AC T15350
XX
ID T15350
XX
DT 10.03.2005 (created); nvo.
DT 23.09.2014 (updated); pos.
CO Copyright (C), QIAGEN.
XX
FA PARP
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SY ADPRT; NAD+ ADP-ribosyltransferase-1; PARP-1; poly polymerase; poly(ADP-ribose) polymerase; poly-ADP-ribose synthetase-1.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T10504 AP-2alpha; Mammalia.
IN T16699 B-Myb; Mammalia.
IN T09570 E2F-1; Mammalia.
IN T21588 NOR1; Mammalia.
IN T24736 nucleolin; Mammalia.
IN T01427 p300; human, Homo sapiens.
IN T08628 POU2F1; Mammalia.
IN T24182 PR; Mammalia.
IN T30703 SIRT1; Mammalia.
IN T09133 YY1; Mammalia.
XX
MX M01211 V$PARP_Q3.
MX M02027 V$PARP_Q4.
XX
BS R25795.
BS R42341.
BS R60838.
XX
DR TRANSPATH: MO000047552.
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RN [1]; RE0025744.
RX PUBMED: 12011073.
RA Saxena A., Saffery R., Wong L. H., Kalitsis P., Choo K. H.
RT Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated.
RL J. Biol. Chem. 277:26921-6 (2002).
RN [2]; RE0031390.
RX PUBMED: 12897160.
RA Leppard J. B., Dong Z., Mackey Z. B., Tomkinson A. E.
RT Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair.
RL Mol. Cell. Biol. 23:5919-27 (2003).
RN [3]; RE0031924.
RX PUBMED: 12217960.
RA Saxena A., Wong L. H., Kalitsis P., Earle E., Shaffer L. G., Choo K. H.
RT Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc.
RL Hum. Mol. Genet. 11:2319-29 (2002).
RN [4]; RE0033479.
RX PUBMED: 9889285.
RA Kannan P., Yu Y., Wankhade S., Tainsky M. A.
RT PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation.
RL Nucleic Acids Res. 27:866-74 (1999).
RN [5]; RE0034200.
RX PUBMED: 11403206.
RA Sharp C., Warren A., Oshima T., Williams L., Li J. H., Alexander J. S.
RT Poly ADP ribose-polymerase inhibitors prevent the upregulation of ICAM-1 and E-selectin in response to Th1 cytokine stimulation.
RL Inflammation 25:157-63 (2001).
RN [6]; RE0034201.
RX PUBMED: 11841805.
RA Cuzzocrea S., McDonald M. C., Mazzon E., Dugo L., Serraino I., Threadgill M., Caputi A. P., Thiemermann C.
RT Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury.
RL Biochem. Pharmacol. 63:293-304 (2002).
RN [7]; RE0034286.
RX PUBMED: 9603959.
RA Ruscetti T., Lehnert B. E., Halbrook J., Le Trong H., Hoekstra M. F., Chen D. J., Peterson S. R.
RT Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase.
RL J. Biol. Chem. 273:14461-7 (1998).
RN [8]; RE0036748.
RX PUBMED: 12640039.
RA Augustin A., Spenlehauer C., Dumond H., Menissier-de Murcia J., Piel M., Schmit A. C., Apiou F., Vonesch J. L., Kock M., Bornens M., de Murcia G.
RT PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression
RL J. Cell Sci. 116:1551-62 (2003).
RN [9]; RE0036931.
RX PUBMED: 10075978.
RA Schneider T. J., Fischer G. M., Donohoe T. J., Colarusso T. P., Rothstein T. L.
RT A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes
RL J. Exp. Med. 189:949-56 (1999).
RN [10]; RE0038019.
RX PUBMED: 9928945.
RA Griesenbeck J., Ziegler M., Tomilin N., Schweiger M., Oei S. L.
RT Stimulation of the catalytic activity of poly(ADP-ribosyl) transferase by transcription factor Yin Yang 1
RL FEBS Lett. 443:20-4 (1999).
RN [11]; RE0038490.
RX PUBMED: 12675907.
RA Chiarugi A., Moskowitz M. A.
RT Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders
RL J. Neurochem 85:306-17 (2003).
RN [12]; RE0038491.
RX PUBMED: 11432840.
RA Conde C., Mark M., Oliver F. J., Huber A., de Murcia G., Menissier-de Murcia J.
RT Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice
RL EMBO J. 20:3535-43 (2001).
RN [13]; RE0041244.
RX PUBMED: 14627987.
RA Simbulan-Rosenthal C. M., Rosenthal D. S., Luo R., Samara R., Espinoza L. A., Hassa P. O., Hottiger M. O., Smulson M. E.
RT PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase
RL Oncogene 22:8460-71 (2003).
RN [14]; RE0042226.
