TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T14458 XX ID T14458 XX DT 10.03.2005 (created); nvo. DT 23.03.2016 (updated); ros. CO Copyright (C), QIAGEN. XX FA STAT3 XX SY Signal Transducer and Activator of Transcription 3. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T08487 AR-isoform1; human, Homo sapiens. IN T15601 AR; Mammalia. IN T00133 c-Jun; human, Homo sapiens. IN T09446 c-Jun; Mammalia. IN T15118 CBP; Mammalia. IN T09920 CREB1; Mammalia. IN T17209 ERK2; Mammalia. IN T14067 FOXO1A; Mammalia. IN T30386 Fra-1; Mammalia. IN T10217 GATA-1; Mammalia. IN T17995 GATA-2; Mammalia. IN T10446 GR; Mammalia. IN T24920 HEN2; Mammalia. IN T13841 HES-1; Mammalia. IN T22503 IkappaBzeta; human, Homo sapiens. IN T06054 islet1-isoform1; mouse, Mus musculus. IN T10027 MyoD; Mammalia. IN T05299 NR1B1; human, Homo sapiens. IN T14193 NR1B1; Mammalia. IN T23091 p300; Mammalia. IN T29721 Pkm2-isoform-M2; human, Homo sapiens. IN T08628 POU2F1; Mammalia. IN T24182 PR; Mammalia. IN T10397 RelA-p65; Mammalia. IN T30231 SIRT1-isoform1; human, Homo sapiens. IN T10783 Smad1; Mammalia. IN T09538 Smad3; Mammalia. IN T08484 Sp1-isoform1; human, Homo sapiens. IN T00759 Sp1; human, Homo sapiens. IN T08326 Sp1; Mammalia. IN T23076 STAT1; Mammalia. IN T16670 STAT2; Mammalia. IN T16672 STAT4; Mammalia. IN T16819 STAT5A; Mammalia. IN T14270 STAT5B; Mammalia. IN T01417 TEL1; human, Homo sapiens. IN T08814 TEL1; human, Homo sapiens. IN T10505 TTF-1; Mammalia. XX MX M00225 V$STAT3_01. MX M00497 V$STAT3_02. MX M01595 V$STAT3_03. MX M07065 V$STAT3_Q4. MX M00223 V$STAT_01. MX M00777 V$STAT_Q6. XX BS R12445. BS R67543. BS R32825. BS R68172. BS R62116. BS R22348. BS R65552. BS R74041. BS R61535. BS R59996. BS R24503. BS R62620. BS R59402. BS R64943. BS R61596. BS R61597. BS R61598. BS R61599. BS R73316. BS R24453. BS R24504. BS R25400. BS R62911. BS R33133. BS R25729. BS R14446. BS R30913. XX DR TRANSPATH: MO000047945. DR TRANSCOMPEL: C00179. DR TRANSCOMPEL: C00294. DR TRANSCOMPEL: C00296. DR TRANSCOMPEL: C00641. DR TRANSCOMPEL: C00642. XX RN [1]; RE0018085. RX PUBMED: 11278353. RA Lim C. P., Cao X. RT Regulation of Stat3 activation by MEK kinase 1. RL J. Biol. Chem. 276:21004-21011 (2001). RN [2]; RE0020762. RX PUBMED: 11350938. RA Deb A., Zamanian-Daryoush M., Xu Z., Kadereit S., Williams B. R. RT Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3 RL EMBO J. 20:2487-2496 (2001). RN [3]; RE0022192. RX PUBMED: 10954736. RA Collum R. G., Brutsaert S., Lee G., Schindler C. RT A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. RL Proc. Natl. Acad. Sci. USA 97:10120-10125 (2000). RN [4]; RE0023482. RX PUBMED: 12244095. RA Schreiner S. J., Schiavone A. P., Smithgall T. E. RT Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. RL J. Biol. Chem. 277:45680-45687 (2002). RN [5]; RE0024704. RX PUBMED: 12551922. RA Xiao H., Chung J., Kao H. Y., Yang Y. C. RT Tip60 is a co-repressor for STAT3. RL J. Biol. Chem. 278:11197-11204 (2003). RN [6]; RE0025137. RX PUBMED: 11134186. RA Harris M., Aschkenasi C., Elias C. F., Chandrankunnel A., Nillni E. A., Bjoorbaek C., Elmquist J. K., Flier J. S., Hollenberg A. N. RT Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. RL J. Clin. Invest. 