AC T01696
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ID T01696
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DT 05.03.1996 (created); ewi.
DT 17.09.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA HOXA1
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SY ERA-1; Hox-1.6; Hox1-y; HOX1F (human); Hoxa-1; Xhox.lab2 (Xenopus).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001826 Hoxa1.
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HO Lab (Drosophila) T02064.
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CL C0006; homeo; 3.1.1.1.1.
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SF the splice variant originally designated ERA-1-399 encodes a 133 AA peptide that lacks the homeo domain [2];
SF no specifically binding DNA sequence could be selected unless positions 226/227 (N-terminal arm of homeo domain) were replaced by the corresponding residues of HOXD4 [7];
SF interaction HOXA1/Pbx-1 [9] [10];
SF retinoic acid induced by downstream enhancer containing a RARE (retinoic acid responsive element) [11];
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FF potential trans-activator [7];
FF most anterior expression boundary among HOX A cluster genes [3] [4];
FF specifies neurogenic cell of the neural crest before HOXA3 specifies mesenchymal neural crest cells [3] [4];
FF disruption of HOXA1 gene causes lack of rhombomeres and defective development of ear, hindbrain, cranial nerves, ganglia [4] [5] [6];
FF HOXA1 in conjunction with Pbx-1 can activate rhombomere-specific expression of Eph receptors [9];
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IN T04954 HELIOS; human, Homo sapiens.
IN T03331 Hox-D3; human, Homo sapiens.
IN T11379 Hox-D3; human, Homo sapiens.
IN T01695 HOXA1; human, Homo sapiens.
IN T23884 HSFY1; human, Homo sapiens.
IN T02767 Nur77; human, Homo sapiens.
IN T02413 pitx2; human, Homo sapiens.
IN T02336 PLZF; human, Homo sapiens.
IN T20070 PRDM14; human, Homo sapiens.
IN T20071 PRDM14; human, Homo sapiens.
IN T19381 TZFP; human, Homo sapiens.
IN T19382 TZFP; human, Homo sapiens.
IN T21253 ZZZ3; human, Homo sapiens.
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MX M01487 V$HOXA1_01.
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DR TRANSPATH: MO000025878.
DR UniProtKB: P09022;
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RN [1]; RE0003857.
RX PUBMED: 2891503.
RA Baron A., Featherstone M. S., Hill R. E., Hall A., Galliot B., Duboule D.
RT Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex
RL EMBO J. 6:2977-2986 (1987).
RN [2]; RE0003858.
RX PUBMED: 2906112.
RA LaRosa G. J., Gudas L. J.
RT Early retinoic acid-induced F9 teratocarcinoma stem cell gene ERA-1: Alternate splicing creates transcripts for a homeobox- containing protein and one lacking the homeobox
RL Mol. Cell. Biol. 8:3906-3917 (1988).
RN [3]; RE0003859.
RX PUBMED: 2569969.
RA Duboule D., Dolle P.
RT The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes
RL EMBO J. 8:1497-1505 (1989).
RN [4]; RE0003860.
RX PUBMED: 1680563.
RA Lufkin T., Dierich A., LeMeur M., Mark M., Chambon P.
RT Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression
RL Cell 66:1105-1119 (1991).
RN [5]; RE0003861.
RX PUBMED: 1346922.
RA Chisaka O., Musci T. S., Capecchi M. R.
RT Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6
RL Nature 355:516-521 (1992).
RN [6]; RE0003862.
RX PUBMED: 8102800.
RA Dolle P., Lufkin T., Krumlauf R., Mark M., Duboule D., Chambon P.
RT Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos
RL Proc. Natl. Acad. Sci. USA 90:7666-7670 (1993).
RN [7]; RE0003863.
RX PUBMED: 7913516.
RA Phelan M. L., Sadoul R., Featherstone M. S.
RT Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm
RL Mol. Cell. Biol. 14:5066-5075 (1994).
RN [8]; RE0014020.
RX PUBMED: 7917011.
RA Chalepakis G., Wijnholds J., Giese P., Schachner M., Gruss P.
RT Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1
RL DNA Cell Biol. 13:891-900 (1994).
RN [9]; RE0014613.
RX PUBMED: 9733765.
RA Chen J., Ruley H. E.
RT An enhancer element in the EphA2 (Eck) gene sufficient for rhombomere-specific expression is activated by HOXA1 and HOXB1 homeobox proteins
RL J. Biol. Chem. 273:24670-24675 (1998).
RN [10]; RE0014614.
RX PUBMED: 8763497.
RA Mann R. S., Chan S. K.
RT Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins
RL Trends Genet. 12:258-262 (1996).
RN [11]; RE0014859.
RX PUBMED: 1360810.
RA Langston A. W., Gudas L. J.
RT Identification of a retinoic acid responsive enhancer 3' of the murine homeobox gene Hox-1.6
RL Mech. Dev. 38:217-227 (1992).
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