AC T08432
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ID T08432
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DT 19.01.2006 (created); din.
DT 01.08.2014 (updated); pos.
CO Copyright (C), QIAGEN.
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FA PPARdelta
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SY FAAR; fatty acid activated receptor; NR1C2; NUC1; nuclear hormone receptor 1; peroxisome proliferator-activated receptor beta; PPAR-delta; PPARb/d; PPARbeta; PPARdelta.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002770 Ppard.
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CL C0002; CC (rec); 2.1.2.5.2.1.
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SZ 440 AA; 49.7 kDa (cDNA) (calc.).
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SQ MEQPQEETPEAREEEKEEVAMGDGAPELNGGPEHTLPSSSCADLSQNSSPSSLLDQLQMG
SQ CDGASGGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCDRICKIQKKN
SQ RNKCQYCRFQKCLALGMSHNAIRFGRMPDGEKRKLVAGLTASEGCQHNPQLADLKAFSKH
SQ IYNAYLKNFNMTKKKARSILTGKSSHNAPFVIHDIETLWQAEKGLVWKQLVNGLPPYNEI
SQ SVHVFYRCQSTTVETVRELTEFAKNIPNFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKD
SQ GLLVANGSGFVTHEFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDR
SQ PGLMNVPQVEAIQDTILRALEFHLQVNHPDSQYLFPKLLQKMADLRQLVTEHAQMMQWLK
SQ KTESETLLHPLLQEIYKDMY
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SC translated from EMBL #U10375
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FT 70 140 
SM00399; c4gold.
FT 70 144 
PS51030; NUCLEAR_REC_DBD_2.
FT 71 145 
PF00105; Zinc finger, C4 type (two domains).
FT 72 137 
DNA-binding domain [5].
FT 245 440 
ligand-binding domain [5].
FT 250 409 
SM00430; holi.
FT 253 435 
PF00104; Ligand-binding domain of nuclear hormon.
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IN T08641 NCOR1-isoform1; mouse, Mus musculus.
IN T04687 NCOR1; human, Homo sapiens.
IN T10397 RelA-p65; Mammalia.
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MX M00763 V$PPARDR1_Q2.
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BS R73524.
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DR TRANSPATH: MO000057689.
DR EMBL: U10375;
DR UniProtKB: P35396;
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RN [1]; RE0025706.
RX PUBMED: 11903058.
RA Krogsdam A. M., Nielsen C. A., Neve S., Holst D., Helledie T., Thomsen B., Bendixen C., Mandrup S., Kristiansen K.
RT Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.
RL Biochem. J. 363:157-65 (2002).
RN [2]; RE0047960.
RX PUBMED: 8910358.
RA Chu R., Lin Y., Rao M. S., Reddy J. K.
RT Cloning and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha.
RL J. Biol. Chem. 271:27670-27676 (1996).
RN [3]; RE0050102.
RX PUBMED: 17382197.
RA Coleman J. D., Prabhu K. S., Thompson J. T., Reddy P. S., Peters J. M., Peterson B. R., Reddy C. C., Vanden Heuvel J. P.
RT The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta).
RL Free Radic. Biol. Med. 42:1155-1164 (2007).
RN [4]; RE0050602.
RX PUBMED: 16943204.
RA Woo C. H., Massett M. P., Shishido T., Itoh S., Ding B., McClain C., Che W., Vulapalli S. R., Yan C., Abe J.
RT ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation.
RL J. Biol. Chem. 281:32164-32174 (2006).
RN [5]; RE0018281.
RX PUBMED: 8041794.
RA Kliewer S. A., Forman B. M., Blumberg B., Ong E. S., Borgmeyer U., Mangelsdorf D. J., Umesono K., Evans R. M.
RT Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
RL Proc. Natl. Acad. Sci. USA 91:7355-7359 (1994).
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