107:111-120 (2001). RN [7]; RE0025723. RX PUBMED: 11889125. RA Panopoulos A. D., Bartos D., Zhang L., Watowich S. S. RT Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1. RL J. Biol. Chem. 277:19001-7 (2002). RN [8]; RE0026400. RX PUBMED: 10675331. RA Goi T., Shipitsin M., Lu Z., Foster D. A., Klinz S. G., Feig L. A. RT An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity. RL EMBO J. 19:623-30 (2000). RN [9]; RE0026745. RX PUBMED: 10878010. RA Priel-Halachmi S., Ben-Dor I., Shpungin S., Tennenbaum T., Molavani H., Bachrach M., Salzberg S., Nir U. RT FER kinase activation of Stat3 is determined by the N-terminal sequence. RL J. Biol. Chem. 275:28902-10 (2000). RN [10]; RE0026865. RX PUBMED: 10770494. RA Peters C. A., Maizels E. T., Robertson M. C., Shiu R. P., Soloff M. S., Hunzicker-Dunn M. RT Induction of relaxin messenger RNA expression in response to prolactin receptor activation requires protein kinase C delta signaling. RL Mol. Endocrinol. 14:576-90 (2000). RN [11]; RE0026943. RX PUBMED: 11021822. RA Bone-Larson C. L., Hogaboam C. M., Steinhauser M. L., Oliveira S. H., Lukacs N. W., Strieter R. M., Kunkel S. L. RT Novel protective effects of stem cell factor in a murine model of acute septic peritonitis : dependence on MCP-1 RL Am. J. Pathol. 157:1177-86 (2000). RN [12]; RE0027113. RX PUBMED: 10616907. RA Kirillova I., Chaisson M., Fausto N. RT Tumor necrosis factor induces DNA replication in hepatic cells through nuclear factor kappaB activation. RL Cell Growth Differ. 10:819-28 (1999). RN [13]; RE0027502. RX PUBMED: 10688651. RA Tsai Y. T., Su Y. H., Fang S. S., Huang T. N., Qiu Y., Jou Y. S., Shih H. M., Kung H. J., Chen R. H. RT Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. RL Mol. Cell. Biol. 20:2043-54 (2000). RN [14]; RE0028237. RX PUBMED: 11309383. RA Lukashova V., Asselin C., Krolewski J. J., Rola-Pleszczynski M., Stankova J. RT G-protein-independent activation of Tyk2 by the platelet-activating factor receptor. RL J. Biol. Chem. 276:24113-21 (2001). RN [15]; RE0028834. RX PUBMED: 10449753. RA Li C., Friedman J. M. RT Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. RL Proc. Natl. Acad. Sci. USA 96:9677-82 (1999). RN [16]; RE0029513. RX PUBMED: 11923478. RA Ray S., Sherman C. T., Lu M., Brasier A. R. RT Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity. RL Mol. Endocrinol. 16:824-36 (2002). RN [17]; RE0030219. RX PUBMED: 12444102. RA Scoles D. R., Nguyen V. D., Qin Y., Sun C. X., Morrison H., Gutmann D. H., Pulst S. M. RT Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. RL Hum. Mol. Genet. 11:3179-89 (2002). RN [18]; RE0030289. RX PUBMED: 12697721. RA Munzberg H., Huo L., Nillni E. A., Hollenberg A. N., Bjorbaek C. RT Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. RL Endocrinology 144:2121-31 (2003). RN [19]; RE0030449. RX PUBMED: 12637586. RA Hwang J. H., Kim D. W., Suh J. M., Kim H., Song J. H., Hwang E. S., Park K. C., Chung H. K., Kim J. M., Lee T. H., Yu D. Y., Shong M. RT Activation of signal transducer and activator of transcription 3 by oncogenic RET/PTC (rearranged in transformation/papillary thyroid carcinoma) tyrosine kinase: roles in specific gene regulation and cellular transformation. RL Mol. Endocrinol. 17:1155-66 (2003). RN [20]; RE0032103. RX PUBMED: 15044588. RA Yang L., Lian X., Cowen A., Xu H., Du H., Yan C. RT Synergy between signal transducer and activator of transcription 3 and retinoic acid receptor-alpha in regulation of the surfactant protein B gene in the lung. RL Mol. Endocrinol. 