AC T10397
XX
ID T10397
XX
DT 16.03.2006 (created); kau.
DT 02.06.2016 (updated); mom.
CO Copyright (C), QIAGEN.
XX
FA RelA-p65
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SY Nuclear Factor kappa B p65 (RelA); nuclear factor NF-kappa-B P65 subunit; p65; RelA; Transcription factor p65.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T08796 ASC-2; human, Homo sapiens.
IN T15204 brca1; Mammalia.
IN T08664 C/EBPalpha; Mammalia.
IN T10398 C/EBPdelta; Mammalia.
IN T15118 CBP; Mammalia.
IN T09570 E2F-1; Mammalia.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T09637 ER-alpha; Mammalia.
IN T10210 Evi-1; human, Homo sapiens.
IN T10391 FKLF; Mammalia.
IN T27186 GILZ-isoform1; human, Homo sapiens.
IN T19181 GLEA2-isoform1; human, Homo sapiens.
IN T21852 HDAC1; Mammalia.
IN T23418 HDAC1; mouse, Mus musculus.
IN T10358 HMGIY; Mammalia.
IN T14419 Id1; human, Homo sapiens.
IN T00950 IkappaB-alpha; human, Homo sapiens.
IN T18455 IkappaB-alpha; Mammalia.
IN T00414 IkappaB-beta; human, Homo sapiens.
IN T22504 IkappaBzeta-isoform2; human, Homo sapiens.
IN T09323 IRF-1; human, Homo sapiens.
IN T18624 mkl1; Mammalia.
IN T08800 nanog-isoform1; mouse, Mus musculus.
IN T10399 NF-kappaB1-p50; Mammalia.
IN T09437 NF-kappaB1; mouse, Mus musculus.
IN T19130 NF-kappaB2-p52; mouse, Mus musculus.
IN T05894 NRF-isoform1; human, Homo sapiens.
IN T23075 p100; Mammalia.
IN T01427 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T14054 PARP; human, Homo sapiens.
IN T08432 PPARdelta; mouse, Mus musculus.
IN T09963 PPARgamma; Mammalia.
IN T08433 RXR-alpha; human, Homo sapiens.
IN T29717 SIRT1; human, Homo sapiens.
IN T14458 STAT3; Mammalia.
IN T19297 T-bet; mouse, Mus musculus.
IN T02113 TAFII31; human, Homo sapiens.
IN T14175 TBP; Mammalia.
IN T09133 YY1; Mammalia.
XX
MX M00052 V$NFKAPPAB65_01.
MX M00054 V$NFKAPPAB_01.
MX M00774 V$NFKB_Q6_01.
MX M03563 V$RELA_Q6.
XX
BS R20825.
BS R36413.
BS R24146.
BS R32594.
BS R32595.
BS R72669.
BS R31915.
BS R73825.
BS R08088.
BS R00940.
BS R65202.
BS R01634.
BS R30143.
BS R56488.
BS R56489.
BS R37979.
BS R37993.
BS R19783.
BS R33535.
BS R62185.
BS R63897.
BS R63900.
BS R40298.
BS R24686.
BS R40651.
BS R64783.
BS R57234.
BS R56099.
BS R57794.
BS R70165.
BS R32848.
BS R57555.
BS R24177.
BS R38403.
BS R38407.
BS R71069.
BS R71070.
BS R42174.
BS R69034.
BS R67523.
BS R22559.
BS R72520.
XX
DR TRANSPATH: MO000079255.
DR TRANSCOMPEL: C00563.
XX
RN [1]; RE0004503.
RX PUBMED: 7651415.
RA Stein B., Yang M. X.
RT Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappaB and C/EBPbeta
RL Mol. Cell. Biol. 15:4971-4979 (1995).
RN [2]; RE0004538.
RX PUBMED: 8458581.
RA Mercurio F., Didonato J. A., Rosette C., Karin M.
RT p105 and p98 precursor proteins play an active role in NF-kappaB-mediated signal transduction
RL Genes Dev. 7:705-718 (1993).
RN [3]; RE0024028.
RX PUBMED: 10562553.
RA Nourbakhsh M., Hauser H.
RT Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB.
RL EMBO J. 18:6415-6425 (1999).
