AC T24182
XX
ID T24182
XX
DT 10.03.2005 (created); nvo.
DT 10.01.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA PR
XX
SY NR3C3; PGR; PR; progesterone receptor.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T15204 brca1; Mammalia.
IN T15118 CBP; Mammalia.
IN T16474 HMGB1; Mammalia.
IN T32445 Ku70; Mammalia.
IN T32444 Ku80; Mammalia.
IN T15350 PARP; Mammalia.
IN T08628 POU2F1; Mammalia.
IN T08326 Sp1; Mammalia.
IN T14458 STAT3; Mammalia.
IN T16819 STAT5A; Mammalia.
IN T14270 STAT5B; Mammalia.
XX
MX M00954 V$PR_01.
MX M00957 V$PR_02.
MX M00960 V$PR_Q2.
MX M03799 V$PR_Q6.
XX
BS R38693.
BS R38727.
BS R38728.
BS R01107.
XX
DR TRANSPATH: MO000048021.
DR TRANSCOMPEL: C00002.
DR TRANSCOMPEL: C00043.
XX
RN [1]; RE0020444.
RX PUBMED: 11165037.
RA Fazzari A., Catalano M. G., Comba A., Becchis M., Raineri M., Frairia R., Fortunati N.
RT The control of progesterone receptor expression in MCF-7 breast cancer cells: effects of estradiol and sex hormone-binding globulin (SHBG)
RL Mol. Cell. Endocrinol. 172:31-36 (2001).
RN [2]; RE0025703.
RX PUBMED: 11809754.
RA Hernandez M. P., Chadli A., Toft D. O.
RT HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor.
RL J. Biol. Chem. 277:11873-81 (2002).
RN [3]; RE0027017.
RX PUBMED: 9658403.
RA Le Bihan S., Marsaud V., Mercier-Bodard C., Baulieu E. E., Mader S., White J. H., Renoir J. M.
RT Calcium/calmodulin kinase inhibitors and immunosuppressant macrolides rapamycin and FK506 inhibit progestin- and glucocorticosteroid receptor-mediated transcription in human breast cancer T47D cells.
RL Mol. Endocrinol. 12:986-1001 (1998).
RN [4]; RE0027854.
RX PUBMED: 11117529.
RA Kotaja N., Aittomaki S., Silvennoinen O., Palvimo J. J., Janne O. A.
RT ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation.
RL Mol. Endocrinol. 14:1986-2000 (2000).
RN [5]; RE0028495.
RX PUBMED: 9830049.
RA Kosano H., Stensgard B., Charlesworth M. C., McMahon N., Toft D.
RT The assembly of progesterone receptor-hsp90 complexes using purified proteins.
RL J. Biol. Chem. 273:32973-9 (1998).
RN [6]; RE0028839.
RX PUBMED: 10750018.
RA Sartorius C. A., Takimoto G. S., Richer J. K., Tung L., Horwitz K. B.
RT Association of the Ku autoantigen/DNA-dependent protein kinase holoenzyme and poly(ADP-ribose) polymerase with the DNA binding domain of progesterone receptors.
RL J. Mol. Endocrinol. 24:165-82 (2000).
RN [7]; RE0028914.
RX PUBMED: 9222609.
RA Nair S. C., Toran E. J., Rimerman R. A., Hjermstad S., Smithgall T. E., Smith D. F.
RT A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor.
RL Cell Stress Chaperones 1:237-50 (1996).
RN [8]; RE0029304.
RX PUBMED: 11606780.
RA Liu Z., Wong J., Tsai S. Y., Tsai M. J., O'Malley B. W.
RT Sequential recruitment of steroid receptor coactivator-1 (SRC-1) and p300 enhances progesterone receptor-dependent initiation and reinitiation of transcription from chromatin.
RL Proc. Natl. Acad. Sci. USA 98:12426-31 (2001).
RN [9]; RE0030664.
RX PUBMED: 12604642.
RA Shao R., Markstrom E., Friberg P. A., Johansson M., Billig H.
