: 10958795.
RA Ha T. U., Segev D. L., Barbie D., Masiakos P. T., Tran T. T., Dombkowski D., Glander M., Clarke T. R., Lorenzo H. K., Donahoe P. K., Maheswaran S.
RT Mullerian inhibiting substance inhibits ovarian cell growth through an Rb-independent mechanism
RL J. Biol. Chem. 275:37101-9 (2000).
RN [36]; RE0037331.
RX PUBMED: 9697699.
RA Woitach J. T., Zhang M., Niu C. H., Thorgeirsson S. S.
RT A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability
RL Nat. Genet. 19:371-4 (1998).
RN [37]; RE0037344.
RX PUBMED: 11489836.
RA Jung C. P., Motwani M. V., Schwartz G. K.
RT Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit
RL Clin. Cancer Res. 7:2527-36 (2001).
RN [38]; RE0037400.
RX PUBMED: 12532331.
RA Strachan G. D., Jordan-Sciutto K. L., Rallapalli R., Tuan R. S., Hall D. J.
RT The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein
RL J. Cell. Biochem. 88:557-68 (2003).
RN [39]; RE0037403.
RX PUBMED: 9083010.
RA Birchenall-Roberts M. C., Yoo Y. D., Bertolette D. C. 3rd, Lee K. H., Turley J. M., Bang O. S., Ruscetti F. W., Kim S. J.
RT The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity
RL J. Biol. Chem. 272:8905-11 (1997).
RN [40]; RE0037432.
RX PUBMED: 15169882.
RA Louie M. C., Zou J. X., Rabinovich A., Chen H. W.
RT ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance
RL Mol. Cell. Biol. 24:5157-71 (2004).
RN [41]; RE0037435.
RX PUBMED: 12947005.
RA Gery S., Gombart A. F., Fung Y. K., Koeffler H. P.
RT C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis
RL Blood 103:828-35 (2004).
RN [42]; RE0037436.
RX PUBMED: 15044096.
RA Ishii H., Mimori K., Vecchione A., Sutheesophon K., Fujiwara T., Mori M., Furukawa Y.
RT Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX
RL Biochem. Biophys. Res. Commun. 316:1088-93 (2004).
RN [43]; RE0037437.
RX PUBMED: 11042687.
RA Sansal I., Dupont E., Toru D., Evrard C., Rouget P.
RT NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity
RL Oncogene 19:5000-9 (2000).
RN [44]; RE0037440.
RX PUBMED: 10559858.
RA Marti A., Wirbelauer C., Scheffner M., Krek W.
RT Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation
RL Nat. Cell Biol. 1:14-9 (1999).
RN [45]; RE0037442.
RX PUBMED: 10570427.
RA Dong Y. B., Yang H. L., Elliott M. J., Liu T. J., Stilwell A., Atienza C. Jr, McMasters K. M.
RT Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells
RL Cancer 86:2021-33 (1999).
RN [46]; RE0037463.
RX PUBMED: 9154817.
RA Rogatsky I., Trowbridge J. M., Garabedian M. J.
RT Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms
RL Mol. Cell. Biol. 17:3181-93 (1997).
RN [47]; RE0039011.
RX PUBMED: 11418595.
RA Lang S. E., McMahon S. B., Cole M. D., Hearing P.
RT E2F transcriptional activation requires TRRAP and GCN5 cofactors
RL J. Biol. Chem. 276:32627-34 (2001).
RN [48]; RE0040467.
RX PUBMED: 11146619.
RA Raveh T., Droguett G., Horwitz M. S., DePinho R. A., Kimchi A.
RT DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
RL Nat. Cell Biol. 3:1-7 (2001).
RN [49]; RE0041244.
RX PUBMED: 14627987.
RA Simbulan-Rosenthal C. M., Rosenthal D. S., Luo R., Samara R., Espinoza L. A., Hassa P. O., Hottiger M. O., Smulson M. E.
RT PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
RL Oncogene 22:8460-71 (2003).
RN [50]; RE0045557.
RX PUBMED: 15464731.
RA Seelan R. S., Parthasarathy L. K., Parthasarathy R. N.