RN [4]; RE0030415.
RX PUBMED: 12842894.
RA Sakurai H., Suzuki S., Kawasaki N., Nakano H., Okazaki T., Chino A., Doi T., Saiki I.
RT Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.
RL J. Biol. Chem. 278:36916-23 (2003).
RN [5]; RE0031419.
RX PUBMED: 12972430.
RA Viatour P., Legrand-Poels S., van Lint C., Warnier M., Merville M. P., Gielen J., Piette J., Bours V., Chariot A.
RT Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3.
RL J. Biol. Chem. 278:46541-8 (2003).
RN [6]; RE0046561.
RX PUBMED: 11468175.
RA Ayroldi E., Migliorati G., Bruscoli S., Marchetti C., Zollo O., Cannarile L., D'Adamio F., Riccardi C.
RT Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB
RL Blood 98:743-53 (2001).
RN [7]; RE0047668.
RX PUBMED: 15465828.
RA Buss H., Dorrie A., Schmitz M. L., Frank R., Livingstone M., Resch K., Kracht M.
RT Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity.
RL J. Biol. Chem. 279:49571-49574 (2004).
RN [8]; RE0047680.
RX PUBMED: 9812988.
RA Na S. Y., Choi H. S., Kim J. W., Na D. S., Lee J. W.
RT Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor.
RL J. Biol. Chem. 273:30933-30938 (1998).
RN [9]; RE0047693.
RX PUBMED: 15489227.
RA Buss H., Dorrie A., Schmitz M. L., Hoffmann E., Resch K., Kracht M.
RT Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.
RL J. Biol. Chem. 279:55633-55643 (2004).
RN [10]; RE0047851.
RX PUBMED: 10847592.
RA Lee S. K., Na S. Y., Jung S. Y., Choi J. E., Jhun B. H., Cheong J., Meltzer P. S., Lee Y. C., Lee J. W.
RT Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2.
RL Mol. Endocrinol. 14:915-925 (2000).
RN [11]; RE0048086.
RX PUBMED: 11526476.
RA Heppner C., Bilimoria K. Y., Agarwal S. K., Kester M., Whitty L. J., Guru S. C., Chandrasekharappa S. C., Collins F. S., Spiegel A. M., Marx S. J., Burns A. L.
RT The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.
RL Oncogene 20:4917-4925 (2001).
RN [12]; RE0048551.
RX PUBMED: 16254192.
RA Paz-Priel I., Cai D. H., Wang D., Kowalski J., Blackford A., Liu H., Heckman C. A., Gombart A. F., Koeffler H. P., Boxer L. M., Friedman A. D.
RT CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.
RL Mol. Cancer Res. 3:585-596 (2005).
RN [13]; RE0049828.
RX PUBMED: 16204234.
RA Hassa P. O., Haenni S. S., Buerki C., Meier N. I., Lane W. S., Owen H., Gersbach M., Imhof R., Hottiger M. O.
RT Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.
RL J. Biol. Chem. 280:40450-40464 (2005).
RN [14]; RE0050028.
RX PUBMED: 14690596.
RA Ryo A., Suizu F., Yoshida Y., Perrem K., Liou Y. C., Wulf G., Rottapel R., Yamaoka S., Lu K. P.
RT Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.
RL Mol. Cell 12:1413-1426 (2003).
RN [15]; RE0050802.
RX PUBMED: 12700228.
RA Benezra M., Chevallier N., Morrison D. J., MacLachlan T. K., El-Deiry W. S., Licht J. D.
RT BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit.
RL J. Biol. Chem. 278:26333-26341 (2003).
RN [16]; RE0051535.
RX PUBMED: 16585559.
RA Sanchez-Valdepenas C., Martin A. G., Ramakrishnan P., Wallach D., Fresno M.
RT NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity.
RL J. Immunol. 176:4666-4674 (2006).
RN [17]; RE0051727.
RX PUBMED: 15140884.
RA Jang H. D., Yoon K., Shin Y. J., Kim J., Lee S. Y.
RT PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit.
RL J. Biol. Chem. 279:24873-24880 (2004).
RN [18]; RE0051818.
RX PUBMED: 18178962.
RA Gao N., Asamitsu K., Hibi Y., Ueno T., Okamoto T.