RX PUBMED: 12960163.
RA Hassa P. O., Buerki C., Lombardi C., Imhof R., Hottiger M. O.
RT Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1
RL J. Biol. Chem. 278:45145-53 (2003).
RN [15]; RE0042430.
RX PUBMED: 14521911.
RA Ota K., Kameoka M., Tanaka Y., Itaya A., Yoshihara K.
RT Expression of histone acetyltransferases was down-regulated in poly(ADP-ribose) polymerase-1-deficient murine cells
RL Biochem. Biophys. Res. Commun. 310:312-7 (2003).
RN [16]; RE0042690.
RX PUBMED: 11437367.
RA Oei S. L., Shi Y.
RT Poly(ADP-ribosyl)ation of transcription factor Yin Yang 1 under conditions of DNA damage
RL Biochem. Biophys. Res. Commun. 285:27-31 (2001).
RN [17]; RE0044094.
RX PUBMED: 11035063.
RA Hossain K., Akhand A. A., Kato M., Du J., Takeda K., Wu J., Takeuchi K., Liu W., Suzuki H., Nakashima I.
RT Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase
RL J. Immunol. 165:4290-7 (2000).
RN [18]; RE0044237.
RX PUBMED: 9872931.
RA del Bello B., Paolicchi A., Comporti M., Pompella A., Maellaro E.
RT Hydrogen peroxide produced during gamma-glutamyl transpeptidase activity is involved in prevention of apoptosis and maintainance of proliferation in U937 cells
RL FASEB J. 13:69-79 (1999).
RN [19]; RE0044696.
RX PUBMED: 9393748.
RA Akahani S., Nangia-Makker P., Inohara H., Kim H. R., Raz A.
RT Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family
RL Cancer Res. 57:5272-6 (1997).
RN [20]; RE0045497.
RX PUBMED: 9584196.
RA Masson M., Niedergang C., Schreiber V., Muller S., Menissier-de Murcia J., de Murcia G.
RT XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
RL Mol. Cell. Biol. 18:3563-71 (1998).
RN [21]; RE0045695.
RX PUBMED: 11781564.
RA Ullrich O., Diestel A., Eyupoglu I. Y., Nitsch R.
RT Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1
RL Nat. Cell Biol. 3:1035-42 (2001).
RN [22]; RE0046148.
RX PUBMED: 11134536.
RA Akiyama T., Takasawa S., Nata K., Kobayashi S., Abe M., Shervani N. J., Ikeda T., Nakagawa K., Unno M., Matsuno S., Okamoto H.
RT Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation
RL Proc. Natl. Acad. Sci. USA 98:48-53 (2001).
RN [23]; RE0046320.
RX PUBMED: 10744766.
RA Cervellera M. N., Sala A.
RT Poly(ADP-ribose) polymerase is a B-MYB coactivator
RL J. Biol. Chem. 275:10692-6 (2000).
RN [24]; RE0046321.
RX PUBMED: 11781832.
RA Santilli G., Cervellera M. N., Johnson T. K., Lewis R. E., Iacobelli S., Sala A.
RT PARP co-activates B-MYB through enhanced phosphorylation at cyclin/cdk2 sites
RL Oncogene 20:8167-74 (2001).
RN [25]; RE0047279.
RX PUBMED: 12114629.
RA Yu S. W., Wang H., Poitras M. F., Coombs C., Bowers W. J., Federoff H. J., Poirier G. G., Dawson T. M., Dawson V. L.
RT Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor
RL Science 297:259-63 (2002).
RN [26]; RE0048080.
RX PUBMED: 12930846.
RA Frouin I., Maga G., Denegri M., Riva F., Savio M., Spadari S., Prosperi E., Scovassi A. I.
RT Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners.
RL J. Biol. Chem. 278:39265-39268 (2003).
RN [27]; RE0048367.
RX PUBMED: 15664982.
RA Liu H., Chang D. W., Yang X.
RT Interdimer processing and linearity of procaspase-3 activation. A unifying mechanism for the activation of initiator and effector caspases.
RL J. Biol. Chem. 280:11578-11582 (2005).
RN [28]; RE0049701.
RX PUBMED: 17167422.
RA Ribeil J. A., Zermati Y., Vandekerckhove J., Cathelin S., Kersual J., Dussiot M., Coulon S., Moura I. C., Zeuner A., Kirkegaard-Sorensen T., Varet B., Solary E., Garrido C., Hermine O.
RT Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
RL Nature 445:102-105 (2007).
RN [29]; RE0049828.
RX PUBMED: 16204234.
RA Hassa P. O., Haenni S. S., Buerki C., Meier N. I., Lane W. S., Owen H., Gersbach M., Imhof R., Hottiger M. O.
RT Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.
RL J. Biol. Chem. 280:40450-40464 (2005).
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