18:1520-32 (2004). RN [21]; RE0032490. RX PUBMED: 15150095. RA El-Hashemite N., Zhang H., Walker V., Hoffmeister K. M., Kwiatkowski D. J. RT Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment. RL Cancer Res. 64:3436-43 (2004). RN [22]; RE0032494. RX PUBMED: 15176047. RA Lee S. O., Lou W., Johnson C. S., Trump D. L., Gao A. C. RT Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway. RL Prostate 60:178-86 (2004). RN [23]; RE0032507. RX PUBMED: 9154828. RA Chaturvedi P., Sharma S., Reddy E. P. RT Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs. RL Mol. Cell. Biol. 17:3295-304 (1997). RN [24]; RE0032541. RX PUBMED: 14715258. RA Song H., Ethier S. P., Dziubinski M. L., Lin J. RT Stat3 modulates heat shock 27kDa protein expression in breast epithelial cells. RL Biochem. Biophys. Res. Commun. 314:143-50 (2004). RN [25]; RE0032617. RX PUBMED: 14975242. RA Wang L. H., Yang X. Y., Zhang X., Huang J., Hou J., Li J., Xiong H., Mihalic K., Zhu H., Xiao W., Farrar W. L. RT Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells. RL Immunity 20:205-18 (2004). RN [26]; RE0032861. RX PUBMED: 9169415. RA Kim H., Baumann H. RT The carboxyl-terminal region of STAT3 controls gene induction by the mouse haptoglobin promoter. RL J. Biol. Chem. 272:14571-14579 (1997). RN [27]; RE0032932. RX PUBMED: 9872331. RA Jain N., Zhang T., Fong S. L., Lim C. P., Cao X. RT Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK). RL Oncogene 17:3157-67 (1998). RN [28]; RE0034096. RX PUBMED: 15356135. RA Kamiya S., Owaki T., Morishima N., Fukai F., Mizuguchi J., Yoshimoto T. RT An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells. RL J. Immunol. 173:3871-7 (2004). RN [29]; RE0037097. RX PUBMED: 10918073. RA Odajima J., Matsumura I., Sonoyama J., Daino H., Kawasaki A., Tanaka H., Inohara N., Kitamura T., Downward J., Nakajima K., Hirano T., Kanakura Y. RT Full oncogenic activities of v-Src are mediated by multiple signaling pathways. Ras as an essential mediator for cell survival RL J. Biol. Chem. 275:24096-105 (2000). RN [30]; RE0037874. RX PUBMED: 14749354. RA Tong M., Tai H. H. RT Synergistic induction of the nicotinamide adenine dinucleotide-linked 15-hydroxyprostaglandin dehydrogenase by an androgen and interleukin-6 or forskolin in human prostate cancer cells RL Endocrinology 145:2141-7 (2004). RN [31]; RE0038052. RX PUBMED: 12867595. RA Zhang J., Yang J., Roy S. K., Tininini S., Hu J., Bromberg J. F., Poli V., Stark G. R., Kalvakolanu D. V. RT The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3 RL Proc. Natl. Acad. Sci. USA 100:9342-7 (2003). RN [32]; RE0038053. RX PUBMED: 12628925. RA Lufei C., Ma J., Huang G., Zhang T., Novotny-Diermayr V., Ong C. T., Cao X. RT GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction RL EMBO J. 22:1325-35 (2003). RN [33]; RE0038387. RX PUBMED: 9826561. RA Marrero M. B., Venema V. J., He H., Caldwell R. B., Venema R. C. RT Inhibition by the JAK/STAT pathway of IFNgamma- and LPS-stimulated nitric oxide synthase induction in vascular smooth muscle cells RL Biochem. Biophys. Res. Commun. 