TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02336 XX ID T02336 XX DT 23.01.1998 (created); ili. DT 17.09.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA PLZF XX SY PLZF; promyelocytic leukemia zinc finger; ZBTB16; Zinc finger and BTB domain-containing protein 16; Zinc finger protein PLZF; ZNF145. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G013835 ZBTB16; HGNC: ZBTB16. XX CL C0001; CH; XX SF phosphoprotein [11]; SF structure-function analysis revealed the presence of two repression domains (POZ/BTB domain and RD2) [10]; SF contains 9 zinc finger motifs and BTB/POZ domain [1] [2]; XX CP PLZF is highly expressed in hematopoietic progenitor cells and developing central nervous system [3]; PLZF expression during development of central nervous system, limb buds, perinatal kidney, liver and heart [11]. XX FF effective repression of the r3/r5 enhancer of Hoxb2 reporter by PLZF requires both the PLZF-RE motif and Box1 (A/T-rich binding site) [3]; FF PLZF contains both: repression and (weak) activation domains, the activation domain is masked when linked to repression domains [10]; FF might play a role in the circuitry regulation hindbrain segmentation [3]; FF the N-terminal POZ domain is required for cooperative binding of PLZF to a multimerized PLZF-RE (PLZF response element) [3]; FF the sequence-specific DNA-binding activity of PLZF resides primarily in th C-terminal seven zinc fingers [10]; FF related to acute promyelocytic leukemia with a t(11; FF 17) translocation [1]; FF at least some zinc fingers may participate in protein-protein interaction [2]; XX IN T00040 AR; human, Homo sapiens. IN T00306 GATA-1; human, Homo sapiens. IN T21852 HDAC1; Mammalia. IN T01696 HOXA1; mouse, Mus musculus. IN T27226 lyar; human, Homo sapiens. IN T16997 MTG8; human, Homo sapiens. IN T04687 NCOR1; human, Homo sapiens. IN T04688 NCOR1; mouse, Mus musculus. IN T21984 p300; human, Homo sapiens. IN T00722 pRb; human, Homo sapiens. IN T19338 RFP; human, Homo sapiens. IN T14622 sin3a; human, Homo sapiens. IN T04689 SMRT; human, Homo sapiens. IN T00885 VDR; human, Homo sapiens. IN T04995 ZBP99; human, Homo sapiens. IN T04981 ZNF-24; human, Homo sapiens. XX MX M04625 V$PLZFB_Q3. MX M01075 V$PLZF_02. XX BS R18287. BS R18288. BS R18289. BS R18290. BS R18291. BS R18292. BS R18293. BS R18294. BS R18297. BS R18298. BS R18299. BS R18300. BS R26688. BS R71196. BS R71198. BS R71200. BS R71192. BS R71194. BS R41126. BS R26680. BS R26681. BS R26682. BS R26683. BS R26684. BS R26685. BS R61413. BS R38076. BS R26634. XX DR TRANSPATH: MO000046078. DR UniProtKB: Q05516; PLZF_HUMAN. XX RN [1]; RE0006530. RX PUBMED: 8384553. RA Chen Z., Brand N. J., Chen A., Chen S.-J., Tong J.-H., Wang Z.-Y., Waxman S., Zelent A. RT Fusion between a novel Krueppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia RL EMBO J. 112:1161-1167 (1993). RN [2]; RE0006531. RX PUBMED: 9294197. RA Koken M. H. M., Reid A., Quignon F., Chelbi-Alix M. K., Davies J. M., Kabarowski J. H. S., Zhu J., Dong S., Chen S. - J., Chen Z., Tan C. C., Licht J., Waxman S., de The H., Zelent A. RT Leukemia-associated retinoic acid receptor alpha fusion partners PML and PLZF, heterodimerize and colocalize to nucelar bodies RL Proc. Natl. Acad. Sci. USA 94:10255-10260 (1997). RN [3]; RE0035545. RX PUBMED: 12802276. RA Ivins S., Pemberton K., Guidez F., Howell L., Krumlauf R., Zelent A. RT Regulation of Hoxb2 by APL-associated PLZF protein. RL Oncogene 22:3685-3697 (2003). RN [4]; RE0044001. RX PUBMED: 14657020. RA Senbonmatsu T., Saito T., Landon E. J., Watanabe O., Price E. Jr, Roberts R. L., Imboden H., Fitzgerald T. G., Gaffney F. A., Inagami T. RT A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy RL EMBO J. 22:6471-82 (2003). RN [5]; RE0047504. RX PUBMED: 15964811. RA Guidez F., Howell L., Isalan M., Cebrat M., Alani R. M., Ivins S., Hormaeche I., McConnell M. J., Pierce S., Cole P. A., Licht J., Zelent A. RT Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. RL Mol. Cell. Biol. 25:5552-5566 (2005). RN [6]; RE0048466. RX PUBMED: 14527952. RA Kang S. I., Chang W. J., Cho S. G., Kim I. Y. RT Modification of promyelocytic leukemia zinc finger protein (PLZF) by SUMO-1 conjugation regulates its transcriptional repressor activity. RL J. Biol. Chem. 278:51479-51483 (2003). RN [7]; RE0048530. RX PUBMED: 11865059. RA Melnick A., Carlile G., Ahmad K. F., Kiang C. L., Corcoran C., Bardwell V., Prive G. G., Licht J. D. RT Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors. RL Mol. Cell. Biol. 22:1804-1818 (2002). RN [8]; RE0053648. RX PUBMED: 11719366. RA Ward J. O., McConnell M. J., Carlile G. W., Pandolfi P. P., Licht J. D., Freedman L. P. RT The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor. RL Blood 98:3290-3300 (2001). RN [9]; RE0063261. RX PUBMED: 16169070. RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E. RT A human protein-protein interaction network: a resource for annotating the proteome. RL Cell 122:957-968 (2005). RN [10]; RE0035557. RX PUBMED: 9278395. RA Li J. Y., English M. A., Ball H. J., Yeyati P. L., Waxman S., Licht J. D. RT Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein. RL J. Biol. Chem. 272:22447-22455 (1997). RN [11]; RE0035559. RX PUBMED: 10497277. RA Ball H. J., Melnick A., Shaknovich R., Kohanski R. A., Licht J. D. RT The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase. RL Nucleic Acids Res. 27:4106-4113 (1999). XX //