RT AKIP1 augments NF-kappa B-dependent gene expression by promoting the nuclear retention and phosphorylation of p65.
RL J. Biol. Chem. 283:7834-7843 (2008).
RN [19]; RE0051974.
RX PUBMED: 15494311.
RA Hoberg J. E., Yeung F., Mayo M. W.
RT SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival.
RL Mol. Cell 16:245-255 (2004).
RN [20]; RE0052059.
RX PUBMED: 11931769.
RA Zhong H., May M. J., Jimi E., Ghosh S.
RT The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.
RL Mol. Cell 9:625-636 (2002).
RN [21]; RE0052155.
RX PUBMED: 15152190.
RA Yeung F., Hoberg J. E., Ramsey C. S., Keller M. D., Jones D. R., Frye R. A., Mayo M. W.
RT Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.
RL EMBO J. 23:2369-2380 (2004).
RN [22]; RE0052737.
RX PUBMED: 11564889.
RA Ashburner B. P., Westerheide S. D., Baldwin AS J. r.
RT The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression.
RL Mol. Cell. Biol. 21:7065-7077 (2001).
RN [23]; RE0053124.
RX PUBMED: 17540171.
RA Liu B., Yang Y., Chernishof V., Loo R. R., Jang H., Tahk S., Yang R., Mink S., Shultz D., Bellone C. J., Loo J. A., Shuai K.
RT Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.
RL Cell 129:903-914 (2007).
RN [24]; RE0053206.
RX PUBMED: 17183367.
RA Maine G. N., Mao X., Komarck C. M., Burstein E.
RT COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.
RL EMBO J. 26:436-447 (2007).
RN [25]; RE0053645.
RX PUBMED: 18045535.
RA Wan F., Anderson D. E., Barnitz R. A., Snow A., Bidere N., Zheng L., Hegde V., Lam L. T., Staudt L. M., Levens D., Deutsch W. A., Lenardo M. J.
RT Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation.
RL Cell 131:927-939 (2007).
RN [26]; RE0053762.
RX PUBMED: 12874295.
RA Maier H. J., Marienfeld R., Wirth T., Baumann B.
RT Critical role of RelB serine 368 for dimerization and p100 stabilization.
RL J. Biol. Chem. 278:39242-39250 (2003).
RN [27]; RE0054060.
RX PUBMED: 12789342.
RA Yamamoto Y., Verma U. N., Prajapati S., Kwak Y. T., Gaynor R. B.
RT Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.
RL Nature 423:655-659 (2003).
RN [28]; RE0054100.
RX PUBMED: 15858576.
RA Lawrence T., Bebien M., Liu G. Y., Nizet V., Karin M.
RT IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation.
RL Nature 434:1138-1143 (2005).
RN [29]; RE0054132.
RX PUBMED: 11726516.
RA Xiao G., Cvijic M. E., Fong A., Harhaj E. W., Uhlik M. T., Waterfield M., Sun S. C.
RT Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha.
RL EMBO J. 20:6805-6815 (2001).
RN [30]; RE0055135.
RX PUBMED: 18542057.
RA Araki K., Kawauchi K., Tanaka N.
RT IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors.
RL Oncogene 27:5696-5705 (2008).
RN [31]; RE0055277.
RX PUBMED: 10934192.
RA Chung S. W., Kang B. Y., Kim S. H., Pak Y. K., Cho D., Trinchieri G., Kim T. S.
RT Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B.
RL J. Biol. Chem. 275:32681-32687 (2000).
RN [32]; RE0056181.
RX PUBMED: 19340308.
RA Sudhakar C., Nagabhushana A., Jain N., Swarup G.
RT NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.
RL PLoS ONE 4:e5114 (2009).
RN [33]; RE0060774.
RX PUBMED: 16608838.
RA Gu X., Ke S., Liu D., Sheng T., Thomas P. E., Rabson A. B., Gallo M. A., Xie W., Tian Y.
RT Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.
RL J. Biol. Chem. 281:17882-17889 (2006).
RN [34]; RE0062846.
RX PUBMED: 17884819.
RA Wu S., Flint J. K., Rezvani G., De Luca F.
RT Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis.
RL J. Biol. Chem. 282:33698-33706 (2007).