252:508-12 (1998). RN [34]; RE0038605. RX PUBMED: 12426389. RA Nakayama K., Kim K. W., Miyajima A. RT A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3 RL EMBO J. 21:6174-84 (2002). RN [35]; RE0038747. RX PUBMED: 11248243. RA Kamiya A., Kinoshita T., Miyajima A. RT Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways RL FEBS Lett. 492:90-4 (2001). RN [36]; RE0038782. RX PUBMED: 10383440. RA O'Brien C. A., Gubrij I., Lin S. C., Saylors R. L., Manolagas S. C. RT STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone RL J. Biol. Chem. 274:19301-8 (1999). RN [37]; RE0038973. RX PUBMED: 9670957. RA Mellado M., Rodriguez-Frade J. M., Aragay A., del Real G., Martin A. M., Vila-Coro A. J., Serrano A., Mayor F. Jr, Martinez-A C. RT The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor RL J. Immunol. 161:805-13 (1998). RN [38]; RE0040131. RX PUBMED: 11180401. RA Huang J. S., Guh J. Y., Chen H. C., Hung W. C., Lai Y. H., Chuang L. Y. RT Role of receptor for advanced glycation end-product (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells RL J. Cell. Biochem. 81:102-13 (2001). RN [39]; RE0040843. RX PUBMED: 10639189. RA Spiotto M. T., Chung T. D. RT STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells RL Prostate 42:186-95 (2000). RN [40]; RE0040852. RX PUBMED: 10618415. RA Kunisada K., Negoro S., Tone E., Funamoto M., Osugi T., Yamada S., Okabe M., Kishimoto T., Yamauchi-Takihara K. RT Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy RL Proc. Natl. Acad. Sci. USA 97:315-9 (2000). RN [41]; RE0040904. RX PUBMED: 12875976. RA Ren X., Carpenter A., Hogaboam C., Colletti L. RT Mitogenic properties of endogenous and pharmacological doses of macrophage inflammatory protein-2 after 70% hepatectomy in the mouse RL Am. J. Pathol. 163:563-70 (2003). RN [42]; RE0040976. RX PUBMED: 12865943. RA Wu R., Sun S., Steinberg B. M. RT Requirement of STAT3 activation for differentiation of mucosal stratified squamous epithelium RL Mol. Med. 9:77-84 (2003). RN [43]; RE0040977. RX PUBMED: 12032172. RA Feister H. A., Auerbach B. J., Cole L. A., Krause B. R., Karathanasis S. K. RT Identification of an IL-6 response element in the human LCAT promoter RL J. Lipid Res. 43:960-970 (2002). RN [44]; RE0040979. RX PUBMED: 10329429. RA Ohtomo T., Sugamata Y., Ozaki Y., Ono K., Yoshimura Y., Kawai S., Koishihara Y., Ozaki S., Kosaka M., Hirano T., Tsuchiya M. RT Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells RL Biochem. Biophys. Res. Commun. 258:583-91 (1999). RN [45]; RE0040983. RX PUBMED: 15207851. RA Ozawa Y., Nakao K., Shimazaki T., Takeda J., Akira S., Ishihara K., Hirano T., Oguchi Y., Okano H. RT Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina RL Mol. Cell. Neurosci. 26:258-70 (2004). RN [46]; RE0041039. RX PUBMED: 11463827. RA Prisco M., Peruzzi F., Belletti B., Baserga R. RT Regulation of Id gene expression by type I insulin-like growth factor: roles of Stat3 and the tyrosine 950 residue of the receptor RL Mol. Cell. Biol. 21:5447-58 (2001). RN [47]; RE0041048. RX PUBMED: 14688368. RA Williams L., Bradley L., Smith A., Foxwell B. RT Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages RL J. Immunol. 172:567-76 (2004). RN [48]; RE0041051. RX PUBMED: 11546821. RA Yanagita M., Arai H., Nakano T., Ohashi K., Mizuno K., Fukatsu A., Doi T., Kita T. RT Gas6 induces mesangial cell proliferation via latent transcription factor STAT3 RL J. Biol. Chem. 276:42364-9 (2001). RN [49]; RE0041057. RX PUBMED: 12526081. RA Shin M. H., Lee E. G., Lee S. H., Lee Y. S., Son H. RT Neural cell adhesion molecule (NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type RL Exp. Mol. Med. 34:401-10 (2002). RN [50]; RE0041338. RX PUBMED: 14968112. RA Crockett D. K., Lin Z., Elenitoba-Johnson K. S., Lim