AC T04687
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ID T04687
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DT 03.09.2001 (created); mas.
DT 23.10.2013 (updated); spk.
CO Copyright (C), QIAGEN.
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FA NCOR1
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SY N-COR; N-COR1; nuclear receptor co-repressor; retinoid X receptor interacting protein 13; RXRIP13.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002792 NCOR1; HGNC: NCOR1.
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CL C0022; trp; 3.5.1.2.1.
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SF contains separate domains for interaction with nuclear receptors and repression function [3];
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FF involved in mediation of transcriptional repressive effect of (unliganded) nuclear receptors (direct binding to nuclear receptors) [1];
FF recruitment of histone deacetylase complexes which is important for transcriptional repression [1];
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IN T08487 AR-isoform1; human, Homo sapiens.
IN T00040 AR; human, Homo sapiens.
IN T00065 B-Myb; human, Homo sapiens.
IN T22424 BAF57; human, Homo sapiens.
IN T05453 BAF60A; human, Homo sapiens.
IN T21924 BCL-11A; human, Homo sapiens.
IN T09129 BCL-6-isoform1; human, Homo sapiens.
IN T16043 BCL-6; Mammalia.
IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T01261 Brm; human, Homo sapiens.
IN T00149 COUP-TF1; human, Homo sapiens.
IN T08505 COUP-TF1; human, Homo sapiens.
IN T02944 Daxx; human, Homo sapiens.
IN T04682 FAC1; human, Homo sapiens.
IN T04110 HDAC3; human, Homo sapiens.
IN T08522 HDAC4-isoform1; human, Homo sapiens.
IN T06042 HDAC4; human, Homo sapiens.
IN T22507 HMG2L1; human, Homo sapiens.
IN T10687 huntingtin; rat, Rattus norvegicus.
IN T08297 Kaiso; human, Homo sapiens.
IN T02752 LXR-alpha; human, Homo sapiens.
IN T04453 LXR-beta; human, Homo sapiens.
IN T09029 LXR-beta; human, Homo sapiens.
IN T08888 LXRalpha-isoform1; human, Homo sapiens.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T05299 NR1B1; human, Homo sapiens.
IN T14193 NR1B1; Mammalia.
IN T02336 PLZF; human, Homo sapiens.
IN T08632 PPARalpha-isoform1; human, Homo sapiens.
IN T08431 PPARalpha; mouse, Mus musculus.
IN T08432 PPARdelta; mouse, Mus musculus.
IN T05332 PPARgamma2; mouse, Mus musculus.
IN T05351 PPARgamma; human, Homo sapiens.
IN T09963 PPARgamma; Mammalia.
IN T17088 stromelysin1; human, Homo sapiens.
IN T17089 stromelysin1; human, Homo sapiens.
IN T00838 T3R-alpha; human, Homo sapiens.
IN T08501 T3R-alpha; chick, Gallus gallus.
IN T00851 T3R-beta1; human, Homo sapiens.
IN T28757 TBLR1; human, Homo sapiens.
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DR TRANSPATH: MO000028508.
DR UniProtKB: O75376;
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RN [1]; RE0006125.
RX PUBMED: 9139820.
RA Heinzel T., Lavinsky R. M., Mullen T. M., Soederstroem M., Laherty C. D., Torchia J., Yang W. M., Brard G., Ngo S. D., Davie J. R., Seto E., Eisenman R. N., Rose D. W., Glass C. K., Rosenfeld M. G.
RT A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
RL Nature 387:43-48 (1997).
RN [2]; RE0010823.
RX PUBMED: 7566127.
RA Chen J. D., Evans R. M.
RT A transcriptional co-repressor that interacts with nuclear hormone receptors
RL Nature 377:454-457 (1995).
RN [3]; RE0016802.
RX PUBMED: 10617570.
RA Nagy L., Kao H. Y., Love J. D., Li C., Banayo E., Gooch J. T., Krishna V., Chatterjee K., Evans R. M., Schwabe J. W.
RT Mechanism of corepressor binding and release from nuclear hormone receptors
RL Genes Dev. 13:3209-3216 (1999).
RN [4]; RE0025706.
RX PUBMED: 11903058.
RA Krogsdam A. M., Nielsen C. A., Neve S., Holst D., Helledie T., Thomsen B., Bendixen C., Mandrup S., Kristiansen K.
RT Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.
RL Biochem. J. 363:157-65 (2002).
RN [5]; RE0026599.
RX PUBMED: 10898795.
RA Huynh K. D., Fischle W., Verdin E., Bardwell V. J.
RT BCoR, a novel corepressor involved in BCL-6 repression.
RL Genes Dev. 14:1810-23 (2000).
RN [6]; RE0027552.
RX PUBMED: 10640275.
RA Huang E. Y., Zhang J., Miska E. A., Guenther M. G., Kouzarides T., Lazar M. A.
RT Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway.
RL Genes Dev. 14:45-54 (2000).
RN [7]; RE0029293.
RX PUBMED: 11804585.
RA Fischle W., Dequiedt F., Hendzel M. J., Guenther M. G., Lazar M. A., Voelter W., Verdin E.
RT Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
RL Mol. Cell 9:45-57 (2002).
RN [8]; RE0036641.
RX PUBMED: 12628926.
RA Yoon H. G., Chan D. W., Huang Z. Q., Li J., Fondell J. D., Qin J., Wong J.
RT Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1
RL EMBO J. 22:1336-1346 (2003).
RN [9]; RE0038083.
RX PUBMED: 11466315.