RN [35]; RE0063653.
RX PUBMED: 16497732.
RA Miao F., Li S., Chavez V., Lanting L., Natarajan R.
RT Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17.
RL Mol. Endocrinol. 20:1562-1573 (2006).
RN [36]; RE0064775.
RX PUBMED: 18223644.
RA Torres J., Watt F. M.
RT Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3.
RL Nat. Cell Biol. 10:194-201 (2008).
RN [37]; RE0064794.
RX PUBMED: 19088195.
RA Shaw J., Yurkova N., Zhang T., Gang H., Aguilar F., Weidman D., Scramstad C., Weisman H., Kirshenbaum L. A.
RT Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival.
RL Proc. Natl. Acad. Sci. USA 105:20734-20739 (2008).
RN [38]; RE0065000.
RX PUBMED: 15591425.
RA Shen F., Ruddy M. J., Plamondon P., Gaffen S. L.
RT Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells.
RL J. Leukoc. Biol. 77:388-399 (2005).
RN [39]; RE0065087.
RX PUBMED: 17652082.
RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B.
RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
RL J. Biol. Chem. 282:27229-27238 (2007).
RN [40]; RE0065288.
RX PUBMED: 19289499.
RA Copetti T., Bertoli C., Dalla E., Demarchi F., Schneider C.
RT p65/RelA modulates BECN1 transcription and autophagy.
RL Mol. Cell. Biol. 29:2594-2608 (2009).
RN [41]; RE0065527.
RX PUBMED: 19531803.
RA Wall E. A., Zavzavadjian J. R., Chang M. S., Randhawa B., Zhu X., Hsueh R. C., Liu J., Driver A., Bao X. R., Sternweis P. C., Simon M. I., Fraser I. D.
RT Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105.
RL Sci. Signal. 2:ra28 (2009).
RN [42]; RE0065712.
RX PUBMED: 18362156.
RA Yang C. H., Murti A., Pfeffer S. R., Fan M., Du Z., Pfeffer L. M.
RT The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response.
RL J. Biol. Chem. 283:14309-14316 (2008).
RN [43]; RE0065817.
RX PUBMED: 17932106.
RA Nettles K. W., Gil G., Nowak J., Metivier R., Sharma V. B., Greene G. L.
RT CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.
RL Mol. Endocrinol. 22:263-272 (2008).
RN [44]; RE0066175.
RX PUBMED: 12169689.
RA Rani M. R., Hibbert L., Sizemore N., Stark G. R., Ransohoff R. M.
RT Requirement of phosphoinositide 3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 (SCYB11) gene.
RL J. Biol. Chem. 277:38456-38461 (2002).
RN [45]; RE0068457.
RX PUBMED: 20702415.
RA Pakala S. B., Reddy S. D., Bui-Nguyen T. M., Rangparia S. S., Bommana A., Kumar R.
RT MTA1 Coregulator Regulates LPS Response via MyD88-dependent Signaling.
RL J. Biol. Chem. 285:32787-32792 (2010).
RN [46]; RE0069949.
RX PUBMED: 16513645.
RA Totzke G., Essmann F., Pohlmann S., Lindenblatt C., Janicke R. U., Schulze-Osthoff K.
RT A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding.
RL J. Biol. Chem. 281:12645-12654 (2006).
RN [47]; RE0070024.
RX PUBMED: 19841191.
RA Escribano C., Delgado-Martin C., Rodriguez-Fernandez J. L.
RT CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta.
RL J. Immunol. 183:6282-6295 (2009).
RN [48]; RE0070804.
RX PUBMED: 21098220.
RA Lou X., Sun S., Chen W., Zhou Y., Huang Y., Liu X., Shan Y., Wang C.
RT Negative feedback regulation of NF-kappaB action by CITED2 in the nucleus.
RL J. Immunol. 186:539-548 (2011).
RN [49]; RE0070954.
RX PUBMED: 20460684.
RA Tando T., Ishizaka A., Watanabe H., Ito T., Iida S., Haraguchi T., Mizutani T., Izumi T., Isobe T., Akiyama T., Inoue J., Iba H.
RT Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.
RL J. Biol. Chem. 285:21951-21960 (2010).
XX
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