M. S. RT Identification of NPM-ALK interacting proteins by tandem mass spectrometry RL Oncogene 23:2617-29 (2004). RN [51]; RE0041343. RX PUBMED: 12456685. RA Kortylewski M., Feld F., Kruger K. D., Bahrenberg G., Roth R. A., Joost H. G., Heinrich P. C., Behrmann I., Barthel A. RT Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism RL J. Biol. Chem. 278:5242-9 (2003). RN [52]; RE0041392. RX PUBMED: 11032724. RA Arinobu Y., Sugimoto R., Akaiwa M., Arima K., Otsuka T., Hamasaki N., Izuhara K. RT Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells RL Biochem. Biophys. Res. Commun. 277:317-24 (2000). RN [53]; RE0041455. RX PUBMED: 12356680. RA Crepaldi L., Silveri L., Calzetti F., Pinardi C., Cassatella M. A. RT Molecular basis of the synergistic production of IL-1 receptor antagonist by human neutrophils stimulated with IL-4 and IL-10 RL Int. Immunol. 14:1145-53 (2002). RN [54]; RE0041456. RX PUBMED: 12531244. RA Tacchini L., Fusar-Poli D., Sironi M., Mantovani A., Bernelli-Zazzera A. RT Activation of signal transducer and activator of transcription 3 in rat liver after heat shock and reperfusion stress RL Int. J. Biochem. Cell Biol. 35:316-23 (2003). RN [55]; RE0041457. RX PUBMED: 12506013. RA Kawasaki A., Matsumura I., Kataoka Y., Takigawa E., Nakajima K., Kanakura Y. RT Opposing effects of PML and PML/RAR alpha on STAT3 activity RL Blood 101:3668-73 (2003). RN [56]; RE0041505. RX PUBMED: 14764630. RA Guo F., Bakal K., Minokoshi Y., Hollenberg A. N. RT Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo RL Endocrinology 145:2221-7 (2004). RN [57]; RE0041507. RX PUBMED: 12947115. RA Kataoka Y., Matsumura I., Ezoe S., Nakata S., Takigawa E., Sato Y., Kawasaki A., Yokota T., Nakajima K., Felsani A., Kanakura Y. RT Reciprocal inhibition between MyoD and STAT3 in the regulation of growth and differentiation of myoblasts RL J. Biol. Chem. 278:44178-87 (2003). RN [58]; RE0041508. RX PUBMED: 15116091. RA Xie T. X., Wei D., Liu M., Gao A. C., Ali-Osman F., Sawaya R., Huang S. RT Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis RL Oncogene 23:3550-3560 (2004). RN [59]; RE0041513. RX PUBMED: 11807001. RA Nielsen M., Nissen M. H., Gerwien J., Zocca M. B., Rasmussen H. M., Nakajima K., Ropke C., Geisler C., Kaltoft K., Odum N. RT Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3 RL Blood 99:973-7 (2002). RN [60]; RE0041555. RX PUBMED: 15154680. RA Watanabe Y., Hashimoto S., Kakita A., Takahashi H., Ko J., Mizuno M., Someya T., Patterson P. H., Nawa H. RT Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats RL Neurosci. Res. 48:345-53 (2004). RN [61]; RE0041560. RX PUBMED: 12804609. RA Yamamoto T., Sato N., Sekine Y., Yumioka T., Imoto S., Junicho A., Fuse H., Matsuda T. RT Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor RL Biochem. Biophys. Res. Commun. 306:610-5 (2003). RN [62]; RE0041679. RX PUBMED: 11278729. RA Hung W., Elliott B. RT Co-operative effect of c-Src tyrosine kinase and Stat3 in activation of hepatocyte growth factor expression in mammary carcinoma cells RL J. Biol. Chem. 276:12395-403 (2001). RN [63]; RE0041680. RX PUBMED: 11160159. RA Epling-Burnette P. K., Liu J. H., Catlett-Falcone R., Turkson J., Oshiro M., Kothapalli R., Li Y., Wang J. M., Yang-Yen H. F., Karras J., Jove R., Loughran T. P. Jr. RT Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression RL J. Clin. Invest. 