RA Fischle W., Dequiedt F., Fillion M., Hendzel M. J., Voelter W., Verdin E.
RT Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo
RL J. Biol. Chem. 276:35826-35 (2001).
RN [10]; RE0039595.
RX PUBMED: 12077342.
RA Dellaire G., Makarov E. M., Cowger J. J., Longman D., Sutherland H. G., Luhrmann R., Torchia J., Bickmore W. A.
RT Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes
RL Mol. Cell. Biol. 22:5141-56 (2002).
RN [11]; RE0045619.
RX PUBMED: 9405624.
RA Zamir I., Dawson J., Lavinsky R. M., Glass C. K., Rosenfeld M. G., Lazar M. A.
RT Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex
RL Proc. Natl. Acad. Sci. USA 94:14400-5 (1997).
RN [12]; RE0046322.
RX PUBMED: 11997503.
RA Li X., McDonnell D. P.
RT The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT
RL Mol. Cell. Biol. 22:3663-73 (2002).
RN [13]; RE0047677.
RX PUBMED: 11259580.
RA Mathur M., Tucker P. W., Samuels H. H.
RT PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors.
RL Mol. Cell. Biol. 21:2298-2311 (2001).
RN [14]; RE0048072.
RX PUBMED: 12529406.
RA Yamagoe S., Kanno T., Kanno Y., Sasaki S., Siegel R. M., Lenardo M. J., Humphrey G., Wang Y., Nakatani Y., Howard B. H., Ozato K.
RT Interaction of histone acetylases and deacetylases in vivo.
RL Mol. Cell. Biol. 23:1025-1033 (2003).
RN [15]; RE0048154.
RX PUBMED: 10984530.
RA Downes M., Ordentlich P., Kao H. Y., Alvarez J. G., Evans R. M.
RT Identification of a nuclear domain with deacetylase activity.
RL Proc. Natl. Acad. Sci. USA 97:10330-10335 (2000).
RN [16]; RE0048488.
RX PUBMED: 15691842.
RA Yu C., Markan K., Temple K. A., Deplewski D., Brady M. J., Cohen R. N.
RT The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis.
RL J. Biol. Chem. 280:13600-13605 (2005).
RN [17]; RE0048529.
RX PUBMED: 14527417.
RA Yoon H. G., Chan D. W., Reynolds A. B., Qin J., Wong J.
RT N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.
RL Mol. Cell 12:723-734 (2003).
RN [18]; RE0048530.
RX PUBMED: 11865059.
RA Melnick A., Carlile G., Ahmad K. F., Kiang C. L., Corcoran C., Bardwell V., Prive G. G., Licht J. D.
RT Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.
RL Mol. Cell. Biol. 22:1804-1818 (2002).
RN [19]; RE0048612.
RX PUBMED: 16024779.
RA Zhang D., Yoon H. G., Wong J.
RT JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2).
RL Mol. Cell. Biol. 25:6404-6414 (2005).
RN [20]; RE0048630.
RX PUBMED: 15601853.
RA Yoon H. G., Choi Y., Cole P. A., Wong J.
RT Reading and function of a histone code involved in targeting corepressor complexes for repression.
RL Mol. Cell. Biol. 25:324-35 (2005).
RN [21]; RE0048796.
RX PUBMED: 12897148.
RA Wagner B. L., Valledor A. F., Shao G., Daige C. L., Bischoff E. D., Petrowski M., Jepsen K., Baek S. H., Heyman R. A., Rosenfeld M. G., Schulman I. G., Glass C. K.
RT Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.
RL Mol. Cell. Biol. 23:5780-5789 (2003).
RN [22]; RE0048942.
RX PUBMED: 16373395.
RA Yoon H. G., Wong J.
RT The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor.
RL Mol. Endocrinol. 20:1048-1060 (2006).
RN [23]; RE0048965.
RX PUBMED: 15598662.
RA Hodgson M. C., Astapova I., Cheng S., Lee L. J., Verhoeven M. C., Choi E., Balk S. P., Hollenberg A. N.
RT The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists.
RL J. Biol. Chem. 280:6511-6519 (2005).
RN [24]; RE0049111.
RX PUBMED: 16421255.
RA Tiefenbach J., Novac N., Ducasse M., Eck M., Melchior F., Heinzel T.
RT SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.
RL Mol. Biol. Cell 17:1643-1651 (2006).
RN [25]; RE0052481.
RX PUBMED: 12590135.
RA Petrie K., Guidez F., Howell L., Healy L., Waxman S., Greaves M., Zelent A.
RT The histone deacetylase 9 gene encodes multiple protein isoforms.
RL J. Biol. Chem. 278:16059-16072 (2003).
RN [26]; RE0052627.
RX PUBMED: 12634383.
RA Knight J. S., Lan K., Subramanian C., Robertson E. S.
RT Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell lines.
RL J. Virol. 77:4261-4272 (2003).
RN [27]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
RN [28]; RE0062855.
RX PUBMED: 19117054.
RA Karmakar S., Foster E. A., Smith C. L.
RT Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor.
RL Int. J. Cancer 124:1841-1851 (2009).
RN [29]; RE0067377.
RX PUBMED: 19955185.
RA Pourcet B., Pineda-Torra I., Derudas B., Staels B., Glineur C.
RT SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR.
RL J. Biol. Chem. 285:5983-5992 (2010).
RN [30]; RE0074383.
RX PUBMED: 19112178.
RA Zhang L. J., Liu X., Gafken P. R., Kioussi C., Leid M.
RT A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8).
RL J. Biol. Chem. 284:6156-6168 (2009).
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