RT Expression of progesterone receptor (PR) A and B isoforms in mouse granulosa cells: stage-dependent PR-mediated regulation of apoptosis and cell proliferation.
RL Biol. Reprod. 68:914-21 (2003).
RN [10]; RE0032727.
RX PUBMED: 15155784.
RA Zoumpoulidou G., Jones M. C., de Mattos S. F., Francis J. M., Fusi L., Lee Y. S., Christian M., Varshochi R., Lam E. W., Brosens J. J.
RT Convergence of interferon-gamma and progesterone signaling pathways in human endometrium: role of PIASy (protein inhibitor of activated signal transducer and activator of transcription-y).
RL Mol. Endocrinol. 18:1988-1999 (2004).
RN [11]; RE0034422.
RX PUBMED: 12529333.
RA Chauchereau A., Amazit L., Quesne M., Guiochon-Mantel A., Milgrom E.
RT Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.
RL J. Biol. Chem. 278:12335-43 (2003).
RN [12]; RE0034484.
RX PUBMED: 12529413.
RA Labriola L., Salatino M., Proietti C. J., Pecci A., Coso O. A., Kornblihtt A. R., Charreau E. H., Elizalde P. V.
RT Heregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells.
RL Mol. Cell. Biol. 23:1095-111 (2003).
RN [13]; RE0036150.
RX PUBMED: 11574675.
RA Zhou D., Chen S.
RT PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif.
RL Nucleic Acids Res. 29:3939-3948 (2001).
RN [14]; RE0036670.
RX PUBMED: 9857057.
RA Chen S., Smith D. F.
RT Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery
RL J. Biol. Chem. 273:35194-200 (1998).
RN [15]; RE0037606.
RX PUBMED: 9171243.
RA Humphreys R. C., Lydon J., O'Malley B. W., Rosen J. M.
RT Mammary gland development is mediated by both stromal and epithelial progesterone receptors
RL Mol. Endocrinol. 11:801-11 (1997).
RN [16]; RE0037650.
RX PUBMED: 12039952.
RA Qi C., Chang J., Zhu Y., Yeldandi A. V., Rao S. M., Zhu Y. J.
RT Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha
RL J. Biol. Chem. 277:28624-30 (2002).
RN [17]; RE0038774.
RX PUBMED: 9891052.
RA Nawaz Z., Lonard D. M., Smith C. L., Lev-Lehman E., Tsai S. Y., Tsai M. J., O'Malley B. W.
RT The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily
RL Mol. Cell. Biol. 19:1182-9 (1999).
RN [18]; RE0039309.
RX PUBMED: 12746298.
RA Hubler T. R., Denny W. B., Valentine D. L., Cheung-Flynn J., Smith D. F., Scammell J. G.
RT The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness
RL Endocrinology 144:2380-7 (2003).
RN [19]; RE0040387.
RX PUBMED: 15149733.
RA Garibay-Tupas J. L., Okazaki K. J., Tashima L. S., Yamamoto S., Bryant-Greenwood G. D.
RT Regulation of the human relaxin genes H1 and H2 by steroid hormones
RL Mol. Cell. Endocrinol. 219:115-25 (2004).
RN [20]; RE0041703.
RX PUBMED: 12554765.
RA Cui X., Zhang P., Deng W., Oesterreich S., Lu Y., Mills G. B., Lee A. V.
RT Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer
RL Mol. Endocrinol. 17:575-88 (2003).
RN [21]; RE0043194.
RX PUBMED: 10441490.
RA Shaw P. A., Chaparro O.
RT The 5'-flanking sequence and regulatory elements of the cystatin S gene
RL Biochem. Biophys. Res. Commun. 261:705-11 (1999).
RN [22]; RE0043229.
RX PUBMED: 10085091.
RA Kang H. Y., Yeh S., Fujimoto N., Chang C.
RT Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor
RL J. Biol. Chem. 274:8570-6 (1999).
RN [23]; RE0043281.
RX PUBMED: 10965904.