107:351-62 (2001). RN [64]; RE0041905. RX PUBMED: 9388184. RA Chung C. D., Liao J., Liu B., Rao X., Jay P., Berta P., Shuai K. RT Specific inhibition of Stat3 signal transduction by PIAS3 RL Science 278:1803-5 (1997). RN [65]; RE0041911. RX PUBMED: 11279133. RA Bienvenu F., Gascan H., Coqueret O. RT Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism RL J. Biol. Chem. 276:16840-7 (2001). RN [66]; RE0041926. RX PUBMED: 12594516. RA Bates S. H., Stearns W. H., Dundon T. A., Schubert M., Tso A. W., Wang Y., Banks A. S., Lavery H. J., Haq A. K., Maratos-Flier E., Neel B. G., Schwartz M. W., Myers M. G. Jr. RT STAT3 signalling is required for leptin regulation of energy balance but not reproduction RL Nature 421:856-9 (2003). RN [67]; RE0041933. RX PUBMED: 11163768. RA Gao B., Shen X., Kunos G., Meng Q., Goldberg I. D., Rosen E. M., Fan S. RT Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells RL FEBS Lett. 488:179-184 (2001). RN [68]; RE0042965. RX PUBMED: 9714332. RA Park W. Y., Ahn J. H., Feldman R. A., Seo J. S. RT c-Fes tyrosine kinase binds to and activates STAT3 after granulocyte-macrophage colony-stimulating factor stimulation RL Cancer Lett. 129:29-37 (1998). RN [69]; RE0044151. RX PUBMED: 12738234. RA Xuan Y. T., Guo Y., Zhu Y., Han H., Langenbach R., Dawn B., Bolli R. RT Mechanism of cyclooxygenase-2 upregulation in late preconditioning RL J. Mol. Cell. Cardiol. 35:525-37 (2003). RN [70]; RE0047322. RX PUBMED: 15673499. RA Ezoe S., Matsumura I., Gale K., Satoh Y., Ishikawa J., Mizuki M., Takahashi S., Minegishi N., Nakajima K., Yamamoto M., Enver T., Kanakura Y. RT GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity. RL J. Biol. Chem. 280:13163-13170 (2005). RN [71]; RE0047403. RX PUBMED: 15659653. RA Hao A., Novotny-Diermayr V., Bian W., Lin B., Lim C. P., Jing N., Cao X. RT The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities. RL Mol. Biol. Cell 16:1569-1583 (2005). RN [72]; RE0047407. RX PUBMED: 15284113. RA Tonozuka Y., Minoshima Y., Bao Y. C., Moon Y., Tsubono Y., Hatori T., Nakajima H., Nosaka T., Kawashima T., Kitamura T. RT A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line. RL Blood 104:3550-3557 (2004). RN [73]; RE0047424. RX PUBMED: 15465816. RA Huang Y., Li T., Sane D. C., Li L. RT IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. RL J. Biol. Chem. 279:51697-51703 (2004). RN [74]; RE0047428. RX PUBMED: 15229229. RA Schick N., Oakeley E. J., Hynes N. E., Badache A. RT TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity. RL J. Biol. Chem. 279:38787-38796 (2004). RN [75]; RE0047625. RX PUBMED: 15994929. RA Manavathi B., Nair S. S., Wang R. A., Kumar R., Vadlamudi R. K. RT Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation. RL Cancer Res. 65:5571-5577 (2005). RN [76]; RE0049315. RX PUBMED: 11322786. RA Matsuda T., Junicho A., Yamamoto T., Kishi H., Korkmaz K., Saatcioglu F., Fuse H., Muraguchi A. RT Cross-talk between signal transducer and activator of transcription 3 and androgen receptor signaling in prostate carcinoma cells. RL Biochem. Biophys. Res. Commun. 