RT E2F1 regulation of the human myo-inositol 1-phosphate synthase (ISYNA1) gene promoter
RL Arch. Biochem. Biophys. 431:95-106 (2004).
RN [51]; RE0046939.
RX PUBMED: 12185582.
RA Dugan K. A., Wood M. A., Cole M. D.
RT TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis
RL Oncogene 21:5835-43 (2002).
RN [52]; RE0048082.
RX PUBMED: 9244350.
RA Wang H., Shao N., Ding Q. M., Cui J., Reddy E. S., Rao V. N.
RT BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.
RL Oncogene 15:143-157 (1997).
RN [53]; RE0048940.
RX PUBMED: 16135794.
RA Datta A., Sen J., Hagen J., Korgaonkar C. K., Caffrey M., Quelle D. E., Hughes D. E., Ackerson T. J., Costa R. H., Raychaudhuri P.
RT ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.
RL Mol. Cell. Biol. 25:8024-8036 (2005).
RN [54]; RE0048950.
RX PUBMED: 17050006.
RA Garcia-Alvarez G., Ventura V., Ros O., Aligue R., Gil J., Tauler A.
RT Glycogen synthase kinase-3beta binds to E2F1 and regulates its transcriptional activity.
RL Biochim. Biophys. Acta 1773:375-382 (2006).
RN [55]; RE0049004.
RX PUBMED: 16407216.
RA Tu Z., Prajapati S., Park K. J., Kelly N. J., Yamamoto Y., Gaynor R. B.
RT IKK alpha regulates estrogen-induced cell cycle progression by modulating E2F1 expression.
RL J. Biol. Chem. 281:6699-6706 (2006).
RN [56]; RE0049005.
RX PUBMED: 16037820.
RA Fogal V., Hsieh J. K., Royer C., Zhong S., Lu X.
RT Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.
RL EMBO J. 24:2768-2782 (2005).
RN [57]; RE0049020.
RX PUBMED: 16301520.
RA Li X. D., Sun L., Seth R. B., Pineda G., Chen Z. J.
RT Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity.
RL Proc. Natl. Acad. Sci. USA 102:17717-17722 (2005).
RN [58]; RE0049630.
RX PUBMED: 16374512.
RA Markham D., Munro S., Soloway J., O'Connor D. P., La Thangue N. B.
RT DNA-damage-responsive acetylation of pRb regulates binding to E2F-1.
RL EMBO Rep. 7:192-198 (2006).
RN [59]; RE0054493.
RX PUBMED: 15893610.
RA Tencheva Z. S., Praskova M. D., Velichkova A. A., Mitev V. I.
RT delta-Opioid agonist induced regulation of E2F1 DNA binding activity in NG108-15 cells.
RL Mol. Brain Res. 136:271-274 (2005).
RN [60]; RE0054655.
RX PUBMED: 11459832.
RA Lin W. C., Lin F. T., Nevins J. R.
RT Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.
RL Genes Dev. 15:1833-1844 (2001).
RN [61]; RE0054705.
RX PUBMED: 18342022.
RA Tapias A., Ciudad C. J., Noe V.
RT Transcriptional regulation of the 5'-flanking region of the human transcription factor Sp3 gene by NF-1, c-Myb, B-Myb, AP-1 and E2F.
RL Biochim. Biophys. Acta 1779:318-329 (2008).
RN [62]; RE0055135.
RX PUBMED: 18542057.
RA Araki K., Kawauchi K., Tanaka N.
RT IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors.
RL Oncogene 27:5696-5705 (2008).
RN [63]; RE0064794.
RX PUBMED: 19088195.
RA Shaw J., Yurkova N., Zhang T., Gang H., Aguilar F., Weidman D., Scramstad C., Weisman H., Kirshenbaum L. A.
RT Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival.
RL Proc. Natl. Acad. Sci. USA 105:20734-20739 (2008).
RN [64]; RE0066230.
RX PUBMED: 20040599.
RA Paik J. C., Wang B., Liu K., Lue J. K., Lin W. C.
RT Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.
RL J. Biol. Chem. 285:6348-6363 (2010).
XX
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