RA Xu M., Urban J. H., Hill J. W., Levine J. E.
RT Regulation of hypothalamic neuropeptide Y Y1 receptor gene expression during the estrous cycle: role of progesterone receptors
RL Endocrinology 141:3319-27 (2000).
RN [24]; RE0043443.
RX PUBMED: 8649367.
RA Imhof M. O., McDonnell D. P.
RT Yeast RSP5 and its human homolog hRPF1 potentiate hormone-dependent activation of transcription by human progesterone and glucocorticoid receptors
RL Mol. Cell. Biol. 16:2594-605 (1996).
RN [25]; RE0043470.
RX PUBMED: 11884637.
RA Matsui D., Sakari M., Sato T., Murayama A., Takada I., Kim M., Takeyama K., Kato S.
RT Transcriptional regulation of the mouse steroid 5alpha-reductase type II gene by progesterone in brain
RL Nucleic Acids Res. 30:1387-93 (2002).
RN [26]; RE0044121.
RX PUBMED: 9699879.
RA Jung-Testas I., Baulieu E. E.
RT Steroid hormone receptors and steroid action in rat glial cells of the central and peripheral nervous system
RL J. Steroid Biochem. Mol. Biol. 65:243-51 (1998).
RN [27]; RE0044123.
RX PUBMED: 15178746.
RA Shi H. Y., Lydon J. P., Zhang M.
RT Hormonal defect in maspin heterozygous mice reveals a role of progesterone in pubertal ductal development
RL Mol. Endocrinol. 18:2196-207 (2004).
RN [28]; RE0044182.
RX PUBMED: 9514153.
RA Wissink S., van Heerde E. C., vand der Burg B., van der Saag P. T.
RT A dual mechanism mediates repression of NF-kappaB activity by glucocorticoids
RL Mol. Endocrinol. 12:355-63 (1998).
RN [29]; RE0044183.
RX PUBMED: 8961269.
RA Apostolakis E. M., Garai J., Clark J. H., O'Malley B. W.
RT In vivo regulation of central nervous system progesterone receptors: cocaine induces steroid-dependent behavior through dopamine transporter modulation of D5 receptors in rats
RL Mol. Endocrinol. 10:1595-604 (1996).
RN [30]; RE0044184.
RX PUBMED: 8453620.
RA Danforth D. N. Jr, Sgagias M. K.
RT Interleukin-1 alpha and interleukin-6 act additively to inhibit growth of MCF-7 breast cancer cells in vitro
RL Cancer Res. 53:1538-45 (1993).
RN [31]; RE0044185.
RX PUBMED: 9510069.
RA O'Conner J. L., Wade M. F., Prendergast P., Edwards D. P., Boonyaratanakornkit V., Mahesh V. B.
RT A 361 base pair region of the rat FSH-beta promoter contains multiple progesterone receptor-binding sequences and confers progesterone responsiveness
RL Mol. Cell. Endocrinol. 136:67-78 (1997).
RN [32]; RE0044186.
RX PUBMED: 11062008.
RA Moore M. R., Conover J. L., Franks K. M.
RT Progestin effects on long-term growth, death, and Bcl-xL in breast cancer cells
RL Biochem. Biophys. Res. Commun. 277:650-4 (2000).
RN [33]; RE0044236.
RX PUBMED: 7984148.
RA Turgeon J. L., Waring D. W.
RT Activation of the progesterone receptor by the gonadotropin-releasing hormone self-priming signaling pathway
RL Mol. Endocrinol. 8:860-9 (1994).
RN [34]; RE0044251.
RX PUBMED: 8012965.
RA Leavitt J., Chen Z. P., Lockwood C. J., Schatz F.
RT Regulation of synthesis of the transformation-induced protein, leukocyte plastin, by ovarian steroid hormones
RL Cancer Res. 54:3447-54 (1994).
RN [35]; RE0044254.
RX PUBMED: 1958511.
RA Malet C., Vacca A., Kuttenn F., Mauvais-Jarvis P.