283:179-187 (2001). RN [77]; RE0049453. RX PUBMED: 11788590. RA Yan C., Naltner A., Martin M., Naltner M., Fangman J. M., Gurel O. RT Transcriptional stimulation of the surfactant protein B gene by STAT3 in respiratory epithelial cells. RL J. Biol. Chem. 277:10967-10972 (2002). RN [78]; RE0049596. RX PUBMED: 15063116. RA Sarcar B., Ghosh A. K., Steele R., Ray R., Ray R. B. RT Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase. RL Virology 322:51-60 (2004). RN [79]; RE0052153. RX PUBMED: 11726519. RA Nakajima H., Brindle P. K., Handa M., Ihle J. N. RT Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription. RL EMBO J. 20:6836-6844 (2001). RN [80]; RE0053065. RX PUBMED: 18353781. RA Cheng G. Z., Zhang W., Sun M., Wang Q., Coppola D., Mansour M., Xu L., Costanzo C., Cheng J. Q., Wang L. H. RT Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function. RL J. Biol. Chem. 283:14665-14673 (2008). RN [81]; RE0053305. RX PUBMED: 17909010. RA Lo H. W., Hsu S. C., Xia W., Cao X., Shih J. Y., Wei Y., Abbruzzese J. L., Hortobagyi G. N., Hung M. C. RT Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. RL Cancer Res. 67:9066-9076 (2007). RN [82]; RE0055205. RX PUBMED: 16219639. RA Sato N., Kawai T., Sugiyama K., Muromoto R., Imoto S., Sekine Y., Ishida M., Akira S., Matsuda T. RT Physical and functional interactions between STAT3 and ZIP kinase. RL Int. Immunol. 17:1543-1552 (2005). RN [83]; RE0063808. RX PUBMED: 11742534. RA Haan C., Heinrich P. C., Behrmann I. RT Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation. RL Biochem. J. 361:105-111 (2002). RN [84]; RE0065005. RX PUBMED: 18192274. RA Kiryu-Seo S., Kato R., Ogawa T., Nakagomi S., Nagata K., Kiyama H. RT Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons. RL J. Biol. Chem. 283:6988-6996 (2008). RN [85]; RE0065425. RX PUBMED: 19632985. RA Dumoutier L., de Meester C., Tavernier J., Renauld J. C. RT New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain. RL J. Biol. Chem. 284:26377-26384 (2009). RN [86]; RE0069080. RX PUBMED: 12559950. RA Sato N., Yamamoto T., Sekine Y., Yumioka T., Junicho A., Fuse H., Matsuda T. RT Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3. RL Biochem. Biophys. Res. Commun. 300:847-852 (2003). RN [87]; RE0069102. RX PUBMED: 18503751. RA Ohbayashi N., Taira N., Kawakami S., Togi S., Sato N., Ikeda O., Kamitani S., Muromoto R., Sekine Y., Matsuda T. RT An RNA biding protein, Y14 interacts with and modulates STAT3 activation. RL Biochem. Biophys. Res. Commun. 372:475-479 (2008). RN [88]; RE0069145. RX PUBMED: 16636663. RA Sekine Y., Tsuji S., Ikeda O., Sato N., Aoki N., Aoyama K., Sugiyama K., Matsuda T. RT Regulation of STAT3-mediated signaling by LMW-DSP2. RL Oncogene 25:5801-5806 (2006). RN [89]; RE0069167. RX PUBMED: 16331268. RA Muromoto R., Nakao K., Watanabe T., Sato N., Sekine Y., Sugiyama K., Oritani K., Shimoda K., Matsuda T. RT Physical and functional interactions between Daxx and STAT3. RL Oncogene 25:2131-2136 (2006). RN [90]; RE0070029. RX PUBMED: 21325207. RA Ahmad R., Rajabi H., Kosugi M., Joshi M. D., Alam M., Vasir B., Kawano T., Kharbanda S., Kufe D. RT MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. RL Sci. Signal. 4:ra9 (2011). RN [91]; RE0070219. RX PUBMED: 19595668. RA Wu Z., Zhang X., Yang J., Wu G., Zhang Y., Yuan Y., Jin C., Chang Z., Wang J., Yang X., He F. RT Nuclear protein IkappaB-zeta inhibits the activity of STAT3. RL Biochem. Biophys. Res. Commun. 387:348-352 (2009). RN [92]; RE0070563. RX PUBMED: 21689417. RA Shackleford T. J., Zhang Q., Tian L., Vu T. T., Korapati A. L., Baumgartner A., Le X. F., Liao W. S., Claret F. X. RT Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells. RL Breast Cancer Res. 13:R65 (2011). XX //