AC T16819
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ID T16819
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DT 10.03.2005 (created); nvo.
DT 17.12.2014 (updated); sup.
CO Copyright (C), QIAGEN.
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FA STAT5A
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SY signal transducer and activator of transcription 5A.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T15204 brca1; Mammalia.
IN T10012 BRCA2; human, Homo sapiens.
IN T10446 GR; Mammalia.
IN T23091 p300; Mammalia.
IN T24182 PR; Mammalia.
IN T21552 SRC-1; Mammalia.
IN T14458 STAT3; Mammalia.
IN T14270 STAT5B; Mammalia.
IN T09133 YY1; Mammalia.
XX
MX M00457 V$STAT5A_01.
MX M00460 V$STAT5A_02.
MX M00493 V$STAT5A_03.
MX M00499 V$STAT5A_04.
MX M07311 V$STAT5A_Q4.
MX M01890 V$STAT5A_Q6.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
XX
BS R38331.
BS R38336.
BS R56952.
BS R56955.
BS R13351.
BS R73423.
BS R04917.
BS R65340.
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DR TRANSPATH: MO000047433.
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RN [1]; RE0023187.
RX PUBMED: 12089361.
RA Carsol J. L., Gingras S., Simard J.
RT Synergistic action of prolactin (PRL) and androgen on PRL-inducible protein gene expression in human breast cancer cells: a unique model for functional cooperation between signal transducer and activator of transcription-5 and androgen receptor.
RL Mol. Endocrinol. 16:1696-1710 (2002).
RN [2]; RE0024943.
RX PUBMED: 12954634.
RA Litterst C. M., Kliem S., Marilley D., Pfitzner E.
RT NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.
RL J. Biol. Chem. 278:45340-45351 (2003).
RN [3]; RE0024992.
RX PUBMED: 12732616.
RA Wang R. A., Vadlamudi R. K., Bagheri-Yarmand R., Beuvink I., Hynes N. E., Kumar R.
RT Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands.
RL J. Biol. Chem. 161:583-592 (2003).
RN [4]; RE0028333.
RX PUBMED: 11238613.
RA Behbod F., Erwin-Cohen R. A., Wang M. E., Trawick B. W., Qu X., Verani R., Kahan B. D., Stepkowski S. M., Kirken R. A.
RT Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.
RL J. Immunol. 166:3724-32 (2001).
RN [5]; RE0032770.
RX PUBMED: 14684617.
RA Cao J., Wood M., Liu Y., Hoffman T., Hyde J., Park-Sarge O. K., Vore M.
RT Estradiol represses prolactin-induced expression of Na+/taurocholate cotransporting polypeptide in liver cells through estrogen receptor-alpha and signal transducers and activators of transcription 5a.
RL Endocrinology 145:1739-49 (2004).
RN [6]; RE0032930.
RX PUBMED: 9773981.
RA Pfitzner E., Jahne R., Wissler M., Stoecklin E., Groner B.
RT p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response.
RL Mol. Endocrinol. 12:1582-93 (1998).
RN [7]; RE0039373.
RX PUBMED: 11413148.
RA Mahajan S., Vassilev A., Sun N., Ozer Z., Mao C., Uckun F. M.
RT Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells
RL J. Biol. Chem. 276:31216-28 (2001).
RN [8]; RE0041349.
RX PUBMED: 10974037.
RA Zhang S., Fukuda S., Lee Y., Hangoc G., Cooper S., Spolski R., Leonard W. J., Broxmeyer H. E.
RT Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling
RL J. Exp. Med. 192:719-28 (2000).
RN [9]; RE0041350.
RX PUBMED: 12198240.
RA Peng B., Sutherland K. D., Sum E. Y., Olayioye M., Wittlin S., Tang T. K., Lindeman G. J., Visvader J. E.
RT CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity
RL Mol. Endocrinol. 16:2019-33 (2002).
RN [10]; RE0041351.
RX PUBMED: 12529425.
RA Benitah S. A., Valeron P. F., Rui H., Lacal J. C.
RT STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA
RL Mol. Biol. Cell 14:40-53 (2003).
RN [11]; RE0041352.
RX PUBMED: 11254359.
RA Ilan N., Cheung L., Miller S., Mohsenin A., Tucker A., Madri J. A.
RT Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse
RL Dev. Biol. 232:219-32 (2001).
RN [12]; RE0041683.
RX PUBMED: 12048235.
RA Tsuruyama T., Nakamura T., Jin G., Ozeki M., Yamada Y., Hiai H.
RT Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice
RL Proc. Natl. Acad. Sci. USA 99:8253-8 (2002).
RN [13]; RE0041738.
RX PUBMED: 14583472.
RA Xi S., Zhang Q., Gooding W. E., Smithgall T. E., Grandis J. R.
RT Constitutive activation of Stat5b contributes to carcinogenesis in vivo
RL Cancer Res. 63:6763-71 (2003).
RN [14]; RE0041740.
RX PUBMED: 9390692.
RA Nakajima H., Liu X. W., Wynshaw-Boris A., Rosenthal L. A., Imada K., Finbloom D. S., Hennighausen L., Leonard W. J.
RT An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction
RL Immunity 7:691-701 (1997).
RN [15]; RE0042412.
RX PUBMED: 9528750.
RA Cella N., Groner B., Hynes N. E.
RT Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells
RL Mol. Cell. Biol. 18:1783-92 (1998).
RN [16]; RE0042416.
RX PUBMED: 9182578.
RA Kirken R. A., Malabarba M. G., Xu J., DaSilva L., Erwin R. A., Liu X., Hennighausen L., Rui H., Farrar W. L.
RT Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase
RL J. Biol. Chem. 272:15459-65 (1997).
RN [17]; RE0046456.
RX PUBMED: 15534001.
RA Williams C. C., Allison J. G., Vidal G. A., Burow M. E., Beckman B. S., Marrero L., Jones F. E.
RT The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
RL J. Cell Biol. 167:469-78 (2004).
RN [18]; RE0052153.
RX PUBMED: 11726519.
RA Nakajima H., Brindle P. K., Handa M., Ihle J. N.
RT Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription.
RL EMBO J. 20:6836-6844 (2001).
RN [19]; RE0054366.
RX PUBMED: 10194762.
RA Pircher T. J., Petersen H., Gustafsson J. A., Haldosen L. A.
RT Extracellular signal-regulated kinase (ERK) interacts with signal transducer and activator of transcription (STAT) 5a.
RL Mol. Endocrinol. 13:555-565 (1999).
RN [20]; RE0069503.
RX PUBMED: 20974963.
RA Rochman Y., Kashyap M., Robinson G. W., Sakamoto K., Gomez-Rodriguez J., Wagner K. U., Leonard W. J.
RT Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
RL Proc. Natl. Acad. Sci. USA 107:19455-19460 (2010).
RN [21]; RE0070014.
RX PUBMED: 18347089.
RA Hennighausen L., Robinson G. W.
RT Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B.
RL Genes Dev. 22:711-721 (2008).
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