RT 17 beta-estradiol dehydrogenase (E2DH) activity in T47D cells
RL J. Steroid Biochem. Mol. Biol. 39:769-75 (1991).
RN [36]; RE0044255.
RX PUBMED: 1562533.
RA Jung-Testas I., Renoir M., Bugnard H., Greene G. L., Baulieu E. E.
RT Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells
RL J. Steroid Biochem. Mol. Biol. 41:621-31 (1992).
RN [37]; RE0044260.
RX PUBMED: 9671457.
RA Boonyaratanakornkit V., Melvin V., Prendergast P., Altmann M., Ronfani L., Bianchi M. E., Taraseviciene L., Nordeen S. K., Allegretto E. A., Edwards D. P.
RT High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells
RL Mol. Cell. Biol. 18:4471-87 (1998).
RN [38]; RE0044264.
RX PUBMED: 12011095.
RA Henderson M. J., Russell A. J., Hird S., Munoz M., Clancy J. L., Lehrbach G. M., Calanni S. T., Jans D. A., Sutherland R. L., Watts C. K.
RT EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response
RL J. Biol. Chem. 277:26468-78 (2002).
RN [39]; RE0044335.
RX PUBMED: 12114521.
RA Abdel-Hafiz H., Takimoto G. S., Tung L., Horwitz K. B.
RT The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepression
RL J. Biol. Chem. 277:33950-6 (2002).
RN [40]; RE0044348.
RX PUBMED: 12907688.
RA Russell D. L., Doyle K. M., Ochsner S. A., Sandy J. D., Richards J. S.
RT Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation
RL J. Biol. Chem. 278:42330-9 (2003).
RN [41]; RE0044350.
RX PUBMED: 12566092.
RA Garnier M., Giamarchi C., Delrieu I., Rio M. C., Chinestra P., Bayard F., Poirot M., Faye J. C.
RT Insulin and estrogen receptor ligand influence the FGF-2 activities in MCF-7 breast cancer cells
RL Biochem. Pharmacol. 65:629-36 (2003).
RN [42]; RE0044352.
RX PUBMED: 10727250.
RA Kurita T., Lee K. J., Cooke P. S., Lydon J. P., Cunha G. R.
RT Paracrine regulation of epithelial progesterone receptor and lactoferrin by progesterone in the mouse uterus
RL Biol. Reprod. 62:831-8 (2000).
RN [43]; RE0044353.
RX PUBMED: 14593074.
RA Apostolakis E. M., Lanz R., O'Malley B. W.
RT Pituitary adenylate cyclase-activating peptide: a pivotal modulator of steroid-induced reproductive behavior in female rodents
RL Mol. Endocrinol. 18:173-83 (2004).
RN [44]; RE0044354.
RX PUBMED: 11773445.
RA Christian M., Pohnke Y., Kempf R., Gellersen B., Brosens J. J.
RT Functional association of PR and CCAAT/enhancer-binding protein beta isoforms: promoter-dependent cooperation between PR-B and liver-enriched inhibitory protein, or liver-enriched activatory protein and PR-A in human endometrial stromal cells
RL Mol. Endocrinol. 16:141-54 (2002).
RN [45]; RE0044376.
RX PUBMED: 9488452.
RA Wagner B. L., Norris J. D., Knotts T. A., Weigel N. L., McDonnell D. P.
RT The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor
RL Mol. Cell. Biol. 18:1369-78 (1998).
RN [46]; RE0046464.
RX PUBMED: 7790381.
RA Li M., Spitzer E., Zschiesche W., Binas B., Parczyk K., Grosse R.
RT Antiprogestins inhibit growth and stimulate differentiation in the normal mammary gland
RL J. Cell. Physiol. 164:1-8 (1995).
RN [47]; RE0051005.
RX PUBMED: 16109739.
RA Ma Y., Katiyar P., Jones L. P., Fan S., Zhang Y., Furth P. A., Rosen E. M.
RT The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells.
RL Mol. Endocrinol. 20:14-34 